• Journal of Chest Surgery
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• v.6 no.1
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• pp.15-22
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• 1973

The definition of cancer, its diagnosis and its prognosis all depend upon description of growth. To the layman a synonym for cancer is a "growth". There are no quantitative terms for the description of growth or growth rate in clinical use. There has been no attempt to assign values that would define "rapidly" or "slowly" growing. Estimates of growth potentiality are implied in the descriptive phrases "poorly differentiated" or "well differentiated", "highly malignant" or "low grade malignancy". and in systems of grading. These qualifying terms represent a personal impression, clinically useful in prognosis, but relative in nature. They do not lend themselves to uniform application or precise measurement for purpose of comparison. Growth is related to size and time. The volume of tumor depends upon the duration of the period of growth and the rate of growth. If the interval and change in volume are known. the average growth rate can be determined. If the growth rate is determined, and assumed to be constant., the duration of a given tumor and the time of inception can be estimated. The commonest concept of the origin of cancer is that as a result of a mutation involving a single cell, succeeding divisions of cells establish a colony with the characteristics recognizable as cancer. If the growth rate of the hypothetical tumor were constant it could be described in terms of "tumor volume doubling time". In the department of thoracic surgery of St. Mary hospital in Catholic Medical College, a clinical evaluation for the growth rate, degree of malignancy, resectability and prognosis was done on a total 24 cases of primary bronchogenic carcinoma which contour was significant on the chest X-ray film as possible estimating the tumor volume doubling time. The following results were obtained: 1. In the cases of 6.0cm or more in diameter of minor size at operation the resectability rate was lower and in the cases of 60 days or more in the tumor or volume doubling time the resectability rate was higher. 2. If differentiation of cancer cells was lower graded in tissue pathology, the tumor volume was shorter and the resectability rate was lower. 3. The tumor volume doubling time of the primary bronchogenic carcinoma occured more over 60 years of age was slightly shorter than under 60 years of age. 4. The tumor size at operation was more important to evaluate the survival time and prognosis than the tumor volume doubling time because the tumor growth was not always constant, we presume.mor volume doubling time because the tumor growth was not always constant, we presume.

• Journal of the Korean Mathematical Society
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• v.36 no.1
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• pp.73-95
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• 1999

We prove that if a given complete Riemannian manifold is roughly isometric to a complete Riemannian manifold satisfying the volume doubling condition, the Poincar inequality and the finite covering condition at infinity on each end, then every positive harmonic function on the manifold is asymptotically constant at infinity on each end. This result is a direct generalization of those of Yau and of Li and Tam.

• Korean Journal of Radiology
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• v.22 no.3
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• pp.464-475
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• 2021

Objective: This study aimed to evaluate the tumor doubling time of invasive lung adenocarcinoma according to the International Association of the Study for Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) histologic classification. Materials and Methods: Among the 2905 patients with surgically resected lung adenocarcinoma, we retrospectively included 172 patients (mean age, 65.6 ± 9.0 years) who had paired thin-section non-contrast chest computed tomography (CT) scans at least 84 days apart with the same CT parameters, along with 10 patients with squamous cell carcinoma (mean age, 70.9 ± 7.4 years) for comparison. Three-dimensional semiautomatic segmentation of nodules was performed to calculate the volume doubling time (VDT), mass doubling time (MDT), and specific growth rate (SGR) of volume and mass. Multivariate linear regression, one-way analysis of variance, and receiver operating characteristic curve analyses were performed. Results: The median VDT and MDT of lung cancers were as follows: acinar, 603.2 and 639.5 days; lepidic, 1140.6 and 970.1 days; solid/micropapillary, 232.7 and 221.8 days; papillary, 599.0 and 624.3 days; invasive mucinous, 440.7 and 438.2 days; and squamous cell carcinoma, 149.1 and 146.1 days, respectively. The adjusted SGR of volume and mass of the solid-/micropapillary-predominant subtypes were significantly shorter than those of the acinar-, lepidic-, and papillary-predominant subtypes. The histologic subtype was independently associated with tumor doubling time. A VDT of 465.2 days and an MDT of 437.5 days yielded areas under the curve of 0.791 and 0.795, respectively, for distinguishing solid-/micropapillary-predominant subtypes from other subtypes of lung adenocarcinoma. Conclusion: The tumor doubling time of invasive lung adenocarcinoma differed according to the IASCL/ATS/ERS histologic classification.

