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DOI QR Code

Facilitated Protein-DNA Binding: Theory and Monte Carlo Simulation

  • Park, Ki-Hyun (School of Computational Sciences, Korea Institute for Advanced Study) ;
  • Kim, Tae-Jun (Department of Chemistry, Dong-A University) ;
  • Kim, Hyo-Joon (Department of Chemistry, Dong-A University)
  • Received : 2011.12.05
  • Accepted : 2012.01.12
  • Published : 2012.03.20

Abstract

The facilitated diffusion effect on protein-DNA binding is studied. A rigorous theoretical approach is presented to deal with the coupling between one-dimensional and three-dimensional diffusive motions. For a simplified model, the present approach can provide numerically exact results, which are confirmed by the lattice-based Monte Carlo simulations.

Keywords

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