• Food Science and Biotechnology
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• 제14권6호
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• pp.793-797
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• 2005

Optimum conditions for cholesterol removal in egg yolk were evaluated based on ratio of egg yolk-to-water, crosslinked ${\beta}$-cyclodextrin (${\beta}$-CD) concentration, and mixing temperature, time, and speed by adding crosslinked ${\beta}$-CD treated with adipic acid. Cholesterol removal in egg yolk-water mixture increased with increasing ${\beta}$-CD level (10-25%). About 95% was removed by 25% ${\beta}$-CD at 1:1 ratio of egg yolk-to-water and 800 rpm mixing at $40^{\circ}C$ for 30 min. In recycling study, removal rates were measured using ten times recycled crosslinked ${\beta}$-CD in egg yolk, and 85% cholesterol removal was observed with eight times reuse. These results indicated that over 90% cholesterol was removed at 1:1 ratio of egg yolk-to-water, 20% crosslinked ${\beta}$-CD addition, and 30 min mixing with 600 rpm at $40^{\circ}C$.

• 폴리머
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• 제36권1호
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• pp.1-8
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• 2012

본 연구에서는 초임계 aerosol solvent extraction system(ASES) 공정을 이용하여 poly(lactic-$co$-glycolic acid)(PLGA) 미립자를 제조하기 위해 첨가제로 hydroxypropyl-${\beta}$-cyclodextrin (HP-${\beta}$-CD)를 사용하였으며, HP-${\beta}$-CD의 첨가량이 PLGA 입자의 형상에 미치는 영향을 조사하였다. 또한 항암제인 파클리탁셀이 봉입된 미립자를 제조하여 HP-${\beta}$-CD의 함량에 따른 약물 방출 특성의 변화를 고찰하였다. PLGA(75:25)의 경우 HP-${\beta}$-CD를 고분자 중량 대비 약 40%까지, PLGA(50:50)의 경우 약 30%까지 첨가하였을 때 미립자가 형성되었으며, HP-${\beta}$-CD의 첨가량이 이보다 더 적은 경우에는 PLGA가 필름 형태로 형성되었다. 파클리탁셀이 봉입된 PLGA/HP-${\beta}$-CD 미립자의 경우 HP-${\beta}$-CD의 함량이 증가함에 따라 더 빠른 속도로 약물이 방출됨을 확인할 수 있었다.

• Journal of Pharmaceutical Investigation
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• 제14권1호
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• pp.19-30
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• 1984

The pharmaceutical characteristics of solid indoprofen inclusion complex such as dissolution, permeation through a cellophane membrane, model analysis of interfacial tranesfer, absorption behaviors in rat intestine, and the plasma concentration of indoprofen after oral administrations to rabbits were examined in comparison with those indoprofen alone. The inclusion complex obtained by freeze-drying method showed the higher dissolution rate and membrane permeability among the test powders, and increased significantly the amont of indoprofen absorbed in rat intestine and the levels of plasma concentration of indoprofen after oral adminstrations to rabbits. The increase of bioavailability of $indoprofen-{\beta}-cyclodextrin$ complex was considered due to the increased solubility and dissolution rate of solid powder form.

• Bulletin of the Korean Chemical Society
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• 제30권1호
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• pp.145-148
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• 2009

Nucleotides are the building blocks of nucleic acids and essential for many cellular functions. In this study, ultrasonic absorption spectra of $\beta$-cyclodextrin ($\beta$-CD) and adenosine 5'-monophosphate (AMP) in aqueous solution were measured over the broad frequency range 0.1-40 MHz with emphasis on the low-frequency range below 1 MHz. Here we show that the interaction of $\beta$-CD and AMP complies with a typical spectrum of a single relaxation process. We determined reliable rate (kb) and equilibrium (K) constants and a standard volume change ($\Delta$V) of the reaction. They are $k_b=2.3{\times}{{10^{-6}}_s}^{-1},\;K=89M^{-1},\;and\;{\Delta}V=13.8(10^{-6}m^3mol^{-1})$, respectively.

• 분석과학
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• 제17권1호
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• pp.16-22
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• 2004

Inclusion complexes of the p-nitrophenol with ${\beta}$-cyclodextrin (CD), sulfated ${\beta}$-CD, and ${\beta}$-CD polymer cross-linked with epichlorohydrine (EP) were prepared and characterized by Raman spectroscopy. The intensity of vibration peaks of the C-O and C-N at 1284 and $856cm^{-1}$ of the p-nitrophenol in the presence of EP-linked CD polymer was remarkably increased, respectively. The vibration modes at 1284 and $856cm^{-1}$ are assigned to the out-of phase C-C-O stretching mode and the C-N stretching mode, respectively. The vibration peaks at 1284 and $856cm^{-1}$ increased with increasing the content of EP-linked CD polymers, while decreased with increasing the p-nitrophenol content. Furthermore, the vibration mode of the $NO_2$ symmetric stretch at $1344cm^{-1}$ enhanced with increasing the content of p-nitrophenol.

