Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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Effects of combined exercise on the blood inflammatory factors, DHEA-s and arterial stiffness of elderly women

복합운동이 고령여성의 혈중 염증인자, DHEA-s 및 동맥경직도에 미치는 영향

  • Ha, Soo-Min (Department of Physical Education, Pusan National University) ;
  • Kim, Jung-Sook (Department of Physical Education, Pusan National University) ;
  • Kim, Ji-Hyeon (Department of Physical Education, Pusan National University) ;
  • Kim, Do-Yeon (Department of Physical Education, Pusan National University)
  • 하수민 (부산대학교 체육교육과) ;
  • 김정숙 (부산대학교 체육교육과) ;
  • 김지현 (부산대학교 체육교육과) ;
  • 김도연 (부산대학교 체육교육과)
  • Received : 2018.11.30
  • Accepted : 2018.12.17
  • Published : 2018.12.31
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Abstract

The purpose of this study was to investigate the effects of combined exercise on blood inflammatory factors, DHEA-s and arterial stiffness in elderly women. The subjects were 42 elderly females volunteers, aged 70 to 85 years, composed of the combined exercise group (n=21) and control group (n=21). The 60 minute combined exercise program(aquarobics 1 time/week, strength exercise 2 times/week) was performed 3 times per week for 12 weeks, and the intensity was progressively increased every 4 weeks(1-4 weeks: RPE 12 to 13, 5-8 weeks: RPE 13 to 14, 9-12weeks: RPE 14 to 15). The test data were analyzed by two-way repeated measures ANOVA, paired t-test, independent t-test and the alpha level of .05 was set for all tests of significance. As a result, the combined exercise for 12 weeks reduced the inflammatory response of elderly women, and DHEA-s was found to have a positive effect on aging hormone. The arterial stiffness decreased the central arterial blood pressure (systolic and diastolic), prevented the increase of the pulse pressure and the wave increase index, and decreased the pulse wave velocity. These results suggest that regular and continuous combined exercise may be recommended for the healthy aging and longevity of elderly women by inducing anti-inflammation effect and improving the aging hormonal function and the vascular health.

본 연구는 만 70~85세의 고령여성을 대상으로 주 1회 아쿠아로빅과 주 2회 맨손근력운동을 실시하는 복합운동프로그램을 12주간 적용하여 혈중 염증인자, DHEA-s 및 동맥경직도에 미치는 영향을 구명하기 위하여 운동군 21명, 대조군 21명으로 구분하여 실시하였다. 1회 운동지속시간은 60분으로 4주 간격으로 운동강도를 점진적으로 증가시켜 실시하였다. 복합운동 전과 후에 측정된 자료의 상호작용 효과 검증을 위해 이원반복측정 분산분석을 실시하였고, T검정을 사용하여 사후분석을 하였으며, 유의수준은 .05로 설정하여 분석하였다. 그 결과 12주간의 복합운동은 고령여성의 염증반응을 감소 시켰으며, DHEA-s가 증가함에 따라 노화호르몬에도 긍정적인 영향을 미치는 것으로 나타났다. 동맥경직도는 중심동맥혈압(수축기, 이완기)이 감소하였고, 맥압 및 파형증가지수의 증가를 완화하였으며, 맥파전파속도를 감소시키는 것으로 나타났다. 이상의 결과 고령여성의 건강한 노화와 장수를 위해서 항염증, 노화호르몬의 개선 및 혈관건강의 역할로 규칙적이고 지속적인 복합운동이 권장 될 수 있을 것으로 사료된다.

Keywords

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Fig. 1. Changes in blood inflammatory factors after 12-week combined exercise.

