• Nuclear Medicine and Molecular Imaging
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• v.40 no.5
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• pp.237-242
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• 2006

Knowledge of molecular mechanisms governing malignant transformation brings new opportunities for therapeutic intervention against cancer using novel approaches. One of them is gene therapy based on the transfer of genetic material to an organism with the aim of correcting a disease. The application of gene therapy to the cancer treatment has led to the development of new experimental approaches such as suicidal gene therapy, inhibition of oncogenes and restoration of tumor-suppressor genes. Suicidal gene therapy is based on the expression in tumor cells of a gene encoding an enzyme that converts a prodrug into a toxic product. Representative suicidal genes are Herpes simplex virus type 1 thymidine kinase (HSV1-tk) and cytosine deaminase (CD). Especially, physicians and scientists of nuclear medicine field take an interest In suicidal gene therapy because they can monitor the location and magnitude, and duration of expression of HSV1-tk and CD by PET scanner.

• Journal of Korea Entertainment Industry Association
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• v.14 no.5
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• pp.193-205
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• 2020

The purpose of this study was to look into how social support for high school students was affecting suicidal ideation and verify how the moderating effect worked on risk factors in the relationship between social support and suicidal ideation. Specifically, three sub-factors of social support were classified into friend support, teacher support, and parent support, and were set as independent variables. In addition, suicidal ideation was dependent variables, gender, grade level, and school type as moderating variables. The main research results are as follows. First, teacher support, friend support, and parent support all appeared to have a significant negative effect on suicidal ideation. Second, the suicidal thoughts were higher in female students than in male students than in male students and in students of general high school than in those of vocational high school. Third, support from friends and parents was more effects in reducing suicidal thoughts for female students than male students. Fourth, the effect that teacher support that support and parent support reduce suicidal thoughts was greater for first graders than second graders. Bases on the results of the analysis, interviews were also conducted with high school teachers. Through the results of this study, I would like to propose practical measures to alleviate social problems related to suicide in high school students and to provide basic data for policy measures.

• Journal of Convergence for Information Technology
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• v.8 no.2
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• pp.1-9
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• 2018

This study describes predictive factors for elderly suicidal ideation by analyzing the survey data from 359 people who were over 65 years old in Daegu, Korea. The mean score of social support(3.35), self-esteem(3.38), depression(8.64) and suicidal ideation(1.65) of elderly residence. Social support, self-esteem and suicidal ideation had negative correlation. Depression and suicidal ideation had positive correlation. Suicidal ideation was significantly different according to age, education, spouse, living arrangement, type of medical guarantee, pocket money, past job, leisure(time), health status, number of chronic disease, smoking. Others support, self-esteem, pocket money, education, age were influencing factors of suicidal ideation(48.2%). Among them, 41.8% of others support was.

• Journal of Korean Public Health Nursing
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• v.25 no.2
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• pp.276-288
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• 2011

Purpose: The rate of suicide is rising most rapidly among high school students. Teenage suicide is no longer just a personal problem. This study investigated and classified high school students concerning in South Korea with an aim of identifying suicidal ideation and types of teenage suicide. Method: A Q-methodology was used to identify factors in suicidal attitude of high school students. A Q-sample was collected from in-depth and objective interviews and literature reviews. A P-sample consisted of 37 high school students : selected Q-samples were sorted on a 9-point scale. Results: Three types of suicidal attitudes were evident among high school students : abomination(Type 1), understanding of the situation (type 2), and social responsibility(type 3). Conclusion: Precautionary measures against high school students suicide should be formulated according to the types of attitudes toward suicide in south Korea.

• Journal of Korean Academy of Nursing
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• v.45 no.2
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• pp.183-191
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• 2015

Purpose: For the current article an examination was done as to whether engaging in sexual intercourse before or during adolescence has a negative impact on the suicidal behaviors of suicide ideation, suicide attempt, and suicide lethality and whether the impact varies according to the context of sexual intercourse and/or gender. Methods: Adolescents who experienced casual sex and romantic sex were compared to adolescents who retained their virginity. Data was from samples drawn from the three waves (2010~2012) of the Korea Youth Risk Behavior Web-Based Survey. Logistic models were used to adjust for a wide array of confounding variables. Results: Any type of sexual intercourse increases risk of all suicidal behaviors. Sexual intercourse in a romantic relationship exhibits enhanced risk of suicidal behaviors compared to casual sex. Adjusting for experience of sexual violence, however, decreases risk of romantic sex substantially, turning some estimates statistically insignificant. In addition, risks for suicide lethality are greater for girls than boys. Conclusion: Romantic sex put adolescents at higher risk for suicidal behaviors than casual sex owing to prevalent sexual violence in the relationships. Girls suffer more substantively adverse outcomes than boys. These results suggest that adolescents will benefit from comprehensive education on sexuality and sexual behaviors regarding how to form and maintain a romantic relationship that is characterized by personal integrity and mutual respect. It is also important to help victims of sexual violence recover from traumatic events by providing emotional support and effective counseling.

