• The Journal of the Korea Contents Association
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• v.17 no.8
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• pp.121-129
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• 2017

The evolution of biotechnology is no longer strange to the hypothetical scenario of cloning human genes to make cloned human beings. The characters of are cloned humans made in the laboratory by the 100-year-old life planning. They are cohabited in a school called Hailsham, where they are secretly reared. The purpose of this project is to provide healthy organs to real human patients with incurable diseases. The main characters Cathy, Tommy, and Ruth experience the growth of body and consciousness here during adolescence, and they also know the secret of identity as a clone. As adults, they move to a second residence, Cottage and are ready to begin organ donation. The second stage is also part of a program to provide more genuine-like organs to real patients. Even though they know all the plans that humans have built, they do not resist them and fatefully accept their situation. However, their non-responsiveness is not a declaration of renunciation of life, but a self-sacrificing life extension for another future that is the extension of life through their organ donation. The film emphasizes the fraternity and sacrificial attitudes of the cloned human beings and shows that it is necessary to continue the discussions on cloned human beings from a bio-ethical point of view supported by philosophical reasons.

• Journal of Life Science
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• v.28 no.11
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• pp.1321-1331
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• 2018

The aim of this study was to separate the photosensitizer that induces apoptosis of U937 and SK-HEP-1 cells from Nostoc commune. Dried N. commune was extracted with $CH_2Cl_2/MeOH$ (1:1) to separate the photosensitizer using various chromatographic techniques. The isolated compound was identified as pheophytin a ($C_{55}H_{74}N_4O_5$) with a molecular weight of 870. Its photodynamic activities were assessed under different irradiation conditions (light and non-light) at the same concentration range of $1.15-23.0{\mu}M$. The apoptosis inducing activity in U937 or SK-HEP-1 cells appeared only in the light. The mechanisms underlying the pheophytin a-mediated photodynamic inhibition of cancer cells were further investigated by examining cell morphology changes, cytotoxicity, caspase-3/7 activity, fluorescence staining, flow cytometry analysis, and DNA fragmentation in these two cell lines. The positive control and the light irradiation group showed typical apoptotic responses, including morphological changes, cytotoxicity, caspase activity, nucleus shrinkage owing to chromatin condensation, DNA laddering, and the presence of apoptotic bodies. Cytotoxicity markedly increased in a dose-dependent manner after a 12 hr exposure. Caspase-3/7 activity was higher in U937 cells than in SK-HEP-1 cells. Apoptosis induction therefore appeared to be both concentration- and light-dependent. In conclusion, pheophytin a, isolated from the blue green alga N. commune, had a photodynamic apoptosis-inducing effect on U937 and SK-HEP-1 cells. The findings reported here can be used as basic data for the development of next-generation photosensitizers from N. commune.

• Journal of The Korean Society of Emergency Medicine
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• v.29 no.5
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• pp.430-436
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• 2018

Objective: The purpose of this study was to evaluate whether or not the d-dimer level indicating hyperfibrinolysis could be a predictor of early poor outcome (massive transfusion, death within 24 hours) associated with trauma-induced coagulopathy in blunt trauma without significant brain injury. Methods: This study was a retrospective observational study using 516 blunt trauma patients without significant brain injury. The poor outcome group, including patients receiving massive transfusion and those who died within 24 hours, consisted of 33 patients (6.4%). The variables were compared between the poor outcome group and good outcome group, and logistic regression analysis was performed using statistically significant variables. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the poor outcome prediction ability of the initial d-dimer level. Results: The poor outcome group showed more serious anatomical, physiological, and laboratory data than the good outcome group. In the ROC curve analysis for evaluation of the poor outcome prediction of the d-dimer level, the area under the curve value was 0.87 (95% confidence interval [CI], 0.84-0.90) while the cut-off value was 27.35 mg/L. In the logistic regression analysis, the high d-dimer level was shown to be an independent predictor of poor outcome (adjusted odds ratio, 14.87; 95% CI, 2.96-74.67). Conclusion: The high d-dimer level (>27.35 mg/L) can be used as a predictor for the poor outcome of patients with blunt trauma without significant brain injury.

