인간(人間)의 감각(感覺), 운동(運動), 사고등(思考等)에 직접관여(直接關與)하는 체성신경원(體性神經元)이 인체내(人體內)에 있어서 단일세포동물(單一細胞動物)과 비체성신경원(非體性神經元)과 같이 각종(各種)의 자극(刺戟)에 직접응(直接應)하므로써 기능적(機能的) 활동(活動)을 개시(開始)한다는 한연(漢然)한 예상하(豫想下)에서 말초(末梢)에서는 혹종(或種)의 통소(痛素)를, 중추(中樞)에서는 어떤 묘(妙)한 화학적(化學約)인 흥분전달물질(興奮傳達物質)을 탐구(探求)하고 있으며 말초(末梢)의 통흥분시발(痛興奮始發)과 대뇌피질(大腦皮質)의 기능발생(機能發生)같은 중요(重要)한 제기전(諸機轉)이 해명(解明)될 가능성(可能性)조차 보이지 않는 것이 체성신경생리학(體性神經生理學)의 현상(現狀)이다. 저자(著者)는 생태분리(生態分離)한 단일신경섬유실험(單一神經纖維實驗)과 임상적연구(臨床的硏究)로서 인체내(人體內)의 체성신경섬유(體性神經纖維)와 그 구심성종말(求心性終末)은 최종(最終) 공통기계적자극(共通機械的刺戟)을 받는 점(點)을 입증(立證)하고 뇌피질내(腦皮質內)의 입사(入射)에 의(依)한 Synapse 전달(傳達)이 기계적(機械的)인 점(點)과 모세혈관확대(毛細血管擴大)에 의(依)한 Glial Satellite 부(部)의 기계적전달(機械的傳達)과 Spine Koph 에서는 입사(入射) 없이도 Massage에 의(依)하여 초발탈분극(初發脫分極)이 발생(發生)될 필연성(必然性)을 지적(指摘)하는 동시(同時)에 저자(著者)가 부르는 ${\ulcorner}$체성신경계(體性神經系)의 기계적생리학(機械的生理學)${\lrcorner}$에 의(依)하면 난간(難間)에 속(屬)하는 대다수(大多數)의 신경현상(神經現象)과 정신현상(精神現象)이 구체적(具體的)이며 합리적(合理的)이요 또 실용적(實用的)으로 해명(解明)됨을 실례(實例)를 들어서 예시(例示)한다. 본연구(本硏究)는 습수만예(拾數萬例)의 단일신경섬유관찰(單一神經纖維觀察)과 수백예(數百例)의 임상적연구(臨床的硏究)와 최근고도(最近高度)로 발달(發達)된 기술(技術)에 의(依)한 징소생리학적(徵少生理學的) 제연구업속(諸硏究業續)과 전자현미경적형태학성과(電子顯徵鏡的形態學成果)를 종합(綜合)하므로써 성립(成立)된 것이요 하등(何等)적 무리(無理)한 억측(憶測)을 내포(內包)하지 않음을 확신(確信)한다.

Disappearance rate of injected $D_2O$ from the arterial blood as well as the effect of histamine on the rate were studied in rabbits. The concentrations of $D_2O$ in the serial arterial samples obtained through a Polyethylene tubing inserted into the carotid artery were assayed by the freezing point elevation method of Reaser. At zero time 3 ml of isotonic $D_2O$ in normal saline was injected into the jugular vein and at the same time serial sampling of arterial blood started. The serial sampling interval was either 7.7 sec or 12.3 sec. In the histamine treated animals histamine diphosphate (0,5 mg of histamine base) was injected intravenously 30 minutes prior to the zero time. The following results were obtained. 1. $D_2O$ concentration in arterial plasma water, x, was empirically obtained by the sum of 2 exponential terms of time, $x=Ae^{-k1t}+Be^{-k2t},$ and its theoretical basis was sought. The first term of the right member of the equation was regarded to be attributable to the compartment P which possessed instantaneous exchange of water with plasma. The second term was postulated to represent the poorly exchangeable compartment. 2. The constant A of the equation was evaluated as 4,37% and 14.3% in the control and histamine treated groups, respectively. B was 1.19% in the control and 0.849% in histamine treated animals. 3. The disappearance rates determined were; $k_1=0.0519{\pm}0.0221\;sec^{-1}\;K_2=0.00454{\pm}0.00247\;sec^{-1}$ in the control group. $k_1=0.1137{\pm}0.0290\;sec^{-1}\;K_2=0.00499{\pm}0.00204\;sec^{-1}$ in the histamine group. 4. In the histamine treated animals the disappearance rate of the first term was larger than that of the control animals, suggesting an enlarged size of the rapidly exchangeable compartment with regard to the plasma water. On the other hand the constant B was decreased by histamine administration, suggesting a distribution of $D_2O$ in an enlarged volume. This view was also made clear by comparing the apparent asymptotes to which the concentration curves of $D_2O$ approached in respective groups. The asymptotes in the histamine treated group showed lower values.

