• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3613-3618
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• 2014

Stathmin, also called oncoprotein 18, is a founding member of the family of microtubule-destabilizing proteins that play a critical role in the regulation of mitosis. At the same time stathmin has been recognized as one of responsible factors in cancer cells. The aim of this study was to assess stathmin status, its correlations with clinicopathological parameters and its role as a progosnostic marker in EC patients. The protein and mRNA levels of stathmin were examined byimmunohistochemistry (IHC) and in situ hybridization in 100EC tissues and adjacent noncancerous tissues. mRNA and protein expression of stathmin in three EC cell lines(EC9706, ECa109, EC1 commonly used in research) were also analyzed using immunocytochemistry, western blot and in situ hybridization. The prognostic value of Stathmin expression within the tumor tissues were assessed by Cox regression and Kaplan-Meier analysis. We showed that stathmin expression was significantly higher in EC tissues than in adjacent noncancerous tissues. High stathmin immunostaining score in the EC was positively correlated with tumor differentiation, Tumor invasion, Lymph node metastases, and TNM stage. In addition, we demonstrated that three EC cell lines examined, were constitutively expressing a high level of stathmin. Of those, EC-1 showed the strongest mRNA and protein expression for the stathmin analyzed. Kaplan-Meier analysis showed that significantly longer 5-year survival rate was seen in EC patients with high Stathmin expression, compared to those with low expression of Stathmin expression. Furthermore, multivariate Cox proportional hazard analyses revealed that Stathmin was an independent factors affecting the overall survival probability. In conclusion, our data provide a basis for the concept that stathmin might be associated with EC development and progression. High levels of Stathmin expression in the tumor tissues may be a good prognostic marker for patients with EC.

• 여성건강간호학회지
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• 제6권3호
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• pp.358-371
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• 2000

The purpose of this study was to provide the basic, data for developing a program for effective prevention for Postpartum Depression (PPD) by investigating the level of PPD in postpartum 2 weeks women. The subjects were 384 women who visited obstetrical clinics for postnatal care. The data were collected from June 29. 1999 to April. 2000, using a 46-item questionnaire related to PPD, and analyzed by SAS program for t-test, ANOVA, Scheffe test, stepwise multiple regressions. The results were as follows : 1. The level of PPD according to general characteristics Women had mild PPD (Min score; 46.0, Max score; 124.0). The PPD levels were significantly differences according to religion and marital satisfaction (p<0.05). 2. The level of PPD according to obstetrical characteristics 1) Characteristics related to pregnancy The PPD levels were significantly differences according to mood change, confidence of body weight recovery, depression related to appearance change, husband's help to housework, and husband's emotional support (p<0.05). 2) Stressful events during pregnancy The PPD levels were significantly differences according to financial problem, conflict between partners, conflict between family, and husband's job change (p<0.05). 3) Characteristics related to delivery and post natal period The PPD levels were significantly differences according to baby's health state, parenting confidence, and difficulties related to postpartum care (p<0.05). 3. The variables to predict postpartum depression in postpartum women are depression related to appearance change (10.4%), parenting confidence (8.8%), husband's help to housework (2.7%), confidence of body weight recovery (2.4%), husband's job change (1.9%), baby's health state (1.9%), difficulties related to postpartum care (1.6%), mood change (1.2%), conflict between partners (0.6%), marital satisfaction (0.5%), financial problem (0.4%). The sum total of all the above variables can account for 32.4% of postpartum depression. 4. The level of PPD according to PPD factors. Women had the highest degree of PPD in biophysiological phenomena-disturbance of physical functioning factor. The factors of relationship to baby-negative feeling and cognitive phenomena-self concept disturbance were showed the lowest degree of PPD. As a result of the above findings, a systemic and individualized program is strongly recommended for PPD prevention, diagnosis, and care for PPD in postpartum women. In near future, this study should be expanded to investigate the coping skills according to the PPD levels in postpartum women.

