• BMB Reports
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• v.45 no.5
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• pp.305-310
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• 2012

Allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis are heterogeneous diseases characterized by multiple symptoms and phenotypes. Recent advancements in genetic study enabled us to identify disease associated genetic factors. Numerous genome-wide association studies (GWAS) have revealed multiple associated loci for allergic diseases. However, the majority of previous studies have been conducted in populations of European ancestry. Moreover, the associations of single nucleotide polymorphisms (SNPs) with allergic diseases have not been studied amongst the large-scale general Korean population. Herein, we performed the replication study to validate the previous variants, known to be associated with allergic diseases, in the Korean population. In this study, we categorized three allergic related phenotypes, one allergy and two asthma related phenotypes, based on self-reports of physician diagnosis and their symptoms from 8,842 samples. As a result, we found nominally significant associations of 6 SNPs with at least one allergic related phenotype in the Korean population.

• The Journal of Pediatrics of Korean Medicine
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• v.23 no.3
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• pp.37-53
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• 2009

Objectives Because allergic disease is currently prevalent and has tendency to become chronic, the purpose of this study is to examine the effects of allergic diseases on eating and living habits of children when they grow. Methods Questionnaire performed by 203 fourth grade elementary school children in Cheonan was analyzed. Results Disease group had low frequency of eating ramen, watching TV or web-surfing than that of normal group, but had higher frequency of eating meat, eating breakfast. Conclusions The allergic disease group had more desirable habits. It was assumed that parent's greater interest and devotion toward their children to cure their allergic disease was the reason for the children's desire habits.

• Journal of dental hygiene science
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• v.19 no.4
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• pp.228-237
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• 2019

Background: This study aimed to investigate allergic rhinitis and the relationship between allergic diseases, such as asthma and allergic rhinitis, and dental caries and periodontal disease using the raw data from third year of the 6th Korean National Health and Nutrition Examination Survey. Methods: A total of 3,729 subjects aged over 30 years who underwent examination for allergic diseases and an oral health checkup were selected. The data were analyzed using SPSS IBM SPSS ver. 25.0 (IBM Corp., USA). Composite sample cross correlation and composite sample logistic regression analyses were performed using the composite sample general linear model. Results: On examining the socioeconomic characteristics of the subjects suffering from allergic disease and the relationship between allergic disease and oral health, allergic rhinitis was more frequently found in younger subjects with a higher level of education. Periodontal disease and dental caries were more frequent among female, older age groups, lower income earners, and subjects with a lower level of education (p<0.05). On examining the relationship between the oral health characteristics of the subject and allergic diseases and oral health, allergic rhinitis was more common in subjects with a good oral health status perception than those who answered "bad" to the oral health status question. The community periodontal index of treatment needs (CPITN) score was higher in subjects who answered "poor" to the oral health status question, lower frequency of brushing, and higher in subjects using secondary oral hygiene products; the decayed, missing and filled teeth (DMFT) index was higher in subjects with a perception of poor oral health status (p<0.05). The DMFT index was high in the asthma group, and the CPITN score was high in the group who answered "no" to allergic rhinitis. Conclusion: There is a relationship between asthma and allergic rhinitis and the DFMT index and CPITN score. Corresponding oral programs for allergic patients need to be developed.

• Journal of the Korea Convergence Society
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• v.8 no.4
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• pp.37-48
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• 2017

The purpose of the study was to identify factors influencing the knowledge and management of allergic disease. Participants were 220 childcare teachers working in childcare facility, date was collected through self-questionnaire. Data was analyzed using SPSS/WIN 23.0. Age(p=0.13), experience of education(0.49) showed significant difference in athma/ allergic rhinitis. Experience of education(p=0.45), necessity of education(p=.034) in asthma/ allergic rhinitis showed significant difference. There is no significant difference in knowledge and management of atopic dermatitis. Allergic disease management and age accounted for 36.2% influencing on knowledge of asthma/allergic rhinitis. Allergic disease knowlege, education experience and necessity of education accounted for 43.1% influencing management of asthma/ allergic rhinitis. Based on the findings of this study, it can be used to educational programs data for childcare teacher.

