• Title/Summary/Keyword: structured

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Multiple hTAFII31-binding motifs in the intrinsically unfolded transcriptional activation domain of VP16

  • Kim, Do-Hyoung;Lee, Si-Hyung;Nam, Ki-Hoon;Chi, Seung-Wook;Chang, Ik-Soo;Han, Kyou-Hoon
    • BMB Reports
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    • v.42 no.7
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    • pp.411-417
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    • 2009
  • Transcriptional activation domain (TAD) in virion protein 16 (VP16) of herpes simplex virus does not have any globular structure, yet exhibits a potent transcriptional activity. In order to probe the structural basis for the transcriptional activity of VP16 TAD, we have used NMR spectroscopy to investigate its detailed structural features. Results show that an unbound VP16 TAD is not merely "unstructured" but contains four short motifs (residues 424-433, 442-446, 465-467 and 472-479) with transient structural order. Pre-structured motifs in other intrinsically unfolded proteins (IUPs) were shown to be critically involved in target protein binding. The 472-479 motif was previously shown to bind to $hTAF_{II}31$, whereas the $hTAF_{II}31$-binding ability of other motifs found in this study has not been addressed. The VP16 TAD represents another IUP whose pre-structured motifs mediate promiscuous binding to various target proteins.

Robust Nonlinear $H_2$/$H_{\infty}$Control for a Parallel Inverted Pendulum (병렬형 역진자와 비선형 $H_2$/H_{\infty}강인제어)

  • Han, Seong-Ik;Kim, Jong-Sik
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.24 no.4 s.175
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    • pp.1065-1074
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    • 2000
  • A robust nonlinear $H_2$/$H_{\infty}$ control method for a parallel inverted pendulum with structured perturbation and dry friction is proposed. By the random input describing function techniques, the nonlinear dry friction is approximated into the quasi-linear system. Introducing the quadratic robustness theorem, the robust $H_2$/$H_{\infty}$ control system is constructed for the quasi-linear perturbed system. But it is difficult to design a controller due to the nonlinear correction term in Riccati equation. With some transformations on the Riccati equation containing nonlinear correction term, the design of the robust nonlinear controller can be done easily. Hence when the stiffness and mass of the parallel inverted pendulum vary in certain ranges, the proposed control scheme has the robustness for both the structured perturbation and dry friction. The results of computer simulation show the effectiveness of our proposed control method.

Warpage Simulation by the CTE mismatch in Blanket Structured Wafer Level 3D packaging

  • Kim, Seong Keol;Jang, Chong-Min;Hwang, Jung-Min;Park, Man-Chul
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.22 no.1
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    • pp.168-172
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    • 2013
  • In 3D wafer-stacking technology, one of the major issues is wafer warpage. Especially, The important reason of warpage has been known due to CTE(Coefficient of Thermal Expansion) mismatch between materials. It was too hard to choose how to make the FE model for blanket structured wafer level 3D packaging, because the thickness of each layer in wafer level 3D packaging was too small (micro meter or nano meter scale) comparing with diameter of wafer (6 or 8 inches). In this study, the FE model using the shell element was selected and simulated by the ANSYS WorkBench to investigate effects of the CTE on the warpage. To verify the FE model, it was compared by experimental results.

Investigation into Characteristics of Bending Stiffness and Failure for ISB Panel (ISB 판넬의 굽힘강성 및 파손특성에 관한 연구)

  • Ahn Dong-Gyu;Lee Sang-Hoon;Kim Min-Su;Han Gil-Young;Jung Chang-Gyun;Yang Bong-Yol
    • Journal of the Korean Society for Precision Engineering
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    • v.22 no.9 s.174
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    • pp.162-172
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    • 2005
  • The objective of this research works is to investigate into characteristics of bending stiffness and failure for the ISB ultra-lightweight panel with internally structured material. The expanded metal with a crimped pyramid shape and woven metal are employed as an internally structured material. Through three-points bending test, the force-displacement curve and failure shape are obtained to examine the deformation pattern, characteristic data, such as maximum load, displacement at maximum load, etc, and failure pattern of the ISB panel. In addition, the influence of design parameters fur ISB panel on the specific stiffness, the specific stiffness per unit width, failure mode and failure map has been found. Finally, it has been shown that ISB containing expand metal with the crimped pyramidal shape is prefer to that containing woven metal from the view point of optimal design for ISB panel.

Investigation into static and dynamic characteristics of ISB panels with the expanded metal as an internally structured material (익스펜디드 금속을 내부 구조체로 가지는 ISB 판넬의 정적.동적 특성 분석)

  • Ahn D.G.;Lee S.H.;Kim M.S.;Hahn G.Y.;Jung C.G.;Yang D.Y.
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2005.06a
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    • pp.832-835
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    • 2005
  • The objective of this research work is to investigate into static and dynamic characteristics of ISB panels with the expanded metal as an internally structured material. In order to investigate static and dynamic characteristics of ISB panels, several experiments, the tensile test, three-point bending test and impact test, are carried out. From the results of the experiments, the mechanical properties, bending stiffness and impact absorption energy of the ISB panel have been obtained. In addition, it has been shown that the static and dynamic characteristics of ISB panel are highly dependent on the crimping angle of the pyramidal structure for the expanded metal.

