• Journal of Korean Ophthalmic Optics Society
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• v.21 no.2
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• pp.137-146
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• 2016

Purpose: The relationship between retinal conditions such as macular thickness and retinal volume of the eyes with central serous chorioretinopathy(CSC) and visual acuity was investigated. Methods: A total of 136 eyes from 78 subjects was divided into 5 groups: CSC eyes under treatment and its asymptomatic contralateral eyes, fully cured CSC eyes after the diagnosis and its contralateral, and normal eyes. Their uncorrected visual acuity(UCVA), best corrected visual acuity(BCVA), retinal thickness and retinal volume were further examined. Results: All of UCVA, BCVA, retinal thickness and retinal volume of CSC eyes under treatment were significantly different from those of asymptomatic contralateral eyes, fully cured CSC eyes and normal eyes. BCVA of the asymptomatic contralateral eyes was not significantly different from it of normal eyes, however, its retinal thickness and volume were significantly different from those of normal eyes. Increased degree of retinal volume along with the increase of retinal volume was greater in CSC eyes and its asymptomatic contralateral eyes, fully cured CSC eyes and its contralateral eyes than normal eyes. Conclusions: From the present study, it was revealed that the retinal thickness and volume of asymptomatic contralateral eyes of CSC increase as well as CSC eyes, and the change of BCVA due to CSC occurs only when the retinal thickness and volume increase in some extent.

• Journal of the Institute of Convergence Signal Processing
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• v.5 no.1
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• pp.13-17
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• 2004

In order to measure the retina thickness, the retina photographing system and the multi-channel high speed image data acquisition system is developed. This system requires the optical processing techniques and the high speed image processing techniques. The HeNe laser beam is projected the retina in artificial eye and then we sensed the reflected laser signal using APD array. The laser projection system on retina using optical instruments is implemented. In order to project the plane laser beam on retina, laser photographing system used the polygon mirror for horizontal scanning and the galvano mirror for vertical scanning. We acquired retina images in each channel of APD array, transferred computer using PCI interface the image data after real-time A/D converting.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.8 no.1
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• pp.96-101
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• 2004

In order to measure the retina thickness, there are to need the 3-D retina photographing and the high speed signal processing system. In this paper, we introduced the retina photographing system and the 16-channel high speed image data acquisition system. There are able to measure the retina thickness with sensing image the returned laser signal to APD sensor after there were projected the HeNe laser on retina. We developed the laser projection system to sense a reflected image of the retina using APD sensor, the 16-channel high speed A/D converter and PCI master interface card for image transmission into computer.

• Korean Journal of Veterinary Research
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• v.26 no.2
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• pp.221-224
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• 1986

Kainic acid가 오리 망막에 미치는 영향을 알아보기 위하여 kainic acid $50{\mu}l$($1.0{\mu}mol$)를 오리의 안구내로 주입한 후 망막을 경시적으로 관찰하였던 바 다음과 같은 결과를 얻었다. 주사후 8시간째 망막의 내내핵층과 내망상층에서 공포화가 인정되었고 24시간째는 내핵층에서 핵농축이 현저하였으며 48시간째의 예에서는 농축된 핵이 상당수 소실되면서 망막의 두께도 다소 얇게 나타났다. 주사후 96시간과 10일째는 내핵층을 구성하는 대부분의 세포가 소실되어 망막의 두께가 상당히 얇아졌고 내망상층의 두께도 경시적으로 얇아지는 경향이었다.

• The Korean Journal of Vision Science
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• v.20 no.4
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• pp.421-429
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• 2018

