• 대한한의학방제학회지
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• 제29권4호
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• pp.297-310
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• 2021

Objectives : In traditional herbal medicine, as clinical experience increased, the number of herbal formulas also increased. For example, there are 61,739 herbal formulas in Pujifang, and 96,592 in Dictionary of Traditional Chinese Medicine Prescriptions. In chapter of Clear Heat (CH; 淸熱劑) of textbook, the 38 formulas were presented. For enhancing understanding of herbal formula, a large majority of books explained each individual formula with description or figure about interactions between constituent herbs. But there is no study on the interrelationship of each CH herbal formulas. This study investigated the interrelationship of CH herbal formulas. Methods : The CH herbal formula were analyzed with the ingredients, actions and clinical applications by literature study. Results : To improve cognition the interrelationship of CH herbal formulas, we analyzed the formulas and established the 16 interrelations of herbal formulas. Conclusions : Finally, this study established the interrelation of herbal formula as one figure. This result could contribute to improve cognition on the interrelationship of CH herbal formulas.

• Journal of Pharmaceutical Investigation
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• 제24권3호spc1호
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• pp.67-77
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• 1994

The RMS statistical approach has demonstrated its potential in developing pharmaceutical dosage forms and in improving tabletting performance. Using an optimized formula, the tabletting performances of vitamin C-90 such as compressibility, disintegration time, lubrication and friability are significantly enhanced when compared with the performance of a traditional test formula. More important, this method also enables us to serve our customers better. Any customized modification of a suggested formula or any technical problem related performance etc. can be readily resolved by simple examination of the models.

• 한국축산식품학회지
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• 제43권4호
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• pp.659-673
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• 2023

Compared to infant formula, breast milk is the best source of nutrition for infants; it not only improves the neonatal intestinal function, but also regulates the immune system and gut microbiota composition. However, probiotic-fortified infant formula may further enhance the infant gut environment by overcoming the limitations of traditional infant formula. We investigated the probiotic formula administration for one month by comparing 118 Korean infants into the following three groups: infants in each group fed with breast milk (50), probiotic formula (35), or placebo formula-fed group (33). Probiotic formula improved stool consistency and defecation frequency compared to placebo formula-fed group. The probiotic formula helped maintaining the level of secretory immunoglobulin A (sIgA), which had remarkably decreased over time in placebo formula-fed infants (compared to weeks 0 and 4). Moreover, probiotic formula decreased the acidity of stool and considerably increased the butyrate concentration. Furthermore, the fecal microbiota of each group was evaluated at weeks 0 and 4. The microbial composition was distinct between each groups, and the abundance of health-promoting bacteria increased in the probiotic formula compared to the placebo formula-fed group. In summary, supplementation of probiotic infant formula can help optimize the infant gut environment, microbial composition, and metabolic activity of the microbiota, mimicking those of breast milk.

• The Korean Journal of Physiology and Pharmacology
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• 제27권4호
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• pp.365-374
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• 2023

Crohn's disease (CD) is a chronic inflammatory illness of the digestive system with unknown etiology, and its incidence is increasing worldwide. However, there are currently no effective treatments or medications available for individuals with CD. Therefore, novel therapeutic strategies are urgently needed. The bioactive compounds and targets associated with compounds of Qinghua Xiaoyong Formula (QHXYF) were examined using The Traditional Chinese Medicine Systems Pharmacology database, and 5 disease target databases were also used to identify CD-related disease targets. A total of 166 overlapping targets were identified from QHXYF-related and CD-related disease targets and they were found to be enriched in oxidative stress-related pathways and the PI3K/AKT signaling pathway. Molecular docking was then used to predict how the bioactive compounds would bind to the hub targets. It was found that quercetin could be the core bioactive compound and had good binding affinity to the top 5 hub targets. Finally, animal experiments were performed to further validate the findings, and the results revealed that QHXYF or quercetin inhibited 2,4,6-trinitrobenzenesulfonic acid-induced inflammation and oxidative stress processes by inhibiting the PI3K/AKT pathway, thereby improving CD symptoms. These findings suggest that QHXYF and quercetin may be potential novel treatments for CD.