The metabolic patterns of C-1 and C-6-carbon atoms of glucose were observed in the tissue homogenates of the Ehrlich ascites tumor tissue which was incubated for 3 hours in the Dubnuff metabolic shaking incubator. $C^{14}-1-and\;C^{14}-6-glucose$ were used as tracers. The glucose media in which tissue homogenate was incubated was kept at a concentration of 200mg% glucose of carrier and appropriate amount of $C^{14}-1-or\;C^{14}-6-tracer$. At the end of 3 hour incubation, respiratory $CO_2$ samples trapped by alkaline which is placed in the tenter well of incubation flask were analyzed for the total $CO_2$ production rates and their radioactivities. The tissue homogenate samples after incubation were analyzed for their concentrations of glucose, lactate, pyruvate and glycogen and calculations were made on the glucose consumption rate, pyruvate and lactate accumulation rates. The following results were obtained. Data obtained in each group are as follows: 1. In the tissue homogenate, which was incubated with $C^{14}-1-glucose as a substrate, total $CO_2$ production rate averaged $19.0{\pm}5.0{\mu}M/hr/gm$ and the mean specific activity of respiratory $CO_2$ was $840{\pm}296\;cpm/mgC.$ Relative specific activity (RSA) which means the fraction of $CO_2$ derived from medium $C^{14}-1-glucose$ to total $CO_2$ production rate was calculated by ratio of SA of respiratory $CO_2$ and medium $C^{14}-1-glucose.$ RSA was $14.3{\pm}5.0%,$ Accordingly actual $CO_2$ production rate from medium $C^{14}-1-glucose$ showed a mean value of $2.79{\pm}1.35\;{\mu}m$ of which amount was equivalent to the mean value of total glucose consumption rate $(RGDco_2)$, namely, $5.1{\pm}1.3%.$ Lactate and pyruvate appearance rates averaged $7.13{\pm}1.26\;and\;0.21{\pm}0.02{\mu}M/hr/gm,$ respectively. Assuming that these 3 carbon compounds appeared in the medium were derived from glucose, calculations were made that relative glucose disappearance rate into lactate $(RGD_L)$ was $38.0{\pm}5.4%\;and\;RGD_P$ was $1.23{\pm}0.03%.$ Therefore, about 43.3% of the total glucose consumed were accounted for by conversion into the respiratory $CO_2$, lactate and pyruvate. 2. In the second group, which was incubated with $C^{14}-1-glucose$ as a substrate, glucose consumption rate, lactate and pyruvate appearance rates showed almost the same order as the values of the $C^{14}-1-glucose$ substrate group. However, RSA was remarkably decreased showing a mean value of $1.02{\pm}0.13%.$ This fact means that the C-6 carbon of glucose take the minor part in the oxidative metabolism of glucose. The glycogen level in both substrate tissue homogenate showed less than 0.3% of tissue weight. These low value suggested that there was an inhibition of carbohydrate synthesis in the Ehrlich ascites tumor tissue. 3. The catabolic pathway of glucose in the tumor tissue were analyzed on the basis of Bloom's principle from the values of RSA. It was found that in the tumor tissue more than 90% of $CO_2$ derived from glucose were oxidized via the alternate pathway other than principal EMP-TCA cycle such as hexose monophosphate pathway (HMP). From the data described above, it was assumed that in the Ehrlich tumor tissue anaerobic glycolysis proceeds normally although, the oxidation of products of anaerobic glycolysis via the TCA cycle is inhibited resulting in the accumulation of lactate and almost all of oxidative energy from glucose is released by oxidative pathway such as HMP.

