Over the past few decades, changes in patterns of behavior (e.g., diet, smoking, alcohol consumption, and physical activity) have led to major changes in health status, characterized by increases in obesity, Type II diabetes mellitus, cardiovascular disease, and some cancers. This epidemiologic transition is largely the result of rapid increases in immigration to developed countries and rural-urban migration within developing countries, which is usually accompanied by environmental and lifestyle changes. In particular, adoption of “Western” dietary patterns, which tend to be high in fat and low in fruits and vegetables, is of concern since diet is a potent contributor to chronic disease risk. However, until recently, the process by which immigrants and rural-urban migrants adopt the dietary practices predominant in their new environments, known as dietary acculturation, has received very little research attention. Dietary acculturation is multidimensional, dynamic, and complex, and varies considerably depending on a variety of personal, cultural, and environmental characteristics. Therefore, to intervene successfully on the negative aspects of dietary acculturation, it is important to understand the process and identify factors that predispose and enable it to occur. The purpose of this article is to provide a practical model for understanding and investigating the effect of dietary acculturation on food and nutrient intake. Thus, this report 1) gives an overview of acculturation, 2) defines dietary acculturation and presents a model for how it occurs, 3) discusses measurement issues around dietary acculturation,4) reviews the literature on dietary acculturation in Korean Americans; 4) suggests a paradigm for acculturation research; and 5) offers some recommendations for future research in this area.