• 대한한의학원전학회지
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• 제21권2호
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• pp.49-57
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• 2008

Objective : To overcome the limit which is unaware of the herbal effects intensity of Traditional study based on "Yakdaeron(藥對論)", classification methods based on the curative effects, we aimed to express the herbal formula's effects numerically, compare one herbal formula with other herbal formulas and calculate the herbal effects and the herbal effects intensity by using conception, weight of the herbal effects. Method : We calculated the herbal effects through the proportion of each herbal quantity to whole quantity of the herbal formula and weight of the herbal effects through frequency and quantity in use on specific herbal effects field and the other herbal effects fields. We applied the weight of the herbal effects to calculating the herbal effects through the proportion of each herbal quantity to whole quantity of the herbal formula. Results : We expressed the herbal formula's effects numerically. By giving weight to the herbal effects, we found that 3-4 major effects among 4-5 major effects are ranked in 5th.

• 한국조경학회지
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• 제28권2호
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• pp.10-16
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• 2000

The purpose of this study is to identify relationships between a central angle and a radius of curvature of divided roads in flat terrain of traditional villages, suggesting layout criteria for traditional villages: Nak-an, Sung-Eup, Ha-Whe. This study is sought to find the optimum model through the various SAS regression analyses. a regression analysis of this data was adopted to induce the relationship formula between a central angle of curve and a radius of curvature. Results of this study are as follows: 1) Most of the divided roads in traditional villages have a complex curve rather than a simple curve. 2) A central angle of curve has ranged from 11$^{\circ}$to 127$^{\circ}$, with a mean degree of 63.9. 3) In the lower level of central angle(11-40$^{\circ}$), the branch roads have distributed with a high frequency, but with a low frequency in the higher level of central angle(90-140$^{\circ}$). 4) A radius of curvature in the divided roads has ranged from 0.9m to 59.6, but half of the roads have concentrated on 1-6m of the curvature. 5) Compared to the result of hilly villages in previous study(Ahn, 1999), value of central angels in flat villages is lower than that of hilly villages, while a mean value of the curvature is higher than that of hilly villages. 6) A Non-linear regression analysis, resulting from the SAS application, was useful method to induce a relationship formula between a central angle and a radius of curvature in the branch roads. Our study's formula is as follow: R=100.3*EXP(-0.06*$\delta$)+3.91. 7) Our study model has less error than that of the Kishizuka's method, being applicable to a broader range of the branch roads. 8) A minimum radius of curvature in our study has showed 3.9m, suggesting to reconsider applications of the Kishizuka's(5.8m) in the footpass design, In the study for this presupposition model the efficiency and utility of it can be estimated to grow large according to how much and how far it includes both extremes of data. This study is for the application to a design in future through the numerical formula of divided roads of various traditional villages. The studies from now on will be about the quasi-hilly quasi-hilly village and hilly village supplementing these factors more.

• 동의생리병리학회지
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• 제30권6호
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• pp.385-396
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• 2016

It is a fact that the existing pharmacological research method is difficult to explain the effect and mechanism of action of herbal formula of Korean medicine. We are now very pleased with the development of modern science and the development of a methodology for studying herbal formula characterized by network targets and multi-component therapeutics over the human body. In this review, systems pharmacology or network pharmacology is demonstrated how these are applied to explain the effectiveness of herbal medicine. The post-genomic era provides a unique opportunity for the two fields to understand and benefit from each other. In particular, recent research trends, research methodology, useful databases and results of research on herbal formula are introduced. China already has a policy of scientific development of traditional chinese medicine (TCM) and the development of Chinese medicine industry with a focus on herbal formula research at national level, and in Korea, it is urgent to support and nurture the methodology appropriate to the characteristics of the herbal formula in order to study the safety and efficacy of Korean medicine.

