• Genomics & Informatics
• /
• v.4 no.3
• /
• pp.110-117
• /
• 2006

In microarray technology, many diverse experimental features can cause biases including RNA sources, microarray production or different platforms, diverse sample processing and various experiment protocols. These systematic effects cause a substantial obstacle in the analysis of microarray data. When such data sets derived from different experimental processes were used, the analysis result was almost inconsistent and it is not reliable. Therefore, one of the most pressing challenges in the microarray field is how to combine data that comes from two different groups. As the novel trial to integrate two data sets with batch effect, we simply applied standardization to microarray data before the significant gene selection. In the gene selection step, we used new defined measure that considers the distance between a gene and an ideal gene as well as the between-slide and within-slide variations. Also we discussed the association of biological functions and different expression patterns in selected discriminative gene set. As a result, we could confirm that batch effect was minimized by standardization and the selected genes from the standardized data included various expression pattems and the significant biological functions.

• The Journal of Information Systems
• /
• v.30 no.3
• /
• pp.21-45
• /
• 2021

Purpose This paper analyzed the impacts of domestic stock market by a global pandemic such as COVID-19. We investigated how the overall pattern of the stock market changed due to the impact of the COVID-19 pandemic. In particular, we analyzed in depth the pattern of stock price, as well, tried to find what factors affect on stock market index(KOSPI) in the healthcare industry due to the COVID-19 pandemic. Design/methodology/approach We built a data warehouse from the databases in various industrial and economic fields to analyze the changes in the KOSPI due to COVID-19, particularly, the changes in the healthcare industry centered on bio-medicine. We collected daily stock price data of the KOSPI centered on the KOSPI-200 about two years before and one year after the outbreak of COVID-19. In addition, we also collected various news related to COVID-19 from the stock market by applying text mining techniques. We designed four experimental data sets to develop decision tree-based prediction models. Findings All prediction models from the four data sets showed the significant predictive power with explainable decision tree models. In addition, we derived significant 10 to 14 decision rules for each prediction model. The experimental results showed that the decision rules were enough to explain the domestic healthcare stock market patterns for before and after COVID-19.

• The Journal of Information Systems
• /
• v.28 no.3
• /
• pp.249-276
• /
• 2019

Purpose The purpose of this study is to develop a prediction model and decision rules for the elderly's suicidal ideation based on the Korean Welfare Panel survey data. By utilizing this data, we obtained many decision rules to predict the elderly's suicide ideation. Design/methodology/approach This study used classification analysis to derive decision rules to predict on the basis of decision tree technique. Weka 3.8 is used as the data mining tool in this study. The decision tree algorithm uses J48, also known as C4.5. In addition, 66.6% of the total data was divided into learning data and verification data. We considered all possible variables based on previous studies in predicting suicidal ideation of the elderly. Finally, 99 variables including the target variable were used. Classification analysis was performed by introducing sampling technique through backward elimination and data balancing. Findings As a result, there were significant differences between the data sets. The selected data sets have different, various decision tree and several rules. Based on the decision tree method, we derived the rules for suicide prevention. The decision tree derives not only the rules for the suicidal ideation of the depressed group, but also the rules for the suicidal ideation of the non-depressed group. In addition, in developing the predictive model, the problem of over-fitting due to the data imbalance phenomenon was directly identified through the application of data balancing. We could conclude that it is necessary to balance the data on the target variables in order to perform the correct classification analysis without over-fitting. In addition, although data balancing is applied, it is shown that performance is not inferior in prediction rate when compared with a biased prediction model.

• The Korean Journal of Archival Studies
• /
• no.70
• /
• pp.5-40
• /
• 2021

Administrative information dataset records produced by various systems designed for work are difficult to manage on a case-by-case basis, requiring separate procedures to identify and evaluate data-sets. Identified data set records are apprasal and transferred to the records management system or disposed of. In this process, sufficient records management elements must be reflected in the production system itself in order to adhere to the principles of record management. In this paper, the functional requirements of the production system to accurately identify and safely manage data-sets were derived and applied based on the case of the KR property management system. It is hoped that this research on functional requirements of production systems will be added to lead to the creation of standards for functional requirements of data set production systems.

• Korean Journal of Microbiology
• /
• v.44 no.4
• /
• pp.293-298
• /
• 2008

HCV is transmitted via various plasma derived products. Current methods to detect hepatitis C virus (HCV) are based on its antibody detection in the donated blood and plasma. Viral contamination can potentially escape such detection during the window period of infection, when no antibody is present or the level of antibody is too low to detect. It is trying to application of nucleic acid amplification tests (NAT) for the direct detection of HCV. The objective of this study was to develop a reliable NAT for the HCV RNA detection from plasma-derived products. The most useful primers was selected for NAT among 5 sets of primers. We have also found that QIAamp viral RNA isolation kit was the most efficient for HCV RNA isolation. The highest sensitivity and specificity was appeared in $48^{\circ}C$ annealing temperature and 30 pmol of primers. With a spiking of HCV to albumin, immunoglobulins and coagulation factors, NAT can detect up to 100 IU/ml. Meanwhile, COBAS amplicor HCV 2.0 afforded a lower sensitivity in high concentrated intramuscular immunoglobulins to below 500 IU/ml. Our results suggested that NAT appears to be a highly sensitive and specific method for HCV RNA detection in plasma-derived products.

