• Korean Journal of Clinical Pharmacy
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• v.28 no.3
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• pp.216-223
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• 2018

Objective: This study aimed to assess treatment persistence in Korean children and adolescents with attention deficit hyperactivity disorder (ADHD) and the factors influencing their adherence to ADHD pharmacotherapy. Methods: The study included patients between 6 and 18 years of age with ADHD who were taking various formulations of methylphenidate and atomoxetine on June 1, 2014. Patients were dichotomized as "persistent" or "non-persistent", depending on whether they continued ADHD therapy for 6 months (therapy persistence). We also investigated if the patients were taking the same medication(s) as before and also classified the patients as "medication persistent" or "non-persistent". Patient' characteristics were correlated with therapy persistence and medication persistence. Multiple logistic regression analyses were performed to assess potential risk factors for treatment persistence. Results: Overall, 3,317 patients were included in the analysis. A majority of patients were taking stimulants (82.0%), 16.2% were taking non-stimulants and 1.8% were taking a combination therapy of stimulants and non-stimulants. After 6 months, 2,290 patients (69.0%) continued to take medication for ADHD with 1,953 patients taking the same medication(s) as 6 months previously. Common positive factors for therapy persistence and medication persistence were identified as younger age, retardation, and developmental delay, and long-acting formulations of methylphenidate as either monotherapy or in a combination therapy may be used. Conclusion: ADHD medications were proven to improve academic performance and social skills of children. Collaboration between patients, parents, school staffs, and prescribers is required to improve the persistent use of ADHD medications.

• Journal of People, Plants, and Environment
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• v.23 no.3
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• pp.363-375
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• 2020

Background and objective: Recreation or activities in forest are regarded as therapy. Many forest therapy programs have been developed and assessed in the domestic. This study was conducted to investigate the effect of the forest therapy program on academic and job-seeking stress in college students. Methods: Thirty five subjects were selected as the experimental group and 25 as the control group, and 29 subjects in the experimental group and 11 in the control group participated in the follow-up test to verify the persistence of stress reduction effects. The forest therapy program was carried out once a week for 2 hours each from September 4 to December 4, 2018, adding up to total eight sessions. Results: The experimental group showed statistically significant reduction in both academic stress and job-seeking stress, whereas the control group did not. For the persistence of the forest therapy program, the experimental group did not show a statistically significant difference between the posttest and the follow-up test, and thus the stress reduction effect was maintained. Conclusion: This study proved the reduction of academic and job-seeking stress in forest therapy programs and the persistence of the stress reduction effect of the forest therapy program. The result is consistent with the Stress Recovery Theory (SRT) that shows the stress reduction effect of nature. In addition, it has significance in that it has verified that the program using the forest on campus can reduce stress of most college students.

• Journal of Korean Physical Therapy Science
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• v.21 no.1
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• pp.59-63
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• 2014

Purpose : To determined the effect of self-stretching and manual therapy on ankle joint about ROM and persisting effect. Method : Twenty participants(6 male, 14 female) ramdomly divided into self-stretching and manual therapy group. Each participant started with lunge test then self-stretching and manual therapy intervention was performed. After intervention lunge test was performed again. Last lunge test was performed after 30 minute break. Result : Result of lunge test showed both self-stretching and manual therapy group have significant difference in immediate increase of ROM and persistence effect(p<0.05). However, persistence effect of each group did not show significant difference(p>0.05). Conclusion : Manual therapy and well-designed self-stretching by therapist showed the effect in increase ROM.

• The Journal of Korean Academy of Sensory Integration
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• v.20 no.3
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• pp.38-47
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• 2022

Objective : We investigated how sensory processing patterns contribute to temperament and character traits in undergraduate students. Methods : A total of 107 undergraduate students were recruited in September 2022 via convenient sampling method. They completed the Adolescent/Adult Sensory Profile and the Temperament and Character Inventory. Multiple regression models were applied to analyze the effect of sensory processing quadrants (low registration, sensation seeking, sensory sensitivity, sensation avoiding) on each temperament (novelty seeking, harm avoidance, reward dependence, persistence) and character (self-directedness, cooperativeness, self-transcendence) traits. Results : Sensation seeking significantly predicted high levels of novelty seeking, reward dependence, persistence, self-directedness, and self-transcendence but low harm avoidance. Low registration predicted high harm avoidance but low levels of reward dependence, persistence, and self-directedness. Reward dependence was predicted by high sensory sensitivity and low sensation avoiding. Conclusion : This study demonstrated that sensory processing patterns affected novelty seeking, harm avoidance, reward dependence, persistence, self-directedness, and self-transcendence in young adults.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.16 no.5
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• pp.301-306
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• 2023

