• Journal of Life Science
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• v.17 no.7 s.87
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• pp.931-936
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• 2007

The aim of this study was to evaluate the effects of Codium Fragile(CF) extract on the collagen content and collagen cross-link content of the connective tissues, alkaline phosphatase activity and calcium levels of serum in ovariectomized estrogen-deficient rats. Three groups were surgically ovariectomized. The fourth group was sham operated. Sprague-Dawley female rats were randomly assigned to the following groups : sham-oper-ated rats(Sham), ovariectomized control rats (OVX-CON), ovariectomized rats supplemented with CF at 50 mg/kg body wt and 200 mg/kg body wt, respectively The CF were orally administrated at 1mLa day. The ovariectomy caused a decreasing in collagen content in bone, cartilage, skin and lung tissues. However CF groups, supplementation with Codium Fragile extract, increased in collagen contentin bone and cartilage tissues than OVX-CON group. Fyridinoline content in cartilage collagen was de-creased by ovariectomy but supplementation with the CF extracts was similarly increased to Sham. Alkaline phosphatase activity on serum of CF groups decreased than OVX-CON group. These results suggest that CF supplementation prevents post-menopausal bone loss, thus it may be used possibly to improve the quality of life in menopausal women.

• Journal of Life Science
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• v.20 no.1
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• pp.90-96
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• 2010

Menopause increases the onset of hypertension and heart disease. Whereas it increases the blood LDL-cholesterol, triglyceride and total-cholesterol levels, the HDL-cholesterol concentration is reduced. Accordingly, we examined the effect of internal organs of Todarodes pacificus (IOT) on improvement in blood flow ability and changes in serum lipid content by using ovariectomized rats. For this study, the following four groups of 9-week-old Sprague-Dawley strain female rats were evaluated over 6 weeks: normal rats (SHAM), ovariectomized rats (CON) and ovariectomized rats that were treated with IOT extracts. Ovary removal promoted platelet aggregability. However, IOT administration in the CON group after ovary excision resulted in a hinderance of coherence. The blood vessel passing time of ovariectomized rats was slower than the SHAM group. But the blood flow ability, which was slowed down for ovary removal, was improved by IOT administration. Serum triglyceride levels were significantly reduced by IOT administration. Moreover, blood HDL-cholesterol levels were reduced by ovary removal. However, IOT administration after ovary excision significantly increase HDL-cholesterol levels. The biological activity of IOT could be confirmed from these results. Moreover, IOT can be used in the development of functional foods which are meant to improve blood circulation and anti-platelet aggregation function. According to these results, we could know that IOT improved blood flow and anti-platelet aggregation. Therefore, it is expected that IOT can be used for the development of functional foods.

• Journal of Life Science
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• v.19 no.12
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• pp.1841-1846
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• 2009

Menopause is often associated with the incidence of several chronic diseases including osteoporosis, cardiovascular disease, and obesity. Hormone replacement therapy (HRT) is an effective regimen that has been found to prevent these diseases in postmenopausal women. However, HRT is accompanied by an increased risk of unfavorable outcomes. Therefore, this study was conducted to evaluate the effects of Ecklonia cava, a kind of seaweed, extract on bone turnover markers in symptomatic menopausal women. For this study, the following four groups of 9-week-old Sprague-Dawley rats were evaluated over 6 weeks: normal rats (SHAM), ovariectomized rats (OVX-CON) and ovariectomized rats that were treated with Ecklonia cava extracts. The optimum extraction temperature and solvent of Ecklonia cava were found to be $80^{\circ}C$ and 80% ethanol. We measured the osteocalcin and CTx content, enzyme ALP activity in serum and collagen content in the cartilage, bone, skin and lungs. We found that the levels of indicators of bone metabolism such as ALP, osteocalcin and CTx were lower in rats in the Ecklonia cava extract group than the OVX-CON group. In addition, the collagen contents in the bone, cartilage, skin and lungs decreased in response to ovariectomy, but the levels of collagen were greater in the bone of rats that were treated with Ecklonia cava extract than in the bone of rats in the OVX-CON group. According to these results, we were able to know the effects of Ecklonia cava extract on bone aging in ovariectomized rats. Consequently, we expect Ecklonia cava extract to have an effect on bone aging in postmenopausal women.

