• Title/Summary/Keyword: sub G1 phase

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Role of RUNX Family Members in G1 Restriction-Point Regulation

  • Lee, Jung-Won;Bae, Suk-Chul
    • Molecules and Cells
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    • v.43 no.2
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    • pp.182-187
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    • 2020
  • When cells are stimulated by growth factors, they make a critical choice in early G1 phase: proceed forward to S phase, remain in G1, or revert to G0 phase. Once the critical decision is made, cells execute a fixed program independently of extracellular signals. The specific stage at which the critical decision is made is called the restriction point or R-point. The existence of the R-point raises a major question: what is the nature of the molecular machinery that decides whether or not a cell in G1 will continue to advance through the cell cycle or exit from the cell cycle? The R-point program is perturbed in nearly all cancer cells. Therefore, exploring the nature of the R-point decision-making machinery will provide insight into how cells consult extracellular signals and intracellular status to make an appropriate R-point decision, as well into the development of cancers. Recent studies have shown that expression of a number of immediate early genes is associated with the R-point decision, and that the decision-making program constitutes an oncogene surveillance mechanism. In this review, we briefly summarize recent findings regarding the mechanisms underlying the context-dependent R-point decision.

Calcium chloride is a better calcium source rather than calcium carbonate for weanling pigs

  • JunYoung, Mun;ChangBeon, Lee;Abdolreza, Hosseindoust;SangHun, Ha;Habeeb, Tajudeen;JinSoo, Kim
    • Journal of Animal Science and Technology
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    • v.64 no.5
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    • pp.871-884
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    • 2022
  • Two experiments were conducted to evaluate the effects of calcium (Ca) levels in weanling pigs (Landrace × Yorkshire × Duroc). In experiment 1, one hundred and eighty weanling pigs were randomly allotted to one of the three treatments. The treatments were low (Ca 0.60% in phase 1 and 0.50% in phase 2), standard (Ca 0.72% in phase 1 and 0.66% in phase 2), and high (Ca 0.84% in phase 1 and 0.72% in phase 2). In experiment 2, hundred and forty weanling pigs were randomly assigned to one of four treatments differing in Ca levels (high and low) and sources (CaCl2 and CaCO3) in a 2 × 2 factorial arrangement. There were 10 pigs per replicate in both experiments, with 6 replicates in each treatment, and they were conducted in two phases (phase 1, days 0-14; phase 2, days 15-28). In experiment 1, body weight (BW), average daily gain (ADG), and growth to feed ratio (G/F) increased as the Ca level decreased (p < 0.05). P digestibility was higher in the low-Ca diet group than in the high-Ca diet group (p <0.05). In experiment 2, the final BW, ADG, and G/F increased in the CaCl2 diet group compared with the case in the CaCO3 diet group (p < 0.05). The digestibility of crude protein (CP), Ca, and P was higher in the CaCl2 diet group than in the CaCO3 diet group (p < 0.05). Cl- levels were higher in the CaCl2 diet group than in the CaCO3 diet group (p < 0.05). The bicarbonate (HCO3-), base excess (BE), and electrolyte balance (EB) levels were lower in the CaCl2 diet group than in the CaCO3 diet group (p < 0.05). Hematocrit increased as the Ca level decreased (p < 0.05). The HCO3- interacted with the Ca sources and thus, affected the Ca levels (p < 0.05). Bone ash, Ca, and P were downregulated in the low-Ca diet group compared with the case in the high-Ca diet group. Overall, the low dietary Ca supplementation led to greater growth performance. Furthermore, CaCl2 appeared to be a better Ca source than CaCO3 because of the greater digestibility of CP, Ca, and P, and improved EB.

Existence of a vortex-glass phase transition in an optimally doped BaFe1.8Co0.2As2 single crystal

  • Choi, Ki-Young;Kim, Kee Hoon
    • Progress in Superconductivity and Cryogenics
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    • v.15 no.2
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    • pp.16-19
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    • 2013
  • The magneto-resistivity and electric field-current density (E-J) curves were investigated up to a magnetic field 9 T in the optimally doped $BaFe_{1.8}Co_{0.2}As_2$ single crystal with a superconducting temperature ($T_c$) of 24.6 K. The E-J Scaling behaviors below and above vortex glass transition temperature ($T_g$) were found, confirming the existence of the vortex glass phase transition. The critical exponents for the diverging spatial and time correlations at $T_g$, were obtained as v = $1.1{\pm}0.1$ and z = $4.5{\pm}0.3$, respectively. The obtained critical exponents are in good agreement with the predicted values of v ~ 1 - 2 and z > 4 within the 3D vortex glass theory.

