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A Case of Isoniazid Intoxication in a Dog

  • Oh, Jimin;Kim, Hong-Seok;Kang, Ji-Houn;Kang, Byeong-Teck;Yang, Mhan-Pyo;Kim, Hakhyun
    • Journal of Veterinary Clinics
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    • v.38 no.4
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    • pp.204-209
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    • 2021
  • A seven-month-old castrated male Chihuahua weighing 1.6 kg presented with generalized tonic-clonic seizure following ingestion of isoniazid. Emergency treatment with three doses of diazepam (total 1.5 mg/kg, intravenous [IV]) and phenobarbital (15 mg/kg IV) was administered. The seizure stopped after administration of propofol (constant rate infusion [CRI]; 0.2 mg/kg/min). Blood analyses showed mildly increased serum blood glucose concentration, hyperkalemia, and hyperphosphatemia. On suspicion of isoniazid toxicity, activated charcoal (1 g/kg, orally), lipid emulsion (CRI; 9 mL/hr), and pyridoxine hydrochloride (70 mg/kg IV) were added to the treatment regimen. Twelve hours after presentation, the dog showed increased serum liver enzyme activities, serum blood urea nitrogen, and creatinine concentrations indicating hepatic and renal failure. Twenty-two hours after presentation, blood analysis still revealed increased liver enzyme activities, blood urea nitrogen, and creatinine concentrations with low blood glucose concentration. Twenty-six hours after presentation, the dog's vital signs deteriorated and the owner elected for the dog to be euthanized. This is the first report of the clinical course of isoniazid toxicosis in a dog in South Korea. Furthermore, to our best knowledge, this is the first report where secondary multiple organ failure was observed due to isoniazid toxicosis. Clinicians should be aware of the possibility of isoniazid toxicosis in dogs. Rapid initiation of treatment after clinical recognition is warranted in such cases.

Effect of Implementing Candle-Blowing Respiratory Exercise Program on Functional Improvement of Forced Breathing Volume among Adults (촛불끄기 호흡운동 프로그램의 시행이 성인의 노력성 호흡량의 기능향상에 미치는 영향)

  • Lee, Jun-Cheol
    • The Journal of the Convergence on Culture Technology
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    • v.7 no.4
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    • pp.203-210
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    • 2021
  • This study examined the effect of the respiratory training centered at forced breathing exercise of blowing out a candle on the improvement of adults' respiratory ability, which means the increased muscle strength of body trunk. After the four-week candle-blowing breathing training, the forced vital capacity (FVC) increased statistically significantly (p<.05). The forced expiratory volume in one second (FEV1) did not show a statistically significant difference before and after the four-week intervention(p>.05). The peak expiratory flow rate (PEF) statistically significantly increased after the four-week blowing-out-the-candle training (p<.05). This study examined the relationship between forced breathing training and pulmonary function of healthy adults including FVC, FEV1, and PEF, which means the increased muscle strength of body trunk, by implementing blowing-out-the-candle breathing exercise centered at forced respiratory exercise and obtained significant results. Further studies that use a sample of patients with advanced respiratory system disease for whom physical therapy is absolutely necessary will be required in the future.

Effect of Mask Filter on Respiratory Function in Chronic Stroke Patients (마스크 필터가 만성 뇌졸중 환자의 호흡기능에 미치는 영향)

  • Lee, Yun-Hee;Kum, Dong-Min;Shin, Won-Seob
    • Journal of The Korean Society of Integrative Medicine
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    • v.10 no.1
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    • pp.149-155
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    • 2022
  • Purpose : This study investigated the effects of wearing a mask and different mask filters on the respiratory function of stroke patients. Methods : A total of 15 stroke patients were selected according to the inclusion and exclusion criteria. The respiratory functions were compared between participants with and without masks and among respiratory functions with three different mask filters. The order of using masks was non-wearing masks, Dental masks, KF80 masks, and KF94 masks; the difference in respiratory volumes among these conditions were measured. For accuracy of the measurement, sufficient education on the respiratory measurement method was provided to the researcher, and the heart rate of the participants was estimated to confirm their stability before the measurements. To ensure accuracy, the subjects were educated on the researchers' respiratory measurement methods. Each measurement was followed by 10 min breathing stability before replacing the next mask. Results : The results of this study showed that the difference in respiratory functions, including forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and maximal voluntary ventilation (MVV), in stroke patients was statistically significant among different masks (p<.05). Afterwards, the values of FVC, FEV1, and MVV in stroke patients wearing masks were significantly lower than those of the non-masked control group (p<.05). The difference in respiratory functions with different mask filters showed no statistical significance (p<.05). Conclusion : This study showed that participants wearing any of the masks presented a lower respiratory function than that of those without using masks; additionally, no difference in respiratory functions was observed with differences in mask filters. Therefore, wearing a mask for a prolonged period is confirmed to affect breathing in stroke patients with weak respiratory function.

