• Journal of Pharmaceutical Investigation
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• v.39 no.1
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• pp.37-41
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• 2009

The purpose of this study was to compare the efficacy of Lorelin Depot $Injection^{(R)}$ (Dongkook Pharm. Co., LTD) with Lucrin Depot $Injection^{(R)}$ (Abbott) by measuring serum testosterone level in rats. Leuprorelin (leuprolide acetate), which is an active compound for the two formulations, is an LHRH analogue that is used for the treatment of a wide range of sex hormone-related disorders including advanced prostatic cancer, endometriosis and precocious puberty. Lorelin Depot $Injection^{(R)}$ is a micro-encapsulated formulation to suppress testosterone level by releasing leuprorelin continuously for four weeks with a single subcutaneous injection. The comparison study of the efficacy was performed during four weeks, and serum testosterone levels were monitored in the two formulations. The mean serum testosterone levels from the formulations were decreased to that of the castrate range (50 ng/dL or less) after three days after the initial depot injection, and the concentration were remained throughout four weeks' period. There were no significant differences in the $AUC_{0-3day}$ of testosterone and testosterone levels at 3, 7, 14, 21 and 28 days between the two formulations. These results indicate that the two formulations, Lorelin Depot $Injection^{(R)}$ and Lucrin Depot $Injection^{(R)}$, are bioequivalent in terms of the serum testosterone level in rats.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2004.11a
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• pp.526-530
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• 2004

The portion of plant industry has increased within construction market. In spite of plant industry is dynamic field which leads state-of-the-art and creates a value, phased information management and knowledge intensive business accomplishment are insufficient. Henceforth plant is expected to demand increment of industrial project from hereafter international plant industry market. The continuous plan technique and know-how accumulation are urgent from domestic. 1'his research analyzes the areas in which domestic plant industry is insufficient and then elicits project management key success factors from current operation process. In addition, this research compares domestic plant level with overseas plant level. This study establishes work models for critical work phases based on the analysis of domestic plant technical level.

• The Korean Journal of Emergency Medical Services
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• v.10 no.3
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• pp.61-70
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• 2006

Purpose: The purpose of this study is to develop a realistic illustration using watercolors on a complete airway obstruction maneuver that is at an appropriate level for elementary school students from the first grade through the third. The illustration is a series of cuts divided into specific frames designed to illustrate the method to be followed in an action or a practical skill that would otherwise be too difficult to explain in written form. Methods: The fundamental theory of the Jeong In-Sung's instruction learning program based on the WEB to construct an appropriate site of instruction learning was used after modification. In this study analysis, design, and production stages were realized. Results: 1. In Stage 1, impressions of the illustration, in sketch form, were received. In Stage 2, results of impressions from a modified illustration were received. After an appropriate level of understanding and accuracy in the practical steps for emergency maneuvers were achieved the illustrations entering Stage 3 and color was added to the sketches. 2. In Stage 3, the illustration was completed by adding color to the contents for the practical steps in the complete airway obstruction maneuver. 3. For composition evaluation, a result of 100% appropriateness was obtained for both items of harmony between illustration and subject being studied and sufficiency in quantity of illustrations. Also high results for appropriateness in items such as clarity, creating interest, illustration size, and tone preference as related to content were achieved and thus completed the production stages. Conclusion: The Complete Airway Obstruction Maneuver Illustration developed specifically for the characteristics and cognitive level of elementary school students grade 1 through grade 3 was appropriate for teaching and learning. There is a need for future research on developed illustrations aimed at elementary school students grade 1 through 3 on the complete airway obstruction maneuver. There is also a need for continued effort in developing certified evaluating tools that can judge the suitability of illustrations and developing illustrations related to emergency maneuvers for various subjects and appropriate for learner level.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2003.05a
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• pp.312-319
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• 2003

In late 90s, organizations recognized the information technology as an key enabler of the business strategic accomplishment which lead them heavy increment on IT investment. These organizations tried to hold the competitive advantage by focusing on their core competency. And these acts raise their interests on IT outsourcing. Recent trends of the organizations concern on evaluating the effectiveness of the previous IT investment and the reasonable selection on IT investment type. Also, the objective evaluation of the service level and continuous improvement are major concern of the outsourcer. Consequently, interests on Service Level Agreement (SLA), an immanence operating tool for managing the level of the information system service objectively and qualitatively, were raised among IT outsourcing service providers, outsourcers, and operating departments. Yet, only a few domestic conglomerates adopted the SLA, and exact usage of the SLA is currently unknown. Because of the importance of the SLA between a service provider and an outsourcer, the agreement is treated with high confidentiality. This raised the problems to both the private and public organizations, are considering the SLA, with absence of concrete guide line to internalize SLA management process. This study provides the organizational and environmental factors of the adopting and applying the Service Level Agreement (SLA) by conducting multiple case research. The sampled companies are currently implementing the SLA over 1 year of usage period. Factors were used to provide the operational contribution for implementing the SLA. The study also provides the effects on IT performance through the SLA. For this, in depth interview was conducted for each sampled company. As a result, if SLA between outsourcer and service provider can be used as an immanence operation tool and actively implemented, SLA will be an strategic tool for various decision making in IT management practice with long term relationship, better shared partnership, and continuous service improvement.