Impacts of the calcination temperature on the structural and radiation shielding properties of the NASICON compound synthesized from zircon minerals

  • Islam G. Alhindawy;Hany Gamal;Aljawhara.H. Almuqrin;M.I. Sayyed;K.A. Mahmoud
    • Nuclear Engineering and Technology
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    • v.55 no.5
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    • pp.1885-1891
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    • 2023
  • The present work aims to fabricate Na1+xZr2SixP3-xO12 compound at various calcination temperatures based on the zircon mineral. The fabricated compound was calcinated at 250, 500, and 1000℃. The effect of calcination temperature on the structure, crystal phase, and radiation shielding properties was studied for the fabricated compound. The X-ray diffraction diffractometer demonstrates that, the monoclinic crystal phase appeared at a calcination temperature of 250℃ and 500℃ is totally transformed to a high-symmetry hexagonal crystal phase under a calcination temperature of 1000℃. The radiation shielding capacity was also qualified for the fabricated compounds using the Monte Carlo N-Particle transport code in the g-photons energy interval between 15keV and 122keV. The impacts of calcination temperature on the g-ray shielding behavior were clarified in the present study, where the linear attenuation coefficient was enhanced by 218% at energy of 122keV, when the calcination temperature increased from 250 to 1000℃, respectively.

Study on self-diffusion transport phenomena during mercurous bromide (Hg2Br2) vapor processes (브로민화수은(I)(Hg2Br2) 증착공정에서 자체확산 연구)

  • Nam Il Kim;Geug Tae Kim
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.34 no.2
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    • pp.48-54
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    • 2024
  • During the Hg2Br2 physical vapor transport process with self-diffusion, it is concluded that for 10-3g0≤ g ≤ 1g0 the thermal buoyancy driven convection is dominant in the vapor phase; at the gravitational level of g = 10-4g0, the transition region from the convection to diffusion occurs; for 10-6g0 ≤ g ≤ 10-5g0, the diffusion mode is predominant. The total molar flux of Hg2Br2 decays exponentially with the decreasing of one tenth of gravitational magnitude. For 10℃ ≤ ΔT ≤ 50℃, the total molar flux increases linearly and directly with the temperature difference between the source and crystal regions.

Phase Formation and Proton Conduction of La0.6Ba0.4In1-yMyO3-δ(M=Ga3+ , Sc3+, Yb3+) System (La0.6Ba0.4In1-yMyO3-δ(M=Ga3+ , Sc3+, Yb3+)계 조성의 상생성과 Proton 전도)

  • Kim, Hye-Lim;Kim, Shin;Lee, Hong-Lim
    • Journal of the Korean Ceramic Society
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    • v.39 no.6
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    • pp.610-615
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    • 2002
  • Phase formation and proton conduction of L $a_{0.6}$B $a_{0.4}$I $n_{1-y}$ $M_{y}$ $O_{3-{\delta}}$(M=G $a^{3+}$, S $c^{3+}$, Y $b^{3+}$) system were studied. A cubic perovskite structure with a single phase was formed in all of the compositions of this work except for the composition off=G $a^{3+}$ with y=0.5, viz,L $a_{0.6}$B $a_{0.4}$I $n_{1-y}$G $a_{0.5}$ $O_{3-{\delta}}$ For the compositions of M=S $c^{3+}$and Y $b^{3+}$with y=0.25, proton conduction occurred in wet $N_2$ atmosphere(P $h_{H_2O}$=6.1hPa).X>/=6.1hPa).Pa).