Attention is a fundamental aspect in the cognitive process of human. Cognitive system of human body requires to focus on selected information among a vast amount of information from sensory organs. It has widely studied that various environmental factors affected the level of attention; however, few researches have aimed to the effect of direct cryotherapy. In this research, level of attention was studied comparing sub-indexes of FAIR test between groups with different duration of direct cryotheapy to the back of neck. FAIR test is a evaluation tool for visual attention consisting of three sub-indexes. Selective attention, accuracy of attention, and persistence of attention can be independently analyzed by FAIR test. In the analysis of selective attention, cryotherapy for 5 to 20 minutes showed higher result than cryotherapy for 40 minutes. In the analysis of persistence of attention, cryotherapy for 5 to 15 minutes showed higher result than cryotherapy for 40 minutes. Overall, selective attention and persistence of attention turns out to be maximized between 5 to 20 minutes of cryotherapy and tends to decrease afterwards. However, accuracy of attention does not seem to be affected by the duration of cryotherapy. Correlation between selective attention and the skin temperature by cryotherapy tends to be negative supporting the findings by ANOVA and post-hoc test. Correlation between persistence of attention and the skin temperature showed similar results.

• Journal of Community Nutrition
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• v.3 no.1
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• pp.21-29
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• 2001

This study was conducted to examine factors with attendance in hyperlipidemia nutrition eduction program among 101 hyperlipidemic outpatients (38 males 63 females) at Samsung Medical Center We employed the Health Belief Model (HBM) as the theoretical framework The individual nutrition education and counseling program was scheduled with 4- half hour session sin 2 to 4 weeks intervals. Upon initiation of the program a trained dietitian surveyed HBM constructs and psychosocial factors. The following were included perceived susceptibility to cardiovascular disease(CVD) perceived severity to CVD percieved benefits to diet modification perceived barriers to persistence in maintaining therapy and self efficicacy and social support from family Sociodemographic data health factors stress level nutrition knowledge, and 24-hour dietary recall behavior were also surveyed All these data was analyzed according to the number of nutrition sessions attended The subjects were 55.9$\pm$9.4 year old and 24.6$\pm$kg/㎡ Sociodemographic factors were not associated with the number of nutrition sessions attended HBM constructs and psychosocial factors were significantly associated with the number of nutrition sessions attended. According to Spearman correlation coefficients. From stepwis regression analyses using HBM constructs as independent variables perceive barriers to persistence in maintaining diet therapy (negative) proved to be the strongest predictors for the number of nutrition sessions attended (partial R$^2$= 72.3%) followed by perceived severity to CVD and self efficacy (model R$^2$=76.6% The findings indicate that HBM constructs and psychosocial factors were closely associated with patient attendance It suggests that information and guidance to minimize patients perceived barriers to diet therapy might help to improve patients to scheduled appointments in nutrition education programs.

• Journal of the Korean Society of Physical Medicine
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• v.14 no.1
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• pp.111-119
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• 2019

PURPOSE: The aim of this study was to determine how biofeedback training with Shaker exercise effects the activation of the cervical myocardial muscle in stroke with swallowing disorder. METHODS: From June 2018 to September 2018, 30 patients who were hospitalized at C hospital and K hospital in Daegu, and K hospital in Gumi were surveyed to meet the criteria for selection. The participants were classified into three groups, and Shaker exercise was applied three times a day, five times a week, for four weeks; visuoauditory biofeedback group (VABG), visual biofeedback group (VBG), and self-exercises group (SG). In addition, the suprahyoid muscle activity was performed three times (before intervention, after intervention, and after two weeks). RESULTS: The pre and post-test comparisons, revealed a significant difference between the three groups (p<.01); VABG had the highest suprahyoid muscle activity. The post-test and follow-up test produced similar results in, the three groups (p>.05). The mean comparison showed the smallest difference in VABG, indicating that muscle persistence was the best. CONCLUSION: Shaker exercise has an effect on suprahyoid muscle activation. Biofeedback training, which provides an input of multi-sensory information in swallowing disorder treatment is recommended because it has the greatest effect when combined with visuoauditory biofeedback.