• 기록학연구
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• 제65호
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• pp.397-457
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• 2020

이 연구의 목적은 ISO 30301:2019 표준에 대한 세부적인 분석을 통해 전체적인 이해를 돕고, 해당 표준이 시사하는 바를 논의하는데 있다. 이를 위해 본 연구는 먼저 ISO 30301 표준의 개정 배경을 살펴보았으며, 구체적으로는 기록경영시스템 시리즈 표준의 제정 및 개정 과정을 시기별로 정리하였다. 또한 개정판에 적용된 경영시스템 표준의 기본구조(HLS, High Level Structure), ISO 15489:2016 표준의 주요 개정사항과 함께 기록관리를 위해 새롭게 등장한 개념인 '기록 요구사항(Records requirements)'을 살펴보았다. 이어 ISO 30301:2019 표준의 개정사항을 경영시스템 표준의 기본구조와 ISO 30301:2011 표준과 함께 비교하였다. 또한 ISO 30301 개정판에 신규, 강화, 변경된 요구사항을 분석하여 본 표준 개정판의 주요 특징을 파악하였다. 이러한 분석을 바탕으로 본 표준의 개정이 기록관리학계와 실무분야에 시사하는 바를 기록 프로세스의 확대 및 체계적인 기록경영 실현, 기록경영시스템에 대한 리더십 강화 및 효율적인 운영, 본격적인 다른 경영시스템 표준과의 통합 및 활용, 업무 프로세스 단위의 유연한 기록관리 거버넌스 실현의 4가지로 나누어 제시하였다.

• 대한안전경영과학회지
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• 제15권2호
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• pp.135-141
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• 2013

As the country's elderly people who are 65 years or older recently exceeded 10% of the total population with development of medical technology and improvement of living standards, Korea has turned into an aging society. Especially in Gyeonggi-do, as of late December 2012, elderly people who were 65 years or older were 1,135,242 persons, taking up 18.98% of the region's population and registering the largest number of elderly people in the nation's cities or provinces. Due to such a sharp rise in elderly population, support for the elderly is increasing the burden on families and communities. The study aims to take as its subjects elderly people staying at authorized elderly welfare facilities, who are weak in mind and body and have difficulty in daily life with disabilities, or adult day care facilities that take care of elderly people during the day or at night, examine the concept of adult day care facilities and instances in foreign countries, and study the status of the adult day care facilities located in Gyeonggi-do, their services, and safety by figuring out space arrangement based on program implementation. Spacial arrangement in program operation should satisfy fuction and purpose from the manager and user's perspective, and a desirable program operation should provide separate spaces for the elderly with Alzheimer's and those without Alzheimer's. Compared to residential care facilities, adult day care facilities incur less financial burden and, compared to other authorized services, have many right functions that can upgrade the quality of users and satisfy their desires. Major countries like Japan, the UK, and Sweden recognize the right functions of day and night care services and aggressively support and utilize adult day care facilities. For adult day care facilities, quality services should be developed and use and choices should be enhanced as regards services. Development of special programs for the elderly with dementia and stroke, instead of simple protective functions of a program, must be actively promoted, while manpower training is required for program operation, conveniences, and safety. By developing and providing space arrangement models that focus on efficiency, convenience, and safety of program operation, adult day care operation can be revitalized, while quality of elderly care may be enhanced and welfare budget can be saved.