Table 1. Physical characteristics of subjects in each groups

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Table 2. Combined exercise program

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Table 3. Changes in blood inflammatory factors after 12-week combined exercise

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Table 4. Changes in arterial stiffness after 12-week combined exercise

HGOHBI_2018_v35n4_1096_t0004.png 이미지

References

  1. Y. H. Khang, "Burden of Noncommunicable Diseases and National Strategies to Control Them in Korea", Journal of Preventive Medicine and Public Health, Vol.46 No.4 pp. 155-164, (2013). https://doi.org/10.3961/jpmph.2013.46.4.155
  2. Korea Centers for Disease Control and Prevention, 2018 PRESS RELEASE, (2018).
  3. Korea Centers for Disease Control and Prevention, Proposal for National Health Policy to Prevention Effective Cardiologic Disenses 2018, (2018).
  4. C. K. Glass, J. L. Witztum, "Atherosclerosis : Theroad ahead", Cell, Vol.104 pp. 503-516, (2001). https://doi.org/10.1016/S0092-8674(01)00238-0
  5. World Health Organization, Preventing chronic diseases: a vital investment [Internet]2005, (2016).
  6. S. Y. Ryu, Y. S. Lee, J. Park, M. G. Kang, K. S. Kim, "Relations of plasma high-sensitivity C-reactive protein to various cardiovascular risk factors", Journal of Korean medical science, Vol.20 No.3 pp. 379-383, (2005). https://doi.org/10.3346/jkms.2005.20.3.379
  7. L. V. Borovikovq, S. Ivanova, M. Zhang, H. Yang, G. I. Botchkina, L. R. Watkins, H. Wang, N. Abumrad, J. W. Eaton, K. J. Tracey, "Vagus nerve stimulation attenuates the systemic inflammatory respones to endotoxin", Nature, Vol.405 No.6785 pp. 458-462, (2000). https://doi.org/10.1038/35013070
  8. Journal Of The American Medical Association, Simple Blood Test May Help To Predict Cardiovascular Risk In Older Women, (2005).
  9. B. William, Kannel, A. Philip, Wolf, P. William, Castelli, B. Ralph, D'Agostino, "Fibrinogen and Risk of Cardiovascular Disease", JAMA, Vol.258 Vol.9 pp. 1183-1186, (1987). https://doi.org/10.1001/jama.1987.03400090067035
  10. Y. W. Chen, S. Apostolakis, G. Y. Lip, "Exercise-induced changes in inflammatory processes: Implications for thrombogenesis in cardiovascular disease", Annals of medicine, Vol.46 NO.7 pp. 439-455, (2014). https://doi.org/10.3109/07853890.2014.927713
  11. J. A. Woods, K. R. Wilund, S. A. Martin, B. M. Kistler, "Exercise, inflammation and aging", Aging and disease, Vol.3 No.1 pp.130-140, (2012).
  12. D. F. Geffken, Cushman. L. B. Gregory, J. F. Polak, P. A. Sakkinen, R. P. Tracy, "Association between Physical Activity and Markers of Inflammation in a Healthy Elderly Population", Tracy American Journal of Epidemiology, Vol.153 No.3 pp. 242-250, (2001). https://doi.org/10.1093/aje/153.3.242
  13. V. Gremeaux, M. Gayda, R. Lepers, P. Sosner, M. Juneau, A. Nigam, "Exercise and longevity", Maturitas, Vol.73 No.4 pp. 312-317, (2012). https://doi.org/10.1016/j.maturitas.2012.09.012
  14. M. E. Nelson, W. J. Rejeski, Blair, S. N. Duncan, P. W. Judge, J. O. King, A. C. Macera, C. Castaneda-Sceppa, "Physical activity and public health in older adults", American College of Sports Medicine and the American Heart Association. Circulation, Vol.116 No.9 pp. 1094-1105, (2007). https://doi.org/10.1161/CIRCULATIONAHA.107.185650
  15. A. P. Verhagen, J. R. Cardoso, S. M. Bierma-Zeinstra, "Aquatic exercise & balneotherapy in musculoskeletal conditions", Best Practice & Research Clinical Rheumatology, Vol.26 No.3 pp. 335-343, (2012). https://doi.org/10.1016/j.berh.2012.05.008