Modeling of heated concrete-filled steel tubes with steel fiber and tire rubber under axial compression

  • Sabetifar, Hassan;Nematzadeh, Mahdi;Gholampour, Aliakbar
    • Computers and Concrete
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    • v.29 no.1
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    • pp.15-29
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    • 2022
  • Concrete-filled steel tubes (CFSTs) are increasingly used as composite sections in structures owing to their excellent load bearing capacity. Therefore, predicting the mechanical behavior of CFST sections under axial compression loading is vital for design purposes. This paper presents the first study on the nonlinear analysis of heated CFSTs with high-strength concrete core containing steel fiber and waste tire rubber under axial compression loading. CFSTs had steel fibers with 0, 1, and 1.5% volume fractions and 0, 5, and 10% rubber particles as sand alternative material. They were subjected to 20, 250, 500, and 750℃ temperatures. Using flow rule and analytical analysis, a model is developed to predict the load bearing capacity of steel tube, and hoop strain-axial strain relationship, and axial stress-volumetric strain relationship of CFSTs. An elastic-plastic analysis method is applied to determine the axial and hoop stresses of the steel tube, considering elastic, yield, and strain hardening stages of steel in its stress-strain curve. The axial stress in the concrete core is determined as the difference between the total experimental axial stress and the axial stress of steel tube obtained from modeling. The results show that steel tube in CFSTs under 750℃ exhibits a higher load bearing contribution compared to those under 20, 250, and 500℃. It is also found that the ratio of load bearing capacity of steel tube at peak point to the load bearing capacity of CFST at peak load is noticeable such that this ratio is in the ranges of 0.21-0.33 and 0.31-0.38 for the CFST specimens with a steel tube thickness of 2 and 3.5 mm, respectively. In addition, after the steel tube yielding, the load bearing capacity of the tube decreases due to the reduction of its axial stiffness and the increase of hoop strain rate, which is in the range of about 20 to 40%.

Evaluation of pedicled flaps for type IIIB open fractures of the tibia at a tertiary care center

  • Vathulya, Madhubari;Dhingra, Mohit;Nongdamba, Hawaibam;Chattopadhyay, Debarati;Kapoor, Akshay;Dhingra, Vandana Kumar;Mago, Vishal;Kandwal, Pankaj
    • Archives of Plastic Surgery
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    • v.48 no.4
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    • pp.417-426
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    • 2021
  • Background Soft tissue coverage plays a vital role in replacing the vascularity of the underlying bone in Gustilo type IIIB fractures. The aim of this article was to evaluate the feasibility of local pedicled flaps in type IIIB fractures at a tertiary care center. Methods We included all cases of open Gustilo-Anderson type IIIB fractures of the tibia treated with local flap coverage from January 2017 to February 2019. We carried out a retrospective analysis to investigate the relationships of complications, hospital stay, and cost-effectiveness with the choice of flap, infective foci, site and size of the defect, and type of fixation. Results Out of 138 Gustilo type IIIB fractures analyzed in our study, 27 cases had complications, of which 19 (13.76%) involved flap necrosis, four (2.89%) were infections, three (2.17%) involved partial necrosis, and one (0.72%) was related to bone spur development. Flap complications showed a statistically significant association with the perforator flap category (propeller flaps in particular) (P=0.001). Flap necrosis showed a significant positive correlation with cases treated within 3 weeks after trauma (P=0.046). A significant positive correlation was also found between defect size and the duration of hospital stay (P=0.03). Conclusions Although local flaps are harvested from the same leg that underwent trauma, their success rate is at least as high as microvascular flaps as reported from other centers. Amidst the local flaps, complications were predominantly associated with perforator flaps.

