The study focuses on the characterization of asphalt pavement mechanical properties containing two different sizes of irradiated plastic waste polyethylene terephthalate (IP) using gamma irradiation technique as fine aggregate substitutes in a 14mm asphaltic concrete wearing (ACW14). Response Surface Methodology (RSM) was employed in this study to determine the relationships between three independent factors (IP6, IP16, and bitumen content) on mix volumetric and Marshall Characteristics. To fabricate the samples, 0 to 1%, 1 to 2.5%, and 4 to 6% all by weight of aggregate particles were used as percentages for IP6, IP16, and bitumen contents, respectively. RSM statistical analysis demonstrates a high coefficient of correlation (R2) of 0.9700, 0.9896, 0.9869, and 0.8946 for the responses bulk density (BSD), void in the mix (VIM), stability, and flow, respectively. The high correlation coefficient shows that the models developed are in reasonable agreement with the analyzed experimental outcomes. Investigation of the individual effect of the independent factors elucidates that interactions between the three factors influenced all the responses. In view of the outcomes accomplished 0.55%, 1.77%, and 4.63% were observed to be the optimized contents for IP6, IP16, and bitumen contents, respectively.