  16. K. Meredith-Jones, D. Waters, M. Legge, L. Jones, "Upright water-based exercise to improve cardiovascular and metabolic health: a qualitative review", Complementary therapies in medicine, Vol.19 No.2 pp. 93-103, (2011). https://doi.org/10.1016/j.ctim.2011.02.002
  17. M. Maggio, F. Lauretani, F. De Vita, S. Basaria, G. Lippi, V. Butto, M. Luci, C. Cattabiani, G. Ceresini, I. Verzicco, L. Ferrucci, G. Paolo Ceda, "Multiple hormonal dysregulation as determinant of low physical performance and mobility in older persons", Current pharmaceutical design, Vol.20 No.19 pp. 3119-3148, (2014). https://doi.org/10.2174/13816128113196660062
  18. F. Labrie, "DHEA, important source of sex steroids in men and even more in women, In Progress in brain research", Elsevier, Vol.182 pp. 97-148. (2010).
  19. S. Stenholm, M. Maggio, F. Lauretani, S. Bandinelli, F. P. Ceda, A. G. A. Di Iorio, G. Francesco, G. M. Jack, L. "Anabolic and catabolic biomarkers as predictors of muscle strength decline: the InCHIANTI study", Rejuvenation research, Vol.13 No.1 pp. 3-11, (2010). https://doi.org/10.1089/rej.2009.0891
  20. J. L. Sanders, R. M. Boudreau ,A. R. Cappola, A. M. Arnold, J. Robbins, M. Cushman, A. B. Newman, "Cardiovascular disease is associated with greater incident dehydroepiandrosterone sulfate decline in the oldest old: the cardiovascular health study all stars study", Journal of the American Geriatrics Society, Vol.58 No.3 pp. 421-426, (2010). https://doi.org/10.1111/j.1532-5415.2010.02724.x
  21. C. Shufelt, P. Bretsky, C. M. Almeida, B. D. Johnson, L. J. Shaw, R. Azziz, G. D. Braunstein, C. J. Pepine, V. Bittner, D. A. Vido, F. Z. Stanczyk, C. N. Bairey Merz, "DHEA-S levels and cardiovascular disease mortality in postmenopausal women: results from the National Institutes of Health-National Heart, Lung, and Blood Institute (NHLBI)-sponsored Women's Ischemia Syndrome Evaluation (WISE)", The Journal of Clinical Endocrinology & Metabolism, Vol.95 No.11 pp. 4985-4992, (2010). https://doi.org/10.1210/jc.2010-0143
  22. N. A. Shirwany, M. H. Zou, "Arterial stiffness: a brief review", Acta Pharmacologica Sinica, Vol. 31 No.10 pp. 1267-1276, (2010). https://doi.org/10.1038/aps.2010.123
  23. G. Celik, M. S. Demirci, M. Tumuklu, G. Asci, S. Sipahi, H. Toz, A. Basci, E. Ok, "Factors related to pulse wave velocity and augmentation index in chronic hemodialysis patients", Renal failure, Vol.33 No.10 pp. 957-963, (2011). https://doi.org/10.3109/0886022X.2011.615967
  24. R. Hartog, D. Bolignano, E. Sijbrands, G. Pucci, F. Mattace-Raso, "Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly", Clinical interventions in aging, Vol.13 pp. 509-514, (2018). https://doi.org/10.2147/CIA.S151984
  25. B. A. Kingwell, T. L. Medley, T. K. Waddell, T. J. Cole, A. M. Dart, G. L. Jennings, "Large artery stiffness: structural and genetic aspects", Clinicaland experimental pharmacology & physiology, Vol.28 1040-1043, (2001). https://doi.org/10.1046/j.1440-1681.2001.03580.x
  26. G. F. Mitchell, H. Parise, E. J. Benjamin, M. G. Larson, M. J. Keyes, J. A. Vita, R. S. Vassan, D. Levy, "Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study", Hypertension, Vol.43 No.6 pp. 1239-1245, (2004). https://doi.org/10.1161/01.HYP.0000128420.01881.aa
  27. H. Tanaka, F. A. Dinenno, K. D. Monahan, C. M. Clevenger, C. A. DeSouza, D. R. Seals, "Aging, habitual exercise, and dynamic arterial compliance", Circulation, Vol.102 No.11 pp. 1270-1275, (2000). https://doi.org/10.1161/01.CIR.102.11.1270
