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Synthesis of novel Heterocycles Through Reaction of Indolin-2-one Derivatives with Active Methylene and Amino Reagents

  • Abdel-Latif, F.F.;Ahmed, E.Kh.;Mekheimer, R.;Mashaly, M.M.
    • Archives of Pharmacal Research
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    • v.20 no.5
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    • pp.507-509
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    • 1997
  • Several new spiro compounds were synthesized via one-pot ternary condensation of isatin, malononitrile and each of thiobarbituric acid, barbituric, 3-methyl-pyrazolin-5-one, 1-phenyl-3-methyl-pyrazolin-5-one, acetylacetone, benzoylacetone, ethyl acetoacetate, phenacyl cyanide or ethyl-cyanoacetate dimer. Structures and reaction mechanisms were reported and supported via a second synthetic route.

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Improving productivity for a fast food company : a case study (즉석 식품 생산 업체의 생산성 향상을 위한 사례연구)

  • 민선기;김채복
    • Proceedings of the Korean Operations and Management Science Society Conference
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    • 1996.10a
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    • pp.57-60
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    • 1996
  • It is critical that all companies improve productivity in order to maintain their international competitiveness. The productivity can be explained as a measurement of effectiveness that is calculated by "the ratio of what is produced to what is required to produce it". The goal of this paper is to enhance productivity for a small fast food company mainly through work analysis. This work analysis will help the company to downsize by improving efficiency via motion analysis and by reduction of losses via facility improvement.provement.

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Robust LQ control of magnetically levitation systems with a combined lift and guidance using loop-shaping techniques (루프형성 기법을 이용한 편심배치방식 자기부상 시스템의 강인 LQ 제어)

  • 박전수;김종식
    • 제어로봇시스템학회:학술대회논문집
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    • 1992.10a
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    • pp.747-753
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    • 1992
  • The modeling and control design schemes are developed for maglev systems with a combined lift and guidance. First, bond graph techniques are applied for modeling these multi-energy domain systems more logically and systematically. And the stability loop via pole placement and the performance loop via loop-shaping LQ control are designed. The suggested controller satisfies the required characteristics of stability and performance simultaneously. Finally, the robustness of the synthesized maglev control system is evaluated for the variations of air gap and vehicle mass through computer simulation.

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Formation of MgO Thick Film Layer for AC-PDP via Electrophoresis Deposition of Nano-sized MgO Powders

  • Ko, Min-Soo;Kim, Yong-Seog
    • Journal of Information Display
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    • v.8 no.2
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    • pp.25-31
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    • 2007
  • MgO thick film for ac-PDPs was formed via electrophoresis deposition process and its effect on luminance and luminance efficiency were evaluated. The electrophoresis deposition process of MgO thick film was optimized through parametric study and defects levels in MgO powders was evaluated using cathodoluminescence spectra measurements. The results demonstrate a possibility of using MgO thick film as electron emission layer for ac-PDPs.

IN SEARCH OF PEACE ON THE SILK ROAD: FROM THEORY TO PRACTICE

  • TOKSOZ, ITIR
    • Acta Via Serica
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    • v.2 no.1
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    • pp.7-30
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    • 2017
  • Looking beyond the assumptions and arguments of commercial liberalism, which sees economic interdependence and cooperation as fostering peace, this paper demonstrates that peace as an ideal can be found in various theories of international politics. The author finds the commercial liberal perspective to peace to be too narrow to explain the opportunities and challenges posed along the Silk Road and proposes to look at the peace narrative on the Silk Road through the lens of other approaches to peace, including the more interdisciplinary field of peace studies, for a more comprehensive picture.

Convenient Procedure for the Reduction of Carboxylic Acids via Acyloxyborohydrides

  • Cho, Byung-Tae;Yoon, Nung-Min
    • Bulletin of the Korean Chemical Society
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    • v.3 no.4
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    • pp.149-152
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    • 1982
  • A new convenient method for the reduction of carboxylic acids to the corresponding alcohols via acyloxyborohydrides was explored. Acyloxyborohydrides, prepared from the reaction of various carboxylic acids and sodium borohydride, underwent reduction to the corresponding alcohols readily by the addition of dimethyl sulfate or Lewis acids, such as boron trifluoride etherate and triphenyl borate, presumably through acyloxyboranes. By utilizing this procedure, aliphatic and aromatic acids are rapidly and quantitatively reduced to the corresponding alcohols in terahydrofuran either at room temperature (or at $65^{\circ}$). This procedure provides selective reduction of carboxylic acids in the presence of halogen, nitro, and heterocyclic rings such as furan and thiophene.

