• Title/Summary/Keyword: 개념유추

Search Result 106, Processing Time 0.025 seconds

2형 당뇨병 치료제의 최근동향

  • 허갑범
    • Proceedings of the Korean Society of Applied Pharmacology
    • /
    • 2001.04a
    • /
    • pp.115-126
    • /
    • 2001
  • 1988년 Reaven이 인슐린저항성증후군(insulin resistance syndrome)의 개념을 처음 소개한 후 전세계적으로 관심이 증가하고 있다. 인슐린저항성증후군은 대사성증후군 (metabolic syndrome), X 증후군(syndrome X)이라고도 하며, 인슐린 저항성에 따른 고인슐린혈증, 내당능장애(impaired glucose tolerance)와 2형 당뇨병(인슐린 비의존형 당뇨병), 이상지질혈증(dyslipidemia), 고혈압 등 일련의 질환은 동일인에서 흔히 병발하고, 이들은 모두 죽상경화증(atherosclerosis)의 위험인자라는 관점에서 상호연관성을 갖는 질환군이라는 개념이다. 2형 당뇨병은 인슐린에 대한 말초조직의 저항성과 상대적으로 감소된 인슐린 분비능의 결과라고 할 수 있다. 또한 상당수의 2형 당뇨병은 비만, 특히 복부비만을 동반하고 있으며, 비만은 그 자체로 인슐린 저항성을 유발한다. 결국 인슐린 저항성이 장기간 개선되지 못하게 되면 2형 당뇨병이 유발되게 된다. 따라서 2형 당뇨병에 대한 최선의 치료는 혈당조절 뿐만 아니라 인슐린 저항성과 관련된 심혈관계 위험인자를 개선시키는 것을 목표로 해야 한다. 그 증거로 당뇨병 조절과 관련한 대규모 전향적 연구인 UKPDS(United Kingdom Prospective Diabetes Study)의 결과를 보면, 2형 당뇨병에서 설폰요소제(sulfonylurea)나 인슐린으로 10년동안 혈당조절을 했을 때 미세혈관 합병증은 의미있게 감소시켰으나 대혈관 합병증의 발생률은 의미있는 감소를 보이지 못하였다. 반면 대혈관 합병증이 미세혈관 합병증보다 사망에 기여하는 비율이 70배 이상이라는 사실은 당뇨병의 치료가 혈당조절에만 초점이 맞추어져서는 안 되며 심혈관계 위험인자를 개선시키는 치료가 동시에 진행되어야 한다는 점을 시사한다.시료에서 매우 드물게 관찰된다. 음극선발광(cathodoluminescence) 영상의 해석을 통해 저어콘 결정의 성장사를 유추하였으며, 이를 바탕으로 이온현미분석 점(spot)을 정하였다. U-Pb-Th 자료는 퍼스(Perth) 저어콘 스탠다드 (CZ3, 564 Ma, $^{206}$Pb/$^{238}$U=0.0914)를 사용하였다. 아래에 기술하는 연대는 모두 $^{206}$Pb/$^{238}$U 연대에 해당된다. 두 개의 화강암질 편마암 시료로부터 구한 U-Pb 저어콘 연대는 각각 812 $\pm$ 14 Ma(1006-8)와 822 $\pm$ 17 Ma(1006-9)로 분석오차 내에서 서로 일치한다. 이 결과는 춘천 및 전곡 지역의 석류석 각섬암에서 보고된 Sm-Nd 전암연대(852 $\pm$ 24 Ma 및 824 $\pm$ 143 Ma; Lee and Cho, 1995; Ree et al., 1996)와 잘 부합한다. 따라서 후기 원생대 기간 중 화성활동이 한반도에서 광범위하게 일어났음을 시사한다. 한편, 1006-9 시료에서는 예외적으로 한 개의 저어콘 입자 주변부(rim)에서 매우 얇은 과성장띠가 관찰되었으며, 두 개의 점 분석으로부터 구한 U-Pb 저어콘 연대는 약 235 Ma이다. 이 띠는 또한 변성기원의 저어콘에서 흔히 관찰되는 작은 W (<0.05) 비를 보인다. 1006-5 시료는 위 두 시료로부터 수 km 떨어진 지점에서 채집하였으나, 저어콘 연대는 상이한 기록을 보여준다. 즉 매우 작은 Th/U (<0.01) 값을 갖는 저어콘의 주변부에서 223 $\pm$ 5 Ma의 연대가 잘 정의되며, 이는 1006-9 시료에서 관찰된 결과와

