• Biomolecules & Therapeutics
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• v.15 no.3
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• pp.192-198
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• 2007

Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a major constituent of rhubarb. Although it has been claimed to have a wild spectrum of therapeutic value, its side effects, especially in human kidney cells have not been well characterized. In this study, we have carried out in vitro genetic toxicity test of emodin and microarray analysis of differentially expressed genes in response to emodin. The result of Ames test showed mutations with emodin treatment in base substitution strain TA1535 both with and without exogenous metabolic activation. Likewise, emodin showed mutations in frame shift TA98 both with and without exogenous metabolic activation. The result of COMET assay in L5178Y cells with emodin treatment showed DNA damage both with and without exogenous metabolic activation. Emodin did not increase micronuclei in CHO cells both with and without exogenous metabolic activation. 150 Genes were selected as differentially expressed genes in response to emodin by microarray analysis and these genes would be candidate biomarkers of genetic toxic action of emodin.

• Transactions of the Korean Society of Mechanical Engineers
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• v.15 no.6
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• pp.2171-2180
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• 1991

An analysis model for off-design performance of radial inflow turbines with or without variable area guide vane is developed, where two important factors in loss models, total pressure ratio between variable area guide vane exit and scroll casing inlet and rotor loss coefficient are determined without experimental data. The analysis results show that the predicted trends with or without variable area guide vane are consistent with the experimental observations. The comparison of present method with the well-known NASA off-design performance analysis program shows that the mass flow rate and static efficiency by present analysis are in good agreement with those by the NASA program. Therefore, this method can be used to predict off-design performance of radial inflow turbines with validity of the loss models used by present analysis.

• Journal of the Korean Society of Visualization
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• v.8 no.2
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• pp.23-30
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• 2010

Regarding the aircrafts with a rotor blade system, the miniaturization of them is limited due to the rotor blade length and the tail rotor system. To miniaturize an aircraft, an equipment is required that increases thrust and also shortens the length of the rotor blade. The present study will conduct the flow analysis for miniaturizing the aircraft by applying a duct to the coaxial rotor blade system without tail rotor. First, the verification on the calculated results was conducted through the computational flow analysis on the coaxial rotor blade system without a duct. Then, the flow analysis for the coaxial rotor blade systems was performed including Ka-60 duct, Single duct, Twin duct, and Double duct, respectively. From the numerical results, the thrust coefficient appeared higher with the duct than without a duct for the coaxial rotor blade system. Especially, in the case of Double duct, the thrust was improved due to the increase of incoming flow and the extension of the wake area. These results will be used as the basic concepts for miniaturizing the aircraft with the rotor blade system. The flow analysis on the coaxial rotor blade system including the fuselage remains as a future work.

• Steel and Composite Structures
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• v.8 no.6
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• pp.491-510
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• 2008

This paper presents a plan and guidelines that were drawn for Korean based research carried out on the fire-resistance of CFT columns. This research was carried out by reviewing the Korean regulations related to the fire-resistance of CFT columns and examining studies which had been made in Korea as well as overseas. The first phase of the study plan was to compare the fire-resistance of square CFT columns without fire protection (obtained through fire-resistance tests and numerical analyses) with estimated values (obtained through fire-resistance design formulas proposed in Korea and overseas). This comparison provided conclusions as outlined below. Fire-resistance tests conducted in this study proved that, when the actual design load is taken into consideration, square CFT columns without fire protection are able to resist a fire for more than one hour. A comparison was made of test and analysis results with the fire-resistance time based on the AIJ code, the AISC design formula and the estimation formula suggested for Korea. The results of this comparison showed that the test and analysis results for specimens SAH1, SAH2-1, SAH2-2 and SAH3 were almost identical with the AIJ code, the AISC design formula and estimation formula. For specimens SAH4 and SAH5, the estimation formula was more conservative than the AIJ code and the AISC design formula. It was necessary to identify the factors that have an influence on the fire-resistance of CFT columns without fire protection and to draw fire-resistance design formulas for these columns. To achieve this, it is proposed that numerical analyses and tests be conducted in order to evaluate the fire-resistance of circular CFT columns, the influence of eccentricity existing as an additional factor and the influence of the slenderness ratio of the columns. It is also suggested that the overall behavior of CFT structures without fire protection within a fire be evaluated through analysis simulation.

