Journal of the Korea Society of Computer and Information (한국컴퓨터정보학회논문지)

Korean Society of Computer Information (한국컴퓨터정보학회)
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Preparation and evaluation of hydrogels containing Loratadine for the treatment of allergic diseases

  • Chul-Tae Kim (Department of Emergency Medical Service, Konyang University) ;
  • Kwang-Soon Kang (Department of Emergency Medical Technology, Daejeon Health institute of Technology)
  • Received : 2024.11.04
  • Accepted : 2024.11.25
  • Published : 2024.11.29
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Abstract

Anti-histamines are drugs used to relieve allergic diseases such as urticaria. Loratadine is a second-generation ant-ihistamine that works better with fewer side effects such as sleepiness and headaches. However, even if the effect is good, it takes a long time for the effect to take a pill. The method of delivering drugs to the skin is a way to overcome these shortcomings and show quick effects. Therefore, hydrogels containing Loratadine were produced and their properties were evaluated. The content of Loratadine was more than 98%, and the uniformity of the contents was good. When manufacturing hydrogels, the higher the amount of carbomer, the higher the viscosity of the gel. As a result of evaluation of the prepared hydrogel, it was obtained that most of it fell within the range of commercially available gels.

항히스타민제는 두드러기와 같은 알레르기 질환을 완화하는 데 사용되는 약물이다. 로라타딘은 졸음과 두통과 같은 부작용이 적고 더 잘 작동하는 2세대 항히스타민이다. 그러나 효과가 좋더라도 알약을 복용하는데 오랜 시간이 걸린다. 피부에 약물을 전달하는 방법은 이러한 단점을 극복하고 빠른 효과를 나타내는 방법이다. 따라서 로라타딘을 함유한 하이드로 겔을 생산하고 그 특성을 평가했다. 로라타딘의 함량은 98% 이상이었고 내용물의 균일성이 좋았다. 하이드로겔을 제조할 때, 카보머의 양이 많을수록, 겔의 점도가 높아진다. 제조된 하이드로겔을 평가한 결과, 대부분이 시판되는 겔의 범위 내에 있는 것으로 나타났다.

Keywords

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