  • PDF

An Analysis of High School Technology·Home Economics Textbooks' Activities to Improve the Resilience of Youth (청소년의 회복탄력성에 대한 고등학교 기술·가정 교과서 활동과제 분석)

  • Choi, Yoo-ri;Kim, Eun-Jong;Lee, So-Young;Lee, Gi-Sen;Lim, So-Jin;Park, Mi-Jeong
    • Journal of Korean Home Economics Education Association
    • /
    • v.30 no.4
    • /
    • pp.37-55
    • /
    • 2018
  • The purpose of this study is to contribute to the improvement of the resilience of adolescents through the analysis of activities in high school Technology·Home Economics textbooks developed according to the 2015 revised high school Technology·Home Economics curriculum. For this purpose, we analyzed the activities of 12 high school Technology·Home Economics textbooks in the 'human development and family' and 'family life and safety' areas based on the sub-factors of resilience. A total of 303 activities were extracted from 12 textbooks. After analyzing the activities of the three people, the process of revising and supplementing the analysis criteria through consultation was conducted three times and then reviewed by three experts. The analysis found that although there were differences in the number of activities to be dealt with, it was common to focus on raising interpersonal ability(54.8%) among the sub-factors of resilience. Followed by self-regulation(39.4%) and positive(5.8%). Second, the analysis of the activities by core concepts showed that the most activities dealing with the sub-factors of resilience were in the 'family life and safety' area, which deals with 'safety (44.3%)' as a core concept. And in the area of human development and family, which deals with development (25.1%) and relationships (36%) as core concept, the sub-factors of resilience were also covered. This can be inferred that the home curriculum is suitable for systematic education of resilience, and that the term resilience in the curriculum has been considered and dealt with resilience before it is specifically mentioned. I hope that the results of this study will be used as basic data for the development of home and resilience education programs in the future.

A Development of Traffic Queue Length Measuring Algorithm Using ILD(Inductive Loop Detector) Based on COSMOS (실시간 신호제어시스템의 대기길이 추정 알고리즘 개발)

  • seong ki-ju;Lee choul-ki;Jeong Jun-ha;Lee young-in;Park dae-hyun
    • The Journal of The Korea Institute of Intelligent Transport Systems
    • /
    • v.3 no.1 s.4
    • /
    • pp.85-96
    • /
    • 2004
  • The study begin with a basic concept, if the occupancy length of vehicle detector is directly proportional to the delay of vehicle. That is, it analogize vehicle's delay of a occupancy time. The results of a study was far superior in the estimation of a queue length. It is a very good points the operator is not necessary to optimize s1, s2, Thdoc. Thdoc(critical congestion degree) replaced 0.7 with 0.2 - 0.3. But, if vehicles have been experience in delay was not occupy vehicle detector, the study is in existence some problems. In conclusion, it is necessary that stretch queue detector or install paired queue detector. Also I want to be made steady progress a following study relation to this study, because it is required traffic signal control on congestion.

  • PDF

Study on the Performer's Transference and Mental Borderline in a Performance (공연에서 나타나는 '전이'와 배우의 '심리적 경계'에 관한 연구)