• Bulletin of the Korean Mathematical Society
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• v.52 no.6
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• pp.1855-1899
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• 2015

We discuss some additivity properties of the simplicial volume for manifolds with boundary: we give proofs of additivity for glueing amenable boundary components and of superadditivity for glueing amenable submanifolds of the boundary, and we discuss doubling of 3-manifolds.

• Journal of the Korean Mathematical Society
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• v.55 no.6
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• pp.1359-1380
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• 2018

In this paper, we prove that if a metric measure space satisfies the volume doubling condition and the Hardy type inequality with the same exponent n ($n{\geq}3$), then it has exactly the n-dimensional volume growth. Besides, three interesting applications of this fact have also been given. The first one is that we prove that complete noncompact smooth metric measure space with non-negative weighted Ricci curvature on which the Hardy type inequality holds with the best constant are isometric to the Euclidean space with the same dimension. The second one is that we show that if a complete n-dimensional Finsler manifold of nonnegative n-Ricci curvature satisfies the Hardy type inequality with the best constant, then its flag curvature is identically zero. The last one is an interesting rigidity result, that is, we prove that if a complete n-dimensional Berwald space of non-negative n-Ricci curvature satisfies the Hardy type inequality with the best constant, then it is isometric to the Minkowski space of dimension n.

• Wind and Structures
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• v.38 no.3
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• pp.193-202
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• 2024

Modern high-rise tower designs incorporating recessed balcony cavity spaces can be prone to high-frequency and narrow-band Rossiter aerodynamic excitations under glancing incident winds that can harmonize and compete with recessed balcony volume acoustic Helmholtz modes and facade elastic responses. Resulting resonant inertial wind loading to balcony facades responding to these excitations is additive to the peak design wind pressures currently allowed for in wind codes and can present as excessive facade vibrations and sub-audible throbbing in the serviceability range of wind speeds. This paper presents a methodology to determine Cavity Amplification Factors to account for façade resonant inertial wind loads resulting from balcony cavity aero-acoustic-elastic resonances by drawing upon field observations and the results of full-scale monitoring and model-scale wind tunnel tests. Recessed balcony cavities with single orifice type openings and located within curved façade tower geometries appear particularly prone. A Cavity Amplification Factor of 1.8 is calculated in one example representing almost a doubling of local façade design wind pressures. Balcony façade and tower design recommendations to mitigate wind induced aero-acoustic-elastic resonances are provided.

• Journal of Korean Society of Environmental Engineers
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• v.36 no.3
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• pp.214-220
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• 2014

The aim of this study is to optimize the efficiency of a photobiorector on the growth rate of Chlorella vulgaris (C. vulgaris) by varying distance of optical panel (OP). The round shaped C. vulgaris (FC-16) having the size of $3-8{\mu}m$ is employed in this study. The cells of C. vulgaris are cultured in the Jaworski's Medium with deionized water at $22^{\circ}C$ for 15 days. The OP is placed at four different distances i.e., at 225 mm distance (Run 1), 150 mm distance (Run 2), 112.5 mm distance (Run 3) and 90 mm distance (Run 4) having a LED (Light Emitting Diode) source. The diffuse rate is achieved to 86%, 90%, 92% and 94% for Run 1, Run 2 Run 3 and Run 4, respectively. A narrower distance of OP caused to effectively to increase the efficiency of diffuse light rate. For mass cultivation of this biomass, medium is changed according to distance of OP after attaining a maximum biomass concentration; Run 1 in 8 days, Run 2 in 6 days, Run 3 in 4 days and Run 4 in 3 days. In addition, the amount of maximum biomass rate for Run 4 was reached 3 times higher than that of Run1. However, growth rate, chlorophyll per cell, cell volume and doubling time are found to be Run 3 and Run 4 higher than that of Run 1 and Run 2 samples. However, Run 3 and Run 4 are having a slight difference in all these measurements. These findings suggest that in terms of economic consideration and efficiency towards simultaneous mass cultivation of biomass, Run 3 was found to be more effective than other samples.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.25 no.6
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• pp.868-875
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• 2001

