• The Journal of Korean Obstetrics and Gynecology
• /
• v.24 no.1
• /
• pp.15-26
• /
• 2011

Objectives: The purpose of this study was to investigate the anti-inflammatory effects of aqueous extract from Cicadidae Periostracum(CP) on the RAW 264.7 cells. Method: We examined the cytokine productions including nitric oxide(NO), interleukin(IL)-1b, IL-6 and tumor necrosis factor-a(TNF-a) in lipopolysaccharide (LPS)-induced RAW 264.7 cells and also inhibitory mechanisms such as mitogen -activated protein kinases(MAPKs) and nuclear factor kappa BNF-kB) using Western blot. Results: CP inhibited LPS-induced production of NO, IL-1b and TNF-a but not of IL-6 in RAW 264.7 cells. CP respectively inhibited the activation of MAPKs such as extracelluar signal-regulated kinase(ERK 1/2), c-Jun $NH_2$-terminal kinase(JNK), p38 and NF-kB in the LPS-stimulated RAW 264.7 cells. Also oral administration of CP inhibited CLP - induced endotoxin shock. Conclusion: our results showed that CP down-regulated LPS-induced NO, IL-1b and TNF-a productions mainly through ERK, JNK, p38 MAPK and NF-kB pathway, which suggest the anti-inflammatory effects of CP.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.15 no.4
• /
• pp.32-44
• /
• 2002

Onsinhwan(OSH : 溫腎丸) is used in female infertility, especially due to lack of kidney yang or Sinyanghe(腎陽虛). An attempt was made to evaluate the influences of OSH on the serum concentrations of FSH and LH, Estrogen, Progesterone and the histological and optical changes of ovary, ovary weight of rats. The results of the study were as follows : 1. Blood FSH level increased in experimental group as compared with control group on 7th day and 14th day, which showed no efficacy. 2. Blood LH level decreased in experimental group as compared with control group on 14th day, which showed no efficacy. 3. Blood Estrogen level increased in experimental group as compared with control group on 7th day and 14th day, which showed no efficacy. 4. Blood Progesterone level decreased in experimental group as compared with control group on 7th day and 14th day, which showed no efficacy. 5. In histological observations of ovary, ovulation increased in experimental group as compared control group on 7th and on 14th day, which showed no efficacy. 6. In optically observations of ovary, size and weight of ovary increased in experimental group on 7th day and on 14th day, which showed no efficacy. According to these results, OSH did not influence on the ovulation of ovary in rats.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.24 no.4
• /
• pp.95-104
• /
• 2011

Objectives: The purpose of this study is to investigate the relationship between the degree of menopausal symptom and granulocyte/lymphocyte ratio, and heart rate varibility(HRV). Methods: From 11th April 2011 to 20th May 2011, a total 30 female subjects (age 41-60) was recruited. We evaluated the degree of menopausal symptoms by Kupperman' s index and measured subject's WBC differential count and HRV. The data were analyzed by Kruskal-Wallis test and Spearman correlation test using SPSS/PC ver 13.0 program. Results: 1. There was no statistically significant difference in granulocyte/lymphocyte ratio and HRV among 4 classified groups according to Kupperman's index.- Mild, Moderate, Severe and Urgent. 2. Granulocyte ratio and general symptom score(within Kupperman's index) significantly showed negative correlation coefficient(r=-0.499, p=0.005), and Lymphocyte ratio and general symptom score significantly showed positive correlation coefficient (r=0.374, p=0.042). 3. Granulocyte/lymphocyte ratio and HRV showed no significant correlation. Conclusions: There was no significant relation among the degree of menopausal symptoms and granulocyte/lymphocyte ratio, and HRV. But furthermore large scale study is required.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.22 no.1
• /
• pp.161-171
• /
• 2009

Purpose: We intended to observe relation between general symptom and the number of uterine myoma. Methods: We surveyed 948 women from 35 to 45 years old who had received Korean oriental medical questionnaires about general symptom pattern and pelvic ultrasonography at Kyung-Hee university medical center from May, 2007 to October, 2008. After we divided women into three groups (Mono-uterine myoma, Bi-uterine myoma & uterine myoma above 3) by ultrasonography result, we compared general symptom pattern according to the number of uterine myoma. For statistics, we used Kruskal-Wallis Test, SPSS 13.0 for windows. Results: In relation to sleep pattern, severity of dreaming & awaking showed statistical significance according to the number of uterine myoma. In relation to digestion pattern, appetite & heartburn showed statistical significance according to the number of uterine myoma. In relation to evacuation pattern, hardening of stool showed statistical significance according to the number of uterine myoma. In relation to sweating pattern, severity of refreshing after sweating showed statistical significance according to the number of uterine myoma. In relation to the other patterns, hypertonicity of nape neck showed statistical significance according to the number of uterine myoma(p<0.05). Conclusion: The result showed that prevalence of uterine myoma had to be considered in respect of sleep, digestion, evacuation and sweating pattern. we need further study based on this preliminary result.

