한국수정란이식학회지 (Journal of Embryo Transfer)

  • 제26권4호
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  • Pages.297-304
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  • 2011
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  • 2508-755X(pISSN)
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  • 2288-0178(eISSN)
한국수정란이식학회 (The Korean Society of Embryo Transfer)
권호 표지

Distribution and Potential Toxicological Effects of 2,2',4,4'-tetrabromodiphenyl Ether (BDE-47) as a Endocrine Disrupting Chemical in Human and Animals

  • Jung, Eui-Man (College of Veterinary Medicine, Chungbuk National University) ;
  • Yang, Hyun (College of Veterinary Medicine, Chungbuk National University) ;
  • An, Beum-Soo (College of Veterinary Medicine, Chungbuk National University) ;
  • Lee, Geun-Shik (College of Veterinary Medicine, Kangwon National University) ;
  • Hyun, Sang-Hwan (College of Veterinary Medicine, Chungbuk National University) ;
  • Choi, Kyung-Chul (College of Veterinary Medicine, Chungbuk National University) ;
  • Jeung, Eui-Bae (College of Veterinary Medicine, Chungbuk National University)
  • 투고 : 2011.11.07
  • 심사 : 2011.11.15
  • 발행 : 2011.12.31
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초록

Polybrominated diphenyl ethers (PBDEs) are a class of "brominated" (bromine containing) man-made chemicals used as flame retardant additives in plastics, foams, and textiles. PBDEs are found in various environmental contaminants in air, soil, sediment, and water, and 209 individual forms (congeners) of PBDE exist. Among these, 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) is the dominant congener found in the environment. Exposure to BDE-47 is now worldwide, and levels of BDE-47 have been detected in the blood of animals, including humans. BDE-47 can adversely affect the developmental system in both humans and animals. BDEs have structural similarities to polychlorinated biphenyls and thyroid hormones. However, recent studies have shown that BDEs may act as hormonal disrupting chemicals with detrimental effects. Therefore, a reliable assessment of BDE-47 toxicological action is required to understand the detrimental impacts of BDE-47 on human health. In this review, we overview recent studies on the distribution and potential toxicological effects of BDE-47 in humans and animals.

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참고문헌

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