In this paper, we apply a discrete wavelet packet transform (DWPT) to reduce the influence of interference in global positioning system (GPS) signals and compare the interference mitigation performance of various wavelets. By applying DWPT to the received signal, we can gradually divide the received signal band into low-pass and high-pass bands. After calculating the average power for the separate bands, we can determine whether there is interference by comparing the value with the given threshold. For a band that includes interference, we can reconstruct the whole band signal using inverse DWPT (IDWPT) after applying a nulling method that sets all of the wavelet coefficients to 0. The reconstructed signals are correlated with the pseudorandom noise (PRN) codes to acquire GPS signals. The performance evaluation is based on the number of satellite signals whose peak ratio (defined as the ratio of the first and second correlation peak values in the acquisition stage) exceeds the threshold. In this paper, we compare and evaluate the performance of 6 wavelets including Haar, Daubechies, Symlets, Coiflets, Biorthogonal Splines, and Discrete Meyer.