• Journal of the Society of Cosmetic Scientists of Korea
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• v.45 no.1
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• pp.87-93
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• 2019

This study attempted to eatablish a High Performance Liquid Chromatography (HPLC) analysis method for the determination of (-)-epicatechin gallate as a part of the quality control for the development of functional cosmetic materials from Penthorum chinense Pursh. HPLC was performed on a Unison $US-C_{18}$ column ($4.6{\times}250mm$, $5{\mu}m$) with a gradient elution of 0.05% (v/v) trifluoroacetic acid (TFA) and methyl alcohol at a flow rate of 1.0 mL/min at $30^{\circ}C$. The analyte was detected at 280 nm. The HPLC method was performed in accordance with the International Conference on Harmonization (ICH) guideline (version 4, 2005) of analytical procedures with respect to specificity, precision, accuracy, and linearity. The limits of detection and quantitation were 0.11 and 0.33 mg/mL, respectively. Calibration curves showed good linearity ($r^2$ > 0.9999), and the precision of analysis was satisfied (less than 0.6%). Recoveries of quantified compounds ranged from 99.51 to 101.92%. This result indicates that the established HPLC method is very useful for the determination of marker compound in P. chinense Pursh extracts.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.2 no.2
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• pp.11-18
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• 2001

The design method of high potential generator of diagnostic X-ray apparatus by using inverter is presented. For the high potential generator, a line filter, a rectifier, a Pulse width modulation control, bridge drive, a high potential transformer and a high potential rectifier circuit were adopted. The high potential generator with switching frequency to be 40 KHz is fabricated by using design method presented in this method. The experimental results are as followings; variable volts of 0∼620 V and variable currents 50∼500 mA.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.1156-1157
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• 2008

The use of the pulsed electro acoustic (PEA) method allowed us to perform the direct observations of spatio-temporal charge distributions in Electric double layer capacitors (EDLCs) based on polarizable nanoporous carbonaceous electrode. The negative charge density became the maximum, about 205 $C/m^3$ at the region where was near to collector layer in EDLCs for case $V_{DC}$ = 2.5 V, while the positively charged density became the maximum, about 61.1 $C/m^3$ at the region where it was located around the cathode layer. The PEA measurement used here is a very useful method to quantitively investigates the spatio-temporal charge distribution in EDLCs.

• Proceedings of the Materials Research Society of Korea Conference
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• 2010.05a
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• pp.56.1-56.1
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• 2010

A novel electrochemical potentiostatic method has been examined in order to enhance the hole concentration of p-type GaN thin films using KOH and HCl electrolyte. The hole concentration was increased more than 2 times by the electric voltge apply with the mobility of $10{\sim}12cm^2/V.s$. At optimum condition of 3V apply, hole concentration was enhanced more than reference sample from $1.7{\times}10^{-17}cm^{-3}$ to $4.1{\times}10^{-17}cm^{-3}$. Application of this activation method to blue-LED fabrication improved optical output from 18.4mW to 20.6mW, that is ~12% increase. SIMS analysis indicates that nearly 70% of hydrogen atoms could be removed by this method.

• Proceedings of the KAIS Fall Conference
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• 2010.05b
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• pp.1230-1232
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• 2010

A simple, rapid and validated reverse d phase liquid chromatographic method has been developed for the determination of Letrozole (LZ) in pharmaceutical dosage. LZ was separated on ODS analytical column with a mixture of acetonitrile, water in the ratio 50:50 (v/v) as mobile phase at a flow rate of 1.0 mL /min. The effluent was monitored by UV detection at 265nm. Calibration plot was linear in the range of 160 to $240{\mu}g$/mL with the linear regression (r) = 0.999. The method was validated for recovery, precision, specificity.

