Proceedings of the KAIS Fall Conference (한국산학기술학회:학술대회논문집)
- 2010.05b
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- Pages.1230-1232
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- 2010
Determination of Letrozole in formulation by a Validated RP-HPLC method
- Ganesh, Mani (Dept of Chem. Eng., Hanseo University) ;
- Bhagiyalakshm, Margandan (Dept of Chem. Eng., Hanseo University) ;
- Vinoba, Mari (Carbon Dioxide Reduction & Sequestration Research Center, Korea Institute of Energy Research) ;
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Jang, Hyun-Tae
(Dept of Chem. Eng., Hanseo University)
- Published : 2010.05.28
Abstract
A simple, rapid and validated reverse d phase liquid chromatographic method has been developed for the determination of Letrozole (LZ) in pharmaceutical dosage. LZ was separated on ODS analytical column with a mixture of acetonitrile, water in the ratio 50:50 (v/v) as mobile phase at a flow rate of 1.0 mL /min. The effluent was monitored by UV detection at 265nm. Calibration plot was linear in the range of 160 to
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