Objectives : The purpose of this study is to analyze the correlation between fine dust(PM10.5, PM2.5) and the number of acute/chronic sinusitis patients. Methods : A simple regression analysis was performed based on the concentration of PM10 and PM2.5 as independent variables and the number of acute/chronic sinusitis patients as dependent variables. Results : As a result of simple regression analysis, if PM10 increases by $1{\mu}g/m^3$, the number of acute sinusitis patients increases by 7,000.291(P<.001, 95%CI :4,951.983-9,048.600). If PM2.5 increases by $1{\mu}g/m^3$, the number of acute sinusitis patients increases by 17,524.476.(P<.001, 95%CI:9,728.725-25,320.228) In addition, PM10 increases by $1{\mu}g/m^3$, the number of acute sinusitis patients increases by 3,163.471 (P<.001, 95% CI:2,268.642-4,058.301). If PM2.5 increases by $1{\mu}g/m^3$, the number of chronic sinusitis patients increases by 8,651.644.(P<.001, 95%CI:5,115.697-12,187.592) Conclusions : Both PM10 and PM2.5 are correlated with changes in the number of sinusitis patients. PM2.5 has effect on the number of patients than PM10. PM10 is the highest correlation in their 50s, PM2.5 in their 60s and 70s.

Objectives : The purpose of this study is to analyze the use of herbal medicine for the treatment of urticaria in case studies and to find the general tendency of herbal medicine treatment and to establish the primary treatment direction of urticaria. Methods : In the domestic databases, Oriental medicine Advanced Searching Integrated System (OASIS), Korean Traditional Knowledge Portal (KTKP), National Discovery for Science Leader (NDSL), Research Information Sharing Service (RISS), we selected among the case study papers published in the last 20 years using search terms related to "urticaria". Reports related to Sasang Constitutional medicine were excluded and total of 15 papers were finally selected. Results : 23 prescriptions were retrieved from 15 papers. The most commonly used prescription was Seungmagalgeun-tang (升麻葛根湯), and Bangpoongtongsung-san (防風通聖散) and Pyeongwi-san (平胃散) were presented twice. Commonly used herbs are Glycyrrhizae Radix et Rhizoma (甘草), Zingiberis Rhizoma Recens (生薑), and Scutellariae Radix (黃芩). 18 out of 78 herbs are belonging to heat-clearing medicinal (淸熱藥) and 16 out of 78 herbs are belonging to exterior-releasing medicinal (解表藥). Concurrent therapies such as acupuncture, pharmacoacupuncture, moxibustion, cupping therapy, ice pack applying therapy were performed and several evaluation methods were used, patient's subjective remission rate was the most used. Conclusions : Through this study, we were able to discover the tendency of herbal medicine prescription for the treatment of urticaria.

Objectives : The purpose of this study is to investigate the possibility of applying acupuncture to the treatment of meniere's disease, which has no definite treatment methods, by analyzing the latest clinical researches about acupuncture treatment of meniere's disease. Methods : A case study and Randomized Controlled Trial (RCT) related to the acupuncture treatment of meniere's disease were searched using domestic and international thesis search engines including OASIS, CNKI, J-STAGE, PubMed. This study include acupuncture treatment and acupuncture combined with other treatments such as herbal medicine. The search was limitied to the publication date from 2000 to 2018 with free full text. Results : 17 cases were selected. There were 7 case studies in Korea, 5 case studies in China, and 5 RCT papers in China. All 12 cases reported improvement in meniere's disease and all RCT studies showed significantly higher treatment effects in the experimental group than in the control group. Conclusions : Acupuncture treatment showed significant effects for meniere's disease when applied alone or in combination with other treatments. In the future, various systematic studies should be conducted only for acupuncture treatment.

Objectives : This study is designed to clarify whitening, anti-inflammatory effect of fractions extracted from the mixture of Phaseolus radiatus L. and ethanol. Methods : In this experiment, we were intended to reveal whitening, anti-inflammatory effect of fractions extracted from the mixture of Phaseolus radiatus L. and ethanol. The whitening activity was confirmed by UV blocking activity, tyrosinase inhibiting activity, and melanin formation inhibiting activity. Anti-inflammatory activity is confirmed by measurement of cytotoxicity level by MTT assay and measurement of Cytokine expression, which is the main mediator of inflammation reaction. Results : As a results, overall activity was high in the ethyl acetate fraction. Tyrosinase inhibitory activity was less than 20% at all concentrations, but the activity to inhibit melanin self-production was higher than that of ethyl acetate fraction at $32.19{\pm}2.79%$ at $100{\mu}g/m{\ell}$. And ethyl acetate fraction had a relatively high UV blocking activity. In the anti-inflammatory test, the concentration-dependent activity was shown, and the chloroform and ethyl acetate fractions showed significant NO production inhibitory activity. Cytokine expression was superior to that of the final stage of B cell differentiation, and cell viability was over 80% except for the chloroform fraction at the concentration of $200{\mu}g/m{\ell}$. Conclusions : The results of this experiment confirmed the whitening effect and anti-inflammatory effect of Phaseolus radiatus L.'s extracts and fractions and report the possibility of application as external medicine.

