• Journal of Pharmaceutical Investigation
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• v.22 no.2
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• pp.133-137
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• 1992

A novel oral controlled release tablet which may offer more uniform drug level in the body than simple zero-order was developed. The tablet is composed of three layers; outer film layer, middle part compression-coated hydroxypropylmethylcellulose (HPMC) matrix layer, and inner core layer. Each layer contains nicardipine HCl as a model drug. In vitro dissolution test showed that the tablet released the drug in clear three steps; a rapid initial release, followed by a constant rate of release, and then a second phase of fast release of drug. The dissolution characteristics could be modified easily by changing the grade of HPMC, thickness of matrix layer, content of methylcellulose in matrix layer, content of active ingredient in each layer. The pH of dissolution medium did not affect the release profile. This three-step release system is expected to raise the blood concentration rapidly to effective level and to maintain effective blood level longer than simple slow-release systems.

• Korean Journal of Applied Biomechanics
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• v.15 no.4
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• pp.55-66
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• 2005

The present study used a video analysis system to quantify the kinematical data of step shoot motion by male university handball players. From the results of analyzing dynamic variables of step shoot motion according to shooting direction were drawn conclusions as follows. 1. The height of release was proportional to the height of players, and the height of release appeared low in left-side attacks. This is probably because the left-right-throwing angle is larger in left-side attacks than that in center attacks and right-side attacks and, as a result, the throwing arm is lowered down in throwing. 2. The leftward inclination angle of the body was larger in order of right-side attacks > center attacks > left side attacks. 3. Players' throwing form was close to three quarter style in left-side attacks. In center and right-side attacks, the arm was somewhat more upright but still it was more three quarter style than overhand style. 4. The front-rear throwing angle at the moment of release was much higher in right-side attacks than in left-side ones. This is probably because the point of time for releasing the ball is usually late in right-side attacks and, as a result, the front-rear throwing angle becomes quite large. 5. The contribution of body parts on the ball speed was higher in order of the forearm > upper arm, hand > shoulder joint. 6. In players whose distance between the two legs at the moment of release, their body usually did not incline to the side much. Thus it is considered necessary to correct the right leg in their shooting motion. 7. According to the result of analyzing throwing form, the speed of the ball at the moment of leaving the hand was faster in right-side attacks than in left-side and center attacks.

• Current Optics and Photonics
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• v.1 no.1
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• pp.7-11
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• 2017

In this study, multilayered graphene was easily transferred to the target substrate in one step using thermal release tape. The transmittance of the transferred graphene according to the number of layers was measured using a spectrophotometer. The sheet resistance was measured using a four-point probe system. Graphene formed using this transfer method showed almost the same electrical and optical properties as that formed using the conventional poly (methyl methacrylate) transfer method. This method is suitable for the mass production of graphene because of the short process time and easy large-area transfer. In addition, multilayered graphene can be transferred on various substrates without wetting problem using the one-step dry transfer method. In this work, this easy transfer method was used for dielectric substrates such as glass, paper and polyethylene terephthalate, and a sheet resistance of ~240 ohm/sq was obtained with three-layer graphene. By fabricating organic solar cells, we verified the feasibility of using this method for optoelectronic devices.

• Korean Journal of Applied Biomechanics
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• v.17 no.4
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• pp.65-71
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• 2007