• 한국식품과학회지
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• 제26권2호
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• pp.117-122
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• 1994

여러가지 전분에서 AL-complex의 형성에 lysolecithin의 첨가가 미치는 영향과 cyclodextrin의 첨가에 의한 CL-complex 형성효과를 AL-complex 형성과의 관계로 DSC를 이용하여 비교하였다. 옥수수, 밀, 쌀 전분은 모두 $100^{\circ}C$ 전후의 높은 온도에서 endothermic peak을 나타냈으며 2차 가열에서도 그대로 존재하여 AL-complex의 용융은 가역반응이고 3가지 전분에 상당량의 AL-complex가 존재함을 보여주었다. Lysolecithin의 첨가에 의해 AL-complex의 용융엔탈피는 증가하고 용융온도도 증가하는 경향을 보여 lysolecithin에 의한 AL-complex 형성효과가 뚜렷하였다. 형성된 AL-complex에 ${\beta}-CD$을 첨가하면 AL-complex의 peak가 감소하는 반면 $70^{\circ}C$ 근처에서 새로운 peak가 나타났으며 ${\beta}-CD$의 농도를 증가하였을 때 AL-complex의 peak가 비례하여 감소하였다. 이는 $lysolecithin-{\beta}-CD$ complex가 형성되어 lysolecithin이 ${\beta}-CD$으로 전이되었으며 동시에 amylose가 complex로부터 유리되었음을 시사하고 있다. 이를 증명하기 위하여 ${\beta}-CD$의 존재하에 AL-complex를 가열한 후 amylase를 착용시킨 결과 가수분해속도가 현저히 증가하여 AL-complex로부터 amylose가 유리됨을 알 수 있었다.

• Bulletin of the Korean Chemical Society
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• 제26권12호
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• pp.2061-2064
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• 2005

• 약학회지
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• 제37권3호
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• pp.216-227
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• 1993

Complex formations of practically insoluble antelmintic drugs such as mebendazole (MBZ), albendazole (ABZ) and flubendazole (FBZ) with dimethyl-$\beta$-cyclodextrin (DM-$\beta$-CyD) and 2-hydroxypropyl-$\beta$-cyclodextrin (HP-$\beta$-CyD) together with $\alpha$-, $\beta$- and $\gamma$-cyclodextrins(CyDs) in duffered solutions were investigated by solubility method. $A_{L}$ type phase solubility diagrams were obtained in all cases except for the complexation (B$_{s}$, type) of FBZ with $\gamma$-CyD. The highest stability constants were obtained with DM-$\beta$-CyD, followed by $\alpha$-CyD > $\beta$-CyD > HP-$\beta$-CyD > $\gamma$-CyD for ABZ, and HP-$\beta$-CyD > $\gamma$-CyD > $\beta$-CyD > $\alpha$-CyD for FBZ at pH 1.2. On the other hand, solid dispersion systems of ABZ and FBZ with $\beta$- and DM-$\beta$-CyDs were prepared by solvent evaporation method and evaluated by dissolution, differential thermal analysis and powder x-ray diffractometry. The dissolution rates of ABZ- and FBZ-DM-$\beta$-CyD solid dispersions were much faster than those of drugs alone, corresponding physical mixtures and tablets on market both at pH 1.2 and 6.8. Although dissolution rates of all samples at pH 6.8 were by far lower than those obtained at pH 1.2, as explained by pH-solubility profiles for ABZ and FBZ, the dissolution rates at pH 6.8 of ABZ from $\beta$- and DM-$\beta$-CyD solid dispersions exceeded the respective equilibrium solubility (23.9 $\mu\textrm{g}$/ml). Fast dissolution of ABZ from solid dispersions with CyDs was attributed to the reduction of drug crystallinity and particle size which was supported by DTA and powder x-ray diffractometry. Consequently these results suggest that solid dispersion systems with CyDs may provide useful means to markedly enhance the solubility and dissolution of benzimidazole antelmintic drugs.

• 폴리머
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• 제39권2호
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• pp.261-267
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• 2015

The inclusion complexes (ICs) between polylactic acid (PLA) and ${\beta}$-cyclodextrin (CD) were prepared by co-precipitation method in this work. The orthogonal experiments were designed to investigate the influence of different factors on the formation of inclusion complexes. The results suggested that the optimum scheme of inclusion compounds could be obtained when the feeding ratio of CD to PLA (wt%) was 20:1, stirring speed was 6 kr/min and the stirring time was 30 min. The structures and properties of the inclusion complexes were characterized by $^1H$ NMR, FTIR, DSC, FT-Raman, XRD and TGA. The DSC results demonstrated that the crystallization behavior of the inclusion complexes nearly disappeared. It was found that ${\beta}$-CD-PLA inclusion complex had a better thermal stability compared with the neat PLA. The model of the inclusion complexes was proposed on the basis of XRD, $^1H$ NMR and DSC results.

• 산업식품공학
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• 제21권3호
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• pp.215-224
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• 2017

Resveratrol was incorporated into various combinations of single- and double-layer nanoemulsions, prepared by self-assembly emulsification and complex coacervation with chitosan, alginate, and ${\beta}$-cyclodextrin, respectively. Resveratrol nanoemulsions were composed of medium-chain trigacylglycerols (MCTs), $Tween^{(R)}$ 80, water, chitosan, alginate, and ${\beta}$-cyclodextrin. The corresponding mixtures were formulated for the purpose of being used as a nutraceutical delivery system. Resveratrol nanoemulsions were obtained with particle sizes of 10-800 nm, with the size variation dependent on the emulsification parameters including the ratio of aqueous phase and surfactant ratio. Resveratrol nanoemulsions were characterized by evaluating particle size, zeta-potential value, stability, and release rate. There were no significant changes in particle size and zeta-potential value of resveratrol nanoemulsions during storage for 28 days at $25^{\circ}C$. The stability of resveratrol in the double-layer nanoemulsions complexed with chitosan or ${\beta}$-cyclodextrin was higher, compared with the single-layer nanoemulsions.