• Archives of Pharmacal Research
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• v.19 no.1
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• pp.1-5
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• 1996

Laminated films composed of drug-containing reservoir layer and drug-free membrane were prepared. Zero-order drug release with lag time was achieved by laminating drug-free film onto the reservoir layer, while burst effect was observed on cast-on film. The rate controlling membrane was either attached to or cast directly into the reservoir. The release rate was independent on the reservoir composition but dependent on the composition of rate-controlling membrane. In growth inhibitory test of cephalexin from Eudragit RS film to Streptococcus Mutans, the disk even after release test for 72 hours showed more bacterial growth inhibition than that of control. Permeation of drug through rat skin was proportional to the HPC fraction in the film. We could control the release of cephalexin from the film by changing the fraction of Eudragit RS, HPC and DEP content. Consequently, Eudragit RS/HPC film was found to be very effective system for local delivery of drugs.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.14 no.7
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• pp.592-598
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• 2002

The characteristics of a pulsating flow field from a heated block representing heat-dissipating electronic component in a channel have been numerically investigated. At the channel inlet a pulsating sinusoidal flow is imposed. The Reynolds number based on the channel height (H) is fixed at Re=500, and the forcing frequency is varied in the range of $0\leqSt\leq2$. Numerical results on the time-dependent flow field are obtained and averaged over a cycle of pulsation. The effect of the important governing parameters such as the Strouhal number is investigated in detail. The results indicate that the recirculating flow behind the block is substantially affected by the pulsation frequency. To characterize the periodic vortex shedding due to the inflow pulsation, numerical flow visualizations are carried out.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.14 no.7
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• pp.599-606
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• 2002

uniform temperature. The surfaces of the block are taken at a constant higher temperature. The channel walls are assumed to be adiabatic. Results on the time-dependent temperature field are obtained and averaged over a cycle of pulsation. The effect of the important governing parameters, such as the Strouhal number on the flow and the heat transfer is investigated in detail. The results indicate that the recirculating flow behind the block are substantially affected by the pulsation frequency. These, in turn, have a strong influence on the thermal transport from the heated element to the pulsating flow. The frequency at which the enhancement is maximum is determined.

• Journal of Surface Science and Engineering
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• v.34 no.1
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• pp.17-24
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• 2001

A model for quantifying the effect of steam pressure on the oxide thickness growth was developed based on the experimental data available. First, empirical equations for the thickness estimation of oxide formed in 1 atm steam were made. The oxide growth kinetics turned out to be dependent on 0.4th power of oxidation time. With an assumption that the transition oxide thickness be only a function of temperature, a model for the enhancement of steam pressure on oxide growth was developed. The enhancement coefficient for steam pressure is calculated to be 0.01~0.013 $bar^{-}$. The developed model generally well explains the experimental data.a.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 1994.06b
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• pp.19-29
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• 1994

Since Winslow (1) has reported an electro - theological (ER) effect which features remarkable and reversible changes in the properties of the fluid due to an imposed external electric field, numerous applications of ER fluids in mechanical devices, such as clutches, control valves, active dampers, and etc. have been proposed to improye dramatical ly their performances (2,3). When the external electric field is imposed to the ER fluid, it behaves as a Bingham fluid, displaying a field dependent yield shear stress which is widely variable. Without the electric field, the ER fluid has a reversible and constant viscosity so that it flows as a Newtonian fluid. Another salient feature of the ER fluid is that the time required for the variation is very short (< 0.001 sec) (4-6). These attractive.characteristics of the ER fluid provide the possibility of the appearance of new engineering technology , for instance, an active vibration control system. Recently, the application of the ER fluid to rotor-bearing systems has been also initiated.

• Toxicological Research
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• v.7 no.2
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• pp.141-149
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• 1991

The treatment with 5ng/ml of mercuric chloride caused time-dependent decreases, and in the activities of GSH S-transferase and GSH-peroxidase, and in the concentration of GSH in CHO cells. Three hours after treatment of $Hg^{2+}$, the activity of GSH S-transferase was decreased to almost half value of control group and the activity of GSH-peroxidase was reduced significantly at 6 hr after treatment. The concentration of GSH was decreased 2 hr after treatment of $Hg^{2+}$ and was decreased to nearly half value of control group 3 hr after treatment.