The purpose of this study was to investigate variability of kinematic factors affecting the record in women's javelin throwing. For this study, 8 female-javelin thrower participated in this experiment. The three digital video cameras (Sony, 120x) were used to record motions. Kwon3D 2.1 was used to process data and they were analyzed with Excell for factors. The sampling rate of a camera was 60Hz and shutter speed of a camera was 1/1000sec. The coordinate data were filtered using a fourth-order Butterworth low pass filtering with an estimated optimum cut-off frequency of 6Hz. The results were as follows: 1. From cross step to landing of delivery, the average velocities of CoM of non-dominant athletes were greater than dominant athletes and those of CoM of non-dominant athletes less than dominant athletes, but at release dominant athletes had a lower average velocity and a variability than non-dominant athletes. 2. From cross step to landing of delivery, the average throwing velocities and variabilities of a javelin of dominant athletes were greater than dominant athletes, but at release, dominant athletes had a higher velocity than dominant athletes and had a equal variability. 3. At every events, a forward or backward angles and variabilities of non-dominant athletes were greater than dominant athletes. 4. From cross step to landing of delivery, dominant athletes' elbow average angles were greater than non-dominant athletes and the variabilities of latter less than non-dominant athletes, but at release dominant athletes' variabilities were smaller than non-dominant athletes. 5. At landing of delivery, dominant athletes' knee average angles and variabilities of a supporting foot were a greater than non-dominant athletes, and at release, dominant athletes' knee average angles was a greater but variabilities less than non-dominant athletes. In conclusion, the dominant threw javelins fast while having stable postures and the range of elbow's angle large.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.10
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• pp.5244-5259
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• 2019

With the continuous development of LBS (Location Based Service) applications, privacy protection has become an urgent problem to be solved. Differential privacy technology is based on strict mathematical theory that provides strong privacy guarantees where it supposes that the attacker has the worst-case background knowledge and that knowledge has been applied to different research directions such as data query, release, and mining. The difficulty of this research is how to ensure data availability while protecting privacy. Spatial multidimensional data are usually released by partitioning the domain into disjointed subsets, then generating a hierarchical index. The traditional data-dependent partition methods need to allocate a part of the privacy budgets for the partitioning process and split the budget among all the steps, which is inefficient. To address such issues, a novel two-step partition algorithm is proposed. First, we partition the original dataset into fixed grids, inject noise and synthesize a dataset according to the noisy count. Second, we perform IH-Tree (Improved H-Tree) partition on the synthetic dataset and use the resulting partition keys to split the original dataset. The algorithm can save the privacy budget allocated to the partitioning process and obtain a more accurate release. The algorithm has been tested on three real-world datasets and compares the accuracy with the state-of-the-art algorithms. The experimental results show that the relative errors of the range query are considerably reduced, especially on the large scale dataset.

• Korean Journal of Food Science and Technology
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• v.32 no.5
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• pp.1198-1205
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• 2000

Effect of inhibitions of three kinds of Ginkgo biloba extracts(Ginkgo biloba extract, Ginkgolide A, and Ginkgolide B) on induction of reactive oxygen species and release of inflammation mediator arachidonic acid were tested. Three kinds of Ginkgo biloba extracts could not inhibit the pyrogallol auto-oxidation, but they showed the hydrogen atom donating activity in DPPH assay. When 10 ${\mu}M$ hydrogen peroxide and 400 ${\mu}g/mL$ of three kinds of Ginkgo biloba extracts were added to U937 monocytic macrophage, the induction of lipid peroxidation was not observed. The Ginkgo biloba extract showed the most powerful inhibition among the extracts. And only Ginkgolide A was good for the inhibition of the protein degradation. The release of inflammation mediator arachidonic acid was induced by adding TPA and calcimycin to U937. In this assay, even 10 ${\mu}g/mL$ of three different Ginkgo biloba extracts excellently blocked the release of arachidonic acid. Particularly, the inhibition efficiency of Ginkgolide B was about 11 times higher than that of induction, and was about 4 times higher than that of the control of noninduction. This result suggests that the release of arachidonic acid is not inhibited by the antioxidant activity of Ginkgo biloba extracts, but a pre-step of the release of arachidoinc acid is inhibited by Ginkgo biloba extracts.

• Transactions of the Korean hydrogen and new energy society
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• v.19 no.3
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• pp.189-198
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• 2008

Cooperative effects of Rh, Ce and Zr added to Fe-based oxide mediums were investigated using temperature programmed redox reaction (TPR/TPO) and isothermal redox reaction in the view point of hydrogen storage and release. As the results of TPR/TPO, Rh was a sale additive to remarkably promote the redox reaction on the medium as evidenced by the lower highest peak temperature, even though its addition was to accelerate deactivation of the mediums due to sintering. On the other hand, Ce and Zr additives played an important role to suppress deactivation of the medium in repeated redox cycles. The medium co-added by Rh, Ce and Zr (FRCZ) exhibited synergistic performance in the repeated isothermal redox reaction, and the amount of hydrogen produced in the water splitting step at 623 K was highly maintained at ca. $17\;mmol{\cdot}g^{-1}-Fe$ during three repeated redox cycles.

