Nuclear Engineering and Technology

Korean Nuclear Society (한국원자력학회)
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Development of a multi-modal imaging system for single-gamma and fluorescence fusion images

  • Young Been Han (Department of Senior Healthcare, Eulji University) ;
  • Seong Jong Hong (Department of Senior Healthcare, Eulji University) ;
  • Ho-Young Lee (Department of Nuclear Medicine, Seoul National University Bundang Hospital) ;
  • Seong Hyun Song (Department of Senior Healthcare, Eulji University)
  • Received : 2022.09.08
  • Accepted : 2023.06.29
  • Published : 2023.10.25
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Abstract

Although radiation and chemotherapy methods for cancer therapy have advanced significantly, surgical resection is still recommended for most cancers. Therefore, intraoperative imaging studies have emerged as a surgical tool for identifying tumor margins. Intraoperative imaging has been examined using conventional imaging devices, such as optical near-infrared probes, gamma probes, and ultrasound devices. However, each modality has its limitations, such as depth penetration and spatial resolution. To overcome these limitations, hybrid imaging modalities and tracer studies are being developed. In a previous study, a multi-modal laparoscope with silicon photo-multiplier (SiPM)-based gamma detection acquired a 1 s interval gamma image. However, improvements in the near-infrared fluorophore (NIRF) signal intensity and gamma image central defects are needed to further evaluate the usefulness of multi-modal systems. In this study, an attempt was made to change the NIRF image acquisition method and the SiPM-based gamma detector to improve the source detection ability and reduce the image acquisition time. The performance of the multi-modal system using a complementary metal oxide semiconductor and modified SiPM gamma detector was evaluated in a phantom test. In future studies, a multi-modal system will be further optimized for pilot preclinical studies.

Keywords

Acknowledgement

This research was supported by grants from National Research Foundation (NRF) of Korea of the Ministry of Science, ICT, and Future Planning, Nuclear R&D Program (NRF-2020R1F1A1054317); Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (KMDF_PR_20200901_0028, 1711137956); Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (KMDF_PR_20200901_0087, 1711138120).

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