Purpose: This study aimed to investigate the relationships between self-efficacy, communication ability, and problem-solving ability in nursing students, and explore the mediating effects of communication ability on self-efficacy and problem-solving ability. Methods: This study targeted 181 third- and fourth- year nursing students. Data were collected from May 20-25, 2024, and analyzed using SPSS software (version 29.0), employing descriptive statistics, t-tests, analysis of variance, Pearson's correlation coefficients, and multiple regression analysis. Sobel test was used to determine the statistical significance of the mediating effects of communication ability. Results: Nursing students' problem-solving abilities were significantly and positively correlated with self-efficacy (r=.35, p<.001) and communication skills (r=.33, p<.001). Self-efficacy was significantly and positively correlated with communication skills (r=.56, p<.001). Communication skills had a partial mediating effect on the relationship between self-efficacy and problem-solving ability (Z=4.24, p<.001), explaining 51% of the variance. Conclusion: These results can be used to develop a curriculum and intervention programs to enhance the self-efficacy and communication skills and improve the problem-solving abilities of nursing students.