• Journal of Korean Medicine for Obesity Research
• /
• v.11 no.1
• /
• pp.25-34
• /
• 2011

Objectives The purpose of this study was to examine the characteristics of diagnostic pattern questionnaire associated with Body Mass Index in premenopausal women. Methods We studied 41 patients visiting Gangdong Kyung Hee University Hospital from 1st April 2011 to 25th May 2011. The subjects were categorized in two groups, overweight & obesity group (n=12) and low weight & normal group (n=29). We studied the difference of diagnostic pattern questionnaire scores between two groups by Independent samples T-test and correlation between diagnostic pattern questionnaire scores of overweight & obesity group by Pearson's correlation coefficient test using SPSS for windows (version 13.0). Results Blood stasis, retention of undigested food, cold pattern scores of overweight & obesity group were non-significantly higher than low weight & normal group. Heat pattern score of overweight & obesity group was significantly higher than low weight & normal group. Cold-heat, phlegm-cold, blood stasis-cold, phlegm-blood stasis, phlegm-retention of undigested food significantly showed positive correlation coefficient in overweight & obesity group. Conclusions The results suggest that obese women tend to show heat pattern. It seems to be that multiple factors such as phlegm, blood stasis, retention of undigested food are causative of obesity.

• The Journal of Korean Medical History
• /
• v.15 no.2
• /
• pp.83-100
• /
• 2002

The Oriental Obstetrics and Gynecology is a branch of the Oriental Medicine that treat of physiological and pathological diseases of the female. The origin of the Oriental Obstetrics and Gynecology begins at the pregnancy and delivery of the women. Therefore it has significant meanings about the birth of human beings. The field of this study has been very important to the Oriental Medicine. Accordingly the present writer is planning to study of the level of the Oriental Obstetrics and Gynecology and its effects in those days, through Heo Jun(許浚)'s "Eonhaetaesanjipyo" ("諺解胎産集要") that is a work of the Oriental Obstetrics and Gynecology books in the history of Korean Oriental Medicine.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.19 no.4
• /
• pp.77-92
• /
• 2006

Purpose : This study is to examine what are the effects of the Woogwiyeum(WGY) on the ovariectomized rat model of postmenopausal osteoporosis. Methods : We devide mice to 3 Group(Sham operated group, control group, WGY treated group) and analyze each serum component. Results : 1. Body weight in control group showed significant increase in comparison with sham, but that in WGY-treated showed no change in comparison with control. 2. The level of serum albumin, ALP in control group showed significant decrease in comparison with sham. That in WGY-treated was decreased in comparison with control. 3. Trabecular bone area as well as trabecular thickness in control group showed significant decrease in comparison with sham. Those in WGY-treated showed significant increase in comparison with control. 4. Osteoclast number and oseoblast surface in control group showed significant increase in comparison with sham. Those in WGY-treated showed significant decrease in comparison with control. Conclusion : WGY has shown to be capable of preventing and curing osteoporosis caused by old-aged and postmenopause.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.25 no.4
• /
• pp.81-93
• /
• 2012

Objectives: A women's body type or body temperature is often thought to be associated with gynecologic disorders or dysmenorrhea. The purpose of this study is to analyse the characteristics of body type and body temperature in relation to gynecologic disorders and dysmenorrhea. Methods: We studied 40 patients visiting Kangnam Kyung-hee Medical Center from Jan. 1st, 2010 to March 31st, 2012. Body type and body temperature were compared between Gynecologic disorder group and non-Gynecologic disorder group. Body type and body temperature were compared again between Dysmenorrhea group and non-Dysmenorrhea group. SPSS 18.0 for Windows was used to analyse the data. Results: There was no statistically significance difference in body type and body temperature between Gynecologic disorder group and non-Gynecologic disorder group. Dysmenorrhea group had more developed lower body and greater temperature difference between lower abdomen and foot compared to non-Dysmenorrhea group. Conclusions: The results suggest that women with developed lower body and greater temperature difference between abdomen and lower extremity are more prone to dysmenorrhea.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.25 no.4
• /
• pp.113-124
• /
• 2012

Objectives: This study is designed to compare clinical symptoms between Symptom-giving pelvic girdle relaxation and Separation of the pubic symphysis. And report the clinical effectiveness of Traditional Korean Treatment on two case. Methods: Two patients who delivery in one week ago had pain that located symphysis and around. Treatment was acupuncture, Placenta Herbal Acupuncture and herbal medicine. The progress of symptom and aggressiveness of pain and disability were measured by Visual Analogue Scale, McGill pain Questionnaire-short form, Oswestry Disability Index and Active Straight Leg Raise test. Results: After treatment most two patients' pain and disabilty were improved. At first case, width of symphysis pubis were increased in normal range. Conclusions: These cases shows that Traditional Korean therapy might be effective in decreasing symptoms on separation of symphysis pubis during delivery and Symptom-giving pelvic girdle relaxation.

• Journal of Oriental Medical Thermology
• /
• v.7 no.1
• /
• pp.30-36
• /
• 2009

Purpose : The purpose of this study is investigate the characters of DITI, HRV and Body composition analysis in Amenorrhea. Methods : We studied 47 patients visiting OO hospital from 1st October 2007 to 19st September 2009. The subjects were categorized in two groups, amenorrhea group(26) and normal group(21). We studied the difference of DITI, HRV and Body composition analysis between two groups by Mann-whitney test using SPSS for windows(version 12.0). Results : there is not statistically significant difference of DITI, HRV and BMI between amenorrhea group and normal group. But there is statistically significant difference of percent body fat and waist-hip ratio between amenorrhea group and normal group. Conclusion : Percent body fat and Waist-Hip ratio of amenorrhea groups is lower than normal groups. Percent body fat and Waist-Hip ratio can be diagnosis index.