• Biomolecules & Therapeutics
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• v.15 no.3
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• pp.199-204
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• 2007

Carbamates have excellent insecticidal activities against a broad spectrum of insects. They possess knocking-down, fast-killing, and systemic effects, however, they are toxic to mammals. In this study, we have carried out in vitro genetic toxicity test of methylcarbamate and microarray analysis of differentially expressed genes in response to methylcarbamate. Methylcarbamate did not show mutations in base substitution strain TA1535 both with and without exogenous metabolic activation. Methylcarbamate did not show mutations in frame shift TA98 both with and without exogenous metabolic activation. Methylcarbamate showed DNA damage based on single cell gel/comet assay in L5178Y cells both with and without exogenous metabolic activation. Methylcarbamate did not increase micronuclei in CHO cells both with and without exogenous metabolic activation. Microarray analysis of gene expression profiles in L5178Y cells in response to methylcarbamate selected differentially expressed 132 genes that could be candidate biomarkers of genetic toxic action of methylcarbamate.

• Biomolecules & Therapeutics
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• v.14 no.4
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• pp.246-252
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• 2006

1,2-Dibromoethane(DBE) has been widely used as a soil fumigant, an additive to leaded gasoline and an industrial solvent. In this study, we have carried out in vitro genetic toxicity test of 1,2-dibromoethane and microarray analysis of differentially expressed genes in response to 1,2-dibromoethane. 1,2-Dibromoethane showed mutations in base substitution strain TA1535 both with and without exogenous metabolic activation. 1,2-Dibromoethane showed mutations in frame shift TA98 both with and without exogenous metabolic activation. 1,2-Dibromoethane showed DNA damage based on single cell gel/comet assay in L5178Y cells both with and without exogenous metabolic activation. 1,2-Dibromoethane increased micronuclei in CRO cells both with and without exogenous metabolic activation. Microarray analysis of gene expression profiles in L5178Y cells in response to 1,2-dibromoethane selected differentially expressed 241 genes that would be candidate biomarkers of genetic toxic action of 1,2-dibromoethane.

• Physical Therapy Korea
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• v.26 no.3
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• pp.99-105
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• 2019

Background: Although magnetic resonance imaging is accurate, it is expensive to measure the movement of temporomandibular joint. The three-dimensional (3D) motion analysis system is an inexpensive measurement tool. Objects: This study examined the reliability of quantifying the mouth opening and lateral mandibular shift and differences between individuals with and without temporomandibular disorder (TMD) using the hygienic method of surface markers on the skin with 3D ultrasound-based motion analysis. Methods: This study included 24 subjects (12 with and 12 without TMD). Temporomandibular joint motion during mouth opening was recorded using two surface markers with 3D ultrasound-based motion analysis. An intraclass correlation coefficient [ICC (3,k)] was used to confirm the intrarater reliability of quantifying kinematic temporomandibular joint motion, and an independent t-test was used to evaluate differences in maximal mouth opening and lateral mandibular shift between the two groups. Results: Assessment of mouth opening and lateral mandibular shift showed excellent test-retest reliability with low standard error of measurement. The lateral mandibular shift and opening-lateral mandibular shift ratio were significantly increased in the TMD group during maximum mouth opening (p<.05). However, no significant difference in maximal mouth opening was observed between the groups with and without TMD (p>.05). Conclusion: This hygienic and simple surface marker method can be used to quantify the mouth opening and lateral mandibular shift at the end-range of mouth opening. The TMD group showed an increased lateral mandibular shift movement at the end-range of mouth opening. The lateral mandibular shift movement can be regarded as a symptom in the diagnosis and treatment of TMD.