• Journal of Life Science
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• v.15 no.6 s.73
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• pp.1028-1033
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• 2005

Estrogen deficiency in peri-and postmenopausal women results in variety of neurovegetative, psychic and somatic symptoms, and may contribute to severe diseases within the aged female population. Capsosiphon fulvecense (CF), green algae, loaded with large amount of proteins, calcium and ion. This seaweed is distributed in the Southern coast in Korea and widely throughout the world. Our objective was to investigate the effects of Capsosiphon fulvecense (CF) extract on serum lipid concentration and platelet aggregation in ovariectomized rats. Three groups were surgically ovariectomized (OVX). The fourth group was sham operated. Sprague-Dawley female rats were randomly assigned to the following groups : sham-operated rats (Sham), ovariectomized control rats (OVX-Control), ovariectomized rats supplemented with CF at 50mg/kg bw/d (OVX-CF5O) and ovariectomized rats supplemented with CF at 200mg/kg bw/d (OVX-CF200). The serum triglyceride level was significantly decreased after supplemented with the CF extracts. The serum HDL-cholesterol level in the OVX-CF group was significantly higher than the level in the OVX-control group. The ability of platelet aggregation treated with CF extract (CF group) was $7\%$ less than OVX-control group. Taken these together, CF extract may be used to improve the quality of life in menopausal women.

• Proceedings of the Korea Contents Association Conference
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• 2012.05a
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• pp.373-374
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• 2012

치료레크리에이션은 사회에 있는 많은 사람들이 그 대상이 될 수 있다. 이러한 치료레크리에이션 서비스대상은 특수대상과 일반대상으로 구분된다. 한국치료레크리에이션협회에서 실시하고 있는 대상에서 특수대상으로는 발달장애아동, 물질중독청소년, 가출청소년, 정신장애인, 뇌졸중노인, 치매노인, 장애노인 등이고 일반대상으로는 인터넷 중독성향 청소년, 직장인, 일반인가족, 갱년기 주부, 건강노인, 건강노인부부 등이다. 한편, 우리나라에서는 급속한 고령화로 인하여 가족과 사회의 보호를 필요로 하는 의존적 노인들이 점차 증가하고 있다. 특히 보호의 필요성이 가장 높다고 할 수 있는 치매노인의 절대수가 증가할 것으로 예상된다. 그러나 현대화, 산업화에 의해서 발생하는 핵가족화, 여성의 사회참여 증가 등으로 가족의 노부모 부양기능은 급격히 약화되고 있다. 이에 따라 이들의 의료 및 사회적 보호문제는 노인복지제도의 주요한 과제로 등장하게 되었다. 따라서 본(本) 고(稿)에서는 노인복지제도의 향상의 일환으로 노인을 위한 치료레크리에이션의 실제 활동 프로그램을 제안해보도록 하고자 한다.

• Journal of Life Science
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• v.15 no.5 s.72
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• pp.834-839
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• 2005

The aim of this study was to evaluate the effects of three different mulberry cultivars extracts on serum lipid contents in ovariectomized estrogen-deficient rats. Sprague-Dawley female rats were randomly assigned to the following groups: sham-operated rats (sham), ovariectomized control rats (OVX-control), ovariectomized rats supplemented with $ 80\% $ ethyl alcohol extracts from various kinds of Tajikistan mulberry (OVX-TM), Korea mulberry (OVX-KM) and China mulberry (OVX-CM) at 200mg/kg bw/day, respectively. The mulberry extracts were orally administrated at 1mL per day. The body weights of OVX rats were significantly heavier than the sham-operated rats at all values (p <0.05). The ovariectomy caused an expected increasing in the levels of serum total cholesterol and triglyceride. The serum HDL-cholesterol level on the OVX-TM, OVX-KM and OVX-CM groups were higher than in the OVX-control group.