Using Bayesian network and Intuitionistic fuzzy Analytic Hierarchy Process to assess the risk of water inrush from fault in subsea tunnel

  • Song, Qian;Xue, Yiguo;Li, Guangkun;Su, Maoxin;Qiu, Daohong;Kong, Fanmeng;Zhou, Binghua
    • Geomechanics and Engineering
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    • v.27 no.6
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    • pp.605-614
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    • 2021
  • Water inrush from fault is one of the most severe hazards during tunnel excavation. However, the traditional evaluation methods are deficient in both quantitative evaluation and uncertainty handling. In this paper, a comprehensive methodology method combined intuitionistic fuzzy AHP with a Bayesian network for the risk assessment of water inrush from fault in the subsea tunnel was proposed. Through the intuitionistic fuzzy analytic hierarchy process to replace the traditional expert scoring method to determine the prior probability of the node in the Bayesian network. After the field data is normalized, it is classified according to the data range. Then, using obtained results into the Bayesian network, conduct a risk assessment with field data which have processed of water inrush disaster on the tunnel. Simultaneously, a sensitivity analysis technique was utilized to investigate each factor's contribution rate to determine the most critical factor affecting tunnel water inrush risk. Taking Qingdao Kiaochow Bay Tunnel as an example, by predictive analysis of fifteen fault zones, thirteen of them are consistent with the actual situation which shows that the IFAHP-Bayesian Network method is feasible and applicable. Through sensitivity analysis, it is shown that the Fissure development and Apparent resistivity are more critical comparing than other factor especially the Permeability coefficient and Fault dip. The method can provide planners and engineers with adequate decision-making support, which is vital to prevent and control tunnel water inrush.

Evaluating anxiety levels and pain perception while administering local anesthesia using conventional, insulin, and deception syringes in 6-12-year-olds

  • Kohli, Neha;Hugar, Shivayogi M;Patil, Vidyavathi H;Saxena, Nivedita;Kadam, Krishna S;Karmarkar, Sanika
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.22 no.3
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    • pp.197-204
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    • 2022
  • Background: Injections are one of the most fear-provoking stimuli in dentistry. Painless administration of an injection is a vital step in alleviating anxiety, which in turn leads to good behavior in children. The aim is to evaluate and compare anxiety levels and pain perception using conventional, insulin, and deception syringes during the administration of local anesthesia in children. Methods: Forty-five children aged 6-12 were selected using a standard sample size formula and equally divided into three groups. Local anesthesia was administered using a conventional syringe to Group A participants and an insulin syringe for Group B participants. Group C participants were administered local anesthesia using a deception syringe by showing the patient disposable obturation tips, and eventually a conventional syringe was used for administration of local anesthesia after hiding them from the patient. Anxiety levels were assessed using Venham's Picture Scale and pulse rate at baseline and after administration of local anesthesia. The Wong-Baker Faces Pain Rating Scale was used to assess pain perception after the administration of local anesthesia. Results: Insulin and deception syringes showed better reduction in anxiety levels and pain perception than conventional syringes, demonstrating a high statistically significant difference. Conclusion: The use of insulin and deception syringes for administration of anesthesia was demonstrated to be effective in alleviating anxiety in children and is therefore recommended as an alternative to conventional syringes.