The objective of this study is to investigate the average droplet size distributions of a GDI spray by simultaneous fluorescence/scattering image technique. GDI engine is recently very popular because of high engine efficiency and low emissions. However, the injectors must have good spray characteristics because the fuel is directly injected into the cylinder. The fuel mixtures used in this study were 2% of fluorobenzene, 9% of DEMA(diethyl-methyl-amine) and 89% of hexane by volume. The system for obtaining 2-D fluorescence/scattering images of fuel spray was constituted of a laser sheet, a doubling prism, optical filters, and an ICCD camera. Using the ratio of the fluorescence to the scattering intensities, SMD distributions were obtained. SMD measured by the technique was compared with that obtained by PDA. It was found that average droplet size was bigger at spray center in the early stage of injection and at the outer periphery of the spray in the late stage of injection.

• Journal of Korea Trade
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• v.25 no.6
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• pp.126-142
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• 2021

Purpose - This study discusses the effects of human capital in the formation of GVC linkages. We also investigate GVC intensity between Korea and ASEAN. Design/methodology - To solve the doubling-counting problem in evaluating comparative advantage, RCA has been re-computed using domestic value-added (henceforth RCA_VA) at the country-sector level instead of value of trade. The impact of human capital on GVC intensity was empirically analyzed by establishing a panel data set with four industries (ISIC Rev. 4) in eight ASEAN countries from 2005 to 2015 from OECD-TiVA and WDI. Findings - The empirical results show that human capital has a negative effect on GVC intensity in the agriculture and manufacture industries, while it has a positive effect in the service and information industries. The results do not mean that low human capital is a barrier and inefficient to GVC linkages. Low Value-added activities may be more profitable to some emerging countries. These findings suggest that it is important to accurately identify the competitive elements to increase gains from trade under the GVC. Also, it shows that comparative advantages can be misled by an RCA index evaluated in trade volume under the GVC. Originality/value - This study highlights the importance of human capital as a factor for the efficient formation of Global Value Chain (GVC). This study has different from the literature in analyzing the role of human capital in formation of linkage of the GVC. And we clarify the changing patterns of trade by removing the double-counting problem under the GVC.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.8_spc
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• pp.1244-1255
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• 2019

Dairy goat production continues to be a socially, economically and culturally important part of the livestock industry in North, Central and South America and the Caribbean islands. Goat milk, cheese and other dairy products offer consumers food products with nutritional, health and environmental benefits. In North America, Mexico produces the greatest volume of goat milk, but most is for family or local consumption that is typical of a mixed farming system adopted by subsistence farmers in dry areas. The United States is not yet a large global goat milk producer, but the sector has expanded rapidly, with dairy goat numbers doubling between 1997 and 2012. The number of dairy goats has also increased dramatically in Canada. Commercial farms are increasingly important, driven by rising demand for good quality and locally sourced goat cheese. In South America, Brazil has the most developed dairy goat industry that includes government assistance to small-scale producers and low-income households. As of 2017, FAO identified Haiti, Peru, Jamaica, and Bolivia as having important goat milk production in the Western Hemisphere. For subsistence goat producers in the Americas on marginal land without prior history of chemical usage, organic dairy goat production can be a viable alternative for income generation, with sufficient transportation, sanitation and marketing initiatives. Production efficiency, greenhouse gas emission, waste disposal, and animal welfare are important challenges for dairy goat producers in the Americas.