• Research in Community and Public Health Nursing
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• v.17 no.1
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• pp.112-124
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• 2006

Purpose: This study was carried out to investigate the relationships among suicidal risk, self-esteem, and spiritual well-being of high school students, and to provide basic data for developing suicide prevention programs. Method: The subjects of this study were 1.176 high school students from six academic high schools and two technical high schools in Daegu City. Data were collected from the 13th to the 25th of September 2004. The research tools were the Suicide Probability Scale developed by Go. Kim and Lee (2000), the Self-Esteem Inventory modified by Choi and Jeon (1993), and the tool of Spiritual Well-Being modified by Yoo (2002). Data were analyzed with SPSS Windows 11.0. Result: Variables that showed statistically significant difference in suicidal risk were school type, whether to have the best friends, the number of close friends, current relationship with close friends, experience of school violation, respect for the teacher, grades, financial condition, parents marital status, father's education level, mother's education level, home atmosphere, conversation with father, conversation with mother, smoking, drinking, experience of counseling for problems, whether to have physical illnesses, experience of thinking about suicide, experience of attempting suicide. Suicidal risk was in a significantly negative correlation with self-esteem and spiritual well-being. Conclusion: The researcher identified many different variables that affect the suicidal risk of high school students. Self-esteem and spiritual well-being were found to be in a significant correlation with suicidal risk. Therefore, the results of this study can be used as basic data and information for suicidal prevention programs.

• Korean Journal of Culture and Social Issue
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• v.12 no.2
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• pp.1-19
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• 2006

There are less studies on the elderly suicide even though it's steep increase. The purpose of the present study was to investigate factors that influence on the elderly suicide and to categorize them. For these purpose, A total of 23 cases were analyzed through qualitative contents analysis. Specifically, on the basis of the stress-vulnerability model, we scrutinized vulnerability factors(classified personal, family-environment factors) and precipitating events(classified interpersonal events) influencing on the elderly suicide. Personal factor was to be classified into personal mental health, physical health and problematic behavior. Family-environment factor was divided family relationship problem and economic problem. Interpersonal events belonging to the precipitating events was to be classified into interpersonal loss and interpersonal conflict. As the results of this study, elderly suicide classified into 3 types, that is, 'risk type suicide', 'event-response type suicide', 'complex type'. And then we discussed the characteristics of the suicidal types and suggestions for reduction of elderly suicide.

• Korean Journal of Culture and Social Issue
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• v.12 no.1
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• pp.15-33
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• 2006

There are less studies on the adult suicide even though it's steep increase and negative effect on person itself, family and society. The purpose of the present study was to investigate factors that influence on the adult suicide and to categorize it. Using a case-study approach, a total of 61 cases were analyzed. Specifically, on the basis of the stress-vulnerability model, I scrutinized vulnerability factors(classified personal, family-environment, and social-environment factors) and precipitating events(classified personal, interpersonal events) influencing on the adult suicide. As the results of this study, adult suicide classified into 3 types, that is, 'risk type suicide', 'event-response type suicide', 'complex type'. And then I discussed the characteristics of the suicidal types and the method for reduction of adult suicide.

• Journal of Oriental Neuropsychiatry
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• v.26 no.1
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• pp.39-48
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• 2015

Objectives: This study was conducted to analyze the hwa-byung, self-perceived health, life-stress, social support, depression, and factors affecting on suicidal ideation in community dwelling elders. Methods: This study was a cross-sectional descriptive study. The subjects were 165 elderly in I city. The data was collected from November $21^{st}$ to December $5^{th}$ of 2014 by using structured questionnaire. T-test, Pearson's correlation coefficients, and stepwise multiple regression were performed by SPSS/PC 17.0. Results: There were more females than males in hwa-byung (t=.-3.068, p=.003). In the visit parent, more than once a month was a significantly higher in social support (t=.3.333, p=.001). Hwa-byung (t=.-2.577, p=.011), life-stress (t=.-3.800, p=.001), depression (t=.-2.776, p=.006), and suicidal ideation (t=.-4.316, p<.001) were shown to be high in the elders with lower level of living. Subjects with health insurance had high self-perceived health (t=-3.800, p=.001) and low hwa-byung (t=-4.102, p<.001), life-stress (t=-4.482, p<.001), depression (t=-5.296, p<.001), and suicidal ideation (t=.-2.152, p=.036), according to the type of insurance. In the correlation, sleeping hours (r=-.180, p=.020), self-perceived health (r=-.364, p,.001), and suicidal ideation had negative correlation; hwa-byung (r=.404, p<.001), life-stress (r=.300, p<.001), social support (r=-.310, p<.001), depression (r=.423, p<.001) and suicidal ideation had positive correlation. Factors affecting the suicidal ideation in community dwelling elders were depression (${\beta}$=.42, p<.001), hwa-byung (${\beta}$=.23, p=.004), social support (${\beta}$=-.18, p=.012), and level of living (${\beta}$=.24, p=.001). Discussion: For the prevention of elderly suicide, it is necessary to care for psychosocial status and solve economic difficulties through social support.

• Journal of Digital Convergence
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• v.19 no.12
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• pp.541-548
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• 2021

This study analyzed the path through which elderly discrimination experience, sense of loss, and depression lead to suicidal ideation by verifying the influence of elderly discrimination experience on suicidal ideation and the mediating effect sense of loss and depression. The subjects of the study were a 1:1 in-depth interview survey of 400 elderly people aged 65 or older using stratified sampling methods by region and type of 31 city, county, and district the elderly welfare welfare centers(10 locations) in Gyeonggi-do. As a result, a total of 360 samples were finally analyzed. It was verified through frequency analysis, descriptive statistics analysis, correlation analysis, structural equation and bootstrapping analysis methods using SPSS 25.0 and AMOS 23.0. As a result of the study, first, it was found that the more the elderly experienced discrimination, the higher the suicidal ideation. Second, the effect of sense of loss was partially mediated on the effect of discrimination experience on suicidal ideation in the elderly. Third, the feeling of depression was found to play a partial mediating role between the experience of discrimination among the elderly and suicidal ideation. Based on the results of this study, policy and practical suggestions were made to alleviate the suicidal ideation of experiences of discrimination against the elderly and sense of loss and depression to prevent suicide among the elderly.