• Journal of Korea Water Resources Association
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• v.37 no.3
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• pp.173-184
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• 2004

The objective of this study is to examine the usefulness of climate model simulations (GCM) in Korea water resource management. The methods are based on probabilistic measures of the effectiveness of GCM simulations of an indicator variable for discriminating high versus low regional observations of a target variable. The formulation uses the significance probability of the Kolmogorov-Smirnov test for detecting differences between two variables. AMIP-II(Atmospheric Model Intercomparison Project-II) type GCM simulation done by ECMWF(European Centre for Medium-Range Weather Forecasts) was used for indicator variable and observed mean average precipitation(MAP) values on 7 major river basins were used as target variable. Monte Carlo simulation is used to establish the significance of the estimator values. The results show that GCM simulations done by ECMWF are skillful in discriminating the high from the low of the observed MAP for wet season in all seven basins of Korea, but not enough for dry season.

• Progress in Medical Physics
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• v.25 no.2
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• pp.65-71
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• 2014

A Varian Portal Dosimetry system was compared to an isocentrically mounted MapCHECK 2 diode array for volumetric modulated arc therapy (VMAT) QA. A Varian TrueBeam STx with an aS-1000 digital imaging panel was used to acquire VMAT QA images for 13 plans using four photon energies (6, 8, 10 and 15 MV). The EPID-based QA images were compared to the Portal Dose Image Prediction calculated in the Varian Eclipse treatment planning system (TPS). An isocentrically mounted Sun Nuclear MapCHECK 2 diode array with 5 cm water-equivalent buildup was also used for the VMAT QAs and the measurements were compared to a composite dose plane from the Eclipse TPS. A ${\gamma}$ test was implemented in the Sun Nuclear Patient software with 10% threshold and absolute comparison at 1%/1 mm (dose difference/distance-to-agreement), 2%/2 mm, and 3%/3 mm criteria for both QA methods. The two-tailed paired Student's t-test was employed to analyze the statistical significance at 95% confidence level. The average ${\gamma}$ passing rates were greater than 95% at 3%/3 mm using both methods for all four energies. The differences in the average passing rates between the two methods were within 1.7% and 1.6% of each other when analyzed at 2%/2 mm and 3%/3 mm, respectively. The EPID passing rates were somewhat better than the MapCHECK 2 when analyzed at 1%/1 mm; the difference was lower for 8 MV and 10 MV. However, the differences were not statistically significant for all criteria and energies (p-values >0.05). The EPID-based QA showed large off-axis over-response and dependence of ${\gamma}$ passing rate on energy, while the MapCHECK 2 was susceptible to the MLC tongue-and-groove effect. The two fluence-based QA techniques can be an alternative tool of VMAT QA to each other, if the limitations of each QA method (mechanical sag, detector response, and detector alignment) are carefully considered.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2008.04a
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• pp.145-148
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• 2008

The objective of this study is to analyze and to shed light on the evolutions of factors with the wall structure and their relations with production mechanisms of urban form. this study based on followings; literature review of existing study and setting up of examination factors, analytical review of each wall's current situation and problems, analytical review of each wall's urban regeneration. The significance of this study is in that the study use a contemporary map showing the actual spatial arrangement in the period, instead of using the historical map. We understood the planning methods to interpret the site's historical urban trace and memory. Based on the results, this study presented the solution for the placeless and potential energy.

• Journal of the Korean housing association
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• v.15 no.3
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• pp.31-41
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• 2004

The purpose of this study is to find out the spatial arrangement of the administrative district of Seoung-Ju Eup around the 19th century by analyzing a map called Seoung-ju eupgido, made in the late Chosun period. The study analyses the significant elements consisting of the spatial arrangement such as geographical considerations, the street system, and the location of mainfacilities for this purpose. The significance of this study is in that the study uses a contemporary map showing the actual spatial arrangement in the period, instead of using any historical records or written documents that have been mainly used for the same purpose by most researcher so far.

