• Journal of Life Science
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• v.32 no.1
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• pp.63-69
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• 2022

The thioredoxin reductase (TrxR) system is essential for cell survival and function by playing a pivotal role in maintaining homeostasis of cellular redox and regulating signal transduction pathways. The TrxR system comprises thioredoxin (Trx), TrxR, and nicotinamide adenine dinucleotide phosphate. Trx reduced by the catalytic reaction of the TrxR enzyme reduces downstream proteins, resulting in protection against oxidative stress and regulation of cell differentiation, growth, and death. Cancer cells survive by improving their intracellular antioxidant capacity to eliminate excessively generated reactive oxygen species (ROS) due to infinite cell proliferation and a high metabolic rate. Therefore, cancer cells have high dependence and sensitivity to antioxidant systems, suggesting that focusing on TrxR, a representative antioxidant system, is a potential strategy for cancer therapy. Several studies have revealed that TrxR is expressed at high levels in various types of cancers, and research on anticancer activity targeting the TrxR system is increasing. In this review, we discuss the feasibility and value of the TrxR system as a strategy for anticancer activity research by examining the relationship between the function of the intracellular TrxR system and the development and progression of cancer, considering the anticancer activity and mechanism of TrxR inhibitors.

• Korean Journal of Plant Resources
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• v.35 no.5
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• pp.667-674
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• 2022

This study was conducted to determine the three main factors [rooting time, plant growth regulators (PGRs), rooting medium] of cuttage for mass production of Sageretia thea. The experiment was observed on cuttage tray after 120 days and classified by rooting times, plant growth regulators, rooting medium. Materials were collected from natural habitats of S. thea from the Korean peninsula at March, July and September during 2019. As a result of the experiment, rooting times were showed statistically significant differences. March group's rooting rate and root length were 15 and 200% better than others. In PGRs experiment by concentration, There was no significant correlation between the control and experiment in terms of rooting rate. However, In the case of root length, IBA 500 mg/L, IBA 250 mg/L and IAA 1,000 mg/L groups were lengthened up to 170% compared to the control group, confirming statistically significant differences. As a result, we recommend treating cuttings with IBA 500 mg/L in March with Hardwood cutting.

• Korean small business review
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• v.42 no.1
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• pp.107-133
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• 2020

Many researchers conducted studies on the relationship between entrepreneur's characteristic, capability, strategy and performance of new venture. However, the development of scientific technique and the complexity of the business environment have stimulated entrepreneurial teams rather than individuals. Therefore, the necessity of theoretical and practical study on the effect of the characteristics of an entrepreneurial team on the new venture companies was suggested. Initial research on entrepreneurial team diversity has primarily addressed the impact of demographic diversity on performance. In order to verify the research model of this study, 287 delegates of new venture companies that participated in the projects at the 18 Centers for Creative Economy & Innovation in 17 regions of the country conducted validity and reliability test based on the questionnaire to which they answered. The result shows that only gender diversity among demographic diversity affected non-financial performance. Information diversity influenced career diversity on financial performance and diversity in education on non-financial performance. Also, the higher the previous sharing experience, the better the financial performance. Value diversity has negative effect on both financial and non-financial performance. Based on the results, theoretical and practical implications are derived. Also suggested are methodological limitations and future research directions.

• Korean Association of Arts Management
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• no.54
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• pp.59-93
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• 2020

