• Title/Summary/Keyword: syntheses

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Sodium Chloride Regulation of $\alpha$ENaC, ET-1, and COX-2 Genes: A Possible Implication of Hypertension (고혈압 관련 측면에서의 alphaENaC, ET-1, cox-2 유전자의 소금에 의한 조절 기전)

  • Lee, Young-Joo
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 2003.04a
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    • pp.113-130
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    • 2003
  • 1. We have established a model system to study sodium chloride, an environmental factor, induced gene regulations. 2. ${\alpha}$ENaC, cox-2, and c-fos genes are regulated by sodium chloride at mRNA level as well as at protein level. 3. Regulation of ${\alpha}$ENaC requires syntheses of new protein(s). 4. COX-2 may have a important role for homeostasis in hypertonic situation.

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A Study on Roll Stability of Di-Urea Greases (Oi-Urea 그리이스의 알킬기 변화에 따른 Roll Stability에 과한 연구)

  • 조원오;김영운;정근우;이기헌
    • Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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    • 1999.11a
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    • pp.247-256
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    • 1999
  • This paper describes the results of analysis, syntheses and Roll Stability of various Di-urea greases. Di-urea greases were synthesized by reaction of 4,4'-Methylenebis(phenyl isocyanate) and various amines, such as cyclohexylamine, octylamine, stearylamine and p-toluidine with base oil at 80-180 $^{\circ}C$. The synthesized di-urea greases were analyzed by FT-R spectroscopy. The Roll Stability of synthesized di-urea greases was evaluated.

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Studies on the Syntheses of Orotic Acid Dervatives I. Synthesis of Orotyl-$_{DL}$-alanine and Orotyl-$_{L}$-tyrosine. (Orotic Acid 유도체의 합성에 관한 연구(I) Orotyl-$_{DL}$-alanine 및 Orotyl-$_{L}$-tyrosine의 합성)

  • 변온성;채동규
    • YAKHAK HOEJI
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    • v.8 no.2
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    • pp.45-47
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    • 1964
  • Two new orotic acid derivatives orotyl-DL-alanine and orotyl-L-tyrosine were synthesized. They were obtained as high melting crystalline masses by condensing DL-alanine and L-tyrosine each with orotyl chloride in aqueous sodium hydroxide solution, followed by acidifying the reaction mixture.

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Synthesis of Novel Carboacyclic Nucleosides with Vinyl Bromide Moiety as Open-chain Analogues of Neplanocin A

  • Choi, Myung-Hee;Kim, Hee-Doo
    • Archives of Pharmacal Research
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    • v.26 no.12
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    • pp.990-996
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    • 2003
  • A novel carboacyclic nucleoside analogue, 9-[2-bromo-4-hydroxy-3-hydroxymethyl-2-butenyl] adenine, and its derivatives were designed and synthesized as open-chain analogues of neplanocin A. The syntheses were accomplished via the coupling of adenine or pyrimidine bases to the key intermediate allylic bromide 7. The bromide 7 was prepared from epichlorohydrin in a seven step process in a 54% overall yield. The synthesized compounds were evaluated for their antiviral activity against the polio virus, HSV and HIV.