• Korean Journal of Remote Sensing
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• v.6 no.1
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• pp.39-47
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• 1990

The first Marine Observation Satellite(MOS) was launched by National Space Development Agency of Japan on February 19, 1987, and it is equipped with three sensons covering visible, infrared, and microwave region. One of them is Visible and Thermal Infrared Radiometer(VTIR) whose main objective is to detect the Sea Surface Temperature(SST). The objective of this study was to process the MOS data using Cray-2 supercomputer, and to assess the SST in the Yellow Sea. In order to implement this objective, the linear regression model between the ground truth data and the corresponding digital number of VTIR in MOS was used to establish the relationship. After testing the significance of the regression model, the SST map of the whole Yellow Sea was derived based on the model. The digital SST map representing the study area showed certain pattern about the SST of Yellow Sea in March and April. In conclusion, the VTIR data in MOS is also useful in investigating SST which provides the information about the Yellow Sea water current in the spring.

• Spatial Information Research
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• v.16 no.1
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• pp.113-127
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• 2008

This paper proposes an efficient spatial index, named $AR^*$-tree(Area $R^*$-tree) which is a variant of the $R^*$-tree, for mobile software. A MBR(Minimum Bounding Rectangle) structure of the $AR^*$-tree has additional min and max values of area axis as well as x and y axes. The value of area axis is used to determine the significance of a spatial data. If area of a spatial data is large, then it is significant when drawing a map. To reduce complexity of a map on a small screen of mobile device, only significant spatial data can be found by the $AR^*$-tree. The result of a series of tests indicates that the $AR^*$-tree provides a method for control of readability of a map and guarantees an efficient performance at the same time.

• Genomics & Informatics
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• v.19 no.2
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• pp.14.1-14.6
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• 2021

Coronavirus disease 2019 (COVID-19) is an on-going pandemic disease infecting millions of people across the globe. Recent reports of reduction in antibody levels and the re-emergence of the disease in recovered patients necessitated the understanding of the pandemic at the core level. The cases of multiple organ failures emphasized the consideration of different organ systems while managing the disease. The present study employed RNA sequencing data to determine the disease associated differentially regulated genes and their related protein interactions in several organ systems. It signified the importance of early diagnosis and treatment of the disease. A map of protein interactions of multiple organ systems was built and uncovered CAV1 and CTNNB1 as the top degree nodes. A core interactions sub-network was analyzed to identify different modules of functional significance. AR, CTNNB1, CAV1, and PIK3R1 proteins were unfolded as bridging nodes interconnecting different modules for the information flow across several pathways. The present study also highlighted some of the druggable targets to analyze in drug re-purposing strategies against the COVID-19 pandemic. Therefore, the protein interactions map and the modular interactions of the differentially regulated genes in the multiple organ systems would incline the scientists and researchers to investigate in novel therapeutics for the COVID-19 pandemic expeditiously.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.13 no.2
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• pp.200-210
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• 2000

objective to ascertain whether the concept of the therapeutic side is associated with changes in the blind sport mapping that represents the brain function. design Physiological blind spot maps were used as an integer of brain activity before and after acupuncture needling on the meridian point Hapkok(合谷) and Techung(太衝) in the unilateral side decided by double-blind controlled study(20 subjects). setting outpatient clinic participants: adult volunteers intervention twenty subjects were divided into two comparative groups and underwent specific acupuncture therapy on the unilateral side. Blinded examiners obtained reproducible pre and post-acupuncture cortical maps, which were subjected to statistical analysis. main outcome measures Brain activity was demonstrated by reproducible circumferential measurements of cortical hemispheric blind spot maps before and after acupuncture on the unilateral side. in case of acupuncture needling on the ipsilateral side of an enlarged side of bilnd spot, there were reduction of blind spot in 7 cases of 10 subjects, and enlargement in 3 cases. in case of acupuncture needling on the contralateral side of the enlarged side of blind spot, there were enlargement of blind spot in 6 cases of 10 subjects, and reduction in 4 cases. results the significant changes in the blind spots before and after acupuncture were observed Acupuncture needlings on the ipsilateral or contralateral side of an enlarged cortical map were associated with the concept of the therapeutic side traditionally accepted in the oriental medical society. Acupuncture needling on the ipsilateral side of an enlarged blind spot map is associated with the reduction of map, and increaed contralateral cortical activity. Acupuncture needling on the side opposite an enlarged blind spot map is associated with the enlargement of map, and decreased cortical activity. conclusion Reproducible maps of cortical responses can be used to measure the neurological consequences of acupuncture needling. Acupuncture can affect the somatic sensory informations that reach to the contralateral thalamus, and so affect thalamic integration. we found that acupuncture therapy may be associated with an increase or a decrease in brain function depending on the side of acupuncture needling. thus, the traditional concept of the contralateral therapeutic theory in acupuncture approach has the clinical significance in the view of brain function.