Nine male rats in which 90% or more of the hippocampal tissue was removed through a small hole made in the neocortex at the boundary between the parietal and the occipital lobes (hippocampal group), 3 male rats with similar neocortical damage alone (operated control group), and 9 normal control male rats (normal control group) were prepared. Their general activity was measured for 48 hours in an activity cage by recording the number of beams they interrupted. The amount of food and water intake was also checked simultaneously. Results obtained were as follows: 1. The general activity of the hippocampal group was 2 to 3 times as great as that of the operated control or the normal control group. 2. All of the 3 groups demonstrated clear-cut circadian variation of activity, the diurnal and the nocturnal activity being in the ratio 22 : 78. 3. The amount of food and water consumed by the hippocampal group did not differ significantly from that by the opperated control or the normal control group. In the course of the experiment which continued for 3 months the hippocampal group gained weight least among the 3 groups.

In order to find out the effects of GABA on the rabbit's intestinal motility, the following experiments were carried out using Magnus method and the results obtained were as follows: 1. GABA inhibited the intestinal motility of rabbits initially. 2. GABA potentiated the inhibitory action of adrenaline and nor-adrenaline. 3. GABA inhibited the accelerating activity of acetylcholine on the intestinal motility by its anti acetylcholine effect. 4. The inhibitory action of GABA was unaffected with atropinization, strychnin, picrotoxin treatment, but the accelerating activity of GABA observed in some cases was only in the picrotoxin treatment.

Cold $(0^{\circ}C)$ or warm $(25^{\circ}C)$ fresh and sea water were flooded into the lungs of rabbits through tracheal canule. Respiratory arrest ensued in 19.5 minutes in the warm fresh water flooded rabbits and was the longest survival time among the experimental groups. The survival times in the other groups were: 2.32 minutes in cold fresh water group, 2.75 minutes in .warm sea water group, and 4.57 minutes in cold sea water group. Cardiac output was measured by means of T-1824 dilution technique after 2 or 3 minutes of flooding in 27 rabbits. Blood pressure was observed by mercury manometer throughout the survival time in 40 rabbits. The following results were obtained. 1. Cardiac output in the warm fresh water flooded and sea water flooded animal was smaller than that of control rabbits. In the cold fresh water flooded animal cardiac output was greater than that of the control animal. 2. Time constants of T-1824 dilution curve of experimental group were elongated than the normal curve. 3. Central blood volume showed an increase in the fresh water group, a decrease in cold sea water group and no change in warm sea water group. 4. In all of the experimental groups arterial blood Pressure showed an abrupt and great variations after flooding of lungs and lasted about 30 seconds. Thereafter, arterial pressure remained at a plateau level until the sudden fall to zero and this was almost coincided with the time of respiratory arrest. The Plateau level of arterial Pressure in fresh water group was about 10 mmHg higher than the control value, and it was lower than the control value in warm sea water group. In cold sea water group the plateau was made up by fluctuations around the control value. 5. Osmosis of water through the lung alveolar membrane occured in all animals. Fresh water caused hemodilution and sea water caused hemoconcentration. 6. In sea water flooded animal more volume of water was recovered through the tracheal canule than the volume injected into trachea. This was interpreted as the consequence of the shift of water from plasma to alveolar sac. 7. Relative freight of lung was greater in fresh water group than sea water group. In all animal lung edema ensued. 8. The mechanisms of cardiac output variations were discussed.

