• 한국수의병리학회지
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• 제6권2호
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• pp.61-68
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• 2002

모빌리 바이러스에 의한 급성, 아급성, 전염성, 열성, 질환으로 전신형, 호흡기형, 소화기형, 신경형, 안형, 피부형으로 구분할 수 있다. 이 바이러스는 사람의 홍역 바이러스와 밀접한 관련이 있기 때문에 일명 개홍역 또는 모빌리 바이러스 감염증이라고도 한다. (중략)

• 한국임상수의학회지
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• 제27권6호
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• pp.755-759
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• 2010

6년령의 암컷 닥스훈트견이 2일전 발생한 발작증상으로 내원하였다. 기본 신체검사, 실험실 검사 및 신경검사를 통해, 뇌 질환에 의한 발작이 의심되었다. 환자는 1.5T와 7T 자기공명영상을 통한 진단이 시도 되었다. T2 영상에서 간뇌 에서 연수 부위까지 광범위한 고신호성 뇌병변이 관찰되었다. 뇌척수액의 중합효소연쇠반응(RT-PCR)을 통하여, 개 디스템퍼 바이러스가 검출되었으며, 이를 근거로, 개 디스템퍼 바이러스에 의한 뇌수막염이 최종 진단 되었다. 지속적인 상태 악화에 의해, 환자는 진단 7일 뒤 보호자의 요청에 의해 안락사가 실시되었다. 사후 부검을 통한 조직검사에서 자기공명영상과 같은 부위의 뇌병변이 확인 되었다. 결론적으로 본 증례는 바이러스에의한 뇌병변의 1.5T와 7T 자기공명영상을 통한 첫 번째 진단 증례 보고 이다.

• 한국임상수의학회지
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• 제21권2호
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• pp.87-92
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• 2004

본 연구에서는 우리나라 실정에 맞는 개 디스템퍼에 대한 예방접종 프로토콜을 마련하기 위하여, 국내에서 사용 중인 4종류의 상업용 백신과 3 가지의 예방접종 스케줄에 따른 강아지의 면역형성 능력을 비교 평가하였다. 생후 6주령에 예방접종을 실시하기 위하여 동물병원에 내원한 120두의 강아지를 4종류의 백신[C, G, K, V (또는 V3)군]과 예방접종 스케줄(2, V4 군)에 따라 20두씩 임의배치 하여 C, G, K, V(또는 3)군은 3주 간격으로 3회(6, 9, 12주), V2 군은 5회(6, 8, 10, 12, 14주), V4 군은 3회(6, 10, 14주)에 피하로 예방접종을 실시하였다. 초유를 섭취한 7마리 강아지의 모체이행 항체의 소장상태를 확인한 결과 모체이행항체는 생후 6주령에 방어수준 이하로 떨어졌다. 백신에 따른 면역형성능에서 V 백신의 면역형성 능력이 다른 백신보다 우수하였으며 백신 종류에 따라 면역형성 능력에 차이가 인정되어 사용되는 백신의 효능을 주기적으로 평가하여야 할 것으로 판단되었다. 그리고 가장 효과적인 예방접종 스케줄은 6주령에 예방접종을 시작하여 3주 간격으로 3회 접종하는 것으로 판단되었다. 그러나 예방접종을 실시한 모든 군의 대부분의 강아지는 생후 9주령까지 항체가 수준이 방어수준 이하로 나타나 개 디스템퍼의 감염을 예방하기 위하여 이 시기까지는 감영위험성이 높은 곳에 노출되는 것을 피해야 할 것으로 생각되었다.

• 한국임상수의학회지
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• 제21권1호
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• pp.80-82
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• 2004

A 3 month-old male dog with clinical signs of anorexia, soft stool, ocular and nasal discharge, cough and respiratory distress was submitted to the Cheju National University for diagnosis. At necropsy, tan to pulp]e-red sublobar to lobar consolidations were presented in apical and cardiac lobe of lung. Histopathologically, severe diffuse bronchointerstitial pneumonia with necrotic bronchiolitis was noted in the lung. The demyelinating encephalitis and astrocytosis were presented in cerebellum and cerebrum. Numerous round, ovoid or cluster of tachyzoites were also identified in alveolar lumen, alveolar wall and cytoplasm of macrophages in the lung. The orgasnisms were demonstrated as Toxoplasma (T) gondii by immunohistochemistry. Intranuclear or intracytoplasmic eosinophilic inclusion bodies were seen in the glial cells of the cerebellum. Canine distemper virus (CDV) specific antigens were demonstrated in the cerebellum by the immunohistochemistry. In our knowledge, this is believed to be the first confirmed report of co-infection of CDV and T gondii in dog in Korea.

