• 대한임상검사과학회지
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• 제41권3호
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• pp.111-122
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• 2009

Cadmium (Cd) is known to exert gonadotoxic and spermiotoxic effects. The present study was performed to investigate the morphological effects and metallothionein (MT) expression by zinc pretreatment in the course of time of cadmium-induced testicular injury in rat. Fifty male Spraque-Dawley rats weighing 160~180 g were divided into two groups : saline-pretreated cadmium group and zinc-pretreated cadmium group. Rats of two groups received subcutaneous injection of saline and 100 mg/kg $ZnSO_4$ at 0, 2, 5 and 8 hrs intervals respectively. Cadmium chloride (4.5 mg/kg $CdCl_2$) was administrated intraperitoneally at 2 hrs after zinc injection and rats were killed 0, 12, 24, 48 and 72 hrs later. Testicular tissue damages, interstitial (Leydig) cells status and MT expression were determined using hematoxylin-eosin stained sections and a computerized image analysis system on sections immunostained with a mouse anti-metallothionein respectively. Zinc pretreatment was significantly reduced testicular damages in five pathological categories after cadmium administation. The number of surviving interstitial cells was significantly higher in the zinc-pretreated group than in the saline-preatreated group at 48 and 72 hrs after cadmium administration. Non-damaged testis showed the positivity of MT staining in spermatogenic cells, Sertoli cells and endothelium of blood vessel, but not in the Leydig cells. The positivity of MT staining in saline-pretreated group was significantly reduced at 24 hrs after cadmium administration, whereas zinc-pretreated group showed strong MT positive staining similar to the 0 hr by 42 hrs after cadmium administration. In damaged testis, MT positive staining was also observed in the Leydig cells of both groups. These results suggest that a major preventive effect of zinc against cadmium-induced testicular toxicity may be due to its ability to reduce the cytotoxicity of cadmium in spermatogenic cells and Leydig cells by inhibiting the susceptibility of the testis to cadmium but not MT production by cadmium.

• 한국자기학회지
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• 제19권6호
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• pp.197-202
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• 2009

코닝유리(Corning glass) 기판 위에 이온빔 증착법으로 제작한 버퍼(Ta)/코네틱(Conetic; NiFeCuMo) 박막에 대해 버퍼층에 의존하는 결정성장과 열처리 효과를 조사하였다. 또한 코네틱층을 증착할 때에 인가한 자기장 방향으로 용이축과 곤란축의 자기저항 곡선으로부터 얻은 보자력과 포화자기장값을 버퍼층 유무에 따라 서로 비교하였다. Ta 박막의 두께가 5 nm이고 코네틱 박막의 두께가 50 nm일 때에 보자력은 0.12 Oe으로 작았으며, MH 히스테리시스 곡선에서 얻은 자화율($\chi$)은 1.2 ${\times}\;10^4$으로 우수한 연자성의 특성을 가졌다. 저자기장에 민감한 거대자기저항 스핀밸브(GMR-SV; giant magneoresistance-spin valve)나 자기터널링접합(MTJ; megnetic tunnel junction) 박막구조에서 자유층으로 연자성의 특성이 우수한 코네틱 박막을 사용할 수 있는 가능성을 확인하였다.

• 대한간호학회지
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• 제26권3호
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• pp.632-652
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• 1996