Safe Discharge Criteria After Curative Gastrectomy for Gastric Cancer

  • Guner, Ali;Kim, Ki Yoon;Park, Sung Hyun;Cho, Minah;Kim, Yoo Min;Hyung, Woo Jin;Kim, Hyoung-Il
    • Journal of Gastric Cancer
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    • v.22 no.4
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    • pp.395-407
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    • 2022
  • Purpose: This study aimed to investigate the relationship between clinical and laboratory parameters and complication status to predict which patients can be safely discharged from the hospital on the third postoperative day (POD). Materials and Methods: Data from a prospectively maintained database of 2,110 consecutive patients with gastric adenocarcinoma who underwent curative surgery were reviewed. The third POD vital signs, laboratory data, and details of the course after surgery were collected. Patients with grade II or higher complications after the third POD were considered unsuitable for early discharge. The performance metrics were calculated for all algorithm parameters. The proposed algorithm was tested using a validation dataset of consecutive patients from the same center. Results: Of 1,438 patients in the study cohort, 142 (9.9%) were considered unsuitable for early discharge. C-reactive protein level, body temperature, pulse rate, and neutrophil count had good performance metrics and were determined to be independent prognostic factors. An algorithm consisting of these 4 parameters had a negative predictive value (NPV) of 95.9% (95% confidence interval [CI], 94.2-97.3), sensitivity of 80.3% (95% CI, 72.8-86.5), and specificity of 51.1% (95% CI, 48.3-53.8). Only 28 (1.9%) patients in the study cohort were classified as false negatives. In the validation dataset, the NPV was 93.7%, sensitivity was 66%, and 3.3% (17/512) of patients were classified as false negatives. Conclusions: Simple clinical and laboratory parameters obtained on the third POD can be used when making decisions regarding the safe early discharge of patients who underwent gastrectomy.

Determining chlorine injection intensity in water distribution networks: a comparison of backtracking and water age approaches

  • Flavia D. Frederick;Malvin S. Marlim;Doosun Kang
    • Proceedings of the Korea Water Resources Association Conference
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    • 2023.05a
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    • pp.170-170
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    • 2023
  • Providing safe and readily available water is vital to maintain public health. One of the most prevalent methods to prevent the spread of waterborne diseases is applying chlorine injection to the treated water before distribution. During the water transmission and distribution, the chlorine will experience a reduction, which can imply potential risks for human health if it falls below the minimum threshold. The ability to determine the appropriate initial intensity of chlorine at the source would be significant to prevent such problems. This study proposes two methods that integrate hydraulic and water quality modeling to determine the suitable intensity of chlorine to be injected into the source water to maintain the minimum chlorine concentration (e.g., 0.2 mg/l) at each demand node. The water quality modeling employs the first-order decay to estimate the rate of chlorine reduction in the water. The first method utilizes a backtracking algorithm to trace the path of water from the demand node to the source during each time step, which helps to accurately determine the travel time through each pipe and node and facilitate the computation of time-dependent chlorine decay in the water delivery process. However, as a backtracking algorithm is computationally intensive, this study also explores an alternative approach using a water age. This approach estimates the elapsed time of water delivery from the source to the demand node and calculate the time-dependent reduction of chlorine in the water. Finally, this study compares the outcomes of two approaches and determines the suitable and effective method for calculating the chlorine intensity at the source to maintain the minimum chlorine level at demand nodes.

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Long Short-Term Memory Neural Network assisted Peak to Average Power Ratio Reduction for Underwater Acoustic Orthogonal Frequency Division Multiplexing Communication

  • Waleed, Raza;Xuefei, Ma;Houbing, Song;Amir, Ali;Habib, Zubairi;Kamal, Acharya
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.17 no.1
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    • pp.239-260
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    • 2023
  • The underwater acoustic wireless communication networks are generally formed by the different autonomous underwater acoustic vehicles, and transceivers interconnected to the bottom of the ocean with battery deployed modems. Orthogonal frequency division multiplexing (OFDM) has become the most popular modulation technique in underwater acoustic communication due to its high data transmission and robustness over other symmetrical modulation techniques. To maintain the operability of underwater acoustic communication networks, the power consumption of battery-operated transceivers becomes a vital necessity to be minimized. The OFDM technology has a major lack of peak to average power ratio (PAPR) which results in the consumption of more power, creating non-linear distortion and increasing the bit error rate (BER). To overcome this situation, we have contributed our symmetry research into three dimensions. Firstly, we propose a machine learning-based underwater acoustic communication system through long short-term memory neural network (LSTM-NN). Secondly, the proposed LSTM-NN reduces the PAPR and makes the system reliable and efficient, which turns into a better performance of BER. Finally, the simulation and water tank experimental data results are executed which proves that the LSTM-NN is the best solution for mitigating the PAPR with non-linear distortion and complexity in the overall communication system.