Structural health monitoring (SHM) of civil infrastructure using fiber Bragg grating sensor networks (FBGSNs) has received significant public attention in recent years. However, there is currently little research on the health-monitoring technology of high-piled wharfs in coastal ports using the fiber Bragg grating (FBG) sensor technique. The benefits of FBG sensors are their small size, light weight, lack of conductivity, resistance corrosion, multiplexing ability and immunity to electromagnetic interference. Based on the properties of high-piled wharfs in coastal ports and servicing seawater environment and the benefits of FBG sensors, the SHM system for a high-piled wharf in the Tianjin Port of China is devised and deployed partly using the FBG sensor technique. In addition, the health-monitoring parameters are proposed. The system can monitor the structural mechanical properties and durability, which provides a state-of-the-art mean to monitor the health conditions of the wharf and display the monitored data with the BIM technique. In total, 289 FBG stain sensors, 87 FBG temperature sensors, 20 FBG obliquity sensors, 16 FBG pressure sensors, 8 FBG acceleration sensors and 4 anode ladders are installed in the components of the back platform and front platform. After the installation of some components in the wharf construction site, the good signal that each sensor measures demonstrates the suitability of the sensor setup methods, and it is proper for the full-scale, continuous, autonomous SHM deployment for the high-piled wharf in the costal port. The South 27# Wharf SHM system constitutes the largest deployment of FBG sensors for wharf structures in costal ports to date. This deployment demonstrates the strong potential of FBGSNs to monitor the health of large-scale coastal wharf structures. This study can provide a reference to the long-term health-monitoring system deployment for high-piled wharf structures in coastal ports.