It has been noted that a genetic alteration of cells influenced by unhealthy lifestyle in addition to a series of other carcinogens increases the incidence of various neoplasmic diseases. Therefore the importance of a lifestyle that minimizes such an impact on health should be emphasized. Since stomach cancer, the most common neoplasmic disease in Korea, is related to personal lifestyle and as there is a possibility of its recurrence, patients with stomach cancer need to lead a healthy lifestyle. Also the quality of life which patients experience is negatively affected by the side effects of treatments and the possibility of recurrence. Therefore an effective nursing intervention to enhance quality of life and encourage healthy lifestyle is needed. The purpose of this study is to provide a basis for nursing intervention strategies to promote health and thus enhance quality of life. A hypothetical model for this purpose was constructed based on Pender's Health Promotion Model and Becker's Health Belief Model, with the inclusion of some influential factors such as hope for quality of life and health promoting behavior. The aims of study were to : 1) evaluate the effectiveness of patient's cognitive-perceptual factors on health promoting behaviors and quality of life ; 2) examine the causal relationships among perceived benefit, perceived barrier, perceived susceptibility and severity, internal locus of control, perceived health status, hope, health concept, self efficacy, self esteem health promoting behaviors & quality of life ; 3) build and test a global hypothetical model. The subjects for this study were 164 patients who were being treated for stomach cancer were approached in the outpatient clinic on a University Hospital. The data from the completed questionnaires were analyzed using Linear Structural Relationships (LISREL). The results of research are as follows : 1) Hypothetical model and the modified model showed a good fit to the empirical data, revealing considerable explanational power for health promoting behaviors(54.9%) and quality of life(87.6%) 2) Self efficacy and hope had significant effects on health promoting behaviors. Of these, hope was affected indirectly through self efficacy and self esteem. 3) Perceived health status, hope and self esteem had significant direct effect on the quality of life. Of these variables, perceived health status was the most essential factor affecting general satisfaction in life. 4) Self-efficacy, as a mediating variable, was positively affected by perceived benefit and hope. 5) Self-esteem, as a mediating variable, was positively affected by perceived health status and hope. 6) Hope was the main variable affecting self efficacy, self esteem, health promoting behaviors and quality of life. The derived model in this study could effectively be used as a reference model for further study and could suggests a direction for nursing practices

• Tuberculosis and Respiratory Diseases
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• 제83권3호
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• pp.218-227
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• 2020

Background: The national Public-Private Mix (PPM) tuberculosis (TB) control project provides for the comprehensive management of TB patients at private hospitals in South Korea. Surveillance and monitoring of TB under the PPM project are essential toward achieving TB elimination goals. Methods: TB is a nationally notifiable disease in South Korea and is monitored using the surveillance system. The Korea Centers for Disease Control and Prevention quarterly generates monitoring indicators for TB management, used to evaluate activities of the PPM hospitals by the central steering committee of the national PPM TB control project. Based on the notification date, TB patients at PPM hospitals were enrolled in each quarter, forming a cohort, and followed up for at least 12 months to identify treatment outcomes. This report analyzed the dataset of cohorts the first quarter of 2016 through the fourth quarter of 2017. Results: The coverage of sputum, smear, and culture tests among the pulmonary TB cases were 92.8% and 91.5%, respectively. The percentage of positive sputum smear and culture test results were 30.7% and 61.5%, respectively. The coverage of drug susceptibility tests among the culture-confirmed cases was 92.8%. The treatment success rate among the smear-positive drug-susceptible cases was 83.2%. The coverage of latent TB infection treatment among the childhood TB contacts was significantly higher than that among the adult contacts (85.6% vs. 56.0%, p=0.001). Conclusion: This is the first official report to analyze monitoring indicators, describing the current status of the national PPM TB control project. To sustain its effect, strengthening the monitoring and evaluation systems is essential.

• 대한화학회지
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• 제54권5호
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• pp.515-522
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• 2010