• The Journal of Pediatrics of Korean Medicine
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• v.27 no.3
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• pp.41-52
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• 2013

Objectives In pediatrics of Korean Medicine, it is crucial to evaluate the overall symptoms of children, especially in the children who have serious troubles in their life. In the era when diagnosis in Korean Medicine is quite suitable to evaluate multiple allergic diseases, and when growing numbers are in needs, development of an objective measurement scale for diagnosis of allergic disease in Korean Medicine became essential. Therefore, in the study, pediatric Allergic Disease Quality of Life Questionnaire (PADQLQ) was translated into Korean version with validations on some aspects. Methods In this study, we translated and validated the PADQLQ and established psychometric evidence on its utility in Korean children with similar problems. 71 children, age of 6 ~ 18 with allergic disease has participated. Results The internal consistency reliability of the PADQLQ by Cronbach's ${\alpha}$ was 0.94. In three domains (Practical, Physical, Emotional), the Cronbach's ${\alpha}$ was 0.77, 0.90 and 0.69. The Spearman's rank correlation coefficient between PADQLQ total score and VAS was 0.75 (p<0.001). And, Structural validity was evaluated by the ANOVA test. QoL differences of the four groups in the three domains (practical, physical, emotional) were significant. The item discriminative indices were ranged from 0.1651 to 0.8188. Conclusions Korean version PADQLQ is highly reliable and valid for children with allergic diseases. This is significant to assess the relative seriousness of the allergic diseases and to evaluate the efficacy of different treatments in Korean Medicine.

• Clinical and Experimental Pediatrics
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• v.51 no.6
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• pp.640-645
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• 2008

Purpose : It is widely known that allergic diseases progress through an allergic march. However, there have not been any recent reports in Korea on how the diseases progress. Methods : Parents who visited one of the Pediatric Allergy Clinics of four university hospitals in Seoul with a child under the age of 6 years during the period from May 1-30, 2006 were asked to complete a questionnaire. Results : A total of 229 parents answered the questionnaire about their children, of which 122 were male and 107 were female. The most common allergic disease before 2 years of age was atopic dermatitis (79%). Meanwhile, in 2- to 4-year age group, allergic rhinitis (38%) and asthma (37%) were predominant. The most common allergic disease in the 4- to 6-year age group was asthma (72%), followed by allergic rhinitis (64%). Seventy-three percent of the children had a family history of allergic disease, most often in the fathers (39%). Among patients with allergic rhinitis, 50% had experienced asthma in their earlier days and 30% had experienced atopic dermatitis. In addition, 57% of the children with asthma had suffered from atopic dermatitis. Parents believed that asthma was the most serious allergic disease. Conclusion : In the present study, allergic disease showed a tendency to march from atopic dermatitis to asthma and then to allergic rhinitis. Early diagnosis and treatment of atopic dermatitis is, therefore, considered important for prevention of the allergic march.

• 대한상한금궤의학회지
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• v.13 no.1
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• pp.121-132
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• 2021

Objective: This study aimed to report the improvement in a patient with allergic contact dermatitis treated with Sihogyeji-tang based on the Shanghanlun disease pattern identification diagnostic system (DPIDS). Methods: According to the Shanghanlun DPIDS, the patient with allergic contact dermatitis was diagnosed with greater yang disease chest bind (Shanghanlun provision 146), and was administered Sihogyeji-tang for 90 days. The results were evaluated using the Dermatological Life Quality Index (DLQI) and a visual analog scale (VAS). Results: After taking Sihogyeji-tang for 90 days, the DLQI decreased from 28 points to 8 points and the VAS decreased from 10 points to 3 points. Conclusions: This case shows the potential of treatment through herbal medicine for allergic contact dermatitis using the Shanghanlun DPIDS.