  28. S. J. Jung, E. S. Yoon, T. Y. Son, S. Y. Jae, "Effects of recreational dance exercise on cardiovascular risk factors, vascular structure and function in older women", Exercise science, Vol.20 No.1 pp. 36-47.
  29. B. S. Lee, K. A. Kim, M. G. Lee, "Effects of 10 weeks of aerobic exercise training on cardiovascular function, atherosclerosis, and vascular endothelial function in elderly women", Korean Journal of Sport Science, Vol.28 No.2 pp. 300-314, (2017). https://doi.org/10.24985/kjss.2017.28.2.300
  30. F. Faul, E. Erdfelder, A. Buchner, A. G. Lang, "Statistical power analyses using G* Power 3.1: Tests for correlation and regression analyses", Behavior research methods, Vol.41 No.4 pp. 1149-1160, (2009). https://doi.org/10.3758/BRM.41.4.1149
  31. American College of Sports Medicine. ACSM's Exercise for Older Adults. Philadelphia: Lippincott Williams & Wilkins, (2013).
  32. A. Tsoupras, R. Lordan, I. Zabetakis, "Inflammation, not cholesterol, is a cause of chronic disease", Nutrients, Vol.10 No.5 pp. E604, (2018). https://doi.org/10.3390/nu10050604
  33. M. Ferrer, X. Capo, M. Martorell, C. Busquets-Cortes, C. Bouzas, S. Carreres, D. Mateos, A. Sureda, J. A. Tur, A. Pons, "Regular practice of moderate physical activity by older adults ameliorates their anti-inflammatory status", Nutrients, Vol.10 No.11 pp. 1780.(2018). https://doi.org/10.3390/nu10111780
  34. N. I. Kim, "The Effects of Aquatic and Land Exercise on Atherosclerosis Indices and Inflammation Response Markers in Elderly with Metabolic Syndrome", The Korean Journal of Growth and Development, Vol.20 No.4 pp. 277-286, (2012).
  35. C. H. Kim, J. W. Lee, H. Y. Park, "The effect of yoga exercise and band exercise performance in elderly women on the inflammatory makers and ageing hormone", Journal of Wellness, Vol.9 No.2 pp. 209-220, (2014).
  36. D. E. King, P. Carek, W. S. Pearson, "Inflammatory markers and exercise: differences related to exercise type", Medicine and science in sports and exercise, Vol.35 No.4 pp. 575-581, (2003). https://doi.org/10.1249/01.MSS.0000058440.28108.CC
  37. C. E. Donges, R. Duffield, E. J. Drinkwater, "Effects of resistance or aerobic exercise training on interleukin-6, C-reactive protein, and body composition", Medicine and Science in Sport and Exercise, Vol.42 pp. 304-313, (2010).
  38. J. L. Abramson, V. Vaccarino, "Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults", Archives of internal medicine, Vol.162 No.11 pp. 1286-1292, (2002). https://doi.org/10.1001/archinte.162.11.1286
  39. H. S. Chahal, W. M. Drake, "The endocrine system and ageing", The Journal of Pathology: A Journal of the Pathological Society of Great Britain and Ireland, Vol.211 No.2 pp. 173-180, (2007). https://doi.org/10.1002/path.2110
  40. C. Ohlsson, L. Vandenput, A. Tivesten, "DHEA and mortality: what is the nature of the association?", Journal of Steroid Biochemistry and Molecular Biology, Vol.145 pp. 248-253, (2015). https://doi.org/10.1016/j.jsbmb.2014.03.006
  41. K. Rutkowski, P. Sowa, J. Rutkowska-Talipska, A. Kuryliszyn-Moskal, R. Rutkowski, "Dehydroepiandrosterone (DHEA): hypes and hopes", Drugs, Vol.74 No.11 pp. 1195-1207, (2014). https://doi.org/10.1007/s40265-014-0259-8
  42. A. C Phillips, V. E. Burns, J. M. Lord, "Stress and exercise: getting the balance right for aging immunity", Exercise and sport sciences reviews, Vol.35 No.1 pp. 35-39, (2007). https://doi.org/10.1097/jes.0b013e31802d7008
  43. O. Tissandier, G. Peres, J. Fiet, F. Piette, "Testosterone, dehydroepiandrosterone, insulin-like growth factor 1, and insulin in sedentary and physically trained aged men", European journal of applied physiology, Vol.85 No.1-2 pp. 177-184, (2001). https://doi.org/10.1007/s004210100420