o-phenylene diamines, dehydroacetic acid (DHA) 및 p-chloro benzaldehyde에서 유도된 세자리 Schiff 염기 리간드인 4-hydroxy-3(1-{2-(benzylideneamino)-phenylimino}-ethyl)-6-methyl-2H-pyran-2-one (HL)의 Cu(II), Ni(II), Co(II), Mn(II) 및 Fe(III) 착물의 형성상수와 항미생물 활성과의 관계를 연구하였다.리간드와 착물은 원소분석, 전도도, 자기수자율, 열분석, X-선 회절, IR, $^1H$-NMR, UV-vis 및 질량 스펙트럼으로 특성조사를 하였다. 분석데이터로부터 착물들의 화학량론비가 1:2 (금속:리간드)임을 알았다. 금속 착물들의 몰 전도도 값은 이들의 비전해질 성질을 의미한다. X-선 회절 데이터에서 Ni(II) 착물은 단사정계 그리고 Cu(II) 및 Co(II) 착물은 삼사정계 결정계임을 규명하였다. IR 스펙트럼 데이터로부터 리간드는 중심금속에 대해 ONN 주개원자 배열의 세자리 리간드로 행동함을 알았다. 열적 행동 (TG/DTA)과 Coats-Redfern 법에 의해 계산한 반응속도 파라메터는 착물형성 과정에서 좀 더 질서 있는 활성화 상태를 제안하고 있다. 착물의 양성자화 상수를 THF:물 (60:40) 용액, $25^{\circ}C$ 및 이온세기 ${\mu}=0.1\;M$ ($NaClO_4$)에서 전위차법으로 측정하였다. Staphylococcus aureu 및 Escherichia coli.에 대한 항박테리아 활성을 시험관에서 조사하였다. 또한 Aspergillus Niger 및 Trichoderma에 대한 항세균 활성도 조사하였다. 금속 이온 및 착물의 안정도가 항미생물학적 활성에 미치는 영향을 고찰하였다.

• Journal of Yeungnam Medical Science
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• 제8권1호
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• pp.53-62
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• 1991

인체 혈청에서 추출 정제된 ImmunoglobulinG(IgG)가 임상 병소 분리 녹농균(Ps. aeruginosa) 감염증에 대한 quinolone제제 ciprofloxacin(CPFX)과의 병용 및 단독 투여에 의한 항균효과를 생체감염과 시험관내 실험을 통하여 다음과 같이 요약하였다. 녹농균의 마우스 복강내 감염 후에 마우스 생존율에 의한 항균효과를 IgG 단독 투여군, IgG전 처치후 CPFX 투여군, IgG와 CPFX 동시 투여군 및 CPFX 단독 투여군 순이였다. 녹농균 감염 마우스에서 IgG 단독 투여군에서의 혈액 및 간장내의 생균수는 대조군에 비해 혈액내 균수의 증가는 완만하였으나, 간장내의 균수는 양군 모두 급격한 증가를 나타내었다. PMNL수의 추이는 CPFX 단독 투여군을 제외한 IgG투여군은 감염 후 8시간에 PMNL수가 증가 되었으며, 균 접종 전 IgG투여와 접종 후 IgG투여에 의한 유의적인 차이가 없었다. CPFX의 Ps. aeruginosa에 대한 시험관내 최소 발육 억제 농도는 IgG의 병용 투여에 상관없이 $250{\mu}g/ml$의 높은 내성을 나타내었다. 시험관내에서의 IgG의 직접적 항균작용은 인정되지 않았다.

• 대한임상검사과학회지
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• 제42권3호
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• pp.136-148
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• 2010