• Physical Therapy Korea
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• v.29 no.2
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• pp.165-170
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• 2022

Background: The serratus anterior (SA) muscle prevents scapular winging (SW) by stabilizing the medial border of the scapula during arm movement. The upper trapezius (UT) and lower trapezius (LT) muscles may compensate for the weak SA muscle in individuals with SW during shoulder flexion. However, there is no study to examine whether compensation by UT and LT occurs in individuals with SW. Objects: This study compared the muscle activities of UT, LT, and SA as well as the SA/UT activity ratio between individuals with and without SW during shoulder flexion with load. Methods: This study recruited 27 participants with SW (n = 14) and without SW (n = 13). Electromyography data of the SA, UT, and LT muscles and SA/UT activity ratio were recorded and analyzed during shoulder flexion with 25% load of the maximal shoulder flexion force. Independent t-test was used to compare the UT, LT, and SA muscle activities and SA/UT ratio between the groups with and without SW; statistical significance was set at α of 0.05. Results: SA activity was significantly lesser in the group with SW than in the group without SW. However, there were no significant differences in the UT and LT activities and SA/UT activity ratio between the two groups. Conclusion: The SA activity was lesser in the group with SW than in the group without SW with 25% load of the maximal shoulder flexion force, but there was no compensatory muscle activity of the UT and LT observed. Therefore, further studies are warranted to clarify the compensatory strategy of scapular stabilization in individuals with SW during shoulder flexion under other heavy load conditions.

• Journal of Environmental Science International
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• v.14 no.11
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• pp.995-1004
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• 2005

As a research establish reservoir safety operation for small dam systems. This study presents hydrologic analysis conducted in the Duckdong and Bomun dam watershed based on various rainfall data and increase inflow. Especially the Duckdong dam without flood control feature are widely exposed to the risk of flooding, thus it is constructed emergency gate at present. In this study reservoir routing program was simulation for basin runoff estimating using HEC-HMS model, the model simulation the reservoir condition of emergency Sate with and without. At the reservoir analysis results is the Duckdong dam average storage decrease $20\%$ with emergency gate than without emergency gate. Also, the Bomun dam is not affected by the Duckdong flood control augmentation.

• Journal of Korean Neurosurgical Society
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• v.49 no.6
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• pp.355-358
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• 2011

Objective : Subdural hygroma (SDG) is a complication occurring after head trauma that may occur secondary to decompressive craniectomy (DC). However, the mechanism underlying SDG formation is not fully understood. Also, the relationship between the operative technique of DC or the decompressive effect and the occurrence and pathophysiology of SDG has not been clarified. Purpose of this study was to investigate the risk factors of SDG after DC in our series. Methods : From January 2004 to December 2008, DC was performed in 85 patients who suffered from traumatic brain injury. We retrospectively reviewed the clinical and radiological features. For comparative analysis, we divided the patients into 2 groups : one group with SDG after craniectomy (19 patients; 28.4% of the total sample), the other group without SDG (48 patients; 71.6%). The risk factors for developing SDG were then analyzed. Results : The mean Glasgow Outcome Scale (GOS) scores at discharge of the groups with and without SDG were 2.8 and 3.1, respectively (p<0.0001). Analysis of radiological factors showed that a midline shift in excess of 5 mm on CT scans was present in 19 patients (100%) in the group with SDG and in 32 patients (66.7%) in the group without SDG (p<0.05). An accompanying subarachnoid hemorrhage (SAH) was seen in 17 patients (89.5%) in the group with SDG and in 29 patients (60.4%) in the group without SDG (p<0.05). Delayed hydrocephalus accompanied these findings in 10 patients (52.6%) in the group with SDG, versus 5 patients (10.4%) in the group without SDG (p<0.05). On CT, compression of basal cisterns was observed in 14 members (73.7%) in the group with SDG and in 18 members of the group without SDG (37.5%) (p<0.007). Furthermore, tearing of the arachnoid membrane, as observed on CT, was more common in all patients in the group with SDG (100%) than in the group without SDG (31 patients; 64.6%) (p<0.05). Conclusion : GOS showed statistically significant difference in the clinical risk factors for SDG between the group with SDG and the group without SDG. Analysis of radiological factors indicated that a midline shifting exceeding 5 mm, SAH, delayed hydrocephalus, compression of basal cisterns, and tearing of the arachnoid membrane were significantly more common in patients with SDG.