• Nutrition Research and Practice
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• v.2 no.4
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• pp.195-199
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• 2008

Alcoholism has been associated with folate deficiency in humans and laboratory animals. Previous study showed that ethanol feeding reduces the dehydrogenase and hydrolase activity of 10-formyltetrahydrofolate dehydrogenase (FDH) in rat liver. Hepatic ethanol metabolism generates acetaldehyde and acetate. The mechanisms by which ethanol and its metabolites produce toxicity within the liver cells are unknown. We purified FDH from rat liver and investigated the effect of ethanol, acetaldehyde and acetate on the enzyme in vitro. Hepatic FDH activity was not reduced by ethanol or acetate directly. However, acetaldehyde was observed to reduce the dehydrogenase activity of FDH in a dose- and time-dependent manner with an apparent $IC_{50}$ of 4 mM, while the hydrolase activity of FDH was not affected by acetaldehyde in vitro. These results suggest that the inhibition of hepatic FDH dehydrogenase activity induced by acetadehyde may play a role in ethanol toxicity.

• Korean Journal of Remote Sensing
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• v.26 no.6
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• pp.645-652
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• 2010

The performance of the payload Electro-Optical System (EOS) in satellite system is affected by various factors, such as optics design, camera electronics design, and the characteristics of the CCD (Charge Coupled Device) used, etc. Of these factors, the camera electronics design is somewhat unique in that its operational parameters can be adjusted even after the satellite launch. In this paper, the effect of video gain on the non-uniformity correction performance is addressed. And a new optimal non-uniformity correction scheme is proposed and analyzed using the data from real camera electronics unit based on a TDI (Time Delayed Integration) type of CCD. The test results show that the performance of the conventional non-uniformity correction scheme is affected significantly when the video gain is added. On the other hand, in our proposed scheme, the performance is not dependent on the video gain. The insensitivity of the non-uniformity performance on the video-gain is mainly due to the fact that the correction is performed after the dark signal is subtracted from system response.

• Structural Monitoring and Maintenance
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• v.2 no.2
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• pp.133-143
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• 2015

Civil engineering infrastructure is aging and requires cost-effective maintenance strategies to enable infrastructure systems operate reliably and sustainably. This paper presents an approach for determining risk-cost balanced repair strategy of corrosion damaged reinforced concrete structures with consideration of uncertainty in structural resistance deterioration. On the basis of analytical models of cover concrete cracking evolution and bond strength degradation due to reinforcement corrosion, the effect of reinforcement corrosion on residual load carrying capacity of corroded reinforced concrete structures is investigated. A stochastic deterioration model based on gamma process is adopted to evaluate the probability of failure of structural bearing capacity over the lifetime. Optimal repair planning and maintenance strategies during the service life are determined by balancing the cost for maintenance and the risk of structural failure. The method proposed in this study is then demonstrated by numerical investigations for a concrete structure subjected to reinforcement corrosion. The obtained results show that the proposed method can provide a risk cost optimised repair schedule during the service life of corroded concrete structures.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.12 no.1
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• pp.1-11
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• 2000

This study investigates the problem of phase change from liquid to solid in the inviscid stagnation flow. The solution of dimensionless governing equations is determined by the three dimensionless parameters of (temperature ratio/conductivity ratio), Stefan number, and diffusi-vity ratio. The solution at the initial stage of freezing is obtained by expanding it in powers of time, and the final equilibrium state is determined from the steady-state governing equations. The equilibrium state is dependent on (temperature ratio/conductivity ratio), but is independent of Stefan number and diffusivity ratio. The effect of fluid flow on the pure conduction problem can be clearly seen from the solution of the initial stage and the final equilibrium state, and the characteristics of the solidification process for all the dimensionless parameters are elucidated.