• 월간한국양록
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• 제8권2호통권50호
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• pp.107-111
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• 2003

• 월간한국양록
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• 제8권3호통권51호
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• pp.115-119
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• 2003

• 월간한국양록
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• 제8권3호통권51호
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• pp.120-123
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• 2003

• 월간한국양록
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• 제8권3호통권51호
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• pp.124-127
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• 2003

• 월간한국양록
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• 제8권3호통권51호
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• pp.110-114
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• 2003

• 한국축산식품학회지
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• 제35권4호
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• pp.507-514
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• 2015

Deer velvet antler (DVA) is one of the most popular medicines in China. Numerous studies have demonstrated that velvet antler possess biological effects. However, data regarding its anti-migration activity on prostate cancer is scarce. In this study, we investigated the inhibitory effect of top DVA (T-DVA) on the expression of prostate-specific antigen (PSA) and migration-related genes in the human prostate cancer cell, LNCaP. The T-DVA down-regulated the expression of PSA. In addition, the Radius^TM assay revealed that T-DVA inhibited the migration behavior of prostate cancer cells. Furthermore, the expression of matrix metalloproteinase (MMP)-9 and vascular endothelial growth factor (VEGF) was also decreased with T-DVA. On the contrary, T-DVA increased the tissue inhibition of metallo-proteinase (TIMP)-1 and (TIMP)-2. Taken together, our findings indicate that the T-DVA possesses anti-migration activity on prostate cancer cells. This is the first study of DVA to report the anti-migration activity on prostate cancer.

• 한국축산식품학회지
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• 제30권1호
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• pp.20-27
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• 2010

Deer velvet antler was subjected to the extraction process using boiling water at three different temperatures (100, 110 and $120^{\circ}C$) and 70% ethanol solution. Functional components such as uronic acid, sulfated-glycosaminoglycans (sulfated-GAGs) and sialic acid in the extracts were analyzed, and their antioxidant activities were investigated using several in vitro models. Uronic acid and sulfated-GAGs content of each extract significantly decreased with increasing extraction temperature (p<0.05), while the residues obtained from the upper and middle part of the antler had a higher uronic acid content than the residues obtained from the base section. Sialic acid contents were highest in compounds extracted at $110^{\circ}C$, followed by 120 and $100^{\circ}C$. The 70% ethanol extracts also had a high levels of uronic acid content, but not for sulfated-GAGs and sialic acid. All extracts showed good antioxidant ability in a dose-dependant manner, with the $100^{\circ}C$ residue exhibiting the strongest activity compared to the 110 and $120^{\circ}C$ extracts. In relation to the hydroxyl radical scavenging activity and reduction power, the 70% ethanol extract exhibited the strongest activity. Furthermore, the velvet antler extracts inhibited apoptosis in hydrogen peroxide-induced PC-12 cells.

• Asian-Australasian Journal of Animal Sciences
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• 제24권9호
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• pp.1303-1313
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• 2011

This study was conducted to provide the basic information to allow improved scientific assessment of velvet antler's quality by investigating the change of chemical composition during different antler growth stages in elk (Cervus elaphus canadensis). Twenty four antlers were harvested from elk stags (aged 4-5 years) on 65 days (VA65), 80 days (VA80) and 95 days (VA95) after button casting, and the chemical composition of each antler was determined in five sections (top, upper, middle, base, and bottom). Crude protein and ether extract content was the highest in the top section, whereas ash content was the highest in the bottom section in all groups (p<0.05). Glycosaminoglycan (GAG) content was higher in the VA65 group than in the VA95 group in the upper section of antler (p<0.05). The collagen content was higher in the VA65 group compared to the VA95 group in the middle and bottom sections (p<0.05), and increased downward from the top to the bottom section. The proportions of certain amino acids, including aspartic acid, glutamic acid and isoleucine were higher (p<0.05), whereas proline and glycine were lower in the top section of antler compared to all other sections (p<0.05). The proportion of linoleic acid, 11,14,17-eicosatrienoic acid, total ${\omega}$-3 and ${\omega}$-6 fatty acids and polyunsaturated fatty acids (PUFAs) for all sections in the VA65 group was higher than in the VA95 group (p<0.05). These results suggested that the quality of velvet antler is strongly influenced by antler development stage.

• 생물환경조절학회지
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• 제13권4호
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• pp.266-270
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• 2004

장미 식물공장식 양액재배는 고품질의 절화를 대량으로 계획 생산할 수 있는 시스템으로 장미 수출증가에 따라 기존의 재배 방식에서 식물공장 형태로의 전환이 필수적이다. 또한 식물공장에서의 경제적이고, 효율적인 생산을 위한 지하부 환경의 최적 관리 기술 개발이 절실한 실정이다. 따라서 장미 식물공장에 적합한 single-stemmed rose 수경재배시 배양액의 온도과 같은 지하부 환경요인이 장미의 생육과 품질에 미치는 영향을 알아보고자 실험하였다. 배양액의 온도에 따른 'Red Velvet'의 광합성률, 증산량, 생육 및 수량이 $15\~20^{\circ}C$에서 높게 나타나 적정 배양액 온도임을 알 수 있었다. 반면에 'Vital'은 $10\~15^{\circ}C$에서 생육이 가장 왕성하고 $30^{\circ}C$의 고온에서는 거의 생육이 이루어지지 않아 'Red Velvet'과는 달리 고온의 배양액에 대한 적응력이 낮은 것으로 나타났다.

• Asian-Australasian Journal of Animal Sciences
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• 제20권10호
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• pp.1546-1550
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• 2007

This study aimed to provide basic information as the foundation for further studies on the assessment of velvet antler quality by investigating the changes in fatty acid, vitamin A and E, minerals and GAGs contents by development stage of antler in spotted deer (Cervus nippon). Twelve stags (aged 4 to 5 years) were divided into two groups and velvet antler harvested 40 days (FDG) and 60 days (SDG) after casting of the buttons from the previous set. Total saturated fatty acid was lower in FDG than SDG (p<0.05). Total monounsaturated fatty acid, conjugated linoleic acid (p<0.05), polyunsaturated fatty acid and ${\omega}$3 fatty acid were higher in FDG than SDG. The vitamin A content of FDG was higher than that of SDG, but the vitamin E content of FDG was lower than that of SDG (p<0.05). SDG had significantly higher calcium and phosphate content than FDG (p<0.05). The magnesium content showed a similar trend to the contents of calcium and phosphate, but there was no significant difference between SDG and FDG. Uronic acid content was higher in FDG than SDG but there was no significant difference. The contents of GAGs and sialic acid were significantly higher (p<0.05) in FDG than SDG. These results indicated that the longer stage of antler development had lower content of activating components and this lead to a decrease of antler quality.