Present paper is attempted to introduce the phenomenon of 'after contraction' in isolated cardiac-muscle. Papillary muscles were removed from cat right ventricle and were used as a preparation. The muscle strip was Placed in tissue bath which is kept in steady temperature of around $25^{\circ}C$ and was perfuced by Tyrode solution, saturated with 95% $O_2$ and 5% $CO_2.$ under the condition of high calcium (8.2-10.0 mM/l), low sodium (72.4-70.0 mM/l) perfusion with the administration of epinephrine (1-2 mg/l) into tile tissue bath normally triggered muscle contraction was followed by oscillatory, repetitive contractions - after contraction. The phenomenon of after contraction was augumented by decrease in tissue bath temperature and by increase in number of preceding beats and in driving rate. Authors were able to maintain the phenomenon in prominent and steady state giving proper experimental conditions such as fixed bath temperature (ranged from $22^{\circ}C\;to\;27^{\circ}C$), suitable driving rate (20 per minute in average) and perfusion of high calcium, loll sodium and 1-2 mg/l of epinephrine. In some preparations, the strength of after contraction (second contraction) reached up-to 80% of normally triggered contraction and five repetitive contractions were observed as largest number of after contractions. Intracellular action potential measured in the muscle which was beating regulary showing steady after contraction revealed no oscillating after potential in most parts of the muscle but in few cases oscillating changes of after potentials were detectable. In electrogram of the muscle preparation recorded by means of contact electrode prominent, oscillating after potentials were observable when the recorder was set at highest sensitivity. It still is not clear that whether after contraction is the phenomenon which corresponds to those changes in action potential, oscillating after potential, of the muscle preparation. Possible mechanism of the phenomenon of after contraction relating with after potential changes was proposed. Detailed results obtained from further studies on after contraction and concrete discussion on the phenomenon will be reported by authors.

A nomogram of gas exchange ratio (R) in air breathing subjects ,was porposed which enables a simple and rapid determination of R value using the fractional concentrations of nitrogen and carbon dioxide in the expired or alveolar gas. The readable limit of R value seems less than 1/100 of R unit and the average difference between the values from the nomogram and the actually calculated values is less than 0.005 of R unit. The usefulness of this nomogram for rapid and frequent determinations of the oxygen uptake is also suggested.

The normal lung volumes were determined and subdivided under sitting position in 48 middle school girls, 49 high school girls and 44 house wives. All subjects were free of pulmonary and vascular diseases. The vital capacity was measured by Mckessons spirometer and the residual volume was determined by Rahn's three breathing method. 1. The lung volumes (BTPS) of middle school girls determined were: $RV\;0.59{\pm}0.11l\;FRC\;1.45{\pm}2.22l\;VC\;2.68{\pm}0.29l$ 2. The lung volumes (BTPS) of high school girls determined were: $RV\;0.83{\pm}0.19l\;FRC\;1.9{\pm}0.25l\;VC\;3.15{\pm}0.24l$ 3. The lung volumes (BTPS) of house wives determind were: $RV\;0.95{\pm}0.61{\ell}\;FRC\;2.1{\pm}0.25{\ell}\;VC\;3.06{\pm}0.29l$ 4. The calculated residual ratio $(RV/TLC{\times}100)$ were: $17.7{\pm}2.57%$ in middle school girls and $20.6{\pm}3.65%$ in high school girls and $24.0{\pm}2.31%$ in house wives 5. The functional residual ratio $(FRC/TLC{\times}100)$ were: $43.7{\pm}5.98%$ in middle school girls and $48.8{\pm}4.41%4 in high school girls and $52.6{\pm}5.38%$ in house wives. 6. The correlation coefficients between vital capacity and total lung capacity were r=0.96 in middle school girls and r=0.986 in high school girls and r=0.856 in house wives. 7. The regression equations were obtained follows: $TLC(l) =1.105{\times}VC+0.304$ (in middle school girls) $TLC(l) =1.551{\times}VC-0.902$ (in high school girls) $TLC(l) =0.999{\times}VC+0.954$ (in house wives)

In order to evaluate the accuracy of the measurement of maximal oxygen intake (MOI), the MOI in seven subjects was determined 3 to 4 times in each individual. Following a 10 minute warm-up on treadmill (4.3 km/hr with 9 degree grade), the subject was asked to run at a speed of 8.73 km/hr on treadmill for a period of 3 minutes at a given grade which was elevated in a step-wise manner from zero to the level of exhaustion. Following a 3 minute run, the subject was allowed to rest for a period of 3 to 5 minutes. During each period of running, several cardio-pulmonary functions were determined and the range of variability for each measurement was computed. The oxygen consumption during the maximal work load was taken as the MOI. The results may be summarized as follows: (1) The minute volume, the oxygen consumption and the heart rate increased linearly until the grade was elevated to 9 degree above which these values were leveled off. (2) The minute volume and the heart rate during maximal exorcise were $87.4{\pm}8.10\;1/min\;and\;187{\pm}3.7$ per minute, respectively. (3) The maximal oxygen intake which corresponds to the oxygen consumption during maximal exercise was averaged to 3.04 1/min. (4) The coefficient of variance for the maximal oxygen intake was 6.32% while the corresponding values for the minute volume and the heart rate during maximal exercise were 5.22 and 2. 14%, respectively.

