Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.11b
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- Pages.158-158
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- 2002
13-weeks toxicity study of fructus of Aristolochiae contorta in SD rat
- Hwang, Myung-Sil (Department of General Toxicology, Institute of National Toxicological Research) ;
- Park, Mi-Sun (Department of General Toxicology, Institute of National Toxicological Research) ;
- Moon, Gi-Young (Department of General Toxicology, Institute of National Toxicological Research) ;
- Lee, Ji-Sun (Department of General Toxicology, Institute of National Toxicological Research) ;
- Yum, Young-Na (Department of General Toxicology, Institute of National Toxicological Research) ;
- Cho, Dae-Hyun (Department of General Toxicology, Institute of National Toxicological Research) ;
- Yang, Ki-Hwa (Department of General Toxicology, Institute of National Toxicological Research)
- Published : 2002.11.01
Abstract
The potential toxicological effects of aristolochic acid (AA), a natural component in Aristolochiaceae family, were investigated. The 13-week toxicity study consisted of groups of 10 SD rat/sex administrated water containing 0, 0.05, 0.5, or 5 mg/kg per day AA (Study 1). The tested groups were terminated on Test Day 90 due to mortality and overt clinical signs of toxicity.(omitted)