• The Korean Society of Law and Medicine
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• v.22 no.4
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• pp.37-55
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• 2021

On March 19, 2021, the Korean Bioethics Association and related academic circles published a joint statement criticizing the partial revision of Infectious Disease Control And Prevention Act. However, according to the Bioethics And Safety Act of Korea, research conducted by the state or local governments for public welfare is excluded from human subjects research project. In addition, since the Korean legal system is not based on the dichotomy between research and surveillance, the discussion of the US Common Rule cannot be directly applied to Korea. For the harmonious operation of the state's duty to manage infectious diseases and the Institutional Review Boards, institutional alternatives should be prepared in consideration of the following issues. First, the related academic community should first pay attention to the problems of the current laws in Korea. Second, it should be understood that the state is carrying out many tasks without the consent of the parties in order to fulfill its duty to manage infectious diseases. Third, when presenting institutional alternatives, it is necessary to consider the feasibility of implementation in Korea. An in-depth discussion of the institutional alternatives by the Medical Law Society and other related academic circles is necessary.

• Korean Journal of Culture and Social Issue
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• v.23 no.1
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• pp.1-24
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• 2017

This article aimed to test whether specific social values (i.e., achievement vs. benevolence) could cause changes in decision making on bio-ethical issues. Study 1 investigated value preferences among young Korean college students according to Schwartz's (1992) model of social values. According to the results, the preference for achievement value was correlated negatively with the preference for benevolence value. In Study 2, following a sentence completion task which was conducted to trigger specific values, the participants had to indicate their ethical decisions regarding animal experiment, euthanasia, organ transplantation, biotechnology, sex selection and human cloning, Irrespective of the value priming (achievement vs. benevolence), there were more utilitarian decisions about animal experiment, euthanasia and organ transplantation. In contrary, there were more deontological decisions about sex selection and human cloning. Study 3 introduced a word completion task to assess implicit value preferences. The results showed that the participants with implicit preferences for the benevolence value in the condition of benevolence value priming were more frequently against animal experiments and organ transplantation than those with implicit value preferences for the achievement value. Social values are discussed for understanding one's bioethical decision making.

• Research in Plant Disease
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• v.29 no.4
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• pp.459-463
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• 2023

This study was conducted to investigate the plant-parasitic nematodes of ornamental foliage plants, citrus orchards, and tea plantations from July to December 2022. As a result of the investigation of plant-parasitic nematodes in 415 foliage plants, root-lesion nematodes were detected most frequently, followed by root-knot nematodes, pin nematodes, and other nematodes. In tea plantations, spiral nematodes, cyst nematodes, and root-knot nematodes were detected. Citrus nematodes, ring nematodes, and root-knot nematodes were discovered in citrus orchards. In foliage plants, tea plantations, and citrus orchards, the detection rate of plant-parasitic nematodes was not high, but root-lesion nematodes were detected. Therefore, it is necessary to apply appropriate control methods to manage root-lesion nematodes during the cultivation of foliage, tea, and citrus plants.

• Korean journal of applied entomology
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• v.63 no.1
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• pp.53-61
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• 2024

The susceptibility of Aphis gossypii populations collected from three fields (WJ, CC, and GS) was evaluated to three insecticides (afidopyropen, chlorfenapyr and cyantraniliprole) and three binary mixtures. Three field populations showed resistance ratios of over 100 to all insecticides. The Combination Index (CI), %M_(synergism), Co-Toxicity Coefficient (CTC), Wadley Ratio (WR), Synergism Ratio (SR) and Abbott Ratio (AR) were used to evaluate combined effect of the insecticides. Afidopyropen + chlorfenapyr (CI ≤ 0.16; %M_(synergism) ≥ 94; CTC ≥ 764.5; WR ≥ 6.4; SR ≥ 6.9 and AR ≥ 1.1) showed a synergism in all filed populations. WJ and CC populations showed a synergism in all binary mixtures of insecticides, but GS population showed an antagonism for chlorfenapyr + cyantraniliprole (CI, 1.63; %M_(synergism), 30; CTC, 64.0; WR, 0.6 and AR, 0.54) and afidopyropen + cyantraniliprole (CI, 6.7; %M_(synergism), 1; CTC, 19.8; WR, 0.2 and AR ≤ 0.55). All mixtures (afidopyropen + chlorfenapyr, chlorfenapyr + cyantraniliprole and afidopyropen + cyantraniliprole) showed a control value of over 99% after 21 days of treatment in the field. This study highlights that binary mixtures of three insecticides serve as an effective control strategy for A. gossypii.

