Landslides triggered by the combination of heavy precipitation and anthropological disturbance in hilly areas cause severe damage to human lives, properties, and infrastructure constructions. A comprehensive investigation of the influencing factors and failure mechanisms of landslides are significant for disaster mitigation and prevention. This paper utilized the combination of detailed geological investigation, physical experimental testing as well as numerical modelling to determine the failure mechanism, and proposed a countermeasures of the Lantian landslide occurred on 2, July 2017. The results reveal that the Lantian landslide is a catastrophic reactivated slide which occurred in an active tectonic region in Southwest China. Because of the unique geological settings, the fully to highly weathered basalts in the study area with well-developed fractures favored the rainwater infiltration, which is the beneficial to slide reactivation. Engineering excavation and heavy precipitation are the main triggering factors to activate the slide motion. Two failure stages have been identified in the landslide. The first phase involves a shallow mass collapse originated at the upper slopes, which extends from the road to platform at rear part, which is triggered by excavation in the landslide region. Subjected to the following prolonged rainfall from 19 June to 2 July, 2017, the pore water pressure of the slope continually increased, and the groundwater table successively rise, resulting in a significant decrease of soil strength which leads to successive large-scale deep slide. Thereinto, the shallow collapse played a significant role in the formation of the deep slide. Based on the formation mechanisms of the landslide, detailed engineering mitigation measures, involving slope cutting, anchor cable frame, shotcrete and anchorage, retaining wall and intercepting ditch were suggested to reduce the future failure risk of the landslide.