Purpose : We identified correlation between macular thickness and RNFL (retina nerve fiber layer) measured by OCT and axial length in Korean children divided as three groups according to refractive errors. Methods : In total, 134 eyes of 67 Korean children who experienced no eye disease and ophthalmology surgery were involved in this study and then divided as three groups such as hyperopic, emmetropic and myopic groups. Macular thickness and RNFL thickness were measured with Cirrus HD-OCT, and axial length was done with IOL Master.Macular thickness and RNFL thickness were measured by Cirrus HD-OCT, and axial length using IOL Master. Correlation between axial length and retinal thickness in three groups according to refractive errors was investigated. Results : The type of refractive error measured by axial length was myopic, emmetropic and hyperopic groups in order, showing significant difference (p<0.05). The center thickness of macular was myopic, emmetropic and hyperopic groups in order, showing significant difference(p<0.05). The thicknesses of superior, nasal and inferior regions in peripheral macula were the thinnest in myopic group (p<0.05). It was shown that positive correlation was found between the center thickness of macula and axial length (r=0.283, p<0.05), while negative correlation was found between the peripheral thickness of RNFL and axial length. The temporal thickness of RNFL represented the thickest in myopic group, showing positive correlation with axial length(r=0.39, p<0.05). The superior, nasal and inferior thickness of RNFL represented negative correlation with axial length, showing statistically significant in the nasal thickness of RNFL(r=-0.23, p<0.05). Conclusion : Through this study, we identified correlation between macular thickness, the thickness of RNFL and axial length using OCT in Korean children, and also found the differences in three refractive error groups.

• Korean Journal of Cognitive Science
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• v.14 no.3
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• pp.1-11
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• 2003

Two experiments were conducted to investigate effects of target types and retinal eccentricity on the search of a target while both target and background stimuli were static or moving. A visual search task was used in both experiments. The retinal eccentricity was determined by five concentric circles increasing by the unit of 1.6 and the target was different from the background stimuli in either orientation(orientation target) or a distinctive feature(feature target). In Experiment 1 where both the target and background stimuli were presented statically, an interaction between retinal eccentricity arid target type was found. While search time of the orientation target was not affected by the retinal eccentricity, that of the feature target increased as the retinal eccentricity increased. In Experiment 2 where all stimuli were moving, the interaction effect was also found. But the reason was not the same as that in Experiment 1. In the moving condition, while the search time of the orientation target decreased consistently as the retinal eccentricity increased, that of the feature target was not affected by the retinal eccentricity. The implications and limitations of the present results were discussed with respects to the real world situations such as driving cars or flying airplanes.

• Progress in Medical Physics
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• v.19 no.1
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• pp.73-79
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• 2008

Retinal prosthesis is regarded as the most feasible method for the blind caused by retinal diseases such as retinitis pigmentosa (RP) or age related macular degeneration (AMD). Recently Korean consortium launched for developing retinal prosthesis. One of the prerequisites for the success of retinal prosthesis is the optimization of the electrical stimuli applied through the prosthesis. Since electrical characteristics of degenerate retina are expected to differ from those of normal retina, we performed voltage stimulation experiment both in normal and degenerate retina to provide a guideline for the optimization of electrical stimulation for the upcoming prosthesis. After isolation of retina, retinal patch was attached with the ganglion cell side facing the surface of microelectrode arrays (MEA). $8{\times}8$ grid layout MEA (electrode diameter: $30{\mu}m$, electrode spacing: $200{\mu}m$, and impedance: $50k{\Omega}$ at 1 kHz) was used to record in-vitro retinal ganglion cell activity. Mono-polar electrical stimulation was applied through one of the 60 MEA channel, and the remaining channels were used for recording. The electrical stimulus was a constant voltage, charge-balanced biphasic, anodic-first square wave pulse without interphase delay, and 50 trains of pulse was applied with a period of 2 sec. Different electrical stimuli were applied. First, pulse amplitude was varied (voltage: $0.5{\sim}3.0V$). Second, pulse duration was varied $(100{\sim}1,200{\mu}s)$. Evoked responses were analyzed by PSTH from averaged data with 50 trials. Charge density was calculated with Ohm's and Coulomb's law. In normal retina, by varying the pulse amplitude from 0.5 to 3V with fixed duration of $500{\mu}s$, the threshold level for reliable ganglion cell response was found at 1.5V. The calculated threshold of charge density was $2.123mC/cm^2$. By varying the pulse duration from 100 to $1,200{\mu}s$ with fixed amplitude of 2V, the threshold level was found at $300{\mu}s$. The calculated threhold of charge density was $1.698mC/cm^2$. Even after the block of ON-pathway with L-(1)-2-amino-4-phosphonobutyric acid (APB), electrical stimulus evoked ganglion cell activities. In this APB-induced degenerate retina, by varying the pulse duration from 100 to $1200{\mu}s$ with fixed voltage of 2 V, the threshold level was found at $300{\mu}s$, which is the same with normal retina. More experiment with APB-induced degenerate retina is needed to make a clear comparison of threshold of charge density between normal and degenerate retina.