• Journal of Korean Medical classics
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• v.18 no.3 s.30
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• pp.207-212
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• 2005

통과대진사탁명문지설특징적연구득출이하결론(通過對陳士鐸命門之說特徵的硏究得出以下結論): 1. 명문위선천지화(命門爲先天之火), 차종개념상역가위선천지수화(且從槪念上亦可爲先天之水火). 2. 명문지화가칭지위선천지화(命門之火可稱之爲先天之火), 신화(腎火), 신중지화(腎中之火), 무형지화(無形之火), 진화(眞火), 건화(乾火), 원기(原氣), 음중지화(陰中之火), 수중유양등(水中有陽等); 이명문지수가칭지위선천지수(而命門之水可稱之爲先天之水), 신수(腎水), 신중지수(腎中之水), 무형지수(無形之水), 진수(眞水), 원정(原精), 음중지수(陰中之水), 화중유음등(火中有陰等). 3. 진수가생진화(眞水可生眞火), 진화역가생진수(眞火亦可生眞水), 양자위호생적관계(兩者爲互生的關係). 강조료유형지화(强調了有形之火), 수극화(水克火), 단무형지화(但無形之火), 수생화(水生火). 4. 명문지화시일양함어이음지간적감괘상(命門之火是一陽陷於二陰之間的坎卦象). 5. 인적생명활동고수화이생, 이신중적진화진수지명문시기본원(而腎中的眞火眞水之命門是其本源). 6. 명문시운행십이경맥적주체(命門是運行十二經脈的主體), 시십이경지주(是十二經之主), 차위촉사생성십이관공능적십이관지화원(且爲促使生成十二官功能的十二官之化源), 고위십이관지주(故爲十二官之主). 7. 명문적작용가영향정개십이관(命門的作用可影響整個十二官), 우기시인화생토적관계(尤其是因火生土的關係), 대비적공능적영향갱대(對脾的功能的影響更大). 8. 인적생명지성쇠의고명문지화, 고명문지화고갈즉인적생명장종결(故命門之火枯竭則人的生命將終結). 9. 오곤(吳崑), 장개빈등계승료류하간적주장(張介賓等稽承了劉河間的主張), 기인위자하향상수지제칠절처위시명문(旣認爲自下向上數至第七節處爲是命門), 차처기위소심(此處旣爲小心). 10. 진사탁계승상술학설화조헌가지설(陣士鐸繼承上述學說和趙獻可之說), 주장칠절지방시소심(主張七節之芳是小心), 차인위차처기위명문소재(且認爲此處旣爲命門所在).

• Journal of Korea Society of Industrial Information Systems
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• v.18 no.3
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• pp.47-56
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• 2013

With the development of the morden medical science technology, the life of the men is keeping by medical technology. But if a proper treatment could not be provided to the patient in pre-hospital phase and the patient could not be transferred to the necessary hospital timely, it can not prevent the serious damage to the patient. In this paper, when an emergency was generated, the emergency medical technician can give the most suitable first aid to the patient by our proposed efficient emergency medical information system using heuristic knowledge.

• Korean Journal of Environmental Biology
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• v.41 no.3
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• pp.193-203
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• 2023

Ethyl formate (EF) is a naturally occurring insecticidal compound and is used to control pests introduced from abroad, in quarantine, by a fumigation method. In particular, it is mainly used as a substitute for methyl bromide and is less toxic to humans and less harmful to plants. This study aimed to investigate the possible acute toxicity of EF to useful organisms, and how to reduce phytotoxicity in watermelon, zucchini, and oriental melon. After fumigation with EF for 2 h, the LC₅₀ values for earthworms, honey bees, and silkworms were 39.9, 7.09, and 17.9g m^-3, respectively. The degree of susceptibility to EF was in the order of earthworms, silkworms, and honey bees based on the LC₅₀ value, and EF fumigation induced stronger acute toxicity to honey bees. Phytotoxicity was observed in watermelon leaves treated with a concentration of 7.5 g m^-3 EF, and when treated with a concentration of 10.0g m^-3, it was confirmed that the edges of watermelon leaves were charred and seemed to be damaged by acids. Zucchini and melon, and other cucurbits, showed strong damage to the leaves when treated with a concentration of 10 g m^-3, and sodium silicate, at concentrations of 10% and 20%, was used to reduce phytotoxicity. Therefore, acute toxicity towards nontarget organisms and phytotoxicity during the fumigation of EF should be reduced for efficient agricultural pest control.