• Nuclear Engineering and Technology
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• v.48 no.5
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• pp.1140-1153
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• 2016

Since the inception of nuclear power as a commercial energy source, safety has been recognized as a prime consideration in the design, construction, operation, maintenance, and decommissioning of nuclear power plants. The release of radioactivity to the environment requires the failure of multiple safety systems and the breach of three physical barriers: fuel cladding, the reactor cooling system, and containment. In this study, nuclear reactor containment pressurization has been modeled in a large break-loss of coolant accident (LB-LOCA) by programming single-cell and multicell models in MATLAB. First, containment has been considered as a control volume (single-cell model). In addition, spray operation has been added to this model. In the second step, the single-cell model has been developed into a multicell model to consider the effects of the nodalization and spatial location of cells in the containment pressurization in comparison with the single-cell model. In the third step, the accident has been simulated using the CONTAIN 2.0 code. Finally, Bushehr nuclear power plant (BNPP) containment has been considered as a case study. The results of BNPP containment pressurization due to LB-LOCA have been compared between models, final safety analysis report, and CONTAIN code's results.

• Nuclear Engineering and Technology
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• v.28 no.6
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• pp.551-562
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• 1996

This paper introduces the five-step methodology for identifying information needs and assessing instrument availability during the course of severe accidents in nuclear power plants. The methodology is applied to the Yonggwang (YGN) 3&4 to shed light on accident management. It constructs three safety objective trees to prevent the reactor vessel failure, to prevent the containment failure, and to mitigate the fission product release from the containment. The study assesses information needs and instrument availability under severe conditions for preventing the reactor vessel failure of YGN 3&4, and recommends additional instrument that m8y prove to be of vital importance in managing the accident.

• Restorative Dentistry and Endodontics
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• v.27 no.4
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• pp.382-388
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• 2002

Compomer is composed of matrix and filler : matrix is made of the combination of resins and polycarboxylic molecules that are light-cured, and a filler is a glass component which is capable of ion-release. The resin content of compomers produces polymerization shrinkage which can adversely affect marginal adaptation. Pretreatment is a fundamental step which is treated with conditioner or primer in the use of these materials. Microleakage of restorative materials has been investigated mostly by dye penetration method. Dye penetration method was not quantitative and not measured repeatedly. Fluid filtration method, introduced and developed by Pashley's group, has been extensively used for 20 years for research purpose to understand the physiology of dentin, as well as the effects of various restorative treatments on dentin permeability. It permits quantitative, nondestructive measurment of microleakage in a longitudinal manner. The purpose of this study was to evaluate the change of dentin permeability according to the process of compomer restoration. In this study. Cl V cavities were prepared on buccal surface of thirty extracted human molars. The prepared cavities were etched by 37% phosphoric acid. The experimental teeth were randomly divided into three groups. Each group was treated with following materials Group 1 : Prime & Bond NT/Dyract AP, Group2： Single Bond/F2000 compomer, Group 3 : Syntac Single Component/Compoglass. The bonding agent and compomer were applied for each group following manufacturers information. Dentin permeability of each group was measured at each process by fluid filtration method; Step 1 : preparation(smear layer). Step 2 : etching(smear layer removal), Step 3 : applying the bonding agent, Step 4 : filling the compomer. Dentin permeability was expressed by hydraulic conductance ($\mu\textrm{l}$ min$^{-1}$cm$H_2O$$^{-1}$). The data were analysed statistically using One-way ANOVA and Sheffe's method. The results were as follows : 1. Dentin permeability differences between each process were significant except between step 1 and step 2(p<0.01). 2. Dentin permeability after removal of smear layer was highly increased(p<0.01). 3. In most case, decrease of dentin permeability was obtained by applying bonding agent(p<0.01). 4. Dentin permeability differences among the experimental groups were not significant(p>0.05). 5. None of compomers used in this study showed perfect seal at the interface.