• Journal of the Korea institute for structural maintenance and inspection
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• v.9 no.1
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• pp.197-204
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• 2005

Multipurpose Floor Level Joint(MFLJ) is a new construction technology system which was developed in domestic. By using this system, it is possible not only to absorb the deformation at expansion joint due to shrinkages of concrete but also to make ease the floor leveling during the concrete casting at floor. The system consists of two elements, supporting devices and rails. Their structural capacities were verified through several experimental programs, such as compressive strength test of support and bending test of rail. The purpose of this paper is to evaluate the deformation absorbing capacity of the floor level joint. An experimental work was carried out to simulate the deformation condition at the joint and the test result was analyzed and evaluated. In addition, FEM analysis for expansion joint of typical building was also performed to predict the real behavior of MFLJ. The test results showed that MFLJ has sufficient deformation capacity required to act as expansion joint.

• Journal of the Korea Society of Computer and Information
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• v.19 no.2
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• pp.209-219
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• 2014

With rapid convergence of information technology and expending role of software, many organizations have taken interested in We explore the relationship between the level of change awareness and deployment of software process improvement (SPI) approaches using a competing values framework. To measure awareness level of organization's change, DICE framework which provides means for predicting the outcome of change management initiatives is used. The four factors for organizaton's change: duration, integrity, commitment, and effort are evaluated and a score is calculated. In this paper, we apply the DICE(R) score as an independent variable to predict the outcome of a software process improvement. Our results indicated that the Organization have a higher chance of success have the better outcome in software process improvement.

• Korean Journal of Health Education and Promotion
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• v.25 no.1
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• pp.13-23
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• 2008

Objective: The current study was to test if the developed sphygmomanometer was working well and blood pressure information could be collected and monitored systematically through the internet. We tested if the sphygmomanometer and services for blood pressure controlled high blood pressure significantly and the ubiquitous monitoring could be used further. Methods: Kyungwon University, KT Co., Gil Medical Center, LIG Nex1 Co., and Sujeong Health Center conducted an ubiquitous high blood control project in Sujeong-gu, Sungnam, Korea from Mar. 5 to May 16. We developed and applied sphygmomanometer. We distributed the devices to 27 high blood pressure patients. The blood pressures of the residents were monitored through the internet when they measured blood pressures in their homes. A nurse monitored and consulted their blood pressures in the monitoring center in Kyungwon University during the demonstration period. The consultant called them and consulted on their blood pressures in few seconds they used the sphygmomanometers. For the significance of change in blood pressure, we tested statistically with Generalized Additive Model(GAM) and Multi-level Analysis. Results: Both GAM and Multi-level Analysis showed that the blood pressures of persons with ubiquitous blood pressure management decreased significantly as time passed. Conclusions: The internet monitoring and services are considered to be promising because most of the participants were satisfied especially because somebody was caring their health. The decrease of blood pressures was significant by GAM and Multi-level Analysis. Thus, we can apply ubiquitous blood pressure management to health promotion projects.

• The Journal of the Korea Contents Association
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• v.19 no.9
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• pp.11-25
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• 2019

In Korea, there is a high demand for the operation of differentiated programs in basic research considering the characteristics of academic fields. The results of this study shows that the higher the level of research competence, the higher the quality of research outputs. The results also tell us that the quality level of the research outputs is different according to the field of study. Based on the results, we propose a method to differentiate the selection rate of each discipline in the system that operates the individual basic research projects by the level of research capacity.

• Journal of the Korea Society of Computer and Information
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• v.27 no.5
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• pp.181-188
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• 2022

In this paper, we proposed of the results of the noise level and appropriate conversation distance by applying the noise characteristics generated during treatment at a dental clinic to the NR-curve and PSIL. As a result of analyzing the noise characteristics during treatment at a dental clinic, it was analyzed that the noise level exceeded 60dB(A), which is the health preservation limit value caused by noise, and the noise level increased as the frequency increased. the result of evaluation applying it to the NR curve, some treatment exceeded the workplace noise standard, and as a result of analyzing the level of conversational disturbance between the worker and the patient, it is desirable to have the conversation at a distance of less than 1M for accurate communication. In order to improve the quality of medical service in dental clinic and to reduce dental fear, it is judged that soundproofing protective equipment is provided to workers, and soundproofing measures are needed for noise sources (treatment devices used in treatment) and sound sources (patients and workers).

• Korean Journal of Food Science and Technology
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• v.45 no.6
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• pp.693-699
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• 2013

A simple, sensitive, and specific method for quantifying the nicotine content of synthetic favoring substances (SFS) was developed using high performance liquid chromatography (HPLC) with a photo-diode array detector (PDA). Nicotine was extracted from SFS samples by using an acid-base liquid-liquid extraction method with dichloromethane and distilled water. The nicotine content was quantified by HPLC/PDA (261.9 nm) with a $C_{18}$ column under a gradient of 10% acetonitrile with 20 mM ammonium formate (ammonia solution adjusted to pH 8.7) to 100% acetonitrile. The calibration curve, analyzed from concentration standards between 0.1 to 2 mg/L, presented linearity with a correlation coefficient ($r^2$)>0.9999. The limit of quantitation (LOQ) of nicotine in SFS was 0.4 mg/kg, and the average recoveries ranged from 76.4% to 96.3%. The repeatability of measurements, expressed as the coefficient of variation (CV%), ranged from 1.74 to 5.12%. This newly developed method for nicotine quantification in SFS can be considered an analytical method with an acceptable level of sensitivity and repeatability.