• The Monthly Diabetes
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• s.255
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• pp.18-21
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• 2011

당뇨병에 걸리면 조심해야 할 눈에 오는 합병증 중 가장 흔한 것은 망막병증이고, 이 망막병증이 계속 진행되면 녹내장이 발생할 수 있다. 그런데 녹내장은 눈의 구조와 기능을 손상시켜 결국에는 실명에 이르게 할 수 있는 질환이라 주의해야 한다. 녹내장의 발견에서부터 진행과정, 예후 등을 한국녹내장관리협회 정상갑 회장과의 인터뷰로 자세히 알아보자.

• Journal of The Korean Ophthalmological Society
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• v.54 no.9
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• pp.1445-1451
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• 2013

Purpose: To report long-term changes in the average retinal nerve fiber layer (RNFL) thickness in 2 patients who had intravitreal bevacizumab (IVB) injection for diabetic papillopathy. Case summary: A 36-year-old patient with diabetes complained of decreased visual acuity (20/200) in the right eye. The fundus examination showed optic disc swelling in both eyes. The average RNFL thickness based on optical coherence tomography (OCT) increased to $278{\mu}m$ and Goldmann perimetry showed nasal visual field defect in the right eye. The IVB was injected into the right eye. Three weeks after the IVB injection, RNFL thickness decreased to $135{\mu}m$ and visual acuity improved to 20/25 in the right eye. However, RNFL thickness increased from 126 to $207{\mu}m$ and visual acuity decreased to 20/32 in the left eye. Thus, IVB was injected into the left eye. In week 3, RNFL thickness decreased to $147{\mu}m$ and visual acuity improved to 20/20 in the left eye. At 12 months after IVB injection, RNFL thickness was $87{\mu}m$ in the right eye and $109{\mu}m$ in the left eye. A 57-year-old patient with diabetes complained of decreased visual acuity (20/200) and showed optic disc swelling in the right eye. The average RNFL thickness increased to $252{\mu}m$ and Goldmann perimetry showed an enlarged blind spot in the right eye. IVB was injected into the right eye. After 3 weeks, RNFL thickness decreased to $136{\mu}m$ and visual acuity improved to 20/70 in the right eye. Six months after IVB injection, RNFL thickness was $83{\mu}m$ in the right eye. Conclusions: Visual acuity progressively improved within 3 weeks and RNFL thickness measured by spectral domain OCT showed progressive thickness reduction in 2 cases of diabetic papillopathy patients who had IVB injections.

• Applied Microscopy
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• v.32 no.1
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• pp.17-30
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• 2002

The retinae of Todarodes pacificus and Octopus minor are divided into four layers that are an outer segment, a rod base region, an inner segment, and a plexiform layer, respectively. The retina of Octopus minor is about $20{\mu}m$ thicker ($400{\sim}420{\mu}m$) than that of Todarodes pacificus ($385{\sim}400{\mu}m$). A retina is composed of visual cells and supporting cells. The microvilli of length $0.6{\sim}0.7{\mu}m$ are packed densely on top of the supporting cells of Octopus minor while they are not found in Todarodes pacificus. The visual cells and supporting cells have pigment granules that exclude light. In case of Todarodes pacificus, the pigment granules of the visual cell are larger ($2.0{\times}0.5{\mu}m$) than those of the supporting cell ($1.0{\times}0.3{\mu}m$). But, the sizes of both cells are similar in Octopus minor. In the upper portion of a visual cell, microvilli shaped like a comb are forming a rhabdome (diameter, 60 nm) of a hexagonal structure. The rhabdome consists of 4 rhabdomere and the total area of a rhabdom of Octopus minor is larger than that of Todarodes pacificus. The synaptosome constructing a plexiform layer in Todarodes pacificus are divided into two types, each of which possess electron dense-core vesicles and electron lucent vesicles, respectively. Octopus minor also has two types of synaptosomes but each type comprises a mixture of electron dense vesicles and electron lucent vesicles, and electron lucent vesicles only, respectively, which is different from the case of Todarodes pacificus.