• 한국한의학연구원논문집
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• 제4권1호통권4호
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• pp.47-62
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• 1998

We explicate the forming mechanism of Sasang constitution as the principle of energy distribution which is based on the evolutionary hypothesis. The result was obtained as follows: 1. The principle of form-image (形象) in oriental medicine can be explained with the relation between structure and function that a life acquires through the adaptation and evolution. 2. The Sung-jung (性情) in Sasang constitutional medicine can be explained as the strategy for survival or the pattern of adaptation by which an individual or a species lives in this world. 3. The forming mechanism of Sasang constitutional organic phase (臟局) can be explained as the principle of energy distribution which includes three hypothesis (hypothesis of limited resources, hypothesis of preference and hypothesis of effectiveness). 4. It is postulated that the local hemodynamics is one of the most important factors that determine the difference of Sasang constitutional organic function. 5. The relation of metabolic rate, local hemodynamics and thermo-metabolism is inseparable and it is the important point of forming mechanism of Sasang constitution and the diagnosis of pulse.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2027-2033
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• 2014

Background: We aimed to assess RET proto-oncogene polymorphisms in three different Iranian families with medullary thyroid cancer (MTC), and performed molecular dynamics simulations and free energy stability analysis of these mutations. Materials and Methods: This study consisted of 48 patients and their first-degree relatives with MTC confirmed by pathologic diagnosis and surgery. We performed molecular dynamics simulations and free energy stability analysis of mutations, and docking evaluation of known RET proto-oncogene inhibitors, including ZD-6474 and ponatinib, with wild-type and mutant forms. Results: The first family consisted of 27 people from four generations, in which nine had the C.G2901A (P.C634Y) mutation; the second family consisted of six people, of whom three had the C.G2901T (P.C634F) mutation, and the third family, who included 12 individuals from three generations, three having the C.G2251A (P.G691S) mutation. The automated 3D structure of RET protein was predicted using I-TASSER, and validated by various protein model verification programs that showed more than 96.3% of the residues in favored and allowed regions. The predicted instability indices of the mutated structures were greater than 40, which reveals that mutated RET protein is less thermo-stable compared to the wild-type form (35.4). Conclusions: Simultaneous study of the cancer mutations using both in silico and medical genetic procedures, as well as onco-protein inhibitor binding considering mutation-induced drug resistance, may help in better overcoming chemotherapy resistance and designing innovative drugs.

• 한국한의학연구원논문집
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• 제3권1호
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• pp.105-118
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• 1997

Through the theoretical study on Sa-sang constitutional medicine from a evolutionary point of view, the result was obtained as follows. 1. The system of Sa-Sim-Sin-Mul(事心身物) in Sa-sang constitutional medicine is similar to the theory of evolution of Teilhard de Chardin. 2. The concept of Yin and Yang in Sa-sang constitutional medicine can be set up by the demand and necessity in the progress of evolution and the time of the differentiation of functions. 3. The Sung-Jung(性情) of each Sa-sang constitution can be explained as the strategy and form for survival. 4. The theory of physiology, pathology and therapy in Sa-sang constitutional medicine can be hypothesized by the evolutionary standards which are related with the thermo-metabolism and hematopoietic-immune system.

• 한국의류학회지
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• 제31권12호
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• pp.1700-1709
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• 2007

본 연구의 목적은 계절별 의복을 착용하고 쾌적한 상태를 유지하는 동안 불감체중손실과 온열 생리적 요소들간의 관련성을 살펴보는 것이다. 이를 위해 한국의 계절별 실내 환경이 인공기후실에 조성되었고 (봄/가을 환경 기온 평균 22.5, 여름 24.7, 겨울 16.8), 설문조사를 바탕으로 총 26 종의 계절별 한벌의복이 선정되었다(봄/가을 옷 8종, 여름 옷 7종, 겨울 옷 11종). 다섯 명의 젊은 여성이 피험자로 참여하였으며, 결과는 다음과 같다: 1) 불감체중손실(IL)은 봄/가을 의복을 착용한 경우 $19{\pm}5g{\cdot}m^{-2}{\cdot}hr$, 여름 옷 $21{\pm}5g{\cdot}m^{-2}{\cdot}hr$, 겨울 옷 $18{\pm}6g{\cdot}m^{-2}{\cdot}hr$으로, 겨울 환경보다 여름 환경에서 더 컸다(p<.001). 2) 호흡기를 통한 불감수분손실(IWR)은 불감체중손실과 반대의 경향을 보여 주어, 겨울옷을 입은 경우 $6{\pm}1g{\cdot}m^{-2}{\cdot}hr$, 여름 옷을 입은 경우 $5{\pm}1g{\cdot}m^{-2}{\cdot}hr$ 였다(p<.001). 3) 불감수분손실 (IW)에서 호흡기를 통한 불감수분손실이 차지하는 비중은 여름 옷을 착용한 경우 평균 28%, 겨울 의복의 경우 38%였다(p<.001). 4) 쾌적한 상태에서, 산열량 중 불감수분손실이 차지하는 비율은 봄/가을 의복을 착용한 경우 25%, 여름옷의 경우 27%, 겨울옷의 경우 23%였다. 5) 불감체중손실과 의복의 보온력 간, 그리고 불감체중손실과 피복면적 간에는 모두 약한 역상관 관계가 관찰되었다. 6) 불감체중손실은 기온, 기습, 에너지 대사, 환기량, 평균피부온도, 의복내 습도 등의 요소와 유의한 상관을 보였으나, 상관계수들은 모두 0.5 이하였다. 결론적으로, 불감체중손실과 온열 생리 요인들 간에는 약한 상관이 존재했으나, 피험자들이 온열 쾌적을 유지하는 경우 착용한 의복 종류 및 노출 기온에 상관없이 불감체중손실량은 좁은 범위를 유지했다.