• 대한한의학방제학회지
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• 제22권1호
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• pp.33-45
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• 2014

Objectives : Zizyphi spinosi Semen is widely used for treating insomnia in korea and other oriental country. This study is analyzing combination tendency of Zizyphi spinosi Semen in herbal formula for treating insomnia. Methods : Herbal formulas for treating insomia were searched in "The Prescription Dictionary of Traditional Chinese Medicine", and checked in each literary source. Then, the herbal formula was divided in two groups : FCZ(The formula group containing Zizyphi spinosi Semen) and FWZ(The formula group without Zizyphi spinosi Semen). FCZ and FWZ were compared by following criteria; i) Prevalence of herbal formula by period ii) Prevalence of medicinal material's effects iii) Prevalence of medicinal material iv) Prevalence of the nature of midicinals v) Prevalence of flavor of medicinals vi) Prevalence of meridian entry. Results : 116 Herbal formula met our criteria, and herbal formulas were divided in two groups : FCZ(n=59), FWZ(n=57). The result of prevalence in FCZ is following; Herbal formula prevalence increased as time passed to the Qing(淸) dynasty. Tonifying and replenishing medicinal(補益藥), tranquillizing medicinal (安神藥), and inducing diuresis to drain dampness medicinal(利水滲濕藥) are the three most prevalent types of materia medica. In specifically, Panax ginseng radix(人蔘), Liriopis Tuber(麥門冬), Angelicae Gigantis Radix(當歸), Poria Cocos(茯神), Glycyrrhizae Radix(甘草), Poria cocos(茯神), Polygalae Radix(遠志), Thuja Orientalis L.(柏子仁), Paeonia Japonica(白芍藥), and HgS(硃砂) are combined frequently. The most prevalent nature of medicinals were 'warm microwarm(溫 微溫)' and flavor of medicinals was normal(平). Meridian entrys that frequently combined were heart(心), spleen(脾), and liver(肝). Conclusion : We found combination tendency of Zizyphi Semen in herbal formula for treating insomnia.

• 대한한의학방제학회지
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• 제29권2호
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• pp.105-118
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• 2021

Objectives : The process of disease treatment in traditional medicine is defined as differentiating patterns and determining treatment. As an important part of this process, the herbal formulas are specific combinations or configurations of medicinal herbs that serve as tools for treatment. As clinical experience increased, the number of herbal formulas also increased. For example, there are 61,739 herbal formulas in Pujifang, and 96,592 in Dictionary of traditional chinese medicine prescriptions. In chapter of Release the exterior syndrome (RES; 解表劑) of textbook, the 42 formulas were presented. For the understanding on the formula, most of books explained with description or figure about the formulas. But there is no study on the interrelationship of each herbal formulas. This study investigated the interrelationship of RES herbal formulas. Methods : The RES herbal formulas were analyzed with the ingredients, actions and clinical applications by literature study. Results : To improve cognition the interrelationship of RES herbal formulas, we analyzed the formulas and established the 19 interrelations of herbal formulas. Conclusions : Finally, this study established the interrelation of herbal formula as one figure. This result could contribute to improve cognition the interrelationship of RES.

• 대한한의학방제학회지
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• 제32권2호
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• pp.129-139
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• 2024

Objective : This study aims to investigate core herbs and formulas in Internal Medicine on the Liver system (IML) to enhance the efficiency of teaching IML, Herbalogy, and Formula Science, as well as to increase the integration of these courses. Methods : The study employed the frequency concept, commonly utilized in previous studies, alongside network analysis. Results : This study identified frequently used herbs, herbs with high centrality, frequently combined herbs, and core formulas. The herb with the highest frequency was 'Angelicae Gigantis Radix', while the herb with the highest centrality was 'Citri Unshius Pericarpium', and the most frequent herb combination was 'Zingiberis Rhizoma - Citri Unshius Pericarpium'. The network analysis results revealed a total of 5 herbal combination communities. Conclusion : In this study, we identified core herbs using traditional frequency analysis methods. Additionally, to complement traditional analysis methods, we discovered core herbal combinations, and fundamental herbal prescriptions through network analysis. The results of this study can be utilized as foundational data to enhance the efficiency of education in Internal Medicine on the Liver system (IML), Herbology, and Formula Science courses, as well as to improve coherence and consistency between foundational and clinical subjects.