PEDOT:PSS Enhanced Electrochemical Capacitive Performance of Graphene-Templated δ-MnO2

  • Sinan, Neriman;Unur, Ece
    • Journal of Electrochemical Science and Technology
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    • v.11 no.1
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    • pp.50-59
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    • 2020
  • Birnessite-type manganese dioxide (δ-MnO2) with hierarchical micro-/mesoporosity was synthesized via sacrificial graphene template approach under mild hydrothermal conditions for the first time. Graphene template was obtained by a surfactant (cetyltrimethylammonium bromide, CTAB) assisted liquid phase exfoliation (LPE) in water. A thin PEDOT:PSS (poly (3,4-ethylene dioxythiophene): poly (styrene sulfonate)) layer was applied to improve electrical conductivity and rate capability of MnO2. The MnO2 (535 F g-1 at 1 A g-1 and 45 F g-1 at 10 A g-1) and MnO2/PEDOT:PSS nanocomposite (550 F g-1 at 1 A g-1 and 141 F g-1 at 10 A g-1) delivered electrochemical performances superior to their previously reported counterparts. An asymmetric supercapacitor, composed of MnO2/PEDOT:PSS (positive) and Fe3O4/Carbon (negative) electrodes, provided a maximum specific energy of 18 Wh kg-1 and a maximum specific power of 4.5 kW kg-1 (ΔV= 2 V, 1M Na2SO4) with 85% capacitance retention after 1000 cycles. The graphene-templated MnO2/PEDOT:PSS nanocomposite obtained by a simple and green approach promises for future energy storage applications with its remarkable capacitance, rate performance and cycling stability

Hydrogen Prodution by Sulfur Thermochemical Water Splitting Cycle: Part 1. H2O-SO2-I2 Reaction and Separation (황 - 요오드의 열화학적 물분리에 의한 수소제조연구 Part I. 물-이산화황-요오드 반응 및 분리)

  • Lee, K.I.;Min, B.T.;Kwon, S.G.;Kang, Y.H.
    • Transactions of the Korean hydrogen and new energy society
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    • v.1 no.1
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    • pp.40-47
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    • 1989
  • The sulfur-iodine thermochemical water splitting process of GA(General atomic) cycle was studied to produce hydrogen from water by $H_2-I_2-SO_2$ reactions. The experimental scale was 500g based on iodine. The reaction took 100 minutes, products could be separated two liquid phases due to their density difference:HI solution had a density of 2.39~2.61g/cc, and $H_2SO_4$ solution had 1.37~1.38g/cc. The condition of reaction was when weight ratio of $I_2/H_2O$ was 2/1 resulting in good phase separation and productivity.

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Effects of Solutally Dominant Convection on Physical Vapor Transport for a Mixture of Hg2Br2 and Br2 under Microgravity Environments

  • Kim, Geug-Tae;Kwon, Moo Hyun
    • Korean Chemical Engineering Research
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    • v.52 no.1
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    • pp.75-80
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    • 2014
  • The convective flow structures in the vapor phase on earth are shown to be single unicellular, indicating the solutally dominant convection is important. These findings reflect that the total molar fluxes show asymmetrical patterns in a viewpoint of interfacial distributions. With decreasing the gravitational level form $1g_0$ down to $1.0{\times}10^{-4}g_0$, the total molar fluxes decay first order exponentially. It is also found that the total molar fluxes decay first order exponentially with increasing the partial pressure of component B, PB (Torr) form 5 Torr up to 400 Torr. Under microgravity environments less than $1g_0$, a diffusive-convection mode is dominant and, results in much uniformity in front of the crystal regions in comparisons with a normal gravity acceleration of $1g_0$.

STUDY OF MAGNETISM IN THE LAYERED TRANSITION METAL COMPOUND ${(C_{n}H_{2n+1}NH_{3})}_{2}CuCl_{4}\;(n=10,\;14)$

  • Lee, C.H.;Lee, K.W.;Lee, Cheol-Eui;Kang, J.K.
    • Journal of the Korean Magnetics Society
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    • v.5 no.5
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    • pp.358-361
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    • 1995
  • We have investigated the quasi-two-dimensional magnetism for the layered transition metal compound (C/sub n/H/sub 2n+1/NH/sub 3/)/sub 2/CuCl/sub 4/ (n=10, 14) in the high temperature regions by means of EPR (Electron Paramagnetic Resonance) and SQUID measurements. As a result, the magnetic transitions were reflected in the EPR linewidths and the magnetic suceptibilities in a sensitive manner. Fluctuations of the magnetic susceptibility and a similar variation of the .DELTA. g =(g/sub .parallel. -/g/sub .perp. /)g/sub .parallel. / value were also observed around the structural phase transition temperatures.

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