• 한국임상수의학회지
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• 제17권1호
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• pp.13-20
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• 2000

Recently cases of canine distemper have occurred in Korea despite vaccination was carried out nationwidely. This study was performed to establish rapid diagnosis of canine distemper by RT-PCR, nested PCR, and serological test. A total of 30 dogs, which were suspected canine distemper clinically, was examined. RT-PCR and nested PCR were specific for the amplification of CDV H gene and sensitive to detect 7 TCID50 of Onderstepoort strain. By RT-PCR, H gene was detected in 6(20%) of 30 peripheral bloods from dogs. And H gene was detected in 10(33.3%) of 30 samples by nested PCR. H gene was detected from 1 brain of 6 years-old Beagle dog and 1 lung of 2 months-old Shihtzu dog, in which peripheral blood H gene was not detected. Serum neutralizing antibody titer against Onderstepoort strain ranged from 4 to 1,024 in 30 patients. No correlation was observed between the results of nested PCR and titiers of neutralizing antibody.

• 대한수의학회지
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• 제36권2호
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• pp.405-415
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• 1996

This study was carried out to investigate the distribution of inclusion bodies in the tissues as well as to observe the general histopathological lesions of dogs infected with canine distemper. And also, the reliability of diagnostic values of inclusion bodies and the distribution of viral antigen in tissues were inspected by immunohistochemistry with monoclonal antibody. The results obtained were as follows; 1. Pneumonia observed in dogs infected with canine distemper virus was classified into interstitial, broncho-, and broncho-interstitial pneumonia histopathologically. Each occurring ratio was 35, 45 and 20%. 2. Histopathological classification of the canine distemper encephalitis was 20% in acute, 60% in subacute, and 20% in chronic encephalitis, respectively. 3. The organs in which inclusion bodies were predominantly distributed were stomach(82.6%), cerebellum(62.9%), lung(62.1%), cerebrum(50.0%), urinary bladder (46.1%), kidney(36.0%) and pancreas(25.0%). Intracytoplasmic inclusion bodies were mainly observed in the organs except the brain. 4. Canine distemper virus antigens were detected in the numerous tissues as well as in the inclusion bodies observed in the various organs. Antigen detection ratios in the lung, cerebellum and cerebrum were 68.9, 70.4 and 52.2%, respectively. These ratios were somewhat higher than those of inclusion bodies observed in the organs. 5. Canine distemper virus was mainly distributed in astrocytes and ependymal cells in the brain. These results suggested that the histopathologic diagnosis of canine distemper was reliable, and the spread of canine distemper virus in the brain was related with cerebrospinal fluid pathway.

• 한국임상수의학회지
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• 제26권5호
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• pp.423-428
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• 2009

There were outbreaks of canine distemper in Korea from the late 1990's to the early 2000's even though modified live CDV vaccines had been used as the same way as before. The present study was undertaken to investigate the levels of neutralizing antibodies in the Korean dog population, and the factors associated with the levels, with special reference to the vaccination history of the dogs. A total of 772 serum samples were from clinically healthy dogs with over one year old throughout the Korea from January 2003 to April 2004. Details on the sex, breed, age, vaccination status and disease histories were recorded. The level of neutralizing antibodies titer was determined with a modified version of the microneutralization test. Titers over 16 were classified as protective CDV antibody titers. The overall rate of adult dogs with protective antibody titers was 96.0%. The dogs with protective antibody titers varied depending on age, sex, rearing environment and vaccination status. Because the majority of healthy adult dogs in Korea had adequate serum antibody titers against CDV and the immunity provided by the vaccinations is claimed to last for several years, annual revaccination protocol for CDV in adult dogs should be reconsidered.