  44. G. Ravaglia, P. Forti, F. Maioli, L. Pratelli, C. Vettori, L. Bastagli, E. Mariani, A. Facchini, D. Cucinotta, "Regular moderate intensity physical activity and blood concentrations of endogenous anabolic hormones and thyroid hormones in aging men", Mechanisms of ageing and development, Vol.122 No.2 pp. 191-203, (2001). https://doi.org/10.1016/S0047-6374(00)00234-7
  45. A. Tivesten, L. Vandenput, D. Carlzon, M. Nilsson, M. K. Karlsson, O. Ljunggren, E. Barrett-Connor, D. Mellstrom, C. Ohlsson, "Dehydroepiandrosterone and its sulfate predict the 5-year risk of coronary heart disease events in elderly men", Journal of the american college of cardiology, Vol.64 No.17 pp. 1801-1810, (2014). https://doi.org/10.1016/j.jacc.2014.05.076
  46. M. F. O'rourke, J. Hashimoto, "Mechanical factors in arterial aging: a clinical perspective", Journal of the American College of Cardiology, Vol.50 No.1 pp. 1-13, (2007). https://doi.org/10.1016/j.jacc.2006.12.050
  47. M. F. O'Rourke, M. E. Safar, "Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy" Hypertension, Vol.46 No.1 pp. 200-204, (2005). https://doi.org/10.1161/01.HYP.0000168052.00426.65
  48. S. Laurent, M. Briet, P. Boutouyrie Large and small artery cross-talk and recent morbidity-mortality trials in hypertension. Hypertension, Vol.54 No.2 pp. 388-392, (2009). https://doi.org/10.1161/HYPERTENSIONAHA.109.133116
  49. G. F. Mitchell, Y. Lacourciere, J. M. O. Arnold, M. E. Dunlap, P. R. Conlin, J. L. IzzoJr, "Changes in aortic stiffness and augmentation index after acute converting enzyme or vasopeptidase inhibition", Hypertension, Vol.46 No.5 pp. 1111-1117, (2005). https://doi.org/10.1161/01.HYP.0000186331.47557.ae
  50. A. M. Abbatecola, P. Chiodini, C. Gallo, E. Lakatta, K. Sutton-Tyrrell, F. A. Tylavsky, B. Goodpaster, N. Rekeneire, A. V. Schwartz, G. Paolisso, T. Harris, "Pulse wave velocity is associated with muscle mass decline: Health ABC study", Age, Vol.34 No.2 pp. 469-478, (2012). https://doi.org/10.1007/s11357-011-9238-0
  51. Y. Zhang, L. Qi, L. Xu, X. Sun, W. Liu, S. Zhou, F. van de Vosse, S. E. Greenwald, "Effects of exercise modalities on central hemodynamics, arterial stiffness and cardiac function in cardiovascular disease: Systematic review and meta-analysis of randomized controlled trials", PloS one, Vol.13 No.7 e0200829, (2018). https://doi.org/10.1371/journal.pone.0200829
  52. J. H. Kim, Y. S. Jung, J. W. Kim, M. S. Ha, S. M. Ha, D. Y. Kim, "Effects of aquatic and land-based exercises on amyloid beta, heat shock protein 27, and pulse wave velocity in elderly women", Experimental gerontology, Vol.108 pp. 62-68, (2018). https://doi.org/10.1016/j.exger.2018.03.024
  53. M. S. Ha, J. H. Kim, Y. S. Kim, D. Y. Kim, "Effects of aquarobic exercise and burdock intake on serum blood lipids and vascular elasticity in Korean elderly women", Experimental gerontology, Vol.101 pp. 63-68, (2018). https://doi.org/10.1016/j.exger.2017.11.005
  54. Y. J. Kim, J. H. Kim, S. M. Ha, J. S. Kim, J. W. Kim, B. K. Yoon, D. Y. Kim, "Effects of circulation exercise on health-related physical fitness, blood pressure and blood vessel elasticity of obese women in the 50s", Journal of Oil & Applied Science, Vol.34 No. 4, (2017).
  55. M. S. Ha, Y. H. Baek, "Floor exercise improves on senior fitness test, blood lipids and arterial stiffness in elderly women with metabolic syndrome", Journal of Oil & Applied Science, Vol.34 No. 4, (2017).