• Advances in biomechanics and applications
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• 제1권2호
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• pp.95-109
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• 2014

Peri-acetabular bone ingrowth plays a crucial role in long-term stability of press-fit acetabular cups. A poor bone ingrowth often results in increased cup migration, leading to aseptic loosening of the implant. The rate of peri-prosthetic bone formation is also affected by the polar gap that may be introduced during implantation. Applying a mechano-regulatory tissue differentiation algorithm on a two-dimensional plane strain microscale model, representing implant-bone interface, the objectives of the study are to gain an insight into the process of peri-prosthetic tissue differentiation and to investigate its relationship with implant-bone relative displacement and size of the polar gap. Implant-bone relative displacement was found to have a considerable influence on bone healing and peri-acetabular bone ingrowth. An increase in implant-bone relative displacement from $20{\mu}m$ to $100{\mu}m$ resulted in an increase in fibrous tissue formation from 22% to 60% and reduction in bone formation from 70% to 38% within the polar gap. The increase in fibrous tissue formation and subsequent decrease in bone formation leads to weakening of the implant-bone interface strength. In comparison, the effect of polar gap on bone healing and peri-acetabular bone ingrowth was less pronounced. Polar gap up to 5 mm was found to be progressively filled with bone under favourable implant-bone relative displacements of $20{\mu}m$ along tangential and $20{\mu}m$ along normal directions. However, the average Young's modulus of the newly formed tissue layer reduced from 2200 MPa to 1200 MPa with an increase in polar gap from 0.5 mm to 5 mm, suggesting the formation of a low strength tissue for increased polar gap. Based on this study, it may be concluded that a polar gap less than 0.5 mm seems favourable for an increase in strength of the implant-bone interface.

• Reproductive and Developmental Biology
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• 제33권3호
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• pp.133-137
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• 2009

Pluripotent embryonic stem (ES) cells isolated from inner cell mass (ICM) of blastocyst-stage embryos are capable of differentiating into various cell lineages and demonstrate germ-line transmission in experimentally produced chimeras. These cells have a great potential as tools for transgenic animal production, screening of newly-developed drugs, and cell therapy. Miniature pigs, selectively bred pigs for small size, offer several advantages over large breed pigs in biomedical research including human disease model and xenotransplantation. In the present study, factors affecting primary culture of somatic cell nuclear transfer blastocysts from miniature pigs for isolation of ES cells were investigated. Formation of primary colonies occurred only on STO cells in human ES medium. In contrast, no ICM outgrowth was observed on mouse embryonic fibroblasts (MEF) in porcine ES medium. Plating intact blastocysts and isolated ICM resulted in comparable attachment on feeder layer and primary colony formation. After subculture of ES-like colonies, two putative ES cell lines were isolated. Colonies of putative ES cells morphologically resembled murine ES cells. These cells were maintained in culture up to three passages, but lost by spontaneous differentiation. The present study demonstrates factors involved in the early stage of nuclear transfer ES cell isolation in miniature pigs. However, long-term maintenance and characterization of nuclear transfer ES cells in miniature pigs are remained to be done in further studies.

• Structural Engineering and Mechanics
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• 제78권2호
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• pp.163-174
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• 2021

Track-bridge interaction has become an essential part in the design of bridges and rails in terms of modern railways. As a unique ballastless slab track, the longitudinal continuous slab track (LCST) or referred to as the China railway track system Type-II (CRTS II) slab track, demonstrates a complex force mechanism. Therefore, a comprehensive track-bridge interaction study between multi-span simply supported beam bridges and the LCST is presented in this work. In specific, we have developed an integrated finite element model to investigate the overall interaction effects of the LCST-bridge system subjected to the actions of temperature changes, traffic loads, and braking forces. In that place, the deformation patterns of the track and bridge, and the distributions of longitudinal forces and the interfacial shear stress are studied. Our results show that the additional rail stress has been reduced under various loads and the rail's deformation has become much smoother after the transition of the two continuous structural layers of the LCST. However, the influence of the temperature difference of bridges is significant and cannot be ignored as this action can bend the bridge like the traffic load. The uniform temperature change causes the tensile stress of the concrete track structure and further induce cracks in them. Additionally, the influences of the friction coefficient of the sliding layer and the interfacial bond characteristics on the LCST's performance are discussed. The systematic study presented in this work may have some potential impacts on the understanding of the overall mechanical behavior of the LCST-bridge system.

• 한국컴퓨터정보학회논문지
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• 제26권1호
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• pp.27-35
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• 2021

본 연구에서는 레이블 임베딩의 분포를 반영하는 딥러닝 모형을 위한 새로운 스태킹 앙상블 방법론을 제안하였다. 제안된 앙상블 방법론은 기본 딥러닝 분류기를 학습하는 과정과 학습된 모형으로 부터 얻어진 레이블 임베딩을 이용한 군집화 결과로부터 소분류기들을 학습하는 과정으로 이루어져 있다. 본 방법론은 주어진 다중 분류 문제를 군집화 결과를 활용하여 소 문제들로 나누는 것을 기본으로 한다. 군집화에 사용되는 레이블 임베딩은 처음 학습한 기본 딥러닝 분류기의 마지막 층의 가중치로부터 얻어질 수 있다. 군집화 결과를 기반으로 군집화 내의 클래스들을 분류하는 소분류기들을 군집의 수만큼 구축하여 학습한다. 실험 결과 기본 분류기로부터의 레이블 임베딩이 클래스 간의 관계를 잘 반영한다는 것을 확인하였고, 이를 기반으로 한 앙상블 방법론이 CIFAR 100 데이터에 대해서 분류 성능을 향상시킬 수 있다는 것을 확인할 수 있었다.

• Nuclear Engineering and Technology
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• 제54권6호
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• pp.2311-2320
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• 2022

The main outcomes of the experiments H2P6 performed in the thermal-hydraulics large-scale PANDA facility at PSI in the frame of the OECD/NEA HYMERES-2 project are presented in this article. The experiments of the H2P6 series consists of two PANDA tests characterized by the activation of three (H2P6_1) or one (H2P6_2) cooler(s) in an initially stratified and pressurized containment atmosphere. The initial stratification is defined by a helium-rich region located in the upper part of the vessel and a steam/air atmosphere in the lower part. The activation of the cooler(s) results i) in the condensation of the steam in the vicinity of the cooler(s), ii) the corresponding activation of large scale natural circulation currents in the vessel atmosphere, with the result of iii) the re-distribution and mixing of the Helium stratification initially located in the upper half of the vessel and iv) the continuous pressure decay. The initial helium layer represents hydrogen generated in a postulated severe accident. The main question to be answered by the experiments is whether or not the interaction of the different, localized cooler units would be important for the application of numerical methods. The paper describes the initial and boundary conditions and the experimental results of the H2P6 series with the suggestion of simple scaling laws for both experiments in terms of i) the temperature difference(s) across the cooler(s), ii) the transient steam and helium content and iii) the pressure decay in the vessel. The outcomes of this scaling indicate that the interaction between separate, closely localized units does not play a prominent role for the present experiments. It is therefore reasonable to model several units as one large component with equivalent heat transfer area and total water flow rate.

• 전기전자학회논문지
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• 제26권3호
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• pp.456-461
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• 2022

본 논문에서는 차동 증폭기에 필수적으로 필요한 Radio frequency(RF) transformer(TF)을 활용하여 광대역 이득 특성을 가지는 2단 단일 종단 전력증폭기를 제시하였다. RF TF의 특징을 파악하고 광대역 특성을 가지도록 설계한 뒤 2단 전력증폭기의 단간(inter-stage) 임피던스 정합 회로에 적용함으로써 증폭기의 대역폭을 향상시킬 수 있다. 기존의 2단 단일 종단(Single-ended) 증폭기의 성능과 면적을 유지하면서 광대역 이득 특성을 얻을 수 있도록 단간 정합 회로를 Monolithic Microwave Integrated Circuit (MMIC)와 다층 PCB에 구현하고 시뮬레이션을 통해 결과를 비교하였다. InGaP/GaAs HBT 모델을 사용하여 설계한 2단 전력증폭기 모듈을 시뮬레이션 한 결과 중심주파수 3.3GHz에서 기존의 전력증폭기가 11.2%의 fractional 대역폭을 보인 반면 제안된 설계 기법을 적용한 전력증폭기는 19.8%의 개선된 대역폭을 가짐을 확인하였다.

• Steel and Composite Structures
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• 제43권4호
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• pp.447-456
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• 2022

Recent experimental studies showed that deep steel I-shaped profiles classified as high ductility class sections in seismic design international codes exhibit low deformation capacity when subjected to cyclic loading. This paper presents an innovative retrofit solution to increase the rotation capacity of beams using bonded carbon fiber reinforced polymers (CFRP) patches validated with advanced finite element analysis. This investigation focuses on the flexural cyclic behaviour of I-shaped hot rolled steel deep section used as beams in moment-resisting frames (MRF) retrofitted with CFRP patches on the web. The main goal of this CFRP reinforcement is to increase the rotation capacity of the member without increasing the overstrength in order to avoid compromising the strong column-weak beam condition in MRF. A finite element model that simulates the cyclic plasticity behavior of the steel and the damage in the adhesive layer is developed. The damage is modelled using the cohesive zone modelling (CZM) technique that is able to capture the crack initiation and propagation. Details on the modelling techniques including the mesh sensitivity near the fracture zone are presented. The effectiveness of the retrofit solution depends strongly on the selection of the appropriate adhesive. Different adhesive types are investigated where the CZM parameters are calibrated from high fidelity fracture mechanics tests that are thoroughly validated in the literature. This includes a rigid adhesive commonly found in the construction industry and two tough adhesives used in the automotive industry. The results revealed that the CFRP patch can increase the rotation capacity of a steel member considerably when using tough adhesives.

• 천문학회보
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• 제45권1호
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• pp.59.2-59.2
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• 2020

Disks around protostars are the birthplace of planets. The first step toward planet formation is grain growth from ㎛-sized grains to mm/cm-sized grains in a disk, particularly in dense regions. In order to study whether grains grow and segregate at the protostellar stage, we investigate the ALMA Band 3 (3.1 mm) and 7 (0.87 mm) dust continuum observations of the protostellar disk WL 17 in ρ Ophiuchus L1688 cloud. As reported in a previous study, the Band 3 image shows substructures: a narrow ring and a large central hole. On the other hand, the Band 7 image shows different substructures: a non-axisymmetric ring and an off-center hole. The two-band observations provide a mean spectral index of 2.3, which suggests the presence of mm/cm-sized large grains. Its non-axisymmetric distribution may imply dust segregation between small and large grains. We perform radiative transfer modeling to examine the size and spatial distributions of dust grains in the WL 17 disk. The best-fit model suggests that large grains (>1 cm) exist in the disk, settling down toward the midplane, whereas small grains (~10 ㎛) well mixed with gas are distributed off-center and non-axisymmetrically in a thick layer. The low spectral index and the modeling results suggest that grains rapidly grow at the protostellar stage and that grains differently distribute depending on sizes, resulting in substructures varying with observed wavelengths. To understand the differential grain distributions and substructures, we discuss the effects of the protoplanet(s) expected inside the large hole and the possibility of gravitational instability.

• Computers and Concrete
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• 제32권1호
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• pp.61-74
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• 2023

This article investigates the wave propagation analysis of the imperfect functionally graded (FG) sandwich plates based on a novel simple four-variable integral quasi-3D higher-order shear deformation theory (HSDT). The thickness stretching effect is considered in the transverse displacement component. The presented formulation ensures a parabolic variation of the transverse shear stresses with zero-stresses at the top and the bottom surfaces without requiring any shear correction factors. The studied sandwich plates can be used in several sectors as areas of aircraft, construction, naval/marine, aerospace and wind energy systems, the sandwich structure is composed from three layers (two FG face sheets and isotropic core). The material properties in the FG faces sheet are computed according to a modified power law function with considering the porosity which may appear during the manufacturing process in the form of micro-voids in the layer body. The Hamilton principle is utilized to determine the four governing differential equations for wave propagation in FG plates which is reduced in terms of computation time and cost compared to the other conventional quasi-3D models. An eigenvalue equation is formulated for the analytical solution using a generalized displacements' solution form for wave propagation. The effects of porosity, temperature, moisture concentration, core thickness, and the material exponent on the plates' dispersion relations are examined by considering the thickness stretching influence.

• Earthquakes and Structures
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• 제27권1호
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• pp.17-29
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• 2024

The traditional double story isolated structure is a derivative of the base isolated and inter-story isolated structures, while the new double story isolated structure represents a novel variation derived from the traditional double story isolated structure. In order to investigate the seismic response of the new double story isolated structure, a comprehensive structural model was developed. Concurrently, models for the basic fixed, base isolated, inter-story isolated, and traditional double story isolated structures were also established for comparative analysis. The nonlinear dynamic time-history response of the new double story isolated structure under rare earthquake excitations was analyzed. The findings of the study reveal that, in comparison to the basic fixed structure, the new double story isolated structure exhibits superior performance across all evaluated aspects. Furthermore, when compared to the base isolated and inter-story isolated structures, the new double story isolated structure demonstrates significant reductions in inter-story shear force, top acceleration, and inter-frame displacement. The horizontal displacement of the new double story isolated structure is primarily localized within the two isolation layers, effectively dissipating the majority of input seismic energy. In contrast to the traditional double story isolated structure, the new design minimizes displacements within the inter-isolation layer situated in the central part of the frame, as well as mitigates the overturning forces acting on the lower frame column. Consequently, this design ensures the structural integrity of the core tube, thereby preventing potential collapse and structural damage.