Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Sodium Chloride Regulation of $\alpha$ENaC, ET-1, and COX-2 Genes: A Possible Implication of Hypertension

고혈압 관련 측면에서의 alphaENaC, ET-1, cox-2 유전자의 소금에 의한 조절 기전

  • Lee, Young-Joo (Sejong University, Department of Bioscience and Biotechnology)
  • Published : 2003.04.01
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Abstract

1. We have established a model system to study sodium chloride, an environmental factor, induced gene regulations. 2. ${\alpha}$ENaC, cox-2, and c-fos genes are regulated by sodium chloride at mRNA level as well as at protein level. 3. Regulation of ${\alpha}$ENaC requires syntheses of new protein(s). 4. COX-2 may have a important role for homeostasis in hypertonic situation.

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