• Korean Journal of Radiology
• /
• v.24 no.1
• /
• pp.51-61
• /
• 2023

Objective: To develop and test a machine learning model for classifying human papillomavirus (HPV) status of patients with oropharyngeal squamous cell carcinoma (OPSCC) using ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) PET-derived parameters in derived parameters and an appropriate combination of machine learning methods in patients with OPSCC. Materials and Methods: This retrospective study enrolled 126 patients (118 male; mean age, 60 years) with newly diagnosed, pathologically confirmed OPSCC, that underwent ¹⁸F-FDG PET-computed tomography (CT) between January 2012 and February 2020. Patients were randomly assigned to training and internal validation sets in a 7:3 ratio. An external test set of 19 patients (16 male; mean age, 65.3 years) was recruited sequentially from two other tertiary hospitals. Model 1 used only PET parameters, Model 2 used only clinical features, and Model 3 used both PET and clinical parameters. Multiple feature transforms, feature selection, oversampling, and training models are all investigated. The external test set was used to test the three models that performed best in the internal validation set. The values for area under the receiver operating characteristic curve (AUC) were compared between models. Results: In the external test set, ExtraTrees-based Model 3, which uses two PET-derived parameters and three clinical features, with a combination of MinMaxScaler, mutual information selection, and adaptive synthetic sampling approach, showed the best performance (AUC = 0.78; 95% confidence interval, 0.46-1). Model 3 outperformed Model 1 using PET parameters alone (AUC = 0.48, p = 0.047) and Model 2 using clinical parameters alone (AUC = 0.52, p = 0.142) in predicting HPV status. Conclusion: Using oversampling and mutual information selection, an ExtraTree-based HPV status classifier was developed by combining metabolic parameters derived from ¹⁸F-FDG PET/CT and clinical parameters in OPSCC, which exhibited higher performance than the models using either PET or clinical parameters alone.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• v.37 no.6
• /
• pp.435-444
• /
• 2019

Recently, DL (Deep Learning) has been rapidly applied in various fields. In particular, classification and object recognition from images are major tasks in computer vision. Most of the DL utilizing imagery is primarily based on the CNN (Convolutional Neural Network) and improving performance of the DL model is main issue. While most CNNs are involve with images for training data, this paper aims to classify and recognize objects using DSM (Digital Surface Model), and slope and aspect information derived from the DSM instead of images. The DSM data sets used in the experiment were established by DGPF (German Society for Photogrammetry, Remote Sensing and Geoinformatics) and provided by ISPRS (International Society for Photogrammetry and Remote Sensing). The CNN-based SegNet model, that is evaluated as having excellent efficiency and performance, was used to train the data sets. In addition, this paper proposed a scheme for training data generation efficiently from the limited number of data. The results demonstrated DSM and derived data could be feasible for semantic classification with desirable accuracy using DL.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
• /
• v.13 no.6
• /
• pp.461-469
• /
• 2020

In this paper, we propose a PCA-based feature feedback method for extracting important areas of handwritten numeric data sets and face data sets. A PCA-based feature feedback method is proposed by extending the previous LDA-based feature feedback method. In the proposed method, the data is reduced to important feature dimensions by applying the PCA technique, one of the dimension reduction machine learning algorithms. Through the weights derived during the dimensional reduction process, the important points of data in each reduced dimensional axis are identified. Each dimension axis has a different weight in the total data according to the size of the eigenvalue of the axis. Accordingly, a weight proportional to the size of the eigenvalues of each dimension axis is given, and an operation process is performed to add important points of data in each dimension axis. The critical area of the data is calculated by applying a threshold to the data obtained through the calculation process. After that, induces reverse mapping to the original data in the important area of the derived data, and selects the important area in the original data space. The results of the experiment on the MNIST dataset are checked, and the effectiveness and possibility of the pattern recognition method based on PCA-based feature feedback are verified by comparing the results with the existing LDA-based feature feedback method.

• Journal of Korea Water Resources Association
• /
• v.33 no.2
• /
• pp.247-262
• /
• 2000

In this paper, the WSANN(Water Stage Analysis with Neural Network) model was presented so as to predict flood water stage at Jindong which has been the major stream gauging station in Nakdong river basin. The WSANN model used the improved backpropagation training algorithm which was complemented by the momentum method, improvement of initial condition and adaptive-learning rate and the data which were used for this study were classified into training and testing data sets. An empirical equation was derived to determine optimal hidden layer node between the hidden layer node and threshold iteration number. And, the calibration of the WSANN model was performed by the four training data sets. As a result of calibration, the WSANN22 and WSANN32 model were selected for the optimal models which would be used for model verification. The model verification was carried out so as to evaluate model fitness with the two-untrained testing data sets. And, flood water stages were reasonably predicted through the results of statistical analysis. As results of this study, further research activities are needed for the construction of a real-time warning of the impending flood and for the control of flood water stage with neural network method in river basin. basin.

• Geophysics and Geophysical Exploration
• /
• v.17 no.3
• /
• pp.137-146
• /
• 2014

This study presents a procedure for discrimination of artificial events from earthquakes occurred in and around the Korean Peninsula using data set in the Wonju KSRS seismograph network, Korea. Two training sets representing natural and artificial earthquakes were constructed with 150 and 56 events, respectively, with high signal to noise ratio. A frequency band, Pg(4-6 Hz)/Lg(5-7 Hz), which is optimal for the discrimination of seismic sources was derived from the two-dimensional grid of Pg/Lg spectral amplitude ratio. The corrections for the effects of earthquake magnitude and hypocentral distance were carried out for improvement of discrimination capability. For correcting the effect of magnitude dependence due to the inverse proportionality of corner frequency to seismic moment, the Brune's source spectrum was subtracted from the observation spectrum. The spectrum was corrected using the optimal damping coefficient to remove damping effect with the hypocentral distance. The effect of locally varying spectrum ratio was cancelled correcting variation of wave propagation along the ray path. The performance in discrimination between training sets of natural and artificial events was compared using the Mahalanobis distance in each step of correction. The procedure of magnitude, distance, and path corrections show clear improvements of the discrimination results with increasing Mahalanobis distance, from 1.98 to 3.01, between two training sets.