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A risk analysis of step-down equity-linked securities based on regime-switching copula

  • Nguyen, Manh Duc;Ko, Bangwon;Kwon, Hyuk-Sung
    • Communications for Statistical Applications and Methods
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    • v.27 no.1
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    • pp.79-95
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    • 2020
  • The globalization of financial markets has broadened investment opportunities. International investors' investment portfolios consist of financial instruments from various countries; consequently, the risks associated with economic dependence among countries should be carefully considered. Step-down equity-linked securities (ELS) are a structured financial product that have recently become popular among Korean investors. Payoffs are based on two or three stock indices from different regions; therefore, dependence between the indices should be reflected in the risk analysis. In this study, we consider a regime-switching copula model to describe the joint behavior of two stock indices- the Eurostoxx50 and the Hang Seng China Enterprises Index (HSCEI). These indices are commonly used as underlying assets of step-down ELS. Using historical data, we analyze the risk associated with step-down ELS through the probabilities of early redemption. A regime-switching copula model can accommodate complicated dependence. Thus, it should be considered in the risk analysis of step-down ELS.

Simulation of Honeycomb-Structured SiC Heating Elements (허니컴 구조 SiC 발열체 성능 평가 시뮬레이션)

  • Lee, Jong-Hyuk;Cho, Youngjae;Kim, Chanyoung;Kwon, Yongwoo;Kong, Young-Min
    • Korean Journal of Materials Research
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    • v.25 no.9
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    • pp.450-454
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    • 2015
  • A simulation method to estimate microstructure dependent material properties and their influence on performance for a honeycomb structured SiC heating element has been established. Electrical and thermal conductivities of a porous SiC sample were calculated by solving a current continuity equation. Then, the results were used as input parameters for a finite element analysis package to predict temperature distribution when the heating element was subjected to a DC bias. Based on the simulation results, a direction of material development for better heating efficiency was found. In addition, a modified metal electrode scheme to decelerate corrosion kinetics was proposed, by which the durability of the water heating system was greatly improved.

MicroPost: The Design of an Efficient Event Notification Architecture for Distributed Social Applications (MicroPost: 분산형 소셜 애플리케이션을 위한 효율적인 이벤트 통지 아키텍처의 설계)

  • Bae, Joon-Hyun;Kim, Sang-Wook
    • 한국HCI학회:학술대회논문집
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    • 2009.02a
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    • pp.232-239
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    • 2009
  • Emerging social networking services provide a new paradigm for human-to-human communication. However, these services are centralized and managed by single service provider. In this paper, we propose MicroPost, a decentralized event notification service architecture for social applications based on publish/subscribe model. In our design space, event brokers are structured as an overlay network which provides the substrate of distributed peer-to-peer lookup service for storing and retrieving subscriptions with hashed keys. Event clients interact with event brokers to publish or subscribe social messages over the wide-area network. Using XML standards, we present an efficient algorithm to forward events for rendezvous-based matching in this paper. In our design space, the cost of routing is O(${\omega}log_kN$), where N is the number of event brokers, ${\omega}$ is the number of meta-data obtained from event messages, and k is a constant, which is selected by our design, to divide the identifier space and to conquer the lookup of given key. Consequently, what we achieved is an asynchronous social messaging service architecture which is decentralized, efficient, scalable, and flexible.

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A Unified Design Methodology Development For XML Application based on Relational Database using UML Class (UML 클래스를 이용한, 관계형 데이터베이스 기반의 XML 응용을 위한 통합 설계 방법론 개발)

  • 방승윤;주경수
    • The Journal of Society for e-Business Studies
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    • v.8 no.1
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    • pp.85-102
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    • 2003
  • Nowadays an information exchange on XML such as B2B electronic commerce is spreading. Therefore the systematic and stable management mechanism for storing the exchanged information is needed. For this goal there are many research activities for connection between XML application and relational database. But because XML data have hierarchical structures and relational database can store only flat-structured data, we need to make the conversion rule which changes the hierarchical architecture to 2-dimensional information. Accordingly the modeling methodology for storing each structured information in relational database is needed. In this paper, we introduce a XML modeling methodology to design W3C XML schema using UML and we propose a unified design methodology for relational database schema to store XML data efficiently in relational databases. In the second place, in order to verify objectivity of a unified design methodology. By the way of Ronald Bourret, First we introduce the method of the transformation from XML schema to object model and second we translate object model into relational database schema. Therefore we show the mutual consistency between those consequence, and so can verify a unified design methodology.

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Fuzzy Cognitive Map-Based Simulation Framework for Supporting Electronic Commerce

  • Lee, Kun-Chang;Kwon, Soon-Jae
    • Proceedings of the Korea Society for Industrial Systems Conference
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    • 1999.12a
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    • pp.557-575
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    • 1999
  • As the Internet has been used widely in modern firms for gaining competitive advantage in the market, EC (Electronic Commerce) emerged as one of strong alternatives for this purpose. Many researchers and practitioners have proposed a wide variety of EC frameworks that can consider only the structured conditions, but there exists no EC mechanism in which engaged entities can take into account the various unstructured conditions. With the conventional EC framework, the structured EC conditions such as price, quantity, delivery date, etc. can be fully negotiated during the EC process. However, no studies have been conducted on the issue of incorporating those unstructured conditions which are difficult to represent in an explicit form and therefore hard to consider explicitly during the EC process. They are characterized by causal properties. This means that we should have a new EC mechanism which is capable of dealing with causal knowledge. In this sense, we propose a FCM (Fuzzy Cognitive Map)-based simulation framework for EC to resolve the problem of considering the unstructured conditions during the EC process. We experimented our prototype with several illustrative examples and proved that our approach is robust and meaningful.

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