  • Kim, Jong-Gu
    • (The) Research of the performance art and culture
    • /
    • no.25
    • /
    • pp.57-89
    • /
    • 2012
  • The performers preparing for a performance usually experience the process of mental transference, contacting with text (drama) for the first time. It is movement from their everyday life to space in the play, when they try to break the wall between cast and themselves. The transference happens actually at the physical space, such as a dressing room, wing, (place just before appearing at a stage), and a stage (place to contact with audience). Performers keep moving among each psychological and physical space repeatedly, until the performance finishes totally. The transference means moving to each space to another, and the mental borderline means the point of mental change the performers experience during the process of transference. The mental borderline can be guessed to exist through mental aspects the performers feel when they move from each space to another. The most typical example, that shows performer's mental borderline well, is stage fright shown as tension, or anxiety among the variety of aspects. According to a research, the most performers experience that kind of mental aspect just before appearing at a stage. The study on it is already referred by my article.' A Study on Korean Performer's Stage Fright. This study aims at examining the relationship among psychological and physical space the performers experience, mental borderline when transferring and penetrating those spaces, and performer's mental change First, the concept of mental borderline is to be understood totally with preceded research. And the space the performers experience and mental borderline at transference are to be reorganized. Secondly, the area of transference in the process of performance is to be reclassified into physical and mental space. Third, analyzing the actual case of performers experiencing the mental borderline, the diversified use should be searched to make use of mental borderline as a positive element. The psychological symptoms, performers experience in the performance, can have positive consequence beside negative one. The tension occurring at the area of borderline is positive, and it can be the actual borderline for the performers. It will be researched how the performers change at the mental borderline, the state of mind is maintained, and they perform in an overall performance, through the study on the relationship between the transference and the mental borderline. And the stress and concentration caused by stage fright, and shyness will be confirmed, and the positive element of a stage, which is used as various defense mechanism.

Prediction of Reservoir Properties Using Extended Elastic Impedance Inversion (확장 탄성 임피던스 역산을 이용한 저류층 물성 예측)

  • Kim, Hyeonju;Lee, Gwang H.;Moon, Seonghoon
    • Economic and Environmental Geology
    • /
    • v.48 no.2
    • /
    • pp.115-130
    • /
    • 2015
  • Extended elastic impedance (EEI) is an extension of elastic impedance (EI) which is a generalization of acoustic impedance (AI) for nonzero angles of incidence and can be tuned to be proportional to reservoir properties. In this study, we evaluated EEI inversion by estimating the P-($V_p$) and S-wave velocities ($V_s$), P-wave to S-wave velocity ratio ($V_p/V_s$), and Poisson's ratio of the Second Wall Creek Sand of the Teapot Dome field, Wyoming, USA. We also applied the EEI inversion technique to estimate porosity, gamma-ray values, and density of the Second Wall Creek Sand. Data used in the study include 3-D pre-stack seismic data from the southern part of the field and four wells, selected from a large well database. The $V_s$ logs at the wells were constructed from the $V_p$ logs using the empirical relationships. The percent prediction errors for the four velocity properties are less than about 5% except for Poisson's ratio at one well, supporting that the EEI inversion can be used in the prediction of rock properties. However, the results from the EEI inversion analysis of porosity, gamma-ray values, and density at the wells were unsatisfactory and thus these properties, which are not directly computed from velocities, may not be suitable for EEI inversion.

Optimum Mixing Ratio of Epoxy for Glass Fiber Reinforced Composites with High Thermal Stability (에폭시 배합비에 따른 내열성 복합재료 최적조건)

  • Shin, Pyeong-Su;Wang, Zuo-Jia;Kwon, Dong-Jun;Choi, Jin-Yeong;Sung, Ill;Jin, Dal-Saem;Kang, Suk-Won;Kim, Jeong-Cheol;Park, Joung-Man
    • Composites Research
    • /
    • v.27 no.4
    • /
    • pp.168-173
    • /
    • 2014
  • The optimum condition of glass fiber/epoxy composites was investigated according to mixing ratio of two epoxy matrices. Novolac type epoxy and isocyanate modified epoxy were used as composites matrix. Based on chemical composition of mixing matrix, optimum mixing ratio of epoxy resins was obtained through various experiments. In order to investigate thermal stability and interface of epoxy resin, glass transition temperature was observed by DSC instrument, and static contact angle was measured by reflecting microscope. Change of IR peak and $T_g$ was conformed according to different epoxy mixing ratio. After fabrication of glass fiber/epoxy composites, tensile, compression, and flexural properties were tested by UTM by room and high temperature. The composites exhibited best mechanical properties when epoxy mixing ratio was 1:1.