The development of digital technology has made consumers more knowledgeable about products than ever before. In this regard, experts have defined consumers in the digital age as knowledge seekers and pointed out that they are proficient in acquiring and sharing product knowledge prior to purchase. For service goods such as musicals, product prior knowledge executes strong effect due to such characteristics as intangibility, inseparabilit y,and heterogeneity. Prior studies in the field of performing arts, including musicals, have revealed that the prior knowledge of the audience has a positive effect on the satisfaction of the audience and WOM(word-of-mouth) intention. However, studies in the marketing field argue that consumers' high prior knowledge may have a negative impact on customer satisfaction and product evaluation depending on conditions, as they are more likely to compare, review, and expect products more closely. Therefore, in this study, we tried to identify under what conditions the musical prior knowledge enhances audience satisfaction and WOM intention. According to the results of previous studies, a mediating effect model was established in which the musical prior knowledge enhances the WOM intention through the mediation of the audience satisfaction. Then, Transportation was introduced as a mediation variable and it was verified whether the level changed the audience satisfaction and WOM intention. The reason for the introduction of the transportation construct reflects the results of previous research that the story is important component of musical. The results showed that the musical prior knowledge has a significant effect on WOM intention through the mediation of audience satisfaction. The moderating effect of transport was also significant on the relationship between musical prior knowledge and audience satisfaction. Lastly, through moderated-mediation analysis, it was confirmed that transportation moderates the mediating effect that prior knowledge affects on the WOM intention through audience satisfaction. Based on the results, we demonstrated that a musical story is fairly important to satisfy audiences with high prior knowledge. This study could contribute to the related filed in that it introduced the transportation construct for the first time, thereby broadening the understanding of the musical audiences in the era of smart consumers.

• Journal of Practical Engineering Education
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• v.14 no.2
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• pp.267-277
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• 2022

Achievement at university is recognized in a comprehensive sense as the level of qualitative change and development that students have embodied as a result of their experience in university education. Therefore, the academic achievement of university students will be given meaning in cooperation with the historical and social demands for diverse human resources such as creativity, leadership, and global ability, but it is practically an indicator of the outcome of university education. Measurement of academic achievement by such credits involves many problems, but in particular, standardization of academic achievement by credits based on evaluation methods, contents, and university rankings is a very difficult problem. In this study, we present a model that uses machine learning techniques to predict whether or not academic achievement is excellent for D-University graduates. The variables used were analyzed using up to 96 personal information and bachelor's information such as graduation year, department number, department name, etc., but when establishing a future education course, only the data after enrollment works effectively. Therefore, the items to be analyzed are limited to the recommended ability to improve the academic achievement of the department/student. In this research, we implemented an academic achievement prediction model through analysis of core abilities that reflect the philosophy, goals, human resources image, and utilized machine learning to affect the impact of the introduction of the prediction model on academic achievement. We plan to apply the results of future research to the establishment of curriculum and student guidance conducted in the department to establish a basis for improving academic achievement.

• Journal of Korean Elementary Science Education
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• v.41 no.2
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• pp.186-198
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• 2022

With the science curriculum about to be revised in 2022, this study aimed to guide curriculum revision by addressing suggested approaches to the electromagnetism education in elementary school science curriculum. The core concepts of electromagnetism are "electric field" and "magnetic field" as a medium of force, but the current curriculum does not properly describe the core concepts of electromagnetism. Mechanics and electromagnetism should be linked in elementary schools to form science curriculum based on core concepts to solve this problem. Additionally, the nine aspects of technology extracted in this study offer various educational contexts to match the development of engineering technology based on electromagnetism. However, the current curriculum does not comprise these various contexts and focuses on the limited content of electric circuits using light bulbs. Therefore, it is necessary to expand the scope of the curriculum to better mirror real-life technology. Through the use of more diverse materials and contexts, the scope and level of STS education as well as conceptual learning could be expanded. Finally, in the case of electric circuit learning, various issues such as difficulty in connecting electric circuits and electric field concepts, representativeness of electric circuit, students' learning difficulty, and phenomena-oriented learning should be considered.

