• Journal of Veterinary Science
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• v.24 no.5
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• pp.55.1-55.12
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• 2023

Background: Peste des petits ruminants (PPR), caused by the PPR virus (PPRV), is an acute and fatal contagious disease that mainly infects goats, sheep, and other artiodactyls. Peripheral blood mononuclear cells (PBMCs) are considered the primary innate immune cells. Objectives: PBMCs derived from goats were infected with PPRV and analyzed to detect the relationship between PPRV replication and apoptosis or the inflammatory response. Methods: Quantitative real-time polymerase chain reaction was used to identify PPRV replication and cytokines expression. Flow cytometry was conducted to detect apoptosis and the differentiation of CD4⁺ and CD8⁺ T cells after PPRV infection. Results: PPRV stimulated the differentiation of CD4⁺ and CD8⁺ T cells. In addition, PPRV induced apoptosis in goat PBMCs. Furthermore, apoptosis and the inflammatory response induced by PPRV could be suppressed by Z-VAD-FMK and Z-YVAD-FMK, respectively. Moreover, the virus titer of PPRV was attenuated by inhibiting caspase-1-dependent apoptosis and inflammation. Conclusions: This study showed that apoptosis and the inflammatory response play an essential role in PPR viral replication in vitro, providing a new mechanism related to the cell host response.

• Journal of the Korea Society for Simulation
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• v.24 no.3
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• pp.27-35
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• 2015

We analyze an M/G/1/K queueing system with queue-length dependent service and arrival rates. There are a single server and a buffer with finite capacity K including a customer in service. The customers are served by a first-come-first-service basis. We put two thresholds $L_1$ and $L_2$($${\geq_-}L_1$$ ) on the buffer. If the queue length at the service initiation epoch is less than the threshold $L_1$, the service time of customers follows $S_1$ with a mean of ${\mu}_1$ and the arrival of customers follows a Poisson process with a rate of ${\lambda}_1$. When the queue length at the service initiation epoch is equal to or greater than $L_1$ and less than $L_2$, the service time is changed to $S_2$ with a mean of $${\mu}_2{\geq_-}{\mu}_1$$. The arrival rate is still ${\lambda}_1$. Finally, if the queue length at the service initiation epoch is greater than $L_2$, the arrival rate of customers are also changed to a value of $${\lambda}_2({\leq_-}{\lambda}_1)$$ and the mean of the service times is ${\mu}_2$. By using the embedded Markov chain method, we derive queue length distribution at departure epochs. We also obtain the queue length distribution at an arbitrary time by the supplementary variable method. Finally, performance measures such as loss probability and mean waiting time are presented.

• Journal of the Korean Society for Precision Engineering
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• v.23 no.6 s.183
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• pp.81-87
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• 2006

A new gain-scheduled control design is proposed to improve disturbance attenuation for systems with bounded control input. The state feedback controller is scheduled according to the proximity to the origin of the state of the plant. The controllers is derived in the framework of linear matrix inequality(LMI) optimization. This procedure yields a linear time varying control structure that allows higher gain and hence higher performance controllers as the state move closer to the origin. The main results give sufficient conditions for the satisfaction of a parameter-dependent performance measure, without violating the bounded control input condition.

• Transactions of the Korean Society of Automotive Engineers
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• v.18 no.3
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• pp.60-68
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• 2010

In order to understand the flow and filtration characteristics in a wall-flow type DPF(Diesel Particulate Filter), 0-D, 1-D, and 3-D simulations are preformed. In this paper, three model are explained and validated with each other. Based on the comparisons with 1-D and 3-D results for the steady state solution, 3-D CFD analysis is preferable to 1-D for the prediction of wall velocity at the inlet and exit plane. Because PM loading process is transient state phenomena, the combination of full 3-D and time dependent simulation is crucial for the configuration of wall channels. New coupling technique, which is the connection between calculated permeability from 0-D lumped parameter model and UDF(User Defined Functions) of main solver, is proposed for the realisti

• Geomechanics and Engineering
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• v.23 no.5
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• pp.431-439
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• 2020

Soil-water retention curve (SWRC) contains key information for the application of unsaturated soil mechanics principles to engineering practice. The SWRC variables are commonly used to describe the hydro-mechanics of soils. Generally, these parameters are determined using the graphical method which can be time consuming. The SWRC is highly dependent on the pore size distribution (PSD). Theoretically, the PSD obtained by mercury intrusion porosimetry test can be used to determine some SWRC variables. Moreover, the relationship between SWRC and shrinkage curve has been investigated. A new method to determine total SWRC variables directly without curve-fitting procedure is proposed. Substituting the variables into linear SWRC equations construct SWRC. A good agreement was obtained between predicted and measured SWRCs, indicating the validity of the proposed method for unimodal SWRC.

