• 동의생리병리학회지
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• 제20권1호
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• pp.215-223
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• 2006

This research surveyed oriental medicine therapies currently used in oriental medicine circles by referring to oriental medicine books-based existing traditional authentic therapies, as well as market-sold supplementary therapy-related ordinary health books and Internet information, and supplementary therapy-related dissertations, reviewed the fundamental operating significance of these therapies, and pursued their clinical operating measures based on their clinical information as follows Various therapies currently used in oriental medicine circles are categorized into authentic therapies and supplementary therapies in oriental medicine. Authentic therapies in Oriental medicine are based on bodily self-vitality abilities, pursue positive methods of treating diseases, and include medication therapies, acupuncture therapies, and external therapies. Supplementary therapies in oriental medicine are based on bodily self-vitality abilities, pursue indirect methods of treating diseases, and consist of lifestyle therapy and body management therapy. Authentic and supplementary therapies in Oriental medicine are used either separately or together according to clinical treatment methods. In treating diseases, clinical operating methods exclusively based on traditional authentic therapies and supplementary therapies include Donguibogam (anthology of ancient oriental medicine), Uihakipmun (introduction to medicine), Somun school, and bodily acupuncture according to diagnoses of symptoms, as well as sasangbang (prescription based on four types of bodily constitution), myeongribang prescription, hyeongsangbang prescription, and bodily constitution-based acupuncture according to diagnoses of bodily constitutions. In clinical operation of Oriental medicine, supplementary therapies are parity duplicated dy alternative medicine. However, given patients' needs and clinical practicality, Oriental medicine circles should establish a system based on the fundamental viewpoint of Oriental medicine theories, and corresponding policies should also be researched.

• 셀메드
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• 제9권1호
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• pp.3.1-3.5
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• 2019

Bronchial asthma is one of the most common chronic diseases globally and currently affects approximately 300 million people worldwide. As per scientific data, approximately 10-12% of adults; and 15% of children are affected by the disease. The increasing global prevalence of the disease imposes a high health care costs into its mechanisms and treatment. Unani system of medicine (USM) is a well known traditional therapy for number of diseases since ancient times. Time has proved that USM has a special role in treatment of chronic diseases, due its special Usooleillaj (Line of treatment). Dhiq al-Nafas (bronchial asthma) is also considered as a chronic disease. Since ancient times, the disease was cured by number of single as well as compound formulations by renowned Unani scholars. This review provides a comprehensive summary of medicinal plant throughout the world, with reference to renowned Unani scholars and physicians for treatment of Dhiq al-Nafas. A number of Unani single and compound drugs, highly efficacious and safe drugs are available for the asthma. The data were taken from classical literature of USM, Modern reference books & electronic journals. The recent information was collected from different authentic search engines. This review will provide the centuries therapeutic information's of classical literature and recent scientific studies of 12 herbal drugs mentioned in USM, which will help the academia, clinicians, research scholars and post graduate students from Unani Medicine, Traditional & Complementary Medicine and other related disciplines, having research interest or work in the Unani medicine.

• Journal of Digestive Cancer Research
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• 제4권1호
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• pp.1-9
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• 2016

The abundance of multi-drug resistance ATPase binding cassette and deranged self-renewal pathways shown in cancer stem cells (CSCs) played a crucial role in tumorigenesis, tumor resistance, tumor recurrence, and tumor metastasis. Therefore, elucidation of CSCs biology can improve diagnosis, enable targeted treatment, and guide the follow up of GI cancer patients. In order to achieve chemoquiescence, seizing cancer through complete ablation of CSCs, CSCs are rational targets for the design of interventions that will enhance responsiveness to traditional therapeutic strategies and contribute in the prevention of local recurrence as well as metastasis. However, current cancer treatment strategies fail to either detect or differentiate the CSCs from their non-tumorigenic progenies mostly due to the absence of specific biomarkers and potent agents to kill CSCs. Recent advances in knowledge of CSCs enable to produce several candidates to ablate CSCs in gastrointestinal (GI) cancers, especially cancers originated from inflammation-driven mutagenesis such as Barrett's esophagus (BE), Helicobacter pylori-associated gastric cancer, and colitis-associated cancer (CAC). Our research teams elucidated through revisiting old drugs that proton pump inhibitor (PPI) and potassium competitive acid blocker (p-CAB) beyond authentic acid suppression, chloroquine for autophage inhibition, sonic hedgehog (SHH) inhibitors, and Wnt/β-catenin/NOTCH inhibitor can ablate CSCs specifically and efficiently. Furthermore, nanoformulations of these molecules could provide an additional advantage for more selective targeting of the pathways existing in CSCs just like current molecular targeted therapeutics and sustained action, while normal stem cells intact. In this review article, the novel approach specifically to ablate CSCs existing in GI cancers will be introduced with the introduction of explored mode of action.