• Journal of Microbiology and Biotechnology
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• v.27 no.10
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• pp.1892-1895
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• 2017

IK can downregulate interferon-gamma-induced major histocompatibility complex (MHC) class II expression through the MHC class II transactivator, which suggests that IK can inhibit the interactions between immune cells. We delivered adeno-associated virus serotype 2 (AAV2) encoding the genes for truncated IK (tIK) or green fluorescent protein (GFP) to DBA1/J mice via intravenous injection. Seven weeks after injection, collagen-induced arthritis was induced in the AAV2-treated mice. AAV2-tIK injection reduced the severity of arthritis and the percentage of pathogenic Th17 cells compared with AAV2-GFP injection. These results suggest a novel gene therapy strategy for treatment of inflammatory arthritis.

• Journal of Microbiology and Biotechnology
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• v.30 no.12
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• pp.1810-1818
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• 2020

Inhibitor K562 (IK) protein was first isolated from the culture medium of K562 cells, a leukemia cell line, and is an inhibitory regulator of interferon-γ-induced major histocompatibility complex class II expression. Recently, exogenous truncated IK (tIK) protein showed potential as a therapeutic agent for inflammation-related diseases. In this study, we designed a novel putative anti-inflammatory peptide derived from tIK protein based on homology modeling of the human interleukin-10 (hIL-10) structure, and investigated whether the peptide exerted inhibitory effects against pro-inflammatory cytokines such as IL-17 and tumor necrosis factor-α (TNF-α). The peptide contains key residues involved in binding hIL-10 to the IL-10 receptor, and exerted strong inhibitory effects on IL-17 (43.8%) and TNF-α (50.7%). In addition, we used circular dichroism spectroscopy to confirm that the peptide is usually present in a random coil configuration in aqueous solution. In terms of toxicity, the peptide was found to be biologically safe. The mechanisms by which the short peptide derived from human tIK protein exerts inhibitory effects against IL-17 and TNF-α should be explored further. We also evaluated the feasibility of using this novel peptide in skincare products.

• Journal of the Chungcheong Mathematical Society
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• v.22 no.3
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• pp.439-450
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• 2009

In this note we give a connection between the truncated moment problem and the 2-variable subnormal completion problem.

• Journal of the Korean Mathematical Society
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• v.42 no.4
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• pp.761-771
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• 2005

In this paper we present another characterization of (${\pm}1$)-invariant sequences. We also introduce truncated Fibonacci and Lucas sequences of the second kind and show that a sequence $x\;{\in}\;R^{\infty}$ is (-1)-invariant(l-invariant resp.) if and only if $D[_x^0]$ is perpendicular to every truncated Fibonacci(truncated Lucas resp.) sequence of the second kind where $$D=diag((-1)^0,\; (-1)^1,\;(-1)^2,{\ldots})$$.

• Korean journal of applied entomology
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• v.45 no.1 s.142
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• pp.15-24
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• 2006

Inhibitor kB (IkB)-like gene has been found in the genome of Cotesia plutellae bracovirus (CpBV), which is the obligatory symbiont of an endoparsitoid wasp, C. plutellae. The open reading frame of CpBV-IkB was 417 bp and encoded 138 amino acids. Four ankyrin repeat domains were found in CpBV-IkB, which shared high homology with other known polydnavirus IkBs. Considering a presumptive cellular IkB based on Drosophila Cactus, CpBV-IkB exhibited a truncated structure with deletion of signal-receiving domains, which suggested its irreversible inhibitory role in NFkB signal transduction pathway of the parasitized host in response to the wasp parasitization. CpBV-IkB was expressed only in the parasitized diamondback moth, Plutella flostella. Its expression was estimated by quantitative RT-PCR during parasitization period, showing a constitutive expression pattern from the first day of parasitization. An indirect functional analysis of CpBV-IkB was conducted and suggested a hypothesis of host antivirus inhibition.

• International Journal of Industrial Entomology and Biomaterials
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• v.14 no.2
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• pp.147-150
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• 2007

Abaecin is a largest member of the proline-rich anti-microbial peptide family found only in the hymenopterans. A cDNA of abaecin was previously isolated and cloned from Bombus ignitus: the mature peptide of Bombus ignitus abaecin was composed of 39 amino acid residues. In the present study, we determined the antibacterial effect of B. ignitus abaecin synthesized at several lengths against several bacteria by radial diffusion assay. The 37-mer peptide (Ab37) inhibited the growth of Gram-negative bacteria Escherichia coli ML-35, Pseudomonas aeruginosa and Salmonela typhimurium, but showed limited inhibitory activity toward Gram-positive bacteria, except for Micrococcus luteus. The truncated 26-mer peptide (Ab26), which was synthesized after truncating some amino acid residues at both N-terminus and C-terminus from the Ab37 peptide, still showed equivalent antibacterial activity to the Ab37. On the other hand, several further truncated peptides exhibited lower activity then did Ab37 peptide.