• Investigative Magnetic Resonance Imaging
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• v.17 no.4
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• pp.267-274
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• 2013

Purpose : To re-evaluate additional clinical significance of the apparent diffusion coefficient (ADC) map in the inference of infarction stage, authors studied the evolution patterns of the DWI and the ADC map of the brain infarction. Materials and Methods: In 127 patients with cerebral infarctions, including follow-up checks, 199 studies were performed. They were classified as hourly (117 studies)-, daily (108 studies)-, weekly (62 studies)-based groups. The signal intensity (SI) was measured at the core of the infarction and contralateral area with ROI of 0.3 $cm^2$ or more on the images of the DWI and the ADC map, and calculated the ratios of SI and ADC value of the infarction area / contralateral normal area, and compared the patterns of the change according to the evolution. Results: Infarction was detected as early as 1 hour after the attack, and the ratio of SI in the DWI became over than 2 after 12 hours, which showed a plateau until the 6th day. Thereafter, it decreased slowly to 1 on the 30th day, and changed to lower SI than the surrounding brain. The ratio in the ADC map became 0.46 in 24 hours after the attack, and increased slowly to 1 in the 15th day. Thereafter, it became a higher value than the surrounding brain. Overall, the ratio in the ADC map changed earlier than in the DWI, and the ratio curves showed inverse pattern each other according to the evolution of the infarction. Conclusion: The evolution patterns of infarction on the ADC map showed an inverse curve of DWI curve, which means that the ADC value is accurately predictable from DWI, and the ADC map joined with the DWI seems helpful in the determination of subacute infarction between 15 to 30 days.

• Advances in pediatric surgery
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• v.19 no.2
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• pp.122-129
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• 2013

Immature ganglion cell (IGC) is known for its relationship with intestinal motility and its impact on postoperative functional outcomes of Hirschsprung's disease (HD). There are few studies on the relationship between intestinal dysmotility and IGC in HD patients. 67 patients pathologically diagnosed with HD and who received definitive operation in Seoul National University Children's Hospital from 2010 to 2011 were included. 10 patients were excluded due to inadequate immunohistochemical staining results. The proximal end of resected ganglionic segment was evaluated with immunohistochemistry examination with MAP-2, a marker of ganglionic cells and bcl-2, a marker of IGCs The median age at operation was 155 (15-4678) day-old. 55 (96.5%) patients positive for bcl-2, were regarded as having IGC, and 2 (3.5%) patients positive for MAP-2 but negative for bcl-2, were regarded as having only mature ganglion cells. In the bcl-2 positive group, there were 7 patients (12.7%) with constipation, 15 patients (27.3%) with soiling, 3 patients (5.5%) with perianal excoriation and 6 patients (10.9%) with medication use. In bcl-2 negative group, intestinal dysmotility was not seen. There was no statistical significance in the two groups. Considering that HD is diagnosed at a young age, the rate of IGC present is very high and it might be inappropriate to relate IGC to functional outcome at young ages.