• Journal of the Korea institute for structural maintenance and inspection
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• v.7 no.2
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• pp.149-157
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• 2003

The purpose of this paper is to quantitatively investigate aging state of epoxy coating on containment structure at nuclear power plant. In order to evaluate an physical bonding of the epoxy coating, adhesion test was performed on a degraded epoxy coating on concrete specimens fabricated by accelerated aging experiment. In addition, impedance data by ultrasonic test were measured to compare with adhesion data. From almost 50 % of the specimens, aging phenomena of epoxy coating such as pin hole, blistering was discovered. To improve reliability on quality degradation of epoxy, co-relation between two kinds of different data was analyzed. By tracing co-related these data, it was possible to figure out physical state of as-built epoxy coating. The possibility to develop new methodology of time - dependent aging state on epoxy coating was found and discussed.

• Corrosion Science and Technology
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• v.5 no.3
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• pp.99-105
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• 2006

This paper is to investigate feasibility on quantitative aging state of epoxy coating on concrete wall in containment structure under operation of nuclear power plants. For evaluating the physical characteristics of the epoxy coating, adhesion strengths of two kinds of degraded epoxy coating systems on both steel surfaces and concrete surfaces were measured via accelerated aging. Comparatively impedance data taken by ultrasonic test were also taken to relate with adhesion data. After aging, in case of concrete, from half of specimens, aging of epoxy coating was developed. As for steel, on $4^{th}$ inspection day, adhesion force was failed. To improve reliability on quality degradation of epoxy, relationship between adhesion and impedance was analyzed. By tracing to co-respond to these data, it was possible to Fig. out physical state of as-built epoxy coating. The possibility to develop new methodology of time - dependent aging state on epoxy coating was found and discussed.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1993.06a
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• pp.877-880
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• 1993

Fuzzy control algorithms are developed based on fuzzy models of systems. The control issues are posed as multiobjective optimization problems involving goals and constraints imposed on system's variables. Two basic design modes embrace on-and off-line control development. The first type of design deals with the time and state-dependent objectives and pertains to control determination based upon the current state of the system. The second design mode gives rise to explicit forms of fuzzy controller that is learned based on a given list of state-control associations. Both the fuzzy models as well as fuzzy controllers are realized as logic processors.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.4
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• pp.277-285
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• 2022

To investigate the adverse effects of clozapine on cardiovascular ion channels, we examined the inhibitory effect of clozapine on voltage-dependent K⁺ (Kv) channels in rabbit coronary arterial smooth muscle cells. Clozapine-induced inhibition of Kv channels occurred in a concentration-dependent manner with an half-inhibitory concentration value of 7.84 ± 4.86 µM and a Hill coefficient of 0.47 ± 0.06. Clozapine did not shift the steady-state activation or inactivation curves, suggesting that it inhibited Kv channels regardless of gating properties. Application of train pulses (1 and 2 Hz) progressively augmented the clozapine-induced inhibition of Kv channels in the presence of the drug. Furthermore, the recovery time constant from inactivation was increased in the presence of clozapine, suggesting that clozapine-induced inhibition of Kv channels is use (state)-dependent. Pretreatment of a Kv1.5 subtype inhibitor decreased the Kv current amplitudes, but additional application of clozapine did not further inhibit the Kv current. Pretreatment with Kv2.1 or Kv7 subtype inhibitors partially blocked the inhibitory effect of clozapine. Based on these results, we conclude that clozapine inhibits arterial Kv channels in a concentration-and use (state)-dependent manner. Kv1.5 is the major subtype involved in clozapine-induced inhibition of Kv channels, and Kv2.1 and Kv7 subtypes are partially involved.

• Journal of Korea Multimedia Society
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• v.13 no.3
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• pp.369-377
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• 2010

In vocabulary recognition systems based on HMM(Hidden Markov Model)s, training process unseen model bring on show a low recognition rate. If recognition vocabulary modify and make an addition then recreated modeling of executed database collected and training sequence on account of bring on additional expenses and take more time. This study suggest efficient context dependent process modeling method using decision tree-based state tying. On study suggest method is reduce recreated of model and it's offered that robustness and accuracy of context dependent acoustic modeling. Also reduce amount of model and offered training process unseen model as concerns context dependent a likely phoneme model has been used unseen model solve the matter. System performance as a result of represent vocabulary dependence recognition rate of 98.01%, vocabulary independence recognition rate of 97.38%.