Objectives : The aim of this review is to investigate studies on skin adverse reactions and to demonstrate subjects related to the adverse effects in dermatology. Methods : Electric searches were performed with KISS(Korean studies Information Search System) and the key words were combination of 'skin' and 'adverse effect'. 87 literatures investigated in this review were issued from 1900 to 2016. Results : Among the 87 papers, dermatologic adverse reactions were reported in 83 papers in medicine, accounting for 95.4%. Of the adverse effects seen on the skin, 84 discoloration such as erythema, pigmentation and hemotelangiosis were the most common, accounting for 21%. Among the medical adverse reactions not seen on the skin, 21 infection were the most common, accounting for 25%. Among the subjective adverse reactions, of which 32 pruritus were the most common, accounting for 43%. Among the 87 papers, there were 3 cases with underlying diabetes and 3 cases with underlying hypertension, followed by 2 cases with chronic renal failure, HBV, atopic dermatitis and respectively 1 case with alcoholism, depression addiction, multiple myeloma, arthritis and psoriasis. The most frequent period until adverse reactions appeared was within 2 weeks, accounting for 13 papers. And 4 were the most frequent adverse reactions lasting less than 1 month, and 4 were more than 3 months and less than 6 months. There were 48 cases where adverse reactions were caused by nonmedical practioner's treatment. The adverse reactions by the pharmacist were the highest at 11 cases (23%). There were 17 cases of adverse reactions due to medical treatment, among which dermatologists and nondermatologists accounted for the majority of 5 cases, 29%. The most common cause of adverse reactions was the application of external medicine (41 cases), followed by 36 cases of foreign body implantation, eyebrow tattooing, ear piercing, etc. Conclusions : In this report, we demonstrated patterns of adverse reactions in the medical field of dermatology caused by non-medical personnel than medical personnel. We suggest that more effort should be followed by medical personnel to establish clear awareness of skin disease and by patients to be aware of the risks of the illegal medical treatment by non-medical personnel.

Objectives : The purpose of this study is to review the chinese published papers on cauterization of traditional chinese medicine. Methods : We searched chinese published papers from 1958 until May 2017 via CNKI(China National Knowledge Infrastructure) with the keyword "cauterization". We analyzed the studies covered cauterization medical treatment, and classified them by 5 categories including periods, type of study, treatment site, experiment target site, and cauterizing method. Results : We reviewed 112 chinese papers which include 10 Original articles, 43 Review articles, and 59 Case reports. Examining yearly distributions, we can see that research on cauterization is becoming more active than in the past. In classification of 93 clinical studies by treatment site, the number of research on Tonsillitis accounts for almost half(43 studies), followed by Sore throat(14 studies). Among 10 experimental studies, Eye is the most frequently targeted organ which was used to study high intra-ocular pressure(5 studies), and retinal ganglion cell(2 studies). Lastly, there are various methods of cauterization used in papers: Branding iron(54 studies), and Red-hot needle(24 studies) are two major heating methods. Conclusions : This analysis shows that studies on the application of cauterization have been actively conducted in China these days. Furthermore, up-to-date cauterizing methods have been developed such as electric type and microwave type beyond traditional ways. We expect this article will encourage further research on cauterization in order to apply it to a variety of diseases. Then, it could become one of new effective medical treatments in Korean medicine.

목적 : 체계적 문헌고찰을 통하여 지루피부염에 한약복용의 효과와 연구의 질을 평가하기 위함. 방법 : OASIS, NDSL, EMBASE, Pubmed, Cochrane Library, CINAHL, CNKI, WANFANG, CiNii, J-STAGE를 이용하여 검색하였다. 검색은 2018년 6월 21일에 시행되었으며 P는 지루성 피부염, I는 한약 복용으로 진행하였다. 두 명의 연구자가 독립적으로 연구를 평가하고 선정하였으며, 의견이 다를 경우 제 3자가 개입하여 다수결로 결정하였다. 결과 : 중복 검색을 제외하고 총 952개의 연구가 검색되었으며 제목과 초록을 검토한 결과 897개의 연구가 제외되었다. 나머지 55개 연구의 전문을 검토한 결과 4개의 RCT연구가 최종 선정되었다. 선정된 연구는 발행연도, 대상, 중재법, 평가방법, 효과, 부작용, RoB를 통해 평가하였다. 한약 복용을 한 치료군에서 대조군에 비해 유의하게 호전을 보였으며 중대한 부작용은 없었다. 결론 : 지루성 피부염에 있어 한약 복용은 효과적이며 안전성이 있는 하나의 치료법이다. 향후 다양하고 체계적인 RCT의 시행이 요구된다.

Objectives : This study is designed for trend analysis of oriental medicine treatment for visual impairment. Methods : Research studies related to objectives were gathered through OASIS, KTKP, PUBMED with keywords such as "visual impairment", "myopia", "hyperopia", "presbyopia", "astigmatism" and analyzed. Results : As a result of searching domestic and overseas research on oriental medical treatment for visual impairment, 7 domestic research papers and 11 overseas research papers have been selected. Among those research papers, 15 of those are studies related to childhood or juvenile myopia. Acupuncture, ear acupuncture, herb medicine, periocular massage, eye muscle exercise and habit correction are used as treatment methods for visual impairment. 14 out of 17 research papers which mentioned treatment effect of oriental medicine reported oriental treatment of visual impairment is effective. Conclusions : Various types of oriental medical treatment could be effective in treating visual impairment. Thus, related in-depth research must be proceeded.