• 보존과학회지
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• 제8권1호
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• pp.51-57
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• 1999

경북 안동시 정상동에서 발굴된 1560년대의 이명정과 그의 부인 일선 문씨의 시신이 바로 옆에 매장되었음에도 불구하고 부패정도가 큰 차이를 보이고 있는데, 그 원인을 공학적 측면에서 규명하였다. 연구지역 주변은 상당한 심도가지 잘 발달된 마사토 지반으로 인해 배수성이 우수하기 때문에 시신이 부패되지 않는 하나의 요인이 된 것으로 판단된다. 두시신의 부패에 영향을 미치는 수분 및 공기 침투에 대한 방벽역할을 했을 것으로 판단되는 회곽물질을 대상으로 물리적 특성을 조사한 결과, 온전한 상태로 보존된 일선 문씨 시신 주변 회곽물질이 이명정 시신 주변 회곽물질보다 상대적으로 더 치밀하게 밀집된 구조로 밝혀졌으며, 이것은 주변 수분 및 공기로부터 시신을 밀폐시키는 정도가 훨씬 더 탁월했다는 구체적 증거가 된다. 비슷한 시기에 동일한 장소에 매장된 두 시신 주변의 회곽물질의 특성 차이를 유발시키는 원인을 규명하기 위해 두 회곽물질 내 함유된 광물분석을 실시한 결과 두 시료 내에 함유된 광물이 상이하였다. 이것은 두 회곽시료의 구성물질이 상이했음을 말해주며, 광물학적 관점에서 상대적으로 방해석을 더 많이 함유하면서 석고도 포함된 일선 문씨 시신 주변 회곽물질이 밀폐환경 조성에 더 용이했을 것으로 판단된다.

• 대순사상논총
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• 제42집
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• pp.143-165
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• 2022

이 연구는 그동안 고전문학에서도 시도되지 않았던 여성 한시와 대순사상의 융합 연구이자, 대순사상 분야에서도 시도되지 않았던 여성 한시와 대순사상의 융합 연구이다. 대순진리회에서 중요한 해원 사상을 고전 작품을 통해 밝혀보고자 하는 시도였다. 대순사상의 출현과도 시대적 맥락을 같이 하는 20세기 초의 최송설당(崔松雪堂)의 한시 작품을, 여성 해원이라는 틀 위에서 '평(平)'과 '화(和)'의 개념으로 분석하여, 가화(家和)와 상생(相生)으로 나아가는 지점을 찾고자 했다. <왕소군의 원망(昭君怨)>, <자술(自述)>, <송설당원운(松雪堂原韻)> 등과 같은 작품에서 여자로서의 한(恨)이 표현되었다. <정월 초하루(元朝祝)>, <우음(偶吟)> 등과 같은 작품에서는 가족의 평안을 바라는 내용을 표현하고 있었다. 송설당은 가정의 '원(寃)'을 풀기 위해 노력하는 과정에서 남자가 되지 못한 '한(恨)'을 느끼며 한계에 부딪히기도 하였지만, 가화(家和)를 이루기 위해 '평(平)'과 '화(和)'를 중요하게 여기며 평생을 노력해온 것으로 보인다. 이 논문은 문학과 사상의 융합이라는 학문적 확장의 측면에서 중요한 의미가 있을 것으로 판단된다. 대순사상의 측면에서도 사상 자체에만 몰두한 연구에서 나아가 사상과 문학을 융합적으로 살펴봄으로써, 전통시대의 삶과 문화 속에서도 대순사상의 면모를 확인할 수 있고, 이것이 고전에서 현대에 이르는 여전히 현재적인 의미를 지니고 있다는 것을 밝힐 수 있는 의의가 있을 것이다.

• 한국학교보건학회지
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• 제11권1호
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• pp.27-50
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• 1998