The maximal oxygen intake (MOI) was determined in 54 males (23 nonathletes, 10 basketball players, 8 hand ball players, 7 weight lifters and 6 long distance runners) and in 49 females (24 non-athletes, 16 basketball players and 9 volley ball players) by using a treadmill method outlined in Part I of the present investigation and the following results were obtained: (1) The maximal aerobic work capacity varied from the lowest value of 1,008 kg-m/min in female non-athletes to the highest value of approximately 2,000 kg-m/min in male basketball players and long distance runners. Values of other groups varied from 1,400 kg-m/min in male non-athletes and female athletes to 1,800 kg-m/min in male hand ball players. (2) The MOI per unit body weight varied from the lowest value of 41.3 ml/min/kg in female non-athletes to the highest value of 67.6 ml/min/kg in male long distance runners. Values of other groups were in the order of 47 to 55 ml/min/kg. (3) The heart rate during maximal aerobic work performance varied from the lowest value of approximately 180 per min in female basketball players and male long distance runners to the highest value of 190 or above in nonathletes of both sexes. (4) An estimate of oxygen debt as measured during 15 minutes following the maximal work was 3.841 in female non-athletes, 4.681 in female athletes, 5.561 in male non-athletes and 6.321 in male athletes. These results indicate that the MOI per unit body weight as well as the oxygen debt of Korean non-athletes were comparable to, while corresponding values of Korean athletes were considerably lower than, those of other countries such as Japan, the United States of America and Europe.