Cadmium (Cd) is known to exert gonadotoxic and spermiotoxic effects. The present study was performed to investigate the morphological effects and metallothionein (MT) expression by zinc pretreatment in the course of time of cadmium-induced testicular injury in rat. Fifty male Spraque-Dawley rats weighing 160-180 g were divided into two groups: saline-pretreated cadmium group and zinc-pretreated cadmium group. Rats of two groups received subcutaneous injection of saline and 100 mg/kg $ZnSO_4$ at 0, 2, 5 and 8 hrs intervals respectively. Cadmium chloride (4.5 mg/kg $CdCl_2$) was administrated intraperitoneally at 2 hr after zinc injection and rats were killed 0, 12, 24, 48 and 72 hrs later. Testicular tissue damages, Interstitial (Leydig) cells status and MT expression were determined using hematoxylin-eosin stained sections and a computerized image analysis system on sections immunostained with a mouse anti-metallothionein respectively. Zinc pretreatment was significantly reduced testicular damages in five pathological categories after cadmium administation. The number of surviving interstitial cells was significantly higher in the zinc-pretreated group than in the saline-preatreated group at 48 and 72 hrs after cadmium administration. Non-damaged testis showed the positivity of MT staining in spermatogenic cells, Sertoli cells and endothelium of blood vessel, but not in the Leydig cells. The potitivity of MT staining in saline-pretreated group was significantly reduced at 24 hrs after cadmium administration, whereas zinc-pretreated group showed strong MT positive staining similar to the 0 hr by 42 hrs after cadmium administration. In damaged testis, MT positive staining was also observed in the Leydig cells of both groups. These results suggest a major preventive effect of zinc against cadmium-induced testiculat toxicity may be due to its ability to reduce the cytotoxicity of cadmium in spermatogenic cells and Leydig cells by inhibiting the susceptibility of the testis to cadmium but not MT production by cadmium.

• 보건교육건강증진학회지
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• 제18권1호
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• pp.61-78
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• 2001

The purpose of this research was to find out plans to promote the fulfillment of the breast self-examination and breast cancer screening, which is preventive health behavior about women's having breast cancer exam in some part of our country with searching for the primary causes which have an effect on their fulfillment. The subjects of the study were 540 literate volunteers who were of age from 20 to 69 and who visited 8 health centers in Taegu. The survey research was made through questionares in the 8 health centers in Taegu from the 15th to the 30th of September, 1998. Based on Becker's health belief model asking medical staff's opinions with bibliographies, the major findings from the survey was as follow. The fulfillment rate of the breast self-examination and the breast cancer screening was 37.8％(204 subjects), 27.6％ (149 subjects) each. Getting breast self-exam varied significantly depending on subject's age, income of family, religion, occupation and the number of children. As far as the breast cancer screening was concerned, there was remarkably significant difference in accordance with their age, marital status, religion, occupation, income of family, the number of children, ways of nursing and parturition age of the first baby. The subjects in their forties accounted for the highest rate. Based on the fulfillment of the breast self-examination and the breast cancer screening, the average points of all the variables presented from the health belief as well as the points of the susceptibility, seriousness, benefits, knowledge and level of health concern of interest in health were significantly higher than the points of non-fulfillment of them in the statistical analysis whereas the barriers was lower than them. In consequence of the multiple-logistic regression analysis putting the breast self-examination and the breast cancer screening in dependent variables, occupation, knowledge, seriousness, benefits, barriers and cues to action had significant effects on breast self-examination against breast cancer. Looking more attainments, thinking diseases more seriously, feeling more usefulness and there being any patient around with breast cancer led to the higher rate of the breast self-examination against it. On the other hand, feeling more impedition as well as housewives caused the lower rate of it. The breast cancer screening was significantly affected by age, sensitivity, usefulness, impedition and behavior momentum as well. The cases who are older, feeling more sensitivity against breast cancer, more usefulness of the examination and where any patient around, the fulfillment rate was higher. Contrarily the more impedition they felt, the lower the fulfillment rate was. Accordingly, the study of the causes, which have significant effects on the fulfillment of the self-examination and the breast cancer screening in order to find it in an early stage, and the development of health education programs as well as proper education for public health through carrying on campaigns and stepping up public relations must be indispensable.