• The Journal of Korean Academy of Sensory Integration
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• v.20 no.3
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• pp.60-71
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• 2022

Objective : This study aimed to summarize and present the effects of group sensory integration treatment applied to children with and without disabilities in Korea. Methods : The search period was from January 2010 to December 2021, and databases of 'The Journal of Korean Academy of Sensory Integration', 'The Korean Journal of Occupational Therapy', 'Koreanstudies Information Service System', 'Research Information Sharing Service', 'DBpia' were used for data search. A total of 11 studies were selected, and the Patient, Intervention, Comparison, Outcome method was applied to organize them systematically. Results : As a result of the study, single-group non-randomized studies were the most common with 8 out of 11 studies (72.73%). There were 99 subjects, ranging in age from 3 to 11, and an average of 7.39. Among them, there were more children with disabilities, and 40 out of 99 (40.41%) were diagnosed with developmental disabilities the most. A total of 5 to 45 treatment intervention sessions were provided, and 60 minutes were the most frequently provided once or twice a week. The Canadian Occupational Performance Measure and The Penn Interactive Peer Play Scale were the most commonly used evaluation tools in 4 times each (12.90%). As the treatment intervention goal, social interaction skills was the most common with 8 studies (36.36%). As a result of treatment intervention, 8 studies showed significant results. Conclusion : Based on this study, it is expected that in the future, various methods of intervention of sensory integration therapy based on high quality levels can be systematically presented and used as useful information in clinical practice.

• Korean Journal of Culture and Social Issue
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• v.24 no.2
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• pp.131-151
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• 2018

The purpose of this research was to examine the characteristics of typical Korean grit as opposed to Western conceptualizations. We conducted cluster analysis to identify subgroups based on three related but distinct constructs-passion(harmonious vs. obsessive) and meaning in life. Basic needs satisfaction, life satisfaction, and ego-resilience were further assessed to explore potential group-specific differences in psychological attributes. Highly gritty individuals(n=139; M=22.51 yrs) were selected by using the median. According to our results, gritty individuals were subdivided into 3 groups: the initiative who possesses highly adaptive harmonious passion and meaning in life(35.8%), the obsessive who are high in maladaptive obsessive passion(26.1%), and the passive who are the lowest in all(38.1%). The initiative grit scored the highest in all three attributes while the two other subgroups showed culturally unique patterns. Our results suggest that culture specific factors may mold differently the unfolding and psychological outcomes of grit in Korea.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.33 no.2
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• pp.267-280
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• 2023

With development of computing and communications technologies, IoT environments based on high-speed networks have been extending rapidly. Especially, from home to an office or a factory, applications of IoT devices with sensing environment and performing computations are increasing. Unfortunately, IoT devices which have limited hardware resources can be vulnerable to cyber attacks. Hence, there is a concern that an IoT botnet can give rise to information leakage as a national cyber security crisis arising from abuse as a malicious waypoint or propagation through connected networks. In order to response in advance from unknown cyber threats in IoT networks, in this paper, We firstly define four types of We firstly define four types of characteristics by analyzing darknet traffic accessed from an IoT botnet. Using the characteristic, a suspicious IP address is filtered quickly. Secondly, the filtered address is identified by Cyber Threat Intelligence (CTI) or Open Source INTelligence (OSINT) in terms of an unknown suspicious host. The identified IP address is finally fingerprinted to determine whether the IP is a malicious host or not. To verify a validation of the proposed method, we apply to a Darknet on real-world SOC. As a result, about 1,000 hosts who are detected and blocked preemptively by the proposed method are confirmed as real IoT botnets.

• Journal of the Korean Recycled Construction Resources Institute
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• v.11 no.1
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• pp.16-24
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• 2023

Coal ash generated from thermal power plants using briquettes contains Si, Al, and Fe components. These components are the main components required for the manufacture of cement clinker. In particular, Al and Fe components form the interstitial phase of cement clinker and have an important effect on the sintering of cement clinker. In this study, a large amount of coal ash was applied as a raw material for cement clinker by content, and the mineral formation process of cement clinker to which coal ash was applied was confirmed by sintering temperature. It was confirmed that the intermediate phase was generated in the sintering temperature range of 1050 ~ 1150 ℃ in the cement clinker to which a large amount of coal ash was applied. As the content of coal ash increased, the production amount of the intermediate phase increased. The phase produced by the addition of coal ash is expected to be converted to calcium silicate phase and interstitial phase and disappear above 1350 ℃. The cement clinker applied with a large amount of coal ash at 1450 ℃ formed well-developed minerals equivalent to the standard cement clinker.