THE CAYLEY-BACHARACH THEOREM VIA TRUNCATED MOMENT PROBLEMS

  • Yoo, Seonguk
    • Korean Journal of Mathematics
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    • v.29 no.4
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    • pp.741-747
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    • 2021
  • The Cayley-Bacharach theorem says that every cubic curve on an algebraically closed field that passes through a given 8 points must contain a fixed ninth point, counting multiplicities. Ren et al. introduced a concrete formula for the ninth point in terms of the 8 points [4]. We would like to consider a different approach to find the ninth point via the theory of truncated moment problems. Various connections between algebraic geometry and truncated moment problems have been discussed recently; thus, the main result of this note aims to observe an interplay between linear algebra, operator theory, and real algebraic geometry.

Inhibitory Effect of Bee Venom Toxin on Lung Cancer NCI H460 Cells Growth Through Induction of Apoptosis via Death Receptor Expressions

  • Hur, Keun Young;Song, Ho Sueb
    • Journal of Acupuncture Research
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    • v.31 no.1
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    • pp.121-130
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    • 2014
  • Objectives : I investigated whether bee venom inhibit cell growth through enhancement of death receptor expressions in the human lung cancer cells, NCI-H460. Methods : Bee venom(1-5 ${\mu}g/ml$) inhibited the growth of NCI-H460 lung cancer cells by the induction of apoptotic cell death in a dose dependent manner. Results : Consistent with apoptotic cell death, expression of TNF-R1, TNF-R2, FAS, death receptors(DR) 3, 4, 5 and 6 was increased in the cells. Expression of DR downstream pro-apoptotic proteins including Caspase-8, -3, -9 was upregulated and Bax was concomitantly overwhelmed the expression of Bcl-2. NF-kB were inhibited by treatment with bee venom in NCI-H460 cells through TNF response change led by TNF-R1 and TNF-R2. Conclusions : These results suggest that bee venom should exert anti-tumor effect through induction of apoptotic cell death in NCI-H460 human lung cancer cells via enhancement of death receptor expression, and that bee venom could be a promising agent for preventing and treating lung cancer.

Utilizing Channel Bonding-based M-n and Interval Cache on a Distributed VOD Server (효율적인 분산 VOD 서버를 위한 Channel Bonding 기반 M-VIA 및 인터벌 캐쉬의 활용)

  • Chung, Sang-Hwa;Oh, Soo-Cheol;Yoon, Won-Ju;kim, Hyun-Pil;Choi, Young-In
    • The KIPS Transactions:PartA
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    • v.12A no.7 s.97
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    • pp.627-636
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    • 2005
  • This paper presents a PC cluster-based distributed video on demand (VOD) server that minimizes the load of the interconnection network by adopting channel bonding-based MVIA and the interval cache algorithm Video data is distributed to the disks of each server node of the distributed VOD server and each server node receives the data through the interconnection network and sends it to clients. The load of the interconnection network increases because of the large volume of video data transferred. We adopt two techniques to reduce the load of the interconnection network. First, an Msupporting channel bonding technique is adopted for the interconnection network. n which is a user-level communication protocol that reduces the overhead of the TCP/IP protocol in cluster systems, minimizes the time spent in communicating. We increase the bandwidth of the interconnection network using the channel bonding technique with MThe channel bonding technique expands the bandwidth by sending data concurrently through multiple network cards. Second, the interval cache reduces traffic on the interconnection network by caching the video data transferred from the remote disks in main memory Experiments using the distributed VOD server of this paper showed a maximum performance improvement of $30\%$ compared with a distributed VOD server without channel bonding-based MVIA and the interval cache, when used with a four-node PC cluster.