• 한국발생생물학회지:발생과생식
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• 제10권4호
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• pp.247-254
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• 2006

내분비 교란물질들이 연안 어류의 정상적인 성적 발달을 위협할 수 있다는 사실은 잘 알려져 있지만, 해산 어종에 대한 이러한 위협을 파악하는 데 이용할 수 있는 적절한 시험 어종은 아직 개발되지 못했다. 그 이유 중의 하나는 성분화 초기에 어류의 생식소가 외형으로나 조직학적으로 암수 구분이 불분명한 경우가 많기 때문이다. 본 연구에서는 조피 볼락 Sebastes schlegeli의 자연 성비, 생식소 구조, 그리고 외인성 성스테로이드 호르몬에 의한 성분화 교란 여부 등을 조사하여 이 종이 시험 어종으로 개발될 수 있는 지를 조사하였다. 1년생 조피볼락 240마리의 생식소를 조사한 결과, 이들의 성비(암수 비율)는 통계학적으로 1:1을 벗어나지 않았으며, 암컷은 유백색의 두터운 생식소를, 수컷은 검은색의 가느다란 생식소를 가지고 있었다. 성분화 시기의 조피볼락 치어를 $estradiol-17\;{\beta}(E_2)$ 또는 $17\;{\alpha}-methyltestosterone$ (MT)으로 처리하여 성분화 교란 여부를 조사한 결과, $E_2$ 처리는 93%의 암컷 유도율을 보였으나, MT 처리의 경우 수컷은 53%였고, 38%가 암수의 생식소 구조를 모두 갖는 intersex로 나타났다. 본 연구에 의하면 조피볼락은 미성숙 시기에도 암수 생식소의 형태가 뚜렷이 다르고, 외인성 성스테로이드 호르몬에 의해 뚜렷한 성분화 교란 현상이 초래되어 시험 어종으로 개발될 수 있는 가능성 있다.

• 한국학교보건학회지
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• 제13권1호
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• pp.117-129
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• 2000

The relationships between children's health behavior and variables that effect children's health behavior has been investigated in a number of previous studies. This study was conducted to examine the effects of a peer's social reinforcement on children's dental health behavior in an elementary school. The research design was a nonequivalent pre and post-test quasi-experimental design and the study subjects with one hundred and thirteen eight to nine years old children, and their mothers (57 experimental group, 56 control group) were selected as a study group. Subjects were selected by the convenience sampling method. The study was carried out in an elementary school in Namwon city, Korea, from the 26th of April to the 12th of June in 1999. Data were collected in both the pre and post-test portions. Using the "Health Belief Model", each item of the questionnaire for measurement of dental health behavior was modified and administered for the children and their mothers. The questionnaire for the measurement of dental health behavior was developed by Oh, Y.B.(1994). The Cronbach's ${\alpha}$ of the questionnaire for children were .81, and for the mother were .79. In this study, the health belief model consists of "perceived susceptibility", "perceived seriousness", "perceived barrier", "perceived salience", and "perceived benefit". The questionnaire for the children was composed of 37 items, and the questionnaire for the mother was composed of 40 items. Data were analyzed by frequency, ${\chi}^2-test$, ANOVA, Pearson's Correlation, and multiple regression analysis by a SAS program. The results of this study were summarized as follows ; 1. The first hypothesis that the experimental group would have more change in the frequency of brushing per week than that of control group was accepted(t=3.817, p=0.000). Mean tooth brushing scores in the experimental group improved significantly from pre-test to post-test, but in the control group there was no significant improvement in tooth brushing scores. 2. The second hypothesis that the experimental group would have more change in score of dental health behavior than that of control group was accepted(benefit : t=2.804, p=0.006, salience: t=2.608, p=0,010). An evaluation between the experimental group and the control group showed significant change from pre-test to post-test in health behavior scores. 3. The third hypothesis that higher scores of social reinforcement would create more change in the scores of tooth brushing frequency in the experimental group was accepted(${\beta}$=0.169, p=0.000. Multiple regression was used to examine the peer's social reinforcement scores and the relative influence of significant variables in previous ANOVA and Pearson's correlation test on children's frequency of brushing during the post-test. The results of the study indicated that the combination of social reinforcement of peers with variables pertaining to mother and householder were significantly related and effectively improved a child's tooth brushing.