Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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PROTECTIVE EFFECT OF SELENIUM ON GLUTATHIONE METABOLISM BY MERCURY TOXICITY IN THE CHO CELLS

  • Byun, Boo-Hyung (Korea Advanced Institute of Science and Technology) ;
  • Cho, Su-Jung (Korea Advanced Institute of Science and Technology) ;
  • Chung, An-Sik (Korea Advanced Institute of Science and Technology)
  • Published : 1991.12.01
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Abstract

The treatment with 5ng/ml of mercuric chloride caused time-dependent decreases, and in the activities of GSH S-transferase and GSH-peroxidase, and in the concentration of GSH in CHO cells. Three hours after treatment of $Hg^{2+}$, the activity of GSH S-transferase was decreased to almost half value of control group and the activity of GSH-peroxidase was reduced significantly at 6 hr after treatment. The concentration of GSH was decreased 2 hr after treatment of $Hg^{2+}$ and was decreased to nearly half value of control group 3 hr after treatment.

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References

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