Adolescent health is considered to contribute to health promotion in the home and community in the near future as well as individual health. However, adolescent health has been neglected from education field because of competitive school education focused on the university entrance examination That's why I suggest in this study that we should pay much more attention to adolescent health condition and try to make It better, in terms of man-power development and life-health promotion for nation development The purposes of this study are as follows First, to look into a variety of adolescent health problems Second, to find out the situation and problems of current adolescent health promotion and school health education Third, to make an effort to find, based on the current situation, various developments of adolescent health promotion and school health education in terms of practical, political and environmental change There are used study methods as adolescent-related, school heath-related literature review and anlysis of statistical data The results and suggestions are as follows Teenagers have a great variey of health problems including most Important physical, mental and social developments Recently, chronic diseases, emotional problems, health-risk behaviors linked With adolescents are on increase The complicated disorders of physical, mental, social health rather than paricular aspects of health or health-behavior problems influence adolescent health problems adolescence is regarded as the period when most health-related behaviors are formed. Therefore, adolescent health promotion would he assured by developing the ability of controlling multi-dimensional health determinants in the early stage. Health promotion is a positive concept that each individual, family and community makes real efforts to improve their health To achive this, we need health educational, organizational, political and environmental supports. Adolescent health promotion in Korea has been systematically treated in the category of school health Current school health services have had lots of systemic, constitutional, administrative and educational flaws Accordingly, I'm concerned that we can afford to accept a variety of adolescent health needs However, I would say that if were not to make those flaws better, it's certain that Korean national competitive power and the quality of the lives of most Koreans Will he threatened someday We have to develop Comprehensive School Health Crriculum(CSHC) and set up its standards to Improve adolescent health. CSHC is an organizational and costant process. CSHC means an Important part of overall curriculums. In addition, I could say that it's an Important school health education acivity including current school health services-health care service and school health environment. In conclusion, in order to develop CSHC, we require school nurse's role changes, establishment and management of intergrated subject of health education, striking revision of school health law(or legislation of school health promotion law), reorganization of administration system, big changes in curriculum for school health educators.

• 여성건강간호학회지
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• 제5권1호
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• pp.133-145
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• 1999

The purposesof the study are to analyze the community nursing center in U.S.A and to develop the model of nursing care system based on nurse-midwifery clinic in community for women's health in Korea. 1. In America nursing center is defined as nurse-anchored system of primary care delivery or neighborhood health center. Nursing centers are identified the following four types: (1) community outreach centers, which are similar to traditional public health clinics: (2) institutional-based centers following the mission of a large institution, such as a hospital or university: (3) wellness/health promotion centers, which offer screening, education, counseling, triage, and health maintenance services: and (4) independent practice. Nursing centers are a concept of services provided by nurses in practice arrangements in a community. Nursing centers offer a variety of services, ranging from primary care provided by advanced practice nurses with medical acute management and nursing care to the more traditional education, health promotion, screening wellness and coordination services. Some services, such as the care provided by advanced practice nurses are reimbursed under various insurance plan in some instances and states, where as others, such as preventive and educational services, are not. Thus, lack of reimbursement has threatened the survival of some centers. Licensing of nursing centers varies by state and program and accreditation of nursing centers is also limited. 52% of centers are affiliated with another facility and 48% are freestanding centers. The number of registered nurse at the nursing centers ranges from just one to 115, with a mean of eight RNs peragency and a median of three. Nursing centers avail ability varies: 14% are open 24 hours, 27% have variable short hours, 23% are open 6-7 days per week, and 36% are open Monday- Friday. As the result of my visiting three health centers in Seattle and San Francisco, the women's primary care nurse practitioners focus on a systematic and comprehensive assessment of the health status of women and diagnosis and management of common physical and psychosocial health concerns of women in ambulatory settings. Therapeutic nursing strategies are directed toward self-care, risk reoduction, health surveillance, stress reduction, healthy nutrition, social support, healthy coping, psychological well-being, and pharmacological therapy. They function as primary care providers for the well ness and illness care of women from adolescence through the older adult years and pregnant families. 2. In Korea a nurse-midwife practices independently for pregnant women's health including childbearing family at her own clinic in community. Her services are reimbursed under national health insurance but they are not paid on a fee-for-service schedule covering items. Analyzing the nursing centers in America, I suggest that nurse-midwifery clinics offer primary care for women and home care for chronic ill patients. The health law and health insurance policy should be reovised in order to expand nurse-midwife's and home care nurse's roles at nurse-midwifery clinic.