As pointed out by many previous investigators, the cardio-pulmonary system of well trained athletes is so adapted that they can perform a given physical exercise more efficiently as compared to non-trained persons. However, the time course of the development of these cardio-pulmonary adaptations has not been extensively studied in the past. Although the development of these training effects is undoubtedly related to the magnitude of an exercise load which is repeatedly given, it would be practical if one could maintain a good physical fitness with a minimal daily exercise. Hence, the present investigation was undertaken to study the time course of the development of cardio-pulmonary adaptations while a group of non-athletes was subjected to a daily 6 to 10 minutes running exercise for a period of 4 weeks. Six healthy male medical students (22 to 24 years old) were randomly selected as experimental subjects, and were equally divided into two groups (A and B). Both groups were subjected to the same daily running exercise (approximately 1,000 kg-m). 6 days a week for 4 weeks, but the rate of exercise was such that the group A ran on treadmill with 8.6% grade for 10 min daily at a speed of 127 m/min while the group B ran for 6 min at a speed of 200 m/min. In order to assess the effects of these physical trainings on the cardio-pulmonary system, the minute volume, the $O_2$ consumption, the $CO_2$ output and the heart rate were determined weekly while the subject was engaged in a given running exercise on treadmill (8.6% grade and 127 m/min) for a period of 5 min. In addition, the arterial blood pressure, the cardiac output, the acid-base state of arterial blood and the gas composition of arterial blood were also determined every other week in 4 subjects (2 from each group) while they were engaged in exercise on a bicycle ergometer at a rate of approximately 900 kg m/min until exhaustion. The maximal work capacity was also determined by asking the subject to engage in exercise on treadmill and ergometer until exhaustion. For the measurement of minute volume, the expired gas was collected in a Douglas bag. The $O_2$ consumption and the $CO_2$ output were subsequently computed by analysing the expired gas with a Scholander micro gas analyzer. The heart rate was calculated from the R-R interval of ECG tracings recorded by an Offner RS Dynograph. A 19 gauge Cournand needle was inserted into a brachial artery, through which arterial blood samples were taken. A Statham $P_{23}AA$ pressure transducer and a PR-7 Research Recorder were used for recording instantaneous arterial pressure. The cardiac output was measured by indicator (Cardiogreen) dilution method. The results may be summarized as follows: (1) The maximal running time on treadmill increased linearly during the 4 week training period at the end of which it increased by 2.8 to 4.6 times. In general, an increase in the maximal running time was greater when the speed was fixed at a level at which the subject was trained. The mammal exercise time on bicycle ergometer also increased linearly during the training period. (2) In carrying out a given running exercise on treadmill (8.6%grade, 127 m/min), the following changes in cardio·pulmonary functions were observed during the training period: (a) The minute volume as well as the $O_2$ consumption during steady state exercise tended to decrease progressively and showed significant reductions after 3 weeks of training. (b) The $CO_2$ production during steady state exercise showed a significant reduction within 1 week of training. (c) The heart rate during steady state exercise tended to decrease progressively and showed a significant reduction after 2 weeks of training. The reduction of heart rate following a given exercise tended to become faster by training and showed a significant change after 3 weeks. Although the resting heart rate also tended to decrease by training, no significant change was observed. (3) In rallying out a given exercise (900 kg-m/min) on a bicycle ergometer, the following change in cardio-vascular functions were observed during the training period: (3) The systolic blood pressure during steady state exercise was not affected while the diastolic blood Pressure was significantly lowered after 4 weeks of training. The resting diastolic pressure was also significantly lowered by the end of 4 weeks. (b) The cardiac output and the stroke volume during steady state exercise increased maximally within 2 weeks of training. However, the resting cardiac output was not altered while the resting stroke volume tended to increase somewhat by training. (c) The total peripheral resistance during steady state exercise was greatly lowered within 2 weeks of training. The mean circulation time during exorcise was also considerably shortened while the left heart work output during exercise increased significantly within 2 weeks. However, these functions_at rest were not altered by training. (d) Although both pH, $P_{co2}\;and\;(HCO_3-)$ of arterial plasma decreased during exercise, the magnitude of reductions became less by training. On the other hand, the $O_2$ content of arterial blood decreased during exercise before training while it tended to increase slightly after training. There was no significant alteration in these values at rest. These results indicate that cardio-pulmonary adaptations to physical training can be acquired by subjecting non-athletes to brief daily exercise routine for certain period of time. Although the time of appearance of various adaptive phenomena is not identical, it may be stated that one has to engage in daily exercise routine for at least 2 weeks for the development of significant adaptive changes.

Determination of weekly and daily energy expenditure was made on 62 Republic of Korea Army cadets who were selected at random in order to estimate the weekly and daily ealorie expenditure. Basal metabolic rate (B.M.R.), and energy cost of various military and daily activities were measured by indirect calorimetry using open circuit method. Time-motion studies were also carried on using a stop-watch. The total weekly energy expenditure was calculated by summation of data using energy cost per minute, and the time spent on each activity. Determination of daily energy expenditure was deduced from each data of weekly energy expenditure. Food survey was also carried on for a week, and daily calorie intake was determined by a weekly average discounting loss in cooking. All measurements were determined from the Standard Table of Food Composition published by the Ministry of National Defense (1961). Following data were observed. 1. Physical status of cadets are as follows. Please note that the height and weight averages are 1-2cm and 4-5kg respectively over that of the Seoul National University students. First year Height 167.92 cm $(S.D.{\pm}4.09)$ Weight 61.72 kg $(S.D.{\pm}4.53)$ Second year Height 167.89 cm $(S.D.{\pm}3.46)$ Weight 63.01 kg $(S.D.{\pm}4.61)$ Third year Height 168.15 cm $(S.D.{\pm}4.24)$ Weight 43.48 kg $(S.D.{\pm}5.03)$ Fourth year Height 168.10 cm $(S.D.{\pm}3.70)$ Weight 64.02kg $(S.D.{\pm}5.10)$ 2. The B.M.R. of cadets averaged $36.57\;Cal./m^2/hr.(S.D.{\pm}3.63\;Cal./m^2/hr.)$ is almost equal with data on the same ages of civilians and the Japanese, but a lower average of $5.1\;Cal./m^2/hr.$ than that of a common soldier. 3. The energy expenditure during various military activities is close agreement with Consolazio. Passmore and Durnin, and Japanese reports.