• Journal of Korean Physical Therapy Science
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• v.10 no.2
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• pp.29-36
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• 2003

The purpose of this study was to investigate the effects of height of shoe lifts on gait and balance in hemiplegic patients. Twenty-two hemiplegic patients who were receiving rehabilitation treatment at Hanyang University Seoul Hospital and National Rehabilitation Center participated in this study from November 8, 2002 through March 20, 2003. Data analysis using repeated measures ANOVA and Bonferroni method, for a post-test. The results of this study were as follows : First, shoe lift on the height of 3mm, 6mm, 9mm, 12mm significantly improved, as compared to un-lift status, in gait velocity, PCI, weight bearing(p<0.05). Second, gait velocity was significantly difference between 3mm and 9mm, and between 3mm and 12mm, and weight bearing on the affected side was significantly difference between 3mm and 12mm, and between 6mm and 12mm(p<0.05). Third, after the shoe lift removed was significantly improved in gait velocity, PCI, weight bearing than before shoe lifts being added(p<0.05). These results suggest that shoe lift on the unaffected side may helpful for improving the gait efficiency and symmetrically of weight bearing. Furthermore, persistence of gait efficiency and symmetrically of weight bearing after removing the shoe lift suggests carryover effect of gait training on shoe lift of unaffected side.

• Molecules and Cells
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• v.37 no.1
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• pp.66-73
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• 2014

Myeloid-derived suppressor cells (MDSCs) play an important role in impairing the function of T cells. We characterized MDSCs in two chronic hepatitis C (CHC) cohorts: a cross-sectional group that included 61 treatment-naive patients with CHC, 14 rapid virologic response (RVR) cases and 22 early virologic response (EVR) cases; and a longitudinal group of 13 cases of RVR and 10 cases of EVR after pegylated-interferon-${\alpha}$/ribavirin treatment for genotype 1b HCV infection. Liver samples from 32 CHC patients and six healthy controls were subjected to immunohistochemical analysis. MDSCs frequency in treatment-naive CHC was significantly higher than in RVR, EVR, or healthy subjects and was positively correlated with HCV RNA. Patients infected with HCV genotype 2a had a significantly higher frequency of MDSCs than those infected with genotype 1b. Decreased T cell receptor (TCR) ${\zeta}$ expression on $CD8^+$ T cells was significantly associated with an increased frequency of MDSCs in treatment-naive CHC patients and was restored by L-arginine treatment in vitro. Increased numbers of liver arginase-$1^+$ cells were closely associated with the histological activity index in CHC. The TCR ${\zeta}$ chain was significantly downregulated on hepatic $CD8^+$ T cells in CHC. During antiviral follow up, MDSCs frequency in peripheral blood mononuclear cells was directly correlated with the HCV RNA load in the plasma and inversely correlated with TCR ${\zeta}$ chain expression in $CD8^+$ T cells in both RVR and EVR cases. Notably, the RVR group had a higher frequency of MDSCs at baseline than the EVR group. Collectively, this study provides evidence that MDSCs might be associated with HCV persistence and downregulation of CD8 ${\zeta}$ chain expression.

• Journal of Korean Neurosurgical Society
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• v.66 no.4
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• pp.356-381
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• 2023

Although immunotherapy has been broadly successful in the treatment of hematologic malignancies and a subset of solid tumors, its clinical outcomes for glioblastoma are still inadequate. The results could be due to neuroanatomical structures such as the blood-brain-barrier, antigenic heterogeneity, and the highly immunosuppressive microenvironment of glioblastomas. The antitumor efficacy of endogenously activated effector cells induced by peptide or dendritic cell vaccines in particular has been insufficient to control tumors. Effector cells, such as T cells and natural killer (NK) cells can be expanded rapidly ex vivo and transferred to patients. The identification of neoantigens derived from tumor-specific mutations is expanding the list of tumor-specific antigens for glioblastoma. Moreover, recent advances in gene-editing technologies enable the effector cells to not only have multiple biological functionalities, such as cytokine production, multiple antigen recognition, and increased cell trafficking, but also relieve the immunosuppressive nature of the glioblastoma microenvironment by blocking immune inhibitory molecules, which together improve their cytotoxicity, persistence, and safety. Allogeneic chimeric antigen receptor (CAR) T cells edited to reduce graft-versus-host disease and allorejection, or induced pluripotent stem cell-derived NK cells expressing CARs that use NK-specific signaling domain can be a good candidate for off-the-shelf products of glioblastoma immunotherapy. We here discuss current progress and future directions for T cell and NK cell therapy in glioblastoma.