A Theoretical Study on Abduction as an Inquiry Method in Earth Science (지구과학의 한 탐구 방법으로서 귀추법에 대한 이론적 고찰)

  • Oh, Phil-Seok;Kim, Chan-Jong
    • Journal of The Korean Association For Science Education
    • /
    • v.25 no.5
    • /
    • pp.610-623
    • /
    • 2005
  • This was a theoretical study of which the goal was to provide a foundation for developing and implementing earth science inquiry activities based on abduction as a scientific inquiry method. Through a review of relevant literature, the study examined the nature of earth science in terms of the goals of earth science inquiry and the characteristics of what is investigated in earth science. It also explored the forms and meanings of abduction, thinking strategies used in the abductive inference, and the abductive inquiry model. Abduction is the process of inferring certain rules (e.g., scientific facts, principles, laws) and providing explanatory statements or hypotheses in order to explain some phenomena. This method was found to be well-suited to the earth science inquiry which studies the causes and processes of natural phenomena in the earth and space environment. Abduction has the nature of ampliative, selective, evaluative, and creative inference, and several thinking strategies, including reconstruction of data, heuristic generalization, analogy, existential, conceptual combination, and elimination strategies, are employed for inferring rules and suggesting hypotheses. This study found the abductive inquiry model to be adaptable to earth science classrooms, and it is therefore suggested that earth science instructions should be based on the abductive method and that research work concerning the abductive inquiry in the classroom should follow.

The Difference of Gestures between Scientists and Middle School Students in Scientific Discourse: Focus on Molecular Movement and the Change in State of Material (과학담화에서 과학자와 중학생의 제스처 비교 -분자운동과 물질의 상태변화를 중심으로-)

  • Kim, Ji Hyeon;Cho, Hae Ree;Cho, Young Hoan;Jeong, Dae Hong
    • Journal of The Korean Association For Science Education
    • /
    • v.38 no.2
    • /
    • pp.273-291
    • /
    • 2018
  • Gestures accompanied by scientific discourses play an important role in constructing mental models and making model-based inferences. According to embodied cognition literature, gestures can be a source of recognition of the mental models of students and help them in changing naive beliefs about science. This study intends to compare the gestures of scientists with that of middle school students in explaining scientific phenomena and to explore the relationship between gestures and scientific discourse. In the study, 10 scientists and 10 middle school students participated in clinical interviews and the tests of knowledge and self-efficacy. Participants engaged in one-on-one clinical interviews with semi-structured questions about three tasks regarding the molecular movement and the state change of matter. Four researchers carried out open coding and applied a constant comparison method in order to analyze video-recorded gestures. This study found four themes (feature of gesture, use of gesture, content of gesture, function of gesture) about the differences of gestures between scientists and middle school students. Scientists used more diverse and elaborate gestures systematically and frequently in the interview. Although students used gestures in their scientific talk and reasoning, the gestures of students were not well grounded on scientific knowledge and had different functions from those of scientists. The findings revealed that gestures can represent underlying cognition and strengthen scientific thinking. We should encourage students to use gestures as a tool to understand scientific concepts and make inferences.

A Experimental Study on a change of wave overtopping volumea with a reduced scale (축척에 따른 월파량 변화에 관한 실험적 연구)