• The Journal of Pediatrics of Korean Medicine
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• v.30 no.3
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• pp.31-41
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• 2016

Objectives The purpose of this study is to investigate the characteristics of Ryodoraku Score in the children who visited department of pediatrics, hospital of Korean medicine with allergic rhinitis as the chief complaint. Methods Subjects were 80 children with allergic rhinitis. We calculated the average Ryodoraku Score (RS, ${\mu}A$), and compared the average of each meridian system. And we classified the children by several groups (depending on age, additional allergic disease), and accomplished a comparative analysis. Results 1. The average of Ryodoraku Score in 80 children was $76.36{\pm}22.72$. 2. The figure of H3 (心), H5 (三焦), F1 (脾), F2 (肝), F3 (腎), F4 (膀胱), F5 (三焦), F6 (胃) had significant statistical differences compared to the total average. 3. Comparing the group having only allergic rhinitis to group having allergic rhinitis and other allergic disease, showed significant statistical difference in H2 (心包), H3 (心). 4. Analyzed by age, there's a significant statistical difference in F1 (脾), F4 (膀胱). Conclusion We found that H5 (三焦), F1 (脾), F4 (膀胱) showed significant statistical difference in Ryodoraku Score, and F1 (脾) had the highest relevance. The research indicate meaningful difference depending on age, additional allergic disease.

• Child Health Nursing Research
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• v.18 no.1
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• pp.29-35
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• 2012

Purpose: The purpose of this study was to analyze the prevalence of allergic disease among elementary school students in rural and urban areas. Methods: In this study, 1,513 elementary students (1,163 in urban areas, 350 in rural areas) were surveyed. Data were analyzed using frequency, percentage of allergic symptoms and $X^2$ test was used to identify differences in the prevalence of allergic symptoms between urban and rural area students. The SAS program was used in the data analysis. Results: There were significant differences in the prevalence of allergic disease according to whether there was a family member with a prior history of allergy symptoms. 48.7% of surveyed students (49.4% in urban, 46.3% in rural) had allergic symptoms. Allergic rhinitis was the most frequent allergic symptom in both urban and rural students. Conclusion: These results suggest that there is a need to prevent and manage allergies among elementary students. The family history should be considered an important factor when a program for allergy prevention and management is developed. Interventions are needed in both areas, especially for students with allergic rhinitis.

• Journal of Preventive Medicine and Public Health
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• v.48 no.6
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• pp.301-309
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• 2015

Objectives: To investigate trends in the prevalence of allergic disease over a 9-year period. Methods: Using National Health Insurance Service (NHIS) data, the annual number of patients with allergic disease was obtained for each regional subdivisions (small cities, counties, and districts) from 2003 to 2011. Annual populations for each sub-region were obtained and used to calculate the standardized prevalence. To compare prevalence within the study period, data was standardized spatially and temporally. For standardization, demographic data was used to obtain the registered population and demographic structure for 2010, which was used to perform direct standardization of previous years. In addition, a geographic information system (GIS) was used to visualize prevalence for individual sub-regions, and allergic diseases were categorized into five groups according to prevalence. Results: The nationwide outpatient prevalence of allergic rhinitis increased approximately 2.3-fold, from 1.27% in 2003 to 2.97% in 2013, while inpatient prevalence also increased approximately 2.4-fold,. The outpatient prevalence of asthma increased 1.2-fold, and inpatient prevalence increased 1.3-fold. The outpatient prevalence of atopic dermatitis decreased approximately 12%, and inpatient prevalence decreased 5%. Conclusions: There was a large difference between prevalence estimated from actual treatment data and prevalence based on patients' self-reported data, particularly for allergic rhinitis. Prevalence must continually be calculated and trends should be analyzed for the efficient management of allergic diseases. To this end, prevalence studies using NHIS claims data may be useful.