Objectives : Recently, Thread Embedding Acupucnture (TEA) targeting under dermis became known to be effective for facial wrinkles and folds; its practice has begun in clinics. The introduction of a new form of TEA is continuing, and 'Volume TEA' is introduced recently. Therefore, we would like to report on the improvement of facial wrinkles by using the recently introduced 'volume TEA'. Methods : We reviewed the medical records of three patients who received 'Volume TEA' treatment at a Korean medical clinic, the photographs taken before and after the procedure were corrected using a Photoshop program and the length of the each wrinkles and folds were measured. Results : The length of wrinkles measured in all three cases decreased. Especially, the decrease of the length of the nasolabial folds was obvious. In case 1, the length of the nasolabial folds of 177mm and 97mm were reduced to 94mm and 63mm, respectively. In the case 2, the length of the nasolabial folds of 155mm and 155mm were reduced to 0mm and 70mm, respectively, after the procedure. In case 3, the length of the nasolabial folds of 170mm and 50mm decreased to 38mm and 37mm after the procedure, respectively. Conclusions : At present, it seems that the ongoing accumulation of relevant studies on the efficacy and safety of wrinkle and folds of TEA seems necessary. This study also has some significance in the level of case report.

Objectives : The purpose of this paper is to report the effect of Korean medicine treatments on allergic contact dermatitis aggravated after applying steroid ointment. Methods : We treated a 63-year-old woman with allergic contact dermatitis on the both forearm, jaw, neck, chest with Korean medicine. Before Korean medicine treatments she has taken oral steroids and applied steroid ointment for several years to treat dermatitis, but long-tern steroid therapy aggravated her symptoms like skin pruritus, erythema, exudates or edema. After Korean medical treatment for 27 days, we found that the size of erythema was reduced, and symptoms like pruritus, exudates and edema were lost. We recorded pictures of changes on symptoms. Results & Conclusions : The symptoms of allergic contact dermatitis were improved. Erythema, edema, exudate were lost. Thus Korean medicine treatments are effective on allergic contact dermatitis and could be a great alternative to steroid treatment.

Objectives : The purpose of this study is to report the effect of Psoraleae Semen extract and korean medical treatments on 3 psoriasis patients. Methods : 200g of Psoraleae Semen was dipped in $1000m{\ell}$ of alcohol for 7days. The residue was filtered to use the solution. Extract was applied to psoriasis and UVB rays were irradiated for 10 minutes or more. PASI(psoriasis area and severity) score was used to check the prognosis of 3 psoriasis patients. Results : All three cases achieved PASI 50 within 4 weeks and two of 3 cases reached PASI 75 within 4 weeks. Conclusions : Psoraleae Semen extract and korean medical treatments is effective method for treating Psoriasis. It can shorten the duration of treatment of Psoriasis.

Objectives : The purpose of this study is to report the effect of Traditional Korean Medical treatment on Postherpetic Neuralgia. Methods : Five patients suffering from postherpetic neuralgia were treated with Warm Needling, Bee venom Acupuncture, Cupping Therapy, Sipjeondaebo-tang. To evaluate the results of this treatment, we used Visual Analogue Scale(VAS), Pain Rating Scale(PRS), Quality of Sleep(QSP). Results : After treatment, VAS, PRS, QSP and clinical symptoms of 5 patients were improved remarkably. Conclusions : According to the results, These findings suggest that Traditional Korean Medical treatment can be effective for the treatment of postherpetic neuralgia.

Objectives : The aim of this study is to report the effect of herbal medicine and acupuncture on a breastfeeding woman's postpartum urticaria which was unresponsive to a 1st generation antihistamine and a topical steroid. Methods : Wheals and pruritus occurred to a 36-year-old breastfeeding woman 2 days after the parturition. Symptoms were unresponsive to about a week of systemic antihistamine and topical steroid treatments. GamiSamul-tang herbal decoction was administered three times a day for the first 21 days and twice a day for the next 10 days of the treatment. Acupuncture treatment was applied to 12 acupoints (both sides of LI04, LR03, ST36, LI11, SP10, SP6) for 15 minutes once a week, 5 times in total. The patient's symptom was evaluated with Weekly Urticaria Activity Scale (UAS7) and Visual Analogue Scale for Worst Pruritus within 24 hours ($VAS_{Pruritus}$) each time the patient visited out-patient department. Results : The scores of UAS7 and $VAS_{Pruritus}$ at the baseline were 38 and 8.2 respectively. 10 days after the herbal medicine and acupuncture treatment began, both decreased to 0 and wheal, pruritus, erythema didn't appeared again for the rest of the follow up periods. Conclusions : This study shows the possibility of using GamiSamul-tang and acupuncture to treat postpartum urticaria.