  • Park, Hyun Soo;Lee, Sang Jin;Park, Sang Kil
    • Proceedings of the Korea Water Resources Association Conference
    • /
    • 2004.05b
    • /
    • pp.1459-1463
    • /
    • 2004
  • 최근 빈번하게 발생하는 기상이변현상의 하나로 발생한 제14호 태풍 "매미"는 한반도 남부지방을 통과하면서 강풍과 해일을 동반하여 해안에서는 해일이 발생하여 평균해수면의 상승과 파의 쳐올림(run up)에 의한 월파량(wave overtopping volume)으로 예상치 못한 침수피해가 속출하였다. 태풍으로 인한 주된 피해로써 특히, 침수피해는 이상고조로 인해 평균수위 상승이 만조와 겹침으로써 기존의 호안, 제방 등의 천단고를 넘어서 파의 쳐올림에 의한 월파량으로 호안 배후지의 침수피해가 발생하게 된다. 이러한 월파현상에서 월파량이 축척되면서 배후지에 축척된 수량에 의해 침수피해가 발생되는 근본적인 원인은 파의 쳐올림의 높이에 비해 호안의 제방 높이가 상대적으로 낮다는 데 있다. 우리나라 매립지의 지반고는 과거에 설계 시공한 인근 매립지의 지반고와 동일한 높이로 하고 있는 데 이러한 개념은 인근 지대와 동일조건을 부여하여 배후지에서 발생할 수 있는 여러 가지 문제점을 해결할 수 있는 장점이 많지만, 이건 설계방범은 해안공학적인 측면이 강조되어 설계되었다기보다 사회 경제적 측면을 강조하여 설계되어 왔기 때문에 이번과 같은 태풍에 대한 방재대책이 될 수 없었던 것이다. 따라서 원만한 방재대책이 수립되기 위해서는 과거의 설계방법을 탈피하여 현지조건을 정확하게 조사한 후 이를 근거로 하는 설계가 요구된다. 본 연구는 해안공학적 측면에 중점을 두고 수행하였다. 첫째로, 태풍 제14호 "매미"의 현황을 파악하여 조석현황과 이상고조, 파고추정의 범위를 결정한다. 또, 부산지방의 피해현장을 조사하여 피해의 유사성을 밝힌다. 둘째로, 송도 매립지 호안 전면에서의 월파현상과 월파량을 검토한다. 셋째로, 대체블록에 대해 간략 계산을 통해 유동성을 검토하였다. 이와 같은 연구과정을 통해 태풍이 내습했을 때 호안 배후지내의 월파량 철상을 2차원 수리모형실험을 통해 재현시켜 검토하고, 월파량을 평가기준으로 축척모형을 해안수리학적인 측면에서 검증하였다. 본 2차원 수리모형실험에서 재현시킨 월파량이 현실적으로 어느 정도의 월파량이 되는지는 계산에 의한 방법으로만 추정할 수 있으며, 여기서는 2차원 수리모형실험을 실시했던 자료를 이용하여 현재까지 알려진 방법으로 몇 가지 경우 즉, 현실적으로 일어날 가능성이 있는 최악의 경우에 대해 계산한 겉과, 동일조건에서 축척이 적을수록 추정 월파량이 많음을 알 수 있었다. 이것은 태풍이 내습하여 현실적으로 발생했던 월파량이 더욱 많았음을 유추할 수 있다. 또한, 태풍과 같은 자연재해, 특히 월파량에 대해 취약한 구조를 가진 호안의 경우 여러 가지 대안 중 인공쇄파대(artifical reef)와 같은 완충지대를 갖는 호안을 축조함으로써 월파량을 감소시키는 대안으로 제시하고자 한다. 본 연구 수행을 통해 태풍 내습시 발생 가능한 자연재해에 대한 사전 방지를 목적으로 태풍피해의 원인을 제시하고 이를 해결하여 현재의 방재대책이 항구적인 방재대책으로 전환될 수 있는 방안 마련의 기초 자료로 활용되기를 기대한다.

  • PDF

Analysing the Impact of New Risks on Maritime Safety in Korea Using Historical Accident Data (사고기록 데이터를 이용하여 국내 해상안전에 새로운 위기가 미치는 영향 분석)

  • Park, Deuk-Jin;Park, Seong-Bug;Yang, Hyeong-Sun;Yim, Jeong-Bin
    • Journal of the Korean Society of Marine Environment & Safety
    • /
    • v.22 no.7
    • /
    • pp.791-799
    • /
    • 2016
  • The purpose of this work is to analyse the impact of new accident risks on maritime safety in Korea. The new accident risks have been induced from new/rare or unprecedented events in world maritime transportation, as identified by 46 experts in the previous study. To measure the impact of these new accident risks on maritime safety in Korea, the statistical accident data reported by the Korean Maritime Safety Tribunals (KMST) has been used for calculation, and the concept of Risk Index (RI) = Frequency Index (FI) + Severity Index (SI)established in a Formal Safety Assessment (FSA) by the IMO has also been introduced. After calculating two kinds of weight for FI and SI from the statistical accident data, high ranked scenarios were identified and their relationships between new risks and these scenarios were analysed. The results from this analysis showed, the root cause of the top-ranked scenario to be "developing high technology", which leads to "shorten cargo handling time". These results differed from optimum RCOs such as "business competition" and "crewing problems" which were identified in the previous study.