• Journal of Life Science
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• v.15 no.2 s.69
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• pp.242-247
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• 2005

The aim of this study was evaluated the effect of biological activity of Hijikia fusiforme (HF). To investigate the effects of biological activity of HF ethanol extracts, Sprague-Dawley female rats were randomly assigned to the following groups: sham-operated rats (Sham), ovariectomized control rats (OVX-control), ovariectomized rats supplemented ethanol extracts of HF at 50 mg/kg bw/day (OVX-HF50), ovariectomized rats supplemented ethanol extracts of HF at 200 mg/kg bw/day (OVX-HF200). HF ethanol extracts were orally supplemented at the level of 1 mL per day. The body weight gain, food intake and food efficiency ratio were not significantly different between groups. Although total-cholesterol and triglyceride were increased in the ovariectomized control, supplementation with the HF extracts decreased the levels. And HDL-cholesterol levels were significantly increased after supplementation with the HF extracts $(p<0.05)$. According to these results, we could known the effects biological activity of Hijikia fusiforme. Consequently, we expect the effects of Hijikia fusiforme extract on cardiovascular diseases aging coming from postmenopausal.

• The Journal of Korean Obstetrics and Gynecology
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• v.19 no.3
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• pp.257-266
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• 2006

Purpose : The purpose of this study is to evaluate the effects of Insamyang-yeongtang on menopausal disorder patients. Methods : We surveyed 15 menopausal disorder patients who had been administered Insamyang-yeongtang. The patients of menopausal disorder had been estimated twice with Kupperman's index. Results : When patients had been not administered Insamyang-yeongtang, the mean of Kupperman's index score are 42.73(SD ${\pm}$19.16). When administered Insamyang-yeongtang, the mean of kupperman's index score are 25.87(SD ${\pm}$19.16). The difference mean of first and last score are 16.87(p-value 0.001). Conclusion : This study suggests that Insamyang-yeongtang is significantly effective on menopausal disorder patients.

• Journal of Oriental Medical Thermology
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• v.5 no.1
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• pp.59-68
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• 2006

Objective: The purpose of this study is to evaluate the effects of Insamyang-yeongtang on menopausal disorder patients Methods : We surveyed 15 menopausal disorder patients who had been administered Insamyang-yeongtang. The patients of menopausal disorder had been estimated twice with Kupperman's index. Result : When patients had been not administered Insamyang-yeongtang. the mean of Kupperman's index score are $42.73(SD{\pm}19.16)$. When administered Insamyang-yeongtang, the mean of kupperman's index score are $25.87(SD{\pm}19.16)$. The difference mean of first and last score are 16.87(p-value 0.001). Conclusion : This study suggests that Insamyang-yeongtang is significantly effective on menopausal disorder patients.

• The Journal of Korean Obstetrics and Gynecology
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• v.22 no.4
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• pp.46-64
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• 2009

Purpose: The purpose of this study is to discuss the usage of Kamisoyo-san on menopausal disorder by literatual research. Methods: 33 papers and 47 books about Kamisoyo-san and menopausal disorder were used to develop this article. Results: According to the papers and the books, Soyo-san was first appeared in Taepyungheminhwajegookbang. It was modified to Kamisoyo-san and it has been used to treat menopausal disorder for more than several hundreds of years. There is much evidence of the causes, mechanisms, and symptoms of menopausal disorder corresponding with Kamisoyo-san's indications. Currently, scientific research supports that Kamisoyo-san has many effects on the symptoms of menopausal disorder. Conclusions: Kamisoyo-san is effective on menopausal disorder. We suggest that Kamisoyo-san should be given an insurance code for the treatment of menopausal disorder for the benefits to numerous patients suffering from the disorder.