• Bulletin of the Korean Chemical Society
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• v.33 no.7
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• pp.2163-2167
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• 2012

A rapid, specific, and reliable LC-MS/MS-based bioanalytical method was developed and validated in rat plasma for the simultaneous quantitation of amitriptyline and its metabolite nortriptyline. Chromatographic separation of these analytes was achieved on a Gemini C18 column ($50{\times}4.60mm$, $5{\mu}m$) using reversed-phase chromatography. The mobile phase was an isocratic solvent system consisting of 1% formic acid in water and methanol (10:90, v/v), at a flow rate of 0.2 mL/min. The analytical range was set as 0.1-500 ng/mL for amitriptyline and 0.08-500 ng/mL for nortriptyline using a $200{\mu}L$ plasma sample. The accuracy and precision of the assay were in accordance with FDA regulations for the validation of bioanalytical methods. The validated method was successfully applied to a pharmacokinetic study in six rats after oral administration of amitriptyline (15 mg/kg). This method allows laboratory scientists to rapidly determine amitriptyline and nortriptyline concentrations in plasma.

• Fire Science and Engineering
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• v.24 no.1
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• pp.111-115
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• 2010

For the development of fire detector equipments that was fused independent type of fire detector and a wireless communication function, this paper adopted a signal processing method of an independent formation fire sensor by a ZigBee communication method, and it was designed that the combinations of fire detector and wireless communications network were enabled. When a fire occurred, output voltage of a fire detector was 0.4 V, the movement pulse width was $600{\mu}s$, and that was confirmed by an experiment. When it has lookout state, LED worked by 30 s cycle and working current is 0.12 mA. When a fire occurred, LED worked by 0.5 s cycle and working current was 7 mA, and through this experiment of power source, Chamber tester, smoke tester,IRED, LED lighting, the propriety of the method that we showed in this paper confirmed.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.04a
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• pp.102-102
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• 2019

This study developed a HPLC analysis method for the determination of avicularin (AL) and quercitrin (QT) in Astilbe chinensis by HPLC. HPLC was performed on a Capcell Pak C18 MGII column ($4.6{\times}250mm$, $5{\mu}m$) with a gradient elution of 0.05% (v/v) trifluoroacetic acid (TFA) and acetonitrile at a flow rate of 1.0 mL/min at $30^{\circ}C$ and a UV detection wavelength of 254 nm. The analytical method was validated for its specificity, precision, accuracy, and linearity. The limits of detection and quantitation were AL 0.09 and 0.28 mg/mL, QT 0.03 and 0.09 mg/mL respectively. Calibration curves showed good linearity (AL r2 > 0.99990 and QT r2 > 0.99994), and the precision of analysis was satisfied (less than AL 0.59%, QT 0.63%). Recoveries of quantified compounds ranged from AL 100.57 to 102.08%, QT 99.94 to 100.64%. These results indicate that the developed HPLC method was applied successfully to the detection of AL and QT in A. chinensis.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.43 no.10 s.352
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• pp.97-103
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• 2006

This paper presents the method of improving second order intermodulation distortion(IMD2) and dc-offset problems in down-conversion mixer. A simple analysis reveals the IMD2 and dc-offset can be eliminated by controlling the duty cycles of local oscillator(LO) inputs. A mixer with the proposed method has been simulated with a $0.13{\mu}m$ RF CMOS technology with 5% mismatch in the load resistance, the mixer shows 2.04dBm IIP2 and 22mnV input referred DC-offset. By controlling two duty cycles of LO inputs, IIP2 and DC-offset can be improved to 38.8dBm and $777{\mu}V$, respectively.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.10a
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• pp.848-851
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• 2012

In this paper, circuit of reducing the offset voltage in Op-amp, effectively, is newly proposed by using dual capacitor. Capacitors and MOS switches are added in proposed circuit to make up for the weak points of previous circuits ofr reducing the offset voltage in auto-zeroing method. Also, it is designed to reduce the offset voltage in high frequency range by using chopping method, effectively. Circuit simulation and layout are executed by TSMC 1.8V, 0.18um process. From the simulation results, it is verified that magnitude of offset voltage is under 5mV and proposed circuit is good for compensation of offset voltage better than previous auto-zeroing method.