• Journal for History of Mathematics
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• v.19 no.2
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• pp.1-24
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• 2006

We study the theory of finite series in Chosun Dynasty Mathematics. We divide it into two parts by the publication of Lee Sang Hyuk(李尙爀, 1810-?)'s Ik San(翼算, 1868) and then investigate their history. The first part is examined by Gyung Sun Jing(慶善徵, 1616-?)'s Muk Sa Jib San Bub(默思集算法), Choi Suk Jung(崔錫鼎)'s Gu Su Ryak(九數略), Hong Jung Ha(洪正夏)'s Gu Il Jib(九一集), Cho Tae Gu(趙泰耉)'s Ju Su Gwan Gyun(籌書管見), Hwang Yun Suk(黃胤錫)'s San Hak Ib Mun(算學入門), Bae Sang Sul(裵相設)'s Su Gye Soe Rok and Nam Byung Gil(南秉吉), 1820-1869)'s San Hak Jung Ei(算學正義, 1867), and then conclude that the theory of finite series in the period is rather stable. Lee Sang Hyuk obtained the most creative results on the theory in his Ik San if not in whole mathematics in Chosun Dynasty. He introduced a new problem of truncated series(截積). By a new method, called the partition method(分積法), he completely solved the problem and further obtained the complete structure of finite series.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.19 no.4
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• pp.411-417
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• 2008

This paper presents the miniaturization of circularly polarized microstrip patch antenna for UHF-band RFID portable reader. The proposed antenna has a group of four I-slots on a conventional corner-truncated square microstrip patch and it is shown that the antenna size is reduced compared to the antenna without I-slots. A 76 mm by 76 mm small antenna with four I-slots is fabricated with 6.4 mm thick FR4 substrate and its 10 dB return loss bandwidth, the gain and the axial ratio are measured to be $938{\sim}975\;MHz$, $-0.88{\sim}-2\;dBi$, and $3.27{\sim}13.21\;dB$ within the 10 dB return loss bandwidth, respectively.

• ETRI Journal
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• v.41 no.6
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• pp.850-862
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• 2019

This work investigated three-dimensional (3D) focused microwave thermotherapy (FMT) at 925 MHz for a human tissue mimicking phantom using the time reversal (TR) principle for musculoskeletal disorders. We verified the proposed TR algorithm by evaluating the possibility of 3D beam focusing through simulations and experiments. The simulation, along with the electromagnetic and thermal analyses of the human tissue mimicking phantom model, was conducted by employing the Sim4Life commercial tool. Experimental validation was conducted on the developed FMT system using a fabricated human tissue mimicking phantom. A truncated threshold method was proposed to reduce the unwanted hot spots in a normal tissue region, wherein a beam was appropriately focused on a target position. The validation results of the simulation and experiments obtained by utilizing the proposed TR algorithm were shown to be acceptable. Effective beam focusing at the desired position of the phantom could be achieved.

• Investigative Magnetic Resonance Imaging
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• v.18 no.3
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• pp.219-224
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• 2014

Purpose : To determine the incidence of truncated triangle appearance of anterior horn (AH) to body of medial meniscus (MM) and determine its clinical significance. Materials and Methods: IRB approval was obtained, and informed consent waived for this study. The criteria of "pseudoradial tear" was truncated triangle appearance of the tip of AH to body of MM on one or more coronal images with adjacent fluid signal intensity at the blunted tip. Two musculoskeletal radiologists retrospectively evaluated 485 knee MR images independently for the presence and number of sections with "pseudoradial tear" of AH to body of MM using proton density-weighted coronal MR images. Inter-and intraobserver agreement was calculated using kappa coefficients. Medical records were reviewed for arthroscopic correlation. Results: A pseudoradial tear in the AH to body of MM was present in 381 (78.6%) patients. Locations were 112 in AH (29.4%), 143 in AH to body (37.5%), and 126 in body (33.1%). Number of consecutive sections of pseudoradial tear were 1 in 100 (26.2%), 2 in 164 (43.0%), 3 in 94 (24.7%), 4 in 21 (5.5%), and 5 in 2 (0.5%). Interobserver agreement was 0.99 for presence and 0.43 for number of sections of pseudoradial tear. Arthroscopies were performed in 96 patients and none of the pseudoradial tears were proven as true radial tears on arthroscopy. Conclusion: Pseudoradial tears are frequently seen in AH to body of MM on coronal MR images and